• KSII Transactions on Internet and Information Systems (TIIS)
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• 제8권11호
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• pp.3916-3936
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• 2014

Smartphone applications like games, image processing, e-commerce and social networking are gaining exponential growth, with the ubiquity of cellular services. This demands increased computational power and storage from mobile devices with a sufficiently high bandwidth for mobile internet service. But mobile nodes are highly constrained in the processing and storage, along with the battery power, which further restrains their dependability. Adopting the unlimited storage and computing power offered by cloud servers, it is possible to overcome and turn these issues into a favorable opportunity for the growth of mobile cloud computing. As the mobile internet data traffic is predicted to grow at the rate of around 65 percent yearly, even advanced services like 3G and 4G for mobile communication will fail to accommodate such exponential growth of data. On the other hand, developers extend popular applications with high end graphics leading to smart phones, manufactured with multicore processors and graphics processing units making them unaffordable. Therefore, to address the need of resource constrained mobile nodes and bandwidth constrained cellular networks, the computations can be migrated to resourceful servers connected to cloud. The server now acts as a bridge that should enable the participating mobile nodes to offload their computations through Wi-Fi directly to the virtualized server. Our proposed model enables an on-demand service offloading with a decision support system that identifies the capabilities of the client's hardware and software resources in judging the requirements for offloading. Further, the node's location, context and security capabilities are estimated to facilitate adaptive migration.

• Journal of Medicine and Life Science
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• 제15권2호
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• pp.67-71
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• 2018

Neuronal excitotoxicity induces mitochondrial dysfunction and the release of proapoptotic proteins. Excitotoxicity, the process by which the overactivation of excitatory neurotransmitter receptors leads to neuronal cell death. Neuronal death by excitotoxicity was related to neuronal degenerative disorders and hypoxia, results from excessive exposure to excitatory neurotransmitters, such as glutamate. Glutamate acts at NMDA receptors in cultured neurons to increase the intracellular free calcium concentration. Therefore endogenous glutamate may be a key factor to regulate neuronal cell death via activating $Ca^{2+}$ signaling. For this issue, we tested some conditions to alter intracellular $Ca^{2+}$ level in dissociated hippocampal neurons of rats. Cultured hippocampal neuron were treated by KCl (20 mM), $CaCl_2$ (3.8 mM) and glutamate ($5{\mu}M$) for 24 hrs. Interestingly, The Optical Density of hippocampal neurons was increased by high KCl application in MTT assay data. This enhanced response by high KCl was dependent on synaptic $Ca^{2+}$ influx but not on intracellular $Ca^{2+}$ level. However, the number of neurons seemed to be not changed in Hoechst 33342 staining data. These results suggest that enhancement of synaptic activity plays a key role to increase mitochondrial signaling in hippocampal neurons.

• 사회복지연구
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• 제42권3호
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• pp.121-155
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• 2011

본 연구는 교도소와 치료감호소에 수감되어 있는 성폭력 가해자의 경험에 대한 연구로서 이론적으로는 성폭력 가해자의 경험의 본질구조를 살펴보고자 했고 실천적으로는 성폭력 가해자들의 재범을 막고 치료적 감호프로그램을 제공하기 위한 사회복지실천 개입의 근거 자료를 구축하고자 했다. 연구는 Van-Manen(1990)의 분석틀을 원용하여 해석학적 현상학적 방법으로 수행했고 연구에는 7명의 성폭력 가해자가 참여했다. 자료는 심층면담으로 수집했으며 해석한 결과는 다음과 같다. 여론의 피해자라는 인식, 카인의 표식, 견본생활(show window)로 인한 성찰기회의 상실, 구별짓기(distinction)를 통한 집단차별화, 허물을 벗고자 하는 형이상학적 존재의 발현, 과학적 관리기술의 역이용, 상상계(the Imaginary)로부터의 미분화(undifferentiation), 도치된 소통으로 나타난 성행위, 통제받음의 반동형성으로서 지배영역을 찾음, 아동의 성마저 상품화하는 자본주의 속성에서 자유로울 수 없음, 성정체성 사회화과정에서의 왜곡, 억눌린 욕망의 화신으로 각인된 부상, 상실된 어머니의 순결성 회복, 산산이 부서진 이름으로서의 가족 등으로 나타났다.

• 인터넷정보학회논문지
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• 제9권6호
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• pp.1-13
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• 2008

신뢰 컴퓨팅(Trusted Computing)은 하드웨어를 통해 컴퓨터 사용자가 제어할 수 있는 범위 이상에서 보안성을 제공하고, 컴퓨팅 장치에 대한 신뢰를 보장하는 기술을 말한다. 신뢰 컴퓨팅에서 규정한 TPM(Trusted Platform Module)이라는 전용 보안칩은 신뢰성 있는 데이터 저장 및 신뢰성 있는 플랫폼 상태 보고를 가능하게 하는 핵심 장치이다. 데이터 실링은 데이터를 암호화할 때 특정한 플랫폼의 상태와 연관시켜 기존의 암호화를 통한 기밀성 보호를 한층 더 강화한 강력한 보안 기법이다. 데이터 실링에는 이진 해쉬 값 기반의 플랫폼 구성 상태를 직접 활용하는 방식과 플랫폼의 제공 성질(property)을 실링에 활용하는 방식이 있다. 본 논문에서는 Dijkstra가 제안한 최소 전제조건 개념을 이용한 새로운 성질 기반의 데이터 실링 및 해제 프로토콜을 제안한다. 제안하는 프로토콜은 실링 할 때와 동일한 성질에서 실링 해제를 가능하게 하여 정상적 시스템 업데이트 시 실링 해제가 가능하도록 한다. 그러면서 기존 성질 기반 실링 방식의 문제점인 제3자 신뢰 기관의 비현실성 및 플랫폼의 프라이버시 노출 문제를 해결하였다. 본 논문은 제안 프로토콜의 보안성을 분석적으로 제시하였으며, Strasser가 개발한 소프트웨어 TPM 에뮬레이터 환경에서 프로토콜을 구현하여 그 동작성을 실험적으로 입증하였다. 제안 기법은 데스크탑 PC는 물론 무선 이동 네트워크 상의 PDA나 스마트 폰 플랫폼에도 적용 가능하다.

• 한국동물학회:학술대회논문집
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• 한국동물학회 1998년도 한국생물과학협회 학술발표대회
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• pp.360-360
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• 1998

C11, a chloride-containing VK3 analog, acts as a mediator of programmed cell death in SK-Hep-1 cell lines, but its molecular mechanisms linked to cell death are not understood. In this study, we investigated the expression of p21 gene and its relationship to apoptosis induced by C11. In SK -hep-1 cells, the addition of C11 resulted in time-dependent growth suppression and DNA fragmentation characteristics of apoptosis. p21 protein was induced during this process, while the protein level of p53 was not changed at the same condition. This apoptotic cell death with p21 induction was also observed in the Hep3B cells lacking functional p53 after treatment of C11. These results suggest that C11-induced apoptosis is associated with up-regulation of p21 protein in p53-independent pathway. Next, in order to confirm whether the p53-independent p21 induction is required for C11-induced apoptosis, we introduced the p21 gene into Hep3B. Overexpression of p21 did not affect the expression of the bcl-2 gene, but DNA fragmentation and PARa cleavage were significantly increased. These data indicate that p21 is involved in C11-induced apoptosis. Although Bcl-2 has been implicated to interfere with an essential signaling molecule involved in the apoptosis pathway, its molecular mechanism and target molecule are poorly understood. To determine the effects of bcl-2 overexpression on apoptosis and to investigate whether BcI-2 interfers with the p53-independent p21 pathway, we transfected the bcl-2 expression vector into SK - Hep-1 cels. Overexpression of Bcl-2 prevented C11-induced apoptosis. Taken together, C11-induced apoptosis is regulated by p52-independent p21 pathway and bcl-2 may inhibit functional activity of p21, therebe may inhibit the C11-induced apoptosis.ptosis.

• 한국산업보건학회지
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• 제16권1호
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• pp.54-67
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• 2006

This study was performed to deduct the extension possibility of the standards establishment for $NO_2$, $O_3$, Asbestos, Radon, total volatile organic compounds (TVOC) excluded in the indoor air part of Industrial Safety Acts in Korea. The air pollutants were sampled for 30 office buildings from August to September, 2005 in the metropolitan area. The airborne concentrations of $NO_2$, $O_3$, Radon and TVOC were 0.0092 ppm, 0.0035 ppm, 0.57 pCi/L and $423{\mu}g/m^3$, respectively. The management plan and reduction methods is required in the aspect of indoor air quality(IAQ) because the emission sources of those also exist in indoor as well as outdoor even though those were not exceeded the standards of the Ministry of Environment in Korea. The standard for TVOC in the new and remodeling office has to be established based on the risk assessment when hazard index exceeded "1" in the worst case scenario. In the state of art, the management of each volatile organic compounds has a difficulty due to not enough data for toxicological reference. Therefore, it is suggested that first of all, the standard for TVOC be established and then expanded to each materials for decision-making of improvement of IAQ in office.

• Journal of Astronomy and Space Sciences
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• 제19권3호
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• pp.215-224
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• 2002

This paper describes EGSE design for the small satellite such like KOMPSAT-2 satellite. Recent design trend of small satellite and EGSE is to take short development time and less cost. For this purpose, the design for KOMPSAT-2 satellite and EGSE are not much modified from KOMPSAT-1 heritage. It means that it is able to be accommodated the verified hardware and software modules used in KOMPSAT-1 satellite program if possible. The objective of EGSE is to provide hardware and software for efficient electrical testing of integrated KOMPSAT-2 satellite in three general categories. (1) Simulators for ground testing (e.g. solar-simulation power, earth scenes, horizons and sun sensor). (2) Ground station type satellite data acquisition and processing test sets. (3) Overall control of satellite using hardline datum. In KOMPSAT (KOrea Multi-Purpose SATellite) program, KOMPSAT-2 EGSE was developed to support satellite integration and test activities. The KOMPSAT-2 EGSE was designed in parallel with satellite design. Consequently, the KOMPSAT-2 EGSE was based on the KOMPSAT-1 heritage since the spacecraft design followed the heritage. The KOMPSAT-2 baseline was elaborated by taking advantage of experience from KOMPSAT-1 program. The EGSE of KOMPSAT-2 design concept is generic modular design with preference in part selection with commercial off-the-shelf which were proven from KOMPSAT-1 programs, flexible/user friendly operational environment (graphical interface preferred), minimized new design and self test capability.

• Toxicological Research
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• 제33권3호
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• pp.211-218
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• 2017

Cytochrome P450 1B1 (CYP1B1) acts as a hydroxylase for estrogen and activates potential carcinogens. Moreover, its expression in tumor tissues is much higher than that in normal tissues. Despite this association between CYP1B1 and cancer, the detailed molecular mechanism of CYP1B1 on cancer progression in HeLa cells remains unknown. Previous reports indicated that the mRNA expression level of Herc5, an E3 ligase for ISGylation, is promoted by CYP1B1 suppression using specific small interfering RNA, and that ISGylation may be involved in ubiquitination related to ${\beta}-catenin$ degradation. With this background, we investigated the relationships among CYP1B1, Herc5, and ${\beta}-catenin$. RT-PCR and western blot analyses showed that CYP1B1 overexpression induced and CYP1B1 inhibition reduced, respectively, the expression of $Wnt/{\beta}-catenin$ signaling target genes including ${\beta}-catenin$ and cyclin D1. Moreover, HeLa cells were treated with the CYP1B1 inducer $7,12-dimethylbenz[{\alpha}]anthracene$ (DMBA) or the CYP1B1 specific inhibitor, tetramethoxystilbene (TMS) and consequently DMBA increased and TMS decreased ${\beta}-catenin$ and cyclin D1 expression, respectively. To determine the correlation between CYP1B1 expression and ISGylation, the expression of ISG15, a ubiquitin-like protein, was detected following CYP1B1 regulation, which revealed that CYP1B1 may inhibit ISGylation through suppression of ISG15 expression. In addition, the mRNA and protein expression levels of Herc5 were strongly suppressed by CYP1B1. Finally, an immunoprecipitation assay revealed a direct physical interaction between Herc5 and ${\beta}-catenin$ in HeLa cells. In conclusion, these data suggest that CYP1B1 may activate $Wnt/{\beta}-catenin$ signaling through stabilization of ${\beta}-catenin$ protein from Herc5-mediated ISGylation for proteosomal degradation.

• International Journal of Oral Biology
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• 제38권3호
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• pp.93-100
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• 2013

Bile acids and synthetic bile acid derivatives induce apoptosis in various kinds of cancer cells and thus have anticancer properties. Recently, it has been suggested that autophagy may play an important role in cancer therapy. However, few data are available regarding the role of autophagy in oral cancers and there have been no reports of autophagic cell death in OSCCs (oral squamous cell carcinoma cells) induced by HS-1200, a synthetic bile acid derivative. We thus examine whether HS-1200 modulates autophagy in OSCCs. Our findings indicate that HS-1200 has anticancer effects in OSCCs, and we observed in these cells that autophagic vacuoles were visible by monodansylcadaverine (MDC)and acridine orange staining. When we analyzed HS-1200-treated OSCC cells for the presence of biochemical markers, we observed that this treatment directly affects the conversion of LC-3II, degradation of p62/SQSTM1 and full-length beclin-1, cleavage of ATG5-12 and the activation of caspase. An autophagy inhibitor suppressed HS-1200-induced cell death in OSCCs, confirming that autophagy acts as a pro-death signal in these cells. Furthermore, HS-1200 shows anticancer activity against OSCCs via both autophagy and apoptosis. Our current findings suggest that HS-1200 may potentially contribute to oral cancer treatment and thus provide useful information for the future development of a new therapeutic agent.

• 한국안전학회지
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• 제34권3호
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• pp.83-88
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• 2019

The 7,993 cases of Survey Report of Fatal Industrial Accidents conducted jointly by the MEOL and the KOSHA for the recent seven years(2007-2013) were categorized according to personal and occupational characteristics, industry types, business sizes, job types, activities at the time accident, types of accidents, material agents(assailing materials), unsafe conditions, and unsafe acts. And it is found that among the 72.2 percent of fatal occupational accidents in the construction and manufacturing industries are caused by falling, sticking, bumping and being caught under objects & overturning. For this study, through the empirical analysis on causes of fatal industrial accidents, was used to identity high risk groups based on total data of 7,993 victims of occupational accidents. An annual fatal occupational injury (FOI) rate per 10,000 workers was about 0.47‱. The middle-aged group and the elderly group showed the highest FOI rates per 10,000 workers (0.73‱, 0.80‱), and the daily workers showed the highest FOI rate (1.46‱), and the craft and related trades workers showed the highest FOI rate (2.17‱). In case of industry type the mining industry (7.26‱) showed the highest FOI rate, followed by the sewerage, waste management, materials recovery and remediation activity industry (3.91‱) and the construction industry (2.71‱). The primary high risk target group that requires a strategy designed to reduce fatal occupation injuries caused by falling and bumping & contact(collision) is the construction industry, and the secondary high risk target group in the construction industry is classified as the equipment, machine operating and assembling workers in the construction industry, those aged 50 years old and above need the prevention measures against bumping & contact(collision) and being caught under an object & falling(objects), while those aged less than 50 years old need prevention measures against falling(persons).