• The Journal of Internal Korean Medicine
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• v.42 no.1
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• pp.11-24
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• 2021

Objective: Chronic reflux esophagitis (CRE), characterized by esophageal mucosa ulcer, is caused by continuous backflow of gastric acid and consequent inflammation due to unstable gastroesophageal sphincter. The aim of the present study was to clarify the effect of an Arecae Semen and Coptidis Rhizoma mixture (AC-mix) on CRE. Methods: CRE was surgically induced in SD rats with three experimental groups used: normal; CRE control; and CRE treatment (200 mg/kg AC-mix). Blood and esophageal tissue were collected after two weeks of drug administration. The anti-oxidant activity of the AC-mix was measured by total polyphenol and total flavonoid contents as well as by radical scavenging activity with protein levels evaluated using western blotting. Results: CRE damage to the esophageal mucosa was significantly reduced in the AC-mix group as compared with the controls, and administration of the AC-mix was seen to inhibit NF-κBp65 activity. Consequently, the inactivation of NF-κBp65 significantly inhibited inflammatory mediators such as COX-2 and iNOS. Moreover, the anti-oxidant enzyme HO-1 significantly increased through activation of the Nrf2-Keap1 pathway. Matrix metalloproteinase-2 (MMP-2), which can break down collagen from the basement membrane and extracellular matrix, was decreased following AC-mix treatment, and elevated levels of MMP-2 were regulated by its tissue inhibitor. Conclusions: These results show that AC-mix can alleviate esophageal mucosa ulcer though inhibition of the NF-κBp65 inflammatory pathway and enhancement of the anti-oxidant Nrf2-Keap1 pathway.

• Journal of Korea Water Resources Association
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• v.54 no.12
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• pp.1233-1242
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• 2021

In this study, a model was developed to determine whether flooding occurred using image data, which is unstructured data. CNN-based VGG16 and VGG19 were used to develop the flood classification model. In order to develop a model, images of flooded and non-flooded images were collected using web crawling method. Since the data collected using the web crawling method contains noise data, data irrelevant to this study was primarily deleted, and secondly, the image size was changed to 224×224 for model application. In addition, image augmentation was performed by changing the angle of the image for diversity of image. Finally, learning was performed using 2,500 images of flooding and 2,500 images of non-flooding. As a result of model evaluation, the average classification performance of the model was found to be 97%. In the future, if the model developed through the results of this study is mounted on the CCTV control center system, it is judged that the respons against flood damage can be done quickly.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.45 no.2
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• pp.151-159
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• 2019

Ergothioneine has been known as an excellent antioxidant and a cellular protector against oxidative damage in vivo. In the present study, ergothioneine was demonstrated to possess antioxidant and anti-glycation activities. The radical scavenging activity of ergothioneine enhanced the viability of human dermal fibroblasts (HDFs) exposed to ultraviolet (UV) light. The UVA irradiation increased the proportion of senescence-associated ${\beta}$-galactosidase (SA-${\beta}$-gal) positive cells in comparison with the normal control group. The treatment of UVA-irradiated HDFs with ergothioneine decreased the level of SA-b-gal (by approximately 45% at an ergothioneine concentration of $400{\mu}M$) compared with the UVA-irradiated HDFs. We also found that ergothioneine inhibited production of glyceraldehyde-derived advanced glycation endproducts (AGEs) in a concentration-dependent manner. The ergothioneine educed carboxymethyl-lysine (CML) expression in comparison to the glyoxal treatment. In addition, in the Western blot analysis, treatment of glyoxal-stimulated HDFs with ergothioneine resulted in a dose-dependent decrease in the expression level of the receptor for AGE (RAGE). These results suggest that ergothioneine may have potent anti-aging effects and could be used as a cosmetic material against cellular accumulation of AGEs.

• Journal of Korean Society of Rural Planning
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• v.24 no.4
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• pp.135-146
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• 2018

A Visual landscape planning and management system has been introduced and implemented by each ministry so as to solve the problems of visual landscape destruction due to recognition on the value of natural landscape of beautiful territory and various development projects. At present, this system emphasizes the importance of the visual and perceptual aspect of the landscape however, there is a lack of techniques required for comprehensively predicting, evaluating, and managing it. Furthermore, sustainable landscape management after the completion of development projects has been inadequately carried out, as the focus has been only on consultation in the planning process of the development project in institutional performance. To this end, we presented objective and standardized criteria to predict and judge the effects of development projects on landscapes before project implementation. During the implementation of the development project, the influence of the visual landscape becomes accumulated in the construction progress stage. There is a need to identify the main viewpoints and to examine the continuous changes in the landscape-influencing factors, owing to the remarkable influences on the landscape, such as the change in the topography and the change caused by the artificial structure. During the stage of managing the influence on the visual landscape after the completion of the project, the influence on landscape should be monitored by measuring the change in the continuous landscape-influencing factors and determining the extent to which the actual reduction plan has been implemented. These processes should be performed continuously to maintain the quality of the visual landscape. The change in the landscape caused by the development project is shown to cause relatively greater visual damage than other factors composing the landscape owing to the influence of the artificial factors including the structure or the building. This shows that not only detailed examination of the visual impact before the development project but also continuous management is required during and after the development project. For this purpose, we derived eight landscape-influencing factors including form/shape, line, color, texture, scale/volume, height, skyline, and landscape control point. The proposed considering to be of high utilization in that it has a clear target of the landscape influencing factors.

• Journal of Korea Water Resources Association
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• v.52 no.3
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• pp.219-226
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• 2019

Recently, research about Low-Impact Development (LID) techniques has been expanded due to problems with the effects of climate change and urbanization that have been increasing. LID technology is used to control flood damage environmentally to reduce runoff and is reduce runoff on city also restore into previous water circulation system from present developed city. However, studies about quantitative data of LID techniques are insufficient. Therefore in this study, the Curve Number (CN) was calculated with the Planter Box, which is storage type LID technology to conduct the water circulation (infiltration, runoff, overflow) analysis. Rainfall intensity scenario (60.4 mm/hr, 83.1 mm/hr, 97.4 mm/hr, 108.2 mm/hr) about water circulation analysis of Planter Box is selected on the basis of probable rainfall intensity table. According to the experimental results, the storage rate of rainwater in Building Planter Box and Street Planter Box was 43.5% to 52.9% and 33.4% to 39%, respectively. In addition, CN value is estimated to 83 at the Planter box and the runoff reduction effect by applying Horton's infiltration capacity curve showed on 51% to 98%.

• Korean Journal of Heritage: History & Science
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• v.43 no.3
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• pp.122-143
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• 2010

The Shilla Stone Monument in Jungseongri was found during the road-construction in Pohang. It has approximately two hundreds of letters inscribed on the surface of one side, and it is estimated to be older than Shilla Stone Monument in Naengsuri which had been known for the oldest stele in Shilla Period. This monument is made of fine to medium-grained biotite granite, while the Shilla Stone Monument in Naengsuri is made of fine-grained granodioritic porphyry bearing feldspar and amphibole phenocrysts. Both rock types of the monuments are interpreted to be cognate with biotite granite in Shinkwangmyeon, and with granodioritic porphyry in Gigyemyeon. They are characterized by xenolith and miarolitic cavity. Damage aspects in both monuments are discoloring, cracking and breaking. These damages do not cause structural instability of the monuments, but attenuate aesthetic value. Black and brown discoloring contaminants on the surface of the Jungseongri Monument contain a high amount of manganese and iron. As a result of ultrasonic test, both monuments were evaluated to be medium-weathered (MW), although the velocity of the Shilla Monument in Jungseongri was slightly lower than the Shilla Monument in Naengsuri. This is because the Monument in Juengseongri had been exposed to outdoor environment for long time until the discovery. It is necessary for Shilla Monuments to be protected by appropriately environmental control and management.

• Journal of Food Hygiene and Safety
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• v.34 no.3
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• pp.303-308
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• 2019

L-carnitine is found in high levels in muscle tissues. It has been developed as a nutrient and dietary supplement, and also used as a therapeutic supplement in various diseases including type II diabetes, osteoporosis and metabolic neuropathies. However, it is not fully understood how it affects cellular mechanisms in colorectal cancer. Therefore, we attempted to determine the effect of L-carnitine in HCT116 human colorectal cancer cells. First, the HCT116 cells were exposed to L-carnitine for 24 hours at 0-40 mM, and then analyzed for cellular proliferation, oxidative stress and related mechanisms. In a MTT assay, L-carnitine inhibited cellular proliferation and induced reactive oxygen species (ROS) in HCT116 by DCF-DA analysis. To analyze the mechanism of L-carnitine in colorectal cancer cells, we performed a western blot analysis for pERK1/2 and pp38 MAP kinase. The western blot showed that L-carnitine significantly increased protein levels of pERK1/2 and pp38 compared with control. Taken together, we found that L-carnitine has anti-proliferative function via increased ROS and activation of ERK1/2 and p38 pathway in HCT116. These findings suggest that L-carnitine may have an anti-proliferative role on colorectal cancer.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.5
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• pp.627-635
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• 2019

A programmable drone is a drone developed not only to experience the basic principles of flight but also to control drones through Arduino-based programming. Due to the nature of the training drones, the main users are students who are inexperienced in controlling the drones, which often cause frequent collisions with external objects, resulting in high damage to the drones' frame. In this study, the structural stability of the drone was evaluated by means of a structural dynamics based collision simulation for educational drone frame. Collision simulations were performed on three cases according to the impact angle of $0^{\circ}$, $+15^{\circ}$ and $-15^{\circ}$, using an analytical model with approximately 240,000 tetrahedron elements. Using ANSYS LS-DYNA, which provides excellent functions for the simulation of the dynamic behavior of three-dimensional structures, the stress distribution and strain generated on the drone upper, the drone lower, and the ring assembly were analyzed when the drones collided against the wall at a rate of 4 m/s. Safety factors resulting from the equivalent stress and the yield strain were calculated in the range of 0.72 to 2.64 and 1.72 to 26.67, respectively. To ensure structural stability for areas where stress exceeds yield strain and ultimate strain according to material properties, the design reinforcement is presented.

• Journal of the Society of Disaster Information
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• v.15 no.1
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• pp.1-11
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• 2019

Purpose: This study intends to determine how disaster prevention characteristics of important state-designated wooden cultural properties in Gyeongsangnam-do vary according to the surrounding environments and to examine disaster prevention measures for wooden cultural properties that fit their surrounding environments accordingly. Method: The designation status and characteristics of cultural properties in Gyeongsangnam-do and Gyeongsangbuk-do were identified, and the damage status of cultural properties in Gyeongsangnam-do and Gyeongsangbuk-do was reviewed based on the history of disasters. Also, the disaster prevention environments for 58 state-designated wooden cultural properties in Gyeongsangnam-do and Gyeongsangbuk-do were analyzed separately into mountainous area, rural area and urban area, topographic characteristics were drawn. Results: For cultural properties located in urban areas, it was found that security guards were arranged properly and disaster prevention training was carried out well. In addition, access condition to the cultural properties was adequate; prompt access to such properties was possible. In rural areas, flame retardant works have been undertaken properly and many cultural properties were found to be located on a flat ground. Mountainous areas had highly inadequate access condition to cultural properties and disasters occurred most frequently in these areas in the past. Conclution: First, for wooden cultural properties located in urban areas, it is necessary to secure the self-defense fire service manpower for an initial response and reinforce the disaster prevention education. Second, for wooden cultural properties located in rural areas, prevention projects such as insect control project and disaster prevention insurance should be carried out in order to protect the cultural properties. Third, as for wooden cultural properties located in mountainous areas, it is necessary to prepare establish to reinforce self-response capability.

• The Journal of the Korea Contents Association
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• v.21 no.10
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• pp.723-737
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• 2021

This study attempted to understand the meaning and nature of the drinking experience of participants participating in self-sufficiency program with alcohol problems. For this, data were collected by conducting in-depth interviews with seven problem drinkers currently participating in the self-support work project at the local self-support center. It was analyzed by a phenomenological analysis method. As a result of the study, 26 topics, 7 thematic vowels, and 3 categories were derived. The essential meaning of the study participant's drinking experience is as follows. It turned out to be 'a sense of accomplishment and belonging to job performance', 'extension of work life', 'maintaining social relations', 'weekly control drinking for self-support', 'minimum effort not to damage the working environment', 'self-criticism and reflection on absence from work resulting from heavy drinking', 'self-awareness of drinking problems. Through the analysis, the participants drank with a sense of accomplishment and a sense of belonging to job performance, and drinking was considered to extend their work life and maintain social relationships. At the same time, on weekdays when participating in self-support work projects, they we refrain from drinking in their own way and make minimal efforts not to interfere with the working environment under a hangover. The Absent from work due to heavy drinking led to self-reflection and furthermore, it was confirmed that they were aware of their problem drinking.