The Anti-Proliferation and Oxidative Damage-Related Mechanism of L-Carnitine in Human Colorectal Cancer Cells |
Lee, Jooyeon
(Department of Thoracic and Cardiovascular Surgery, Kangwon National University)
Park, Jeong-Ran (Bioceltran Co., Ltd.) Jang, Aera (Department of Animal Products and Food Science, Kangwon National University) Yang, Se-Ran (Department of Thoracic and Cardiovascular Surgery, Kangwon National University) |
1 | Jung, K.W., Won, Y.J., Kong, H.J., Oh, C.M., Cho, H., Lee, D.H., Lee, K.H.: Cancer statistics in Korea : incidence, mortality, survival, and prevalence in 2012. Cancer Res Treat, 47, 127-141 (2015). DOI |
2 | Oh, C.M., Won, Y.J., Jung, K.W., Kong, H.J., Cho, H., Lee, J.K., Lee, D.H., Lee, K.H.: Cancer Statistics in Korea : Incidence, Mortality, Survival, and Prevalence in 2013. Cancer Res Treat, 48, 436-450 (2016). DOI |
3 | Lee, J., Park, J.R., Lee, H., Jang, S., Ryu, S.M., Kim, H., Kim, D., Jang, A., Yang, S.R.: L-carnosine induces apoptosis/cell cycle arrest via suppression of NF-kappaB/STAT1 pathway in HCT116 colorectal cancer cells. In Vitro Cell Dev Biol Anim, 54, 505-512 (2018). DOI |
4 | Jang, S., Lee, J., Ryu, S.M., Lee, H., Park, J.R., Kim, H.J., Kim, D.W., Jang, A, Yang, S.R.: Effect of coenzyme Q10 via nitric oxide production and growth arrest of human colon cancer HCT116 cells. J. Prev. Vet. Med., 41, 59-65 (2017). DOI |
5 | Shimada, K., Sakuma, Y., Wakamatsu, J., Fukushima, M., Sckikawa, M., Kuchida, K., Mikami, M.: Species and muscle differences in L-carnitine levels in skeletal muscles based on a new simple assay. Meat Sci, 68, 357-362 (2004). DOI |
6 | Fielding, R., Riede, L., Lugo, J.P., Bellamine, A.: l-Carnitine Supplementation in Recovery after Exercise. Nutrients, 10, 349 (2018). DOI |
7 | Williams, P.G.: Nutritional composition of red meat. Nutr Diet, 64, S113-S119 (2007). DOI |
8 | Zhang, J.J., Wu, Z.B., Cai, Y.J., Ke, B., Huang, Y.J., Qiu, C.P., Yang, Y.B., Shi, L.Y., Qin, J.: L-carnitine ameliorated fasting-induced fatigue, hunger, and metabolic abnormalities in patients with metabolic syndrome : a randomized controlled study. Nutr J, 13, 110 (2014). DOI |
9 | Ferreira, G.C., McKenna, M.C.: L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochem Res, 42, 1661-1675 (2017). DOI |
10 | Hassan, A., Tsuda, Y., Asai, A., Yokohama, K., Nakamura, K., Sujishi, T., Ohama, H., Tsuchimoto, Y., Fukunishi, S., Abdelaal, U.M., Arafa, U.A., Hassan, A.T., Kassem, A.M., Higuchi, K.: Effects of Oral L-Carnitine on Liver Functions after Transarterial Chemoembolization in Intermediate-Stage HCC Patients. Mediators Inflamm, 2015, 608216 (2015). |
11 | Liou, G.Y., Storz, P.: Reactive oxygen species in cancer. Free Radic. Res., 44, 479-496 (2010). DOI |
12 | Murad, H.A.: L-Carnitine, but not coenzyme Q10, enhances the anti-osteoporotic effect of atorvastatin in ovariectomized rats. J. Zhejiang Univ. Sci. B. B, 17, 43-53 (2016). DOI |
13 | Mingrone, G., Greco, A.V., Capristo, E., Benedetti, G., Giancaterini, A., De Gaetano, A., Gasbarrini, G.: L-carnitine improves glucose disposal in type 2 diabetic patients. J Am Coll Nutr, 18, 77-82 (1999). DOI |
14 | Huang, H.; Liu, N.; Guo, H., Liao, S., Li, X., Yang, C., Liu, S., Song, W., Liu, C., Guan, L., Li, B., Xu, L., Zhang, C., Wang, X., Dou, Q.P., Liu, J.: L-carnitine is an endogenous HDAC inhibitor selectively inhibiting cancer cell growth in vivo and in vitro. PloS one, 7, e49062 (2012). DOI |
15 | Wang, P., Zeng, Y., Liu, T., Zhang, C., Yu, P.W., Hao, Y.X., Luo, H.X., Liu, G.: Chloride intracellular channel 1 regulates colon cancer cell migration and invasion through ROS/ERK pathway. World J. Gastroenterol., 20, 2071-2078 (2014). DOI |
16 | de Sa Junior, P.L., Camara, D.A.D., Porcacchia, A.S., Fonseca, P.M.M., Jorge, S.D., Araldi, R.P., Ferreira, A.K.: The Roles of ROS in Cancer Heterogeneity and Therapy. Oxid Med Cell Longev, 2017, 2467940 (2017). |
17 | Galadari, S., Rahman, A., Pallichankandy, S., Thayyullathil, F.: Reactive oxygen species and cancer paradox : To promote or to suppress? Free Radic Biol Med, 104, 144-164 (2017). DOI |
18 | Yang, J., Zhao, X., Tang, M., Li, L., Lei, Y., Cheng, P., Guo, W., Zheng, Y., Wang, W., Luo, N., Peng, Y., Tong, A., Wei, Y., Nie, C., Yuan, Z.: The role of ROS and subsequent DNA-damage response in PUMA-induced apoptosis of ovarian cancer cells. Oncotarget, 8, 23492-23506 (2017). DOI |
19 | Lee, J., Lee, H., Jang, S., Hong, S.H., Kim, W.J., Ryu, S.M., Park, S.M., Lee, K.H., Cho, S.J., Yang, S.R.: CMIT/MIT induce apoptosis and inflammation in alveolar epithelial cells through p38/JNK/ERK1/2 signaling pathway. Mol Cell Toxicol, 15, 41-48 (2019). DOI |
20 | Lee, H., Lee, J., Hong, S.H., Rahman, I., Yang, S.R.: Inhibition of RAGE Attenuates Cigarette Smoke-Induced Lung Epithelial Cell Damage via RAGE-Mediated Nrf2/DAMP Signaling. Front Pharmacol, 9, 684 (2018). DOI |
21 | Zu, L.D., Peng, X.C., Zeng, Z., Wang, J.L., Meng, L.L., Shen, W.W., Hu, C.T., Yang, Y., Fu, G.H.: Gastrin inhibits gastric cancer progression through activating the ERK-P65-miR23a/27a/24 axis. J Exp Clin Cancer Res : CR, 37, 115 (2018). DOI |
22 | Park, S.J., Park, S.H., Kim, J.O., Kim, J.H., Park, S.J., Hwang, J. J., Jin, D.H., Jeong, S.Y., Lee, S.J., Kim, J.C., Kim, I., Cho, D.H.: Carnitine sensitizes TRAIL-resistant cancer cells to TRAIL-induced apoptotic cell death through the up-regulation of Bax. Biochem Biophys Res Commun, 428, 185-190 (2012). DOI |
23 | Hong, B., Li, H., Zhang, M., Xu, J., Lu, Y., Zheng, Y., Qian, J., Chang, J.T., Yang, J., Yi, Q.: p38 MAPK inhibits breast cancer metastasis through regulation of stromal expansion. Int. J. Cancer, 136, 34-43 (2015). DOI |
24 | Kanungo, J., Cuevas, E., Ali, S.F., Paule, M.G.: L-Carnitine rescues ketamine-induced attenuated heart rate and MAPK (ERK) activity in zebrafish embryos. Reprod Toxicol, 33, 205-212 (2012). DOI |
25 | Roscilli, G., Marra, E., Mori, F., Di Napoli, A., Mancini, R., Serlupi-Crescenzi, O., Virmani, A., Aurisicchio, L., Ciliberto, G.: Carnitines slow down tumor development of colon cancer in the DMH-chemical carcinogenesis mouse model. J Cell Biochem, 114, 1665-1673 (2013). DOI |
26 | Hathcock, J.N., Shao, A.: Risk assessment for carnitine. Regul Toxicol Pharmacol, 46, 23-28 (2006). DOI |