• IMMUNE NETWORK
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• v.11 no.6
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• pp.368-375
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• 2011

Background: Recent clinical observation reported that there was a significant correlation between change in circulating vascular endothelial growth factor (VEGF) levels and the occurrence of severe acute graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT), but the action mechanisms of VEGF in GVHD have not been demonstrated. Methods: This study investigated whether or not blockade of VEGF has an effect on acute GVHD in a lethally irradiated murine allo-HSCT model of $B6\;(H-2^b)\;{\rightarrow}B6D2F1\;(H-2^{b/d})$. Syngeneic or allogeneic recipient mice were injected subcutaneously with anti-VEGF peptides, dRK6 ($50{\mu}g/dose$) or control diluent every other day for 2 weeks (total 7 doses). Results: Administration of the dRK6 peptide after allo-HSCT significantly reduced survival with greaterclinical GVHD scores and body weight loss. Allogeneic recipients injected with the dRK6 peptide exhibited significantly increased circulating levels of VEGF and expansion of donor $CD3^+$ T cells on day +7 compared to control treated animals. The donor $CD4^+$ and $CD8^+$ T-cell subsets have differential expansion caused by the dRK6 injection. The circulating VEGF levels were reduced on day +14 regardless of blockade of VEGF. Conclusion: Together these findings demonstrate that the allo-reactive responses after allo-HSCT are exaggerated by the blockade of VEGF. VEGF seems to be consumed during the progression of acute GVHD in this murine allo-HSCT model.

• Archives of Pharmacal Research
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• v.25 no.4
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• pp.428-432
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• 2002

Three new dammarane glycosides were isolated from the processed ginseng (SG; Sun Ginseng). Their structure were determined to be $3{\beta},{\;}12{\beta}-dihydroxydammar-20(21),24-diene-3-O-{\beta}-D-glucopyranosyl(1{\;}{\rightarrow}{\;}2)-{\beta}-D-glucopyranoside;{\;}3{\beta},{\;}12{\beta}-dihydroxydammar-20(21),24-diene-3-O-{\beta}-D-{\;}glucopyranoside{\;}and{\;}3{\beta},6{\alpha},12{\beta}-trihydroxydammar-20(21),24-diene-6-O-{\beta}-D-glucopyranoside$ based on spectroscopic evidences. The compounds were named as ginsenoside $Rk_1,{\;}Rk_2,{\;}and{\;}Rk_3$ respectively.

• Journal of Korean Ophthalmic Optics Society
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• v.16 no.4
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• pp.433-438
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• 2011

Purpose: To investigate the proper distance from patient to target when measuring refractive error using open view target type auto-refractor(OVTAR), it was compared refractive errors between by OVTAR using N-vision-K5001 auto-refractor and internal fixation target type auto-refractor(IFTAR) using Canon auto-refractor. Methods: 21 subjects(42 eyes) aged 22.2(${\pm}$3.4) years old who had over 1.0 of corrected visual acuity and no ocular disease were participated for this study. Noncycloplegic measurements of refractive error were performed using a IFTAR(RK-F1, Canon, Japan) and an OVTAR(N-vision-K5001, Shin-nippon, Japan). The distances from subjects to targets in using the open the view target type auto-refractor were 1 m, 3 m, 4 m and 6 m. The refractive errors were compared between by IFTAR and by 1 m, 3 m, 4 m and 6 m target distances respectively using OVTAR. Results: At 1 m fixation distance the mean of refractive errors for total subjects was not significantly different between by OVTAR(-2.75${\pm}$1.84 D) and by IFTAR(-2.95${\pm}$2.04 D)(p=0.06). However at 3, 4 and 6 m fixation distance refractive errors by OVTAR were significantly lower myopic refractive errors than by IFTAR(p<0.05). Conclusions: The distance from subject to fixation target is needed over 3 m for the measurement of refractive error using OVTAR even not to 5~6 m distance.

• Korean Journal of Ecology and Environment
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• v.39 no.4 s.118
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• pp.462-470
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• 2006

The zooplankton community dynamics and grazing experiments was evaluated along a 40 km section of the lower Seomjin river system. Zooplankton was sampled twice a month from January 2005 to June 2006 at three sites (River mouth; RKO, Seomjin bridge: RK12 and Gurae bridge: RK36) in the main river channel. During the study period, the values of most limnological parameters in the three sites were fairly similar, except for conductivity. Annual variation of conductivity in River mouth and Seomjin bridge was more dramatic than which of the other site. There were statistically significant spatial and seasonal differences in zooplankton abundance (ANOVA, P<0.01). Total abundance of major zooplankton groups at both stations was much higher than in Gurae bridge. Among the macrozooplankton, cladocerans abundance was negligible in study sites during study periods. Community filtering rates (CFRs) for phytoplankton and bacteria varied from 0 to 50 mL $L^{-1}\;D^{-1}$ and from 0 to 45 mL $L^{-1}\;D^{-1}$, respectively. The spatial variation of CFRs for phytoplankton was significant (ANOVA, P<0.05). The CFRs of copepods for phytoplankton and bacteria was much higher than that of cladocerans at study sites. Total zooplankton filtering rates on bacteria were slightly lower than filtering rates on phytoplankton. The CFRs of microzooplankton (MICZ) for bacteria were much higher than for macrozooplankton (MACZ) at all sites. Considering the total zooplankton community, MICZ generally were more important than MACZ as grazers of bacteria and phytoplankton in freshwater zone, while MACZ were more important than MICZ as grazers of phytoplankton in brackish zone.

• Journal of Astronomy and Space Sciences
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• v.21 no.2
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• pp.101-108
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• 2004

The terrestrial nightglow emission in near infrared region were obtained using a Fourier Transform Spectrometer(FTS) at Esrange, Sweden ($67.90^{\circ}$N, $21.10^{\circ}$E) and the OH(4- 2) bands were used to derive temperature and airglow emission rate of the upper mesosphere. For this study, we analyzed data taken during winter of 2001/2002 and performed spectral analysis to retrieve wave information. From the Lomb-Scargle spectral analysis to the measured temperatures, dominant oscillations at various periods near tidal frequency are found. Most commonly observed waves are 4, 6, and 8 hour oscillations. Because of periods and persistence, the observed oscillations are most likely of tidal origin, i.e. zonally symmetric tides which are known to have their maximum amplitudes at the pole.

• Journal of Korean Ophthalmic Optics Society
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• v.17 no.3
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• pp.249-254
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• 2012

Purpose: To investigate amount of myopic progression with increase of age for children myopes among patients of a Korean optometry clinic. Methods: It has followed up 99 children subjects (male 55, female 44) who had no ocular disease and have visited a Korean optometric clinic for mean $33{\pm}8$ months (13 to 54 months) since June of 2001. Mean age of subjects at first visit was $118{\pm}23$months. Non-cycloplegic refractive error were measured 6 times using Canon RK-3(Japan) every mean 6 months. Results: For all subjects mean of refractive errors increased -0.78 D per year from $-2.02{\pm}1.05D$ at first visit to $-4.18{\pm}1.30D$ at final visit with longitudinal study, but -0.19 D per year with cross-section study, which showed a big difference between two methods. Mean of astigmatic refractive error increased -0.15 D per year. As progression of refractive error according to ages at first visit, refractive errors increased -1.04 D per year for 6 years old, -0.9 D for 7 years old, -0.89 D for 8 years old, -0.89 D for 9 years old, -0.74 D for 10 years old, -0.74 D for 11 years old and -0.72 D for 12 years old. And it showed a tendency that the younger age was the higher progression of myopia. However it was not significantly different between each groups. Conclusions: Follow-up results for myopic children among patients of a Korean optometry clinic showed increase of -0.78 D for myopic refractive error and -0.14 D for astigmatic refractive error per year.

• Journal of the Korean Institute of Gas
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• v.23 no.6
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• pp.39-60
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• 2019

Korea Gas Safety Corporation is developing consequence analysis system for combustible materials release events to enhance risk assessment technology and its efficiency. Unlike general consequence analysis programs, the final consequence area was implemented through ETA analysis based on API-581 standard, and a convenient user interface was constructed based on HTML5-based responsive web technology. In addition, a phase equilibrium module using third-order state equations (such as Peng-Robinson, SRK, and RK) and fugecity was implemented to analyze the mixture quality. Also. using the consequence analysis algorithm introduced in CCPS books and TNO Yellow Book, we developed material leak analysis module, fireball, pool fire, jet fire, flash fire, and vapor cloud explosion consequence assessment module. In addition, the conditions for calculating the safety distance were prepared with using the control values in the EIGA standard, PAC, and Bevi Reference Book.

• Advances in Traditional Medicine
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• v.7 no.5
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• pp.466-476
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• 2008

We have developed the tablet formulation of Triticum aestivum (wheatgrass) and investigated clinically, its effects in patients suffering from b-thalassemia (major) at K. T. Children Hospital, Civil Hospital, Rajkot. The tablets (wheatgrass powder 250 mg.) were given 3 times in a day for 9 months. Blood samples were collected at the start, after 6 months and 9 months and analyzed for various biochemical and hematological parameters. Treatment with wheatgrass formulation for 9 months produced significant decrease in hemoglobin, total RBC, eosinophil and reticulocyte counts. The mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC) were significantly increased was significantly increased. The serum ferritin was also significantly decreased. There was no influence on serum magnesium, serum iron and Thiobarbituric acid reacting substances (TBARS). Our data indicate that treatment with wheatgrass on patients with $\beta$-thalassemia (major) may have beneficial effects in the form of a decrease in ineffective erythropoiesis, stimulation of hemoglobin synthesis in RBC, decrease in iron load and decrease in eosinophil count.

• Advances in nano research
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• v.10 no.3
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• pp.263-270
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• 2021

The present manuscript focuses the effects of suction on the flow of the dusty fluid along permeable exponentially stretching cylinder. Derived PDEs for this work are changed into ODEs by adopting right transformations. Numerical procedure is carried out for the obtained resultant equations by Shooting Technique in accordance with Runge-Kutta (RK-6) technique. Obtained results for the parameters namely, particle interaction parameter, suction parameter and Reynold number parameters are probed thoroughly. Some salient points are: (a) Fluid velocity decreases and the dust phase velocity rises for the higher values of particle interaction parameter; (b) more suction produces retarding velocities for both the phases; (c) high Reynold number slows down the fluid velocity while the speed of dust phase and (d) skin friction coefficient goes high for all these parameters.

• Journal of Ginseng Research
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• v.38 no.3
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• pp.194-202
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• 2014

Background: Ginsenosides, the major ingredients of Panax ginseng, have been studied for many decades in Asian countries as a result of their wide range of pharmacological properties. The less polar ginsenosides, with one or two sugar residues, are not present in nature and are produced during manufacturing processes by methods such as heating, steaming, acid hydrolysis, and enzyme reactions. $^1H$-NMR and $^{13}C$-NMR spectroscopic data for the identification of the less polar ginsenosides are often unavailable or incomplete. Methods: We isolated 21 compounds, including 10 pairs of 20(S) and 20(R) less polar ginsenosides (1-20), and an oleanane-type triterpene (21) from a processed ginseng preparation and obtained complete $^1H$-NMR and $^{13}C$-NMR spectroscopic data for the following compounds, referred to as compounds 1-21 for rapid identification: 20(S)-ginsenosides Rh2 (1), 20(R)-Rh2 (2), 20(S)-Rg3 (3), 20(R)-Rg3 (4), 6'-O-acetyl-20(S)-Rh2 [20(S)-AcetylRh2] (5), 20(R)-AcetylRh2 (6), 25-hydroxy-20(S)-Rh2 (7), 25-hydroxy-20(S)-Rh2 (8), 20(S)-Rh1 (9), 20(R)-Rh1 (10), 20(S)-Rg2 (11), 20(R)-Rg2 (12), 25-hydroxy-20(S)-Rh1 (13), 25-hydroxy-20(R)-Rh1 (14), 20(S)-AcetylRg2 (15), 20(R)-AcetylRg2 (16), Rh4 (17), Rg5 (18), Rk1 (19), 25-hydroxy-Rh4 (20), and oleanolic acid 28-O-b-D-glucopyranoside (21).