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Three New Dammarane Glycosides from Heat Processed Ginseng  

Park, Il-Ho (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University)
Kim, Na-Young (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University)
Han, Sang-Beom (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University)
Kim, Jong-Moon (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University)
Kwon, Sung-Won (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University)
Kim, Hyun-Jung (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University)
Park, Man-Ki (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University)
Park, Jeong-Hill (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University)
Publication Information
Archives of Pharmacal Research / v.25, no.4, 2002 , pp. 428-432 More about this Journal
Abstract
Three new dammarane glycosides were isolated from the processed ginseng (SG; Sun Ginseng). Their structure were determined to be $3{\beta},{\;}12{\beta}-dihydroxydammar-20(21),24-diene-3-O-{\beta}-D-glucopyranosyl(1{\;}{\rightarrow}{\;}2)-{\beta}-D-glucopyranoside;{\;}3{\beta},{\;}12{\beta}-dihydroxydammar-20(21),24-diene-3-O-{\beta}-D-{\;}glucopyranoside{\;}and{\;}3{\beta},6{\alpha},12{\beta}-trihydroxydammar-20(21),24-diene-6-O-{\beta}-D-glucopyranoside$ based on spectroscopic evidences. The compounds were named as ginsenoside $Rk_1,{\;}Rk_2,{\;}and{\;}Rk_3$ respectively.
Keywords
Panax ginseng; Ginsenoside; Dammarane glycoside;
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Times Cited By Web Of Science : 42  (Related Records In Web of Science)
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1 Kim, D. S., Baek, N. I., Park, J. D., Lee, Y. H., Jeong, S. Y., Lee, C. B., and Kim, S. I., Preparation and Structure Detemination of a New Glycoside, (20E)-Ginsenoside $Rh_3$, and its isomer from Diol-type Ginseng Saponins. Yakhak Hoeji, 39, 85-93 (1995)
2 Baek, N. I., Kim, D. S., Lee, Y. H., Park, J. D., Lee, C. B., and Kim, S. I., Ginsenoside $Rh_4$, A Genuine Dammarane Glycoside from Korean Red Ginseng. Planta Med., 62, 86-87 (1996)   DOI   ScienceOn
3 Kim, S. I., Kim, D. S., Lee, Y. H., Park, J. D., and Baek, N. I., Isolation of A Novel Dammarane-Glycoside, Ginsenoside $Rh_4$, from Korean Red Ginseng. Proceedings of 95 Korean-Japan Ginseng Symposium, 107 (1995)
4 Kim, W. Y., Kim, J. M., Han, S. B., Lee, S. K., Kim, N. D., Park, M. K., Kim, C. K., Park, J. H., Steaming of Ginseng at HighTemperature Enhances Biological Activity. J. Nat. Prod., 63, 1702-1704 (2000)   DOI   ScienceOn
5 Kitagawa, I., Yoshikawa, M., Yoshigara, M., Hayashi, T. and Taniyama, T., Chemical Studies on Crude Drug Precession. I. On the Constitution of Ginseng Radix Rubra (1). Yakugaku Zasshi, 103, 612-622 (1983)   DOI   PUBMED
6 Keum, Y. S., Park, K. K., Lee, J. M., Chun, K. S., Park, J. H., Lee, S. K., Kwon, H. J., and Surh, Y. J., Antioxidant and antitumor promoting activities of the methanol extract of heat-processed ginseng. Cancer Letters, 150, 41-48 (2000)   DOI   ScienceOn
7 Kim, S. I., Park, J. D., Lee, Y. H., Nam, G. Y., and Baek , N. I., Preparation of 20(R)- and 20(S)-Ginsenoside $Rh_1$ from Ginsenoside Re. Korean J. Ginseng Sci., 15, 188-191 (1991)
8 Han, D.S., Pharmacognogy, Dong Myoung Sa, Seoul, 1988
9 Sanada, S., Kondo, N., Shoji, J., Tanaka, O., and Shibata, S., Studies on the saponins of Ginseng. II. Structure of Ginsenoside-Re, -Rf, and $Rg_2$. Chem. Pharm. Bull., 22(10), 2407-2412 (1974b)   DOI
10 Kim, S. I., Park, J. H., Ryu, J. H., Park, J. D., Lee, Y. H., Park, J. H., Kim, T. H., Kim, J. M., and Baek, N. I., Ginsenoside $Rg_5$, A Genuine Dammarane Glycoside from Korean Red Ginseng. Arch. Pharm. Res., 19(5), 551-553 (1996)   DOI   ScienceOn
11 Sanada, S., Kondo, N., Shoji, J., Tanaka, O., and Shibata, S., Studies on the saponins of Ginseng. I. Structure of Ginsenoside-Ro, $-Rb_1$, $-Rb_2$, -Rc and Rd. Chem.Pharm. Bull., 22(2), 421-428 (1974a)   DOI
12 Ryu, J. H., Park, J. H., Eun, J. H., Jung, J. H., and Sohn, D. H., A dammarane glycoside from Korean red ginseng. Phytochemistry, 44, 931-933 (1997)   DOI   ScienceOn
13 Kim, S. I., Baek, N. I., Kim, D. S., Lee, Y. H., Kang, K. S., and Park J. D., Preparation of a 20(S)-Ginsenoside $Rh_2$ and the 20(S) Epimer from Protopanaxadiol Saponins of Panax ginseng C.A. Meyer. Yakhak Hoeji, 35, 432-437 (1991)