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Lack of Associations between Vitamin D Metabolism-Related Gene Variants and Risk of Colorectal Cancer

  • Mahmoudi, Touraj;Karimi, Khatoon;Arkani, Maral;Farahani, Hamid;Nobakht, Hossein;Dabiri, Reza;Asadi, Asadollah;Vahedi, Mohsen;Zali, Mohammad Reza
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.2
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    • pp.957-961
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    • 2014
  • Purpose: With regard to the protective effect of vitamin D against colorectal cancer (CRC), we evaluated genetic variants that might influence vitamin D metabolism: vitamin D receptor (VDR), vitamin D binding protein (GC), vitamin D 25-hydroxylase (CYP2R1), and vitamin D 25-hydroxy 1-alpha hydroxylase (CYP27B1). Materials and Methods: A total of 657 subjects, including 303 cases with CRC and 354 controls were enrolled in this case-control study. All 657 were genotyped for the four gene variants using PCR-RFLP methods. Results: In this study, no significant difference was observed for VDR (rs2238136), GC (rs4588), CYP2R1 (rs12794714), and CYP27B1 (rs3782130) gene variants in either genotype or allele frequencies between the cases with CRC and the controls and this lack of difference remained even after adjustment for age, BMI, sex, smoking status, NSAID use, and family history of CRC. Furthermore, no evidence for effect modification of the variants and CRC by BMI, sex, or tumor site was observed. Conclusions: Our findings do not support a role for VDR, GC, and CYP27B1 genes in CRC risk in our Iranian population. Another interesting finding, which to our knowledge has not been reported previously, was the lack of association with the CYP2R1 gene polymorphism. Nonetheless, our findings require confirmation and possible roles of vitamin D metabolism-related genes in carcinogenesis need to be further investigated.

SHAPING ABILITY OF ROOT CANAL INSTRUMENTS ON CURVED ROOT CANALS (수종 근관확대 기구의 만곡된 치근관 성형능력)

  • Kim, Myeong-Su;Son, Ho-Hyun
    • Restorative Dentistry and Endodontics
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    • v.17 no.1
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    • pp.141-152
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    • 1992
  • Four endodontic instruments from different manufacturers(K - file, Hedstrom - file, K - flex - file, Cavi - Endo) were used to shape 80 mesial canals of extracted posterior teeth. The instrument's ability to enlarge and shape the canals as the original canal shape was assessed by superimposing radiographs of canals obtained before and after canal shaping. The results were as follows 1. Hedstrom - file enlarged canals greater than K - file, K - flex - file, and Cavi - Endo(P<0.05). There are no differences in canal enlargement among K - flex, K - flex - file, and Cavi - Endo(P<0.05). 2. All the instruments showed no difference in canal enlargement between convex side and concave side of B point in proximal and clinical radiographic views, but at the concave side of C point canals were enlarged greater than at the convex side(proximal view of K - file: P<0.05, the others: P<0.01). 3. There was no difference m canal enlargement between convex side and concave side in proximal view of A and D points of K - file and K - flex - file(P<0.05). But in clinical view, canal enlargement at convex side of A point and concave side of D point was greater than that at concave side of A point and convex side of D point respectively. 4. Hedstrom - files showed greater canal enlargement at convex side of A points and concave side of D points (P<0.05 or P<0.01). Cavi - Endo showed no difference in canal enlargement between convex side and concave side at A and D points in proximal view(P<0.05). Bur canal enlargement was greater at concave side than at convex side of D point in clinical view. 5. K - file and Cavi - Endo showed no differences in canal enlargement between convex and concave side in proximal and clinical view (P<0.05). K - flex - file showed greater canal enlargement at concave side in proximal and clinical view(P<0.0:5). Hedstrom file showed no difference in canal enlargement between convex side and concave side in proximal view, but showed greater canal enlargement at concave side in clinical view(P<0.05).

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Radiation dose Assesment according to the Adaptive Statistical Iterative Reconstruction Technique of Cardiac Computed Tomography(CT) (심장 CT 검사시 ASIR 적용에 따른 선량 평가)

  • Jang, Hyun-Cheol;Kim, Hyun-Ju;Cho, Jae-Hwan
    • The Journal of the Korea Contents Association
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    • v.11 no.5
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    • pp.252-259
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    • 2011
  • To identify the effects of the application of the adaptive statistical iterative reconstruction (ASIR) technique in combination with the other two factors of body mass Index (BMI) and tube potential on radiation dose in cardiac CT. The patient receiving operation the cardiac CT examination was divided four groups into according to kVp.[A group(n=20), Non-ASIR, BMI < 25, 100 kVp; B group(n=20), Non-ASIR, BMI > 25, 120 kVp; C group(n=20), 40% ASIR BMI < 25, 100 kVp; D group(n=20), 40% ASIR, BMI > 25, 120 kVp] After setting up the region of interest in the main artery central part and right coronary artery and left anterior descending artery, the CT number was measured and an average and standard deviation were analyzed. There were A group and the difference which the image noise notes statistically between C. And A group was high so that the noise could note than C group (group A, 494 ${\pm}$ 32 HU; group C, 482 ${\pm}$ 48 HU: P<0.05) In addition, there were B group and the difference noted statistically between D. And B group was high so that the noise could note than D group (group B, 510 ${\pm}$ 45 HU; group D, 480 ${\pm}$ 82 HU: P<0.05). In the qualitative analysis of an image, there was no difference (p>0.05) which a group, B group, C group, and D as to average, A group 4.13${\pm}$0.2, B group 4.18${\pm}$0.1, and C group 4.1${\pm}$0.2 and D group note statistically altogether with 4.15${\pm}$0.1 as a result of making the clinical evaluation according to the coronary artery segments. And the inappropriate image was shown to the diagnosis in all groups. As to the radiation dose, a group 8.6${\pm}$0.9 and B group 14.9${\pm}$0.4 and C group 5.8${\pm}$0.5 and D group are 10.1${\pm}$0.6 mSv.

The Effect of the Aspect Ratio on the Natural Frequency of the Advanced Composite Structures (복합신소재 구조물의 형상비에 따른 고유진동수의 영향)

  • Kim, Yun Young;Han, Bong Koo
    • Journal of the Korean Society for Advanced Composite Structures
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    • v.5 no.4
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    • pp.18-23
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    • 2014
  • In this paper. the effects of the aspect ratio on the natural frequency of the advanced composite road structures is studied. The advanced composite structures are too difficult for such design engineers for construction and some simple but accurate enough methods are necessary. Some laminate orientations have decreasing values of $D_{16}$, $B_{16}$, $D_{26}$ and $B_{26}$ stiffnesses as the ply number increases. The plate aspect ratio considered is from 1 to 5. Most of the road structures have large aspect ratios, for such cases further simplification is possible by neglecting the effect of the longitudinal moment terms.

Quantitative analysis for evaluating the laser therapy effects of the skin pigmented lesions (피부 색소 질환의 치료 효과 판정을 위한 정량적 분석)

  • Kim, S.C.;Rah, D.K.;Kim, D.W.
    • Proceedings of the KOSOMBE Conference
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    • v.1998 no.11
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    • pp.309-310
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    • 1998
  • Visual observation and subjective assessments lack the objective evaluation of laser therapy effects of the epidermal pigmented lesions. In this study, we proposed the two methods; One is CIE(Commission International d'Eclairage) $L^*,\;a^*,\;b^*$ coordinate system($L^*$ : brightness, $a^*$ : red(+) $\sim$green(-) content, $b^*$ : yellow(+) $\sim$blue(-) content), and the other is the relative color difference measurement. And we applied these two methods for quantitative evaluation of the laser therapy effects.

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Effects of Methionine Addition Level on Quality of Pork Carcasses (Methionine의 첨가수준이 돈육의 품질에 미치는 영향)

  • 이순자
    • The Korean Journal of Food And Nutrition
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    • v.4 no.1
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    • pp.69-74
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    • 1991
  • This study was carried out to investigated the influence of methionine addition on quality of pork carcasses, 48 crossbred pigs were alloted to 4 treatments, NRC methionine requirement(A), additions of 0.035%(B), 0.07%(C) and 0.105%(D) to NRC methionine requirement. The results obtained are summarized as follows : 1. Cut meats were not significantly affected by methionine levels. But the treatment C showed slightly higher than the other treatments. 2. Chemical compositions of cut meats were not different from treatments. However, the treatment D showed slightly higher moisture, crude fat ands ash contents than other treatments. And crude protein content was better in treatment C than the other treatments. 3. There was no significant difference the among treatments, the best value of water bolding capacity was recorded with the treatment C, and pH value of the treatment A and D Increased as compared with the treatment B and C.

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Automatic Parsing of MPEG-Compressed Video (MPEG 압축된 비디오의 자동 분할 기법)

  • Kim, Ga-Hyeon;Mun, Yeong-Sik
    • The Transactions of the Korea Information Processing Society
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    • v.6 no.4
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    • pp.868-876
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    • 1999
  • In this paper, an efficient automatic video parsing technique on MPEG-compressed video that is fundamental for content-based indexing is described. The proposed method detects scene changes, regardless of IPB picture composition. To detect abrupt changes, the difference measure based on the dc coefficient in I picture and the macroblock reference feature in P and B pictures are utilized. For gradual scene changes, we use the macroblock reference information in P and B pictures. the process of scene change detection can be efficiently handled by extracting necessary data without full decoding of MPEG sequence. The performance of the proposed algorithm is analyzed based on precision and recall. the experimental results verified the effectiveness of the method for detecting scene changes of various MPEG sequences.

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The Waveform and Spectrum analysis of Tursiops truncatus (Bottlenose Dolphin) Sonar Signals on the Show at the Aquarium (쇼 학습시 병코돌고래 명음의 주파수 스펙트럼 분석)

  • 윤분도;신형일;이장욱;황두진;박태건
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.36 no.2
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    • pp.117-125
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    • 2000
  • The waveform and spectrum analysis of Tursiops truncatus(bottlenose dolphin) sonar signals were carried out on the basis of data collected during the dolphin show at the aquarium of Cheju Pacificland from October 1998 to February 1999. When greeting to audience, the pulse width, peak frequency and spectrum level from the five dolphins'sonar signals were 3.0ms, 4.54kHz and 125.6dB, respectively. At the time of warm-up just before the show, their figures were 5.0㎳, 5.24kHz and 127.0dB, respectively. During the performance of dolphins, with singing, peak frequency ranged 3.28∼5.78kHz and spectrum level ranged 137.0∼142.0dB. With playing ring, pulse width, peak frequency and spectrum level were 7.0㎳, 2.54kHz and 135.9dB, and when playing the ball, the values were 9.0㎳, 2.78kHz and 135.2dB, respectively. The values determined from the five dolphins during jump-up out of water were : pulse width 2.0㎳, peak frequency 4.50kHz and spectrum level 126.8dB. When they responded to trainer's instructions, the values were 2.25㎳, 248kHz and 148.7dB, respectively, and greeting to audience, the peak frequency and spectrum level were 5.84kHz and 122.5dB. During swimming under water, peak frequency and spectrum level were determined to be 10.10kHz and 126.8dB. It was found that there exited close consistencies in pulse width, frequency distribution and spectrum level between whistle sounds and dolphin's sonar signals. Accordingly, the dolphins can be easily trained by using whistle sound based on the results obtained from the waveform and spectrum of the dolphin's sonar signals.

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Influence of Regional Difference on Growth and Nutrient uptake of Rice in Honam Area. I. Difference of Yield and Nutrient uptake of rice under Application of Nitrogen and Silicate levels (호남지방에 있어서 지대별 차이가 수도의 생육 및 양분흡수에 미치는 영향 제1보 질소 및 규산시용량에 따른 수도수량과 양분흡수차이)

  • Park K. H.;Lee D. B.;Kwon T. O.;Lee S. Y.
    • Proceedings of the Korean Society of Crop Science Conference
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    • 1988.02a
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    • pp.14-15
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    • 1988
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Bond Properties of GFRP Rebar with Cover Thickness and Volume Fraction of Steel Fiber (강섬유 혼입률과 피복두께에 따른 GFRP 보강근의 부착특성)

  • Choi, Yun-Chul
    • Journal of the Korea Concrete Institute
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    • v.24 no.6
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    • pp.761-768
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    • 2012
  • The purpose of this study is to investigate bond properties of GFRP used in SFRC (Steel fiber reinforced concrete) and normal concrete. The experimental variables were rebar diameter (D13, D16), steel fiber volume fraction (0~2%) and cover thickness ($1.5d_b$, $5.4d_b$). The experimental results showed a different failure mode depending on the cover thickness. Through the tested specimens, splitting failure occurred for the specimens with small cover thickness and pull out failure occurred in the specimens with large cover thickness. Introduction of steel fiber caused the specimens to have more ductile behavior of bond stresss-lip after peak stress, but they did not increase the bond strength significantly. These failure modes were shown in both steel reinforcement and GFRP. However, from the difference of micro structure of bond failure mechanism between steel rebar and GFRP rebar, more ductile behavior was observed in GFRP-specimens after maximum bond strength was reached.