• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2563-2566
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• 2013

Background: Interleukin-33 (IL-33) has recently been implicated in tumor immunity. The aim of this study was to explore the clinical role of serum IL-33 in patients with non-small-cell lung cancer (NSCLC). Methods: Sera collected from 250 healthy volunteers (HV), 256 patients with benign lung diseases (BLD) and 262 NSCLC cases were subjected to IL-33 ELISA and relationships between serum IL-33 and clinical characteristics were evaluated. Results: Circulating IL-33 levels were higher in the NSCLC group in comparison with the HV and BLD groups (p<0.001). Using a cut-off level 68 pg/ml (95% specificity in the HV group), IL-33 showed a good diagnostic performance for NSCLC. Multivariate survival analysis indicated that serum IL-33 was an independent prognostic factor in the entire NSCLC group [hazards ratio (HR) = 0.64 for low versus high IL-33 levels, 95% confidence interval (CI) 0.50-0.82; p<0.001] and in 165 selected patients with locally advanced or metastatic disease receiving chemoradiotherapy or chemotherapy (HR 0.70, 95% CI 0.52-0.94; p=0.013). Conclusions: IL-33 is a promising potential diagnostic and prognostic marker in NSCLC, independent of the therapeutic intervention.

• Journal of Acupuncture Research
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• 제23권4호
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• pp.135-148
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• 2006

Objectives : Juglandis Semen herbal acupuncture solution(JSS) has a broad array of clinical applications in oriental medicine, including treatment of chronic musculoskeletal diseases such as arthritis. This study was performed to investigate the global gene expression profiles using microarray assay in RAW 264.7 cell line treated with JSS and to advance our understanding of the pharmacologic effect of Jss. Methods : Change of the gene expression profile in RAW cell line following treatment with JSS alone, with lipopolysaccharide(LPS) alone, or with LPS plus JSS was investigated with a cut-off level of 2 fold change in the expression. Results : Of the 8170 genes profiled in this study, 95 were upragulated and 42 downregulated following JSS treatment, 51 were upragulated and 21 downregulated following LPS treatment, and 88 were upregulated and 69 downregulated following costimulation of JSS and LPS. Conclusion : JSS treatment induced upregulation of some genes including IL-10 with its possible implication in an antiinflammatory action of JSS. However, further research on expression profile changes induced by JSS treatment is expected.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7045-7047
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• 2015

Background: Mean platelet volume (MPV) is a marker which has been investigated in many cancers but data for head and neck lesions are limited. We aimed to study the MPV levels in head and neck cancers as a diagnostic marker. Materials and Methods: A total of 96 head and neck cancer patients and 31 control patients who did not meet exclusion criteria were enrolled in the study. The cancer locations, the platelet and MPV levels at the first diagnosis time were collected. Results: The head and neck cancer location distribution between these patients was 2 (2.1%) buccal, 9 (9.4%) tongue, 6 (6.3) lip, 1 (1%) gingiva, 1 (1%) hypopharynx, 1 (1%) ear, 58 (60.4%) larynx, 2 (2.1%) maxilla, 2 (2.1%) nasal, 1 (1%) nasopharynx, 2 (2.1%) palatal, 3 (3.1%) primary unknown, 1 (1%) retromolar, 1 (1%) thyroid, 2 (2.1%) tonsil, and 4 (4.2%) salivary gland. MPV levels were significantly different between cancer and control group (p=0.002). The cut-off point for MPV predicting head and neck cancer is >10 fL (sensitivity=55.21, specificity=87.10). Conclusions: MPV level increase, a readily assessable parameter which does not bring extra costs can warn us regarding head and neck cancer risk.

• 대한전자공학회논문지SD
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• 제43권2호
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• pp.34-41
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• 2006

본 논문에서는 PDC/GSM/EDGE/WCDMA를 동시에 지원하는 CMOS 다중 모드 기저대역 필터의 구조 및 새롭게 제안하는 자동 튜닝 방법을 제시한다. 기저 대역 채널 선택 필터를 구현하기 위해서 5차 Chebyshev 저대역 통과 필터를 설계하였다. 면적을 최소화하기 위해서 각 모드들 사이의 저항과 커패시터가 효율적으로 공유되었다. 또한, 공정 변화에 의한 영향을 상쇄시키기 위한 새로운 차단 주파수 튜닝 방법이 제안 되었다. 새로운 튜닝 방법은 면적과 MOS 스위치에 의한 노이즈의 영향을 줄일 수 있다.

• Journal of Advanced Marine Engineering and Technology
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• 제30권1호
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• pp.42-49
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• 2006

In this research. the diesel cycle was thermodynamically interpreted to evaluate the possibility of high efficiency by converting diesel engines to the high expansion diesel cycle, and general cycle features were analyzed after comparing these two cycles. Based on these analyses. an experimental single cylinder a long stroke with high expansion-diesel engine. of which S/B ratio was more than 3, was manufactured. After evaluating the base engine through basic experiments, a diesel engine was converted into the high expansion diesel engine by establish VCR device and VVT system Accordingly, the high expansion diesel cycle can be implemented when the quantity of intake air is compensated by supercharge and the effective compression ratio is maintained at its initial level through the reduction of the clearance volume. In this case, heat efficiency increased by $5.0\%$ at the same expansion-compression ratio when the apparent compression ratio was 20 and the fuel cut off ratio was 2. As explained above, when the atkinson cycle was used for diesel cycle, heat efficiency was improved. In order to realize high expansion through retarding the intake value closing time, the engine needs to be equipped with variable valve timing equipment, variable compression ratio equipment and supercharged pressure equipment. Then a high expansion diesel cycle engine is realized.

• 대한약침학회지
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• 제8권3호
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• pp.57-69
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• 2005

Objectives : Neurological disorders have been one of main therapeutic targets of acupuncture. The present study investigated the protective effects of Gwakhyangjeonggisan herbal acupuncture solution (GHAS). Methods : We performed 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in glioblastoma cells, and did microarray analysis with cells exposed to reactive oxigen species (ROS) of hydrogen peroxide by 8.0 k Human cDNA, with cut-off level of 2-fold changes in gene expression. Results : MTT assay showed protective effect of GHAS on the glioblastoma cells exposed to hydrogen peroxide. When glioblastoma cells were exposed to hydrogen peroxide, 24 genes were downregulated. When the cells were pretreated with GHAS before exposure to hydrogen peroxide, 46 genes were downregulated. Many of the genes downregulated by hydrogen peroxide stimulation were decreased in the amount of downregulation or reversed to upregulation. Conclusions : The gene expression changes observed in the present study are supposed to be related to the protective molecular mechanism of GHAS in the glioblastoma cells exposed to ROS stress.

• 한국음향학회지
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• 제13권4호
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• pp.69-76
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• 1994

본 연구에서는 일상회화에서 103,581개의 단음절 목록을 표집하고, 한국에 특성에 맞는 5가지 선정규칙을 적용하여, 국내의 명료도 평가용 단음절 목록을 개발하였으며, 이를 이용하여 음성품질 열화요인에 대한 타당성 검증을 수행하였다. 한귀요인인 S/N비와 차단주파수 변화에 대한 타당성 검증결과, 명료도 점수는 열화요인에 따라 체계적인 변화를 보였다. 또한, 명료도 점수에 미치는 두귀요인의 영향을 살펴보기 위해, 방해잡음의 수평 제시각도 효과에 대해서도 검증한 결과, 명료도는 방해잡음의 수평 제시각도에 따라 변화하였다. 그리고, 모든 실험조건에서 목록간에 어떠한 유의미한 차이도 보이지 않았다.

• Membrane and Water Treatment
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• 제7권5호
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• pp.451-462
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• 2016

The molecular weight of proteins and protein hydrolysis products (PHP) in the fractionated post-production marinating brines left after herring marination process was determined by the HPLC. The proteins and PHP retention was evaluated in the three-stage purification process with the usage of polypropylene bag ($25{\mu}m$) and ceramic membranes with the cut-off of 150 and 1 kDa. It was found that the process of marination contributes to high participation of compounds in the post-production marinating brines. Those are characterised by low molecular weight, formed as a result of protein hydrolysis. Each stage of the scavenging process was reducing the content of proteins and PHP. The lowest retention was observed in the stage at which a PP bag was used, while the highest in the UF process, with the usage of 150 kDa membrane. The total retention of proteins and PHP differed according to the type of post-production marinating brines and reached the level of 16-22%.

• 한국전기전자재료학회논문지
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• 제18권10호
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• pp.960-964
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• 2005

In this paper, we dealt with a partial discharge(PD) measurement method that has been accepted as an effective and non-destructive technique to estimate insulation performance of low-voltage electric and electronic devices. The PD measurement system Is composed of a coupling network, a low noise amplifier, and associated electronics. h shielded box Is adopted to make a better measurement environment against around noise. A low cut-off frequency of the coupling network estimated by a sinusoidal wave input was 125 kHz (-3 dB). Calibration tests on laboratory set-up have shown that the PD measurement system has a stable sensitivity of 10 mV/pC. In an application test oil a low-voltage three phase Induction motor (5 HP), we could detect 0.53 pC level of partial discharge at the applied voltage of AC 650 $V_{peak}$.

• Journal of Acupuncture Research
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• 제22권6호
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• pp.111-123
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• 2005

Objectives : Neurological disorders have been one of main therapeutic targets of acupuncture. The present study investigated the protective effects of Gwakhyangjeonggisan herbal acupuncture solution (GHAS). Methods : We performed 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in glioblastoma cells, and did microarray analysis with cells exposed to reactive oxigen species (ROS) of hydrogen peroxide by 8.0 k Human cDNA, with cut-off level of 2-fold changes in gene expression. Results : MTT assay showed protective effect of GHAS on the glioblastoma cells exposed to hydrogen peroxide. When glioblastoma cells were exposed to hydrogen peroxide, 16 genes were upregulated. When the cells were pretreated with GHAS before exposure to hydrogen peroxide, 22 genes were upregulated. Most of the genes upregulated by hydrogen peroxide stimulation were reversed to downregulation by GHAS. Conclusion : The gene expression changes observed in the present study are supposed to be related to the protective molecular mechanism of GHAS in the glioblastoma cells exposed to ROS stress.