• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2012년도 춘계학술대회
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• pp.198-201
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• 2012

연구는 근육의 기능을 조절하는 신경말단에 전기적인 자극을 가하여 신경의 반응 정도를 측정하는 플랫폼 구현에 관란 연구로써, 전기 자극에 대한 신경반응이 가해지는 전류량, 가해진느 전류지속시간, 전극위치에 따른 반응을 측정하였다. 신경자극의 전극 위치는 표면 말단에 운동신경이면 어느 신경이든지 가능하고, 신경자극 양식에는 단순연축자극(Single Twitch Stimulation), 사연속자극(Train-of-four, TOF), 두 집단 발사자극(Double Burst Stimulation, DBS)이 있다. 임베디드 시스템기반으로 가기위한 저전력 MCU를 선정하고, 기본적인 신경자극반응 측정 센서의 민감도를 알아보기 위해 센서 인터페이스를 구성하여 반응정도를 측정해야 한다. 그리고 측정된 Data의 정확도를 높이기 위해 고성능의 AD Convertor 선정하여 플랫폼을 구현하였다. 또한 본 논문의 플랫폼은 의료기기용으로 개발되었기 때문에 시스템 이용자의 안전을 고려하여 전원회로 구성 시 전원 Isolation를 고려하여 설계하였다.

• 한국통신학회논문지
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• 제41권7호
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• pp.809-815
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• 2016

본 논문은 줄기세포 재생 치료를 위해 사용되는 배지에 직류전압을 인가하여 배지에 반응되는 전기적인 저항 값, 전류 값 그리고 전압 값의 상태에 대해 분석하였다. 배지에 반응되는 전압은 줄기세포 분화 유도 과정에서 전기적인 자극에 연관되며 반응 전압 상태에 따라 분화의 상태에 대해 확인 할 수 있다. 배지의 반응 전압에서 전압변화 레벨이 적으면 줄기세포 자극 조건이 안정적이며 만일 전압 변화 레벨이 심하면 줄기세포 자극 조건이 불안정하여 줄기세포 분화 과정에서 상당한 손실을 따르게 될 수 있다. 본 연구는 줄기세포 재생 치료의 가능성을 위해 전기적인 자극 조건의 최적화 하는데 도움이 될 것으로 기대한다.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2010년도 춘계학술대회
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• pp.459-462
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• 2010

본 논문은 근육의 기능을 조절하는 신경말단에 전기적인 자극을 가하여 신경의 반응 정도를 측정하는 플랫폼 구현에 관한 연구로써, 전기 자극에 대한 신경반응이 가해지는 전류량, 가해지는 전류지속시간, 전극위치에 따른 반응을 측정하였다. 신격자극의 전극 위치는 표면말달 운동신경이면 어느 신경이든지 가능하고, 신격자극 양식에는 단순연축자극(Single Twitch Stimulation), 사연속자극(Train-of-four, TOF), 두 집단 발사자극(Double Burst Stimulation, DBS)이 있다. 임베디드 시스템기반으로 가기위한 저전력 MCU를 선정하고, 기본적인 신경자극반응 측정 센서의 민감도를 알아보기 위해 센서 인터페이스를 구성하여 반응정도를 측정해야 한다. 그리고 측정된 Data의 정확도를 높이기 위해 고성능의 AD Convertor 선정하여 플랫폼을 구현하였다. 또한 본 논문의 플랫폼은 의료기기용으로 개발되었기 때문에 시스템 이용자의 안전을 고려하여 전원회로 구성 시 전원 Isolation를 고려하여 설계하였다.

• 대한수의학회지
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• 제31권1호
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• pp.33-40
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• 1991

For the observations of both the membrane properties and the excitability on the unfertilized eggs of female mice, changes of the membrane resistance and the membrane potential by hyerpolarizing current stimulation were recorded. As current-voltage relation was linear over the entire range (-180mV~+60mV), membrane resistance($R_m$) was calculated from the amplitude of electrotonic potential to a given stimulus current. Also the presence of anode-break excitation was confirmed. The results were as follows; 1. There was a linear relation between the membrane resistance and resting membrane potential, the expected input resistance was 61. 4M$\Omega$(resting membrane potential was $-18.9{\pm}8.7mV$, mean${\pm}$SD, n=30). 2. Transient depolarization with overshoot was generated just after hyperpolarizing current stimulus and showed the dependency of stimulus duration. 3. Transient depolarization lasted over 30ms, amplitude of these depolarization was increased by high $Ca^{{+}{+}}$(20mM) and inhibited by $Ca^{{+}{+}}$-antagonist, $Mn^{{+}{+}}$. 4. From the above results, it was suggested that the unfertilized mouse egg showed the characteristics of the excitable cell.

• 대한임상전기생리학회지
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• 제11권1호
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• pp.45-52
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• 2013

Purpose : The goal of this study is to estimate the effect of SSP electrical stimulation applied to acupoints as conducted in oriental medicine on the swallowing function of patients with swallowing difficulties caused by stroke. Methods : Twenty-two hemiplegic stroke patients with swallowing difficulties were divided into an intervention-only group (Group I; n=11) and an intervention-SSP electrical stimulation group (Group II; n=11). Therapeutic intervention was performed on participants in the intervention-only group and the intervention-SSP electrical stimulation group, for 20 minutes per session, three times per week, for four weeks. In this study, SSP electrical stimulation to the acupoints (Cheondol, Yomchon, Budol, Pungji, and Sanyinjian) of stroke patients with swallowing difficulties was applied, and to investigate the effects of SSP electrical stimulation, Clinical dysphagia scale (CDS) and ultrasonography assessment was used to measure pre and post-intervention scores. Results : In the clinical dysphagia scale assessment, the post-intervention score for group II had significant enhancement unlike group I. In the ultrasonography assessment, the hyolaryngeal movement in group II showed significant increase in the swallowing function unlike group I. Conclusion : From the above results, significant effects came from SSP electrical stimulation of 3Hz, biphasic wave, continuous current when applied to the acupoints as conducted in oriental medicine to improve the swallowing function of stroke patients.

• 대한통합의학회지
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• 제10권3호
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• pp.37-52
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• 2022

Purpose : The purpose of this meta-analysis was to evaluate the effects of electrical stimulation on patients with non-specific low back pain. Methods : Domestic databases were gathered from studies that conducted clinical trials associated with electrical stimulation and its impact on pain of non-specific low back patients. A total of 681 studies were identified, with 12 studies satisfying the inclusion data. The studies consisted of patient, intervention, comparison, outcome, and study design (PICO-SD). The search outcomes were items associated with low back pain. Cochrane risk of bias 2 (RoB 2) was used to evaluate the quality of 12 randomized controlled trials. Effect sizes (Hedges's g) in this study were computed as the corrected standard mean difference (SMD). A random-effect model was used to analyze the effect size because of the high heterogeneity among the studies. Egger's regression and 'trim-and-fill' tests were carried out to analyze the publication bias. Cumulative meta-analysis and sensitivity analysis were conducted to analyze the effect according to the sample size and the consistency of the effect size. Results : The following factors had a large overall effect size (Hedges's g=1.28, 95 % CI=.20~2.36) involving electrical stimulation on non-specific low back pain. The subgroup analysis all showed a statistical difference in the types of study design, electrical stimulation, and assessment tool. No statistically significant difference was found in the meta-regression analysis. Publican bias was found in the data. Conclusion : The findings in this study indicate that electrical stimulation interventions have a positive effect on patients with non-specific low back pain. However, due to the low quality of studies and publication bias, the results of our study should be interpreted cautiously.

• The Journal of Korean Physical Therapy
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• 제9권1호
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• pp.51-57
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• 1997

The purpose of this study was to determine the effect of two different forms of transcutaneous electrical nerve stimulation(TENS) and one of microcurrent high voltage pulsed galvanic current(HVPC) on sympathetic tone in healthy subjects. Fourty subjects received TENS(20) and PVPC(30) during short time(20min). Left finger tip skin temperatures were measured at four interval for each treatment : 1) before treatment, 2) after 10 minutes treatment, 3)after 20 minutes treatment, and 4) after 10 minutes rest. The results were as follows. 1) TENS treatment group increased skin temperature after treatment 20 minutes, but HVPC treatment increased akin temperature after 10 minutes and recovered normal skin temperature after 10 minutes treatment. It means that short time(20min) electrical stimulation decreased sympathetic activities. 2) Sympathetic activities of TENS stimulation were influenced by age, but HVPC were not. 3) During 10 minutes, both treatment increased sympathetic activities, but HVPC treatment reversed sympathetic activity more rapidly than TENS. 4) The changes of skin temperature means by sex, males in TENS treatment group were higher than females, but HVPC were reverted.

• 한국임상수의학회지
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• 제5권1호
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• pp.9-21
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• 1988

Gastro-intestinal mortility and transit time of barium sulfate after electroacupuncture were investigated in normal dogs and administration of xylatine in dogs. Electroacupuncture was performed with a current of 1.5 volt and 20 Hz at the acupoints of Tsu San Li(right(+) left(-) in dogs for 30 minutes. The results were as follows: 1. After electroacupuncture stimnlation in normal dogs, rates of stomach contractions was not changed, but amplitudes of stomach motility was markadly increased. The electroacupuncture stimulation tasted about 60 minutes after the end of electroacupuncture. 2. The stomach contractions was markedly increased, while the amplitudes of stomach motility was sligltly decreased by the administration of xylazine in dogs. 3. The rates of stomach contractions and amplitudes of motility were markedly increased after administration of xylazine in the electroacupuncture stimulated dogs. 4. Gastric emptying time o barium sulfate after electroacupuncture stimulation in dogs was highly significantly decreased compared with that of normal dogs(p < 0.01). 5. Small bowel transit time of barium sulfate after electroacupuncture stimulation in dogs was highly significantly decreased compared with that of normal dogs (p < 0.01). 6. Gastroduodenal transit time of barium sulfate after administration of xylazine following electroacupuncture stimulation dogs was blighty significantly decreased compared to that of dogs dosed with xylazine (p< 0.01). 7. Small bowel transit time of barium sulfate after administration of xylazine following electroacupuncture stimulation dogs markedly decreased compared to that of dogs dosed with xylazine (p < 0.05).

• The Korean Journal of Physiology and Pharmacology
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• 제4권6호
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• pp.455-461
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• 2000

Zinc contained in the neurons of central nervous system is activity-dependently released and then attenuates NMDA (N-methyl-D-aspartate)-induced neurotoxicity while augmenting non-NMDA-induced neurodegeneration. Zinc also has been reported to produce antinociceptive action on the inflammation- and nerve injury-induced hyperalgesia in the behavioral test. In this study, we investigated the effects of zinc on the responses of dorsal horn cells to NMDA, kainate and graded electrical stimulation of C-fibers. In the majority of WDR cells (70.6%), zinc current-dependently inhibited WDR cell responses to NMDA and in the remaining cells, produced biphasic responses; excitation followed by inhibition. Zinc augmented the responses of WDR cells to iontophoretical application of kainate. The dominant effect of $Zn^{2+}$ on the responses of WDR cells to C-fiber stimulation was excitatory, but inhibition, excitation-inhibition and no change of the responses to C-fiber stimulation were induced. $Ca^{2+}-EDTA$ antagonized the excitatory or inhibitory effects of $Zn^{2+}$ on the WDR cell responses. These experimental findings suggest that $Zn^{2+}$ modulates the transmission of sensory information in the rat spinal cord.

• 대한물리의학회지
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• 제15권1호
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• pp.25-32
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• 2020

PURPOSE: This study examined the efficacy of an interferential current (IFC) treatment on the improvement of pain, disability, and quality of life in stroke patients with lumbago. METHODS: A double-blind, randomized clinical trial was conducted on 40 stroke patients with lumbago. The patients were allocated randomly into two groups: the IFC treatment group (n= 20) and the placebo treatment group (n= 20). The IFC group received 30 minutes of IFC treatment on the lumbar region, while the placebo group received IFC treatment but without real electrical stimulation. The intervention was administered five days a week for four weeks. The primary outcomes of pain intensity were measured using a visual analogue scale. The secondary measurements included the Barthel Index, Oswestry Disability Index (ODI), and health-related quality of life (HRQoL). RESULTS: The measurements were conducted before and after the two-week intervention period. Compared to the placebo treatment group, the IFC treatment group showed significantly greater improvement in the pain intensity (p<.05), ODI (p<.05), and SF-36 (p<.05) at the end of the intervention. No significant differences in the Barthel Index were found between the two groups. CONCLUSION: These findings show that an IFC treatment can improve pain, functional ability, and quality of life, highlighting the benefits of somatosensory stimulation from IFC in stroke patients with lumbago.