• 제목/요약/키워드: cryogenic storage

검색결과 143건 처리시간 0.028초

플라스틱 세포치료제 보관용기의 극저온 환경 노출 시 구조적 변화에 대한 해석적 비교 (Analytical comparison of structural changes of plastic cell-based therapeutic drug storage containers when exposed to cryogenic environments)

  • 박정연;이동목;;이순례;윤길상
    • Design & Manufacturing
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    • 제14권2호
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    • pp.1-6
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    • 2020
  • Recently, research and commercialization related to the field of cell-based therapeutic drug development has been actively conducted. In order to maintain cell viability and prevent contamination, refrigeration preservation devices, such as CRF (controlled rate freezer) or vapor type LN2 tanks have been developed. On the other hand, the storage container for liquid nitrogen tanks currently on sale minimizes the flow structure to prevent structural defects when stored in a liquid nitrogen tank having a high thermal conductivity than vapor nitrogen. If the cell-based treatment drug is stored in the gaseous LN2 tank as it is, the cell survival after thawing is greatly reduced. It was estimated that the existing storage container structure was a factor that prevented the rapid entry and circulation of gaseous nitrogen into the container. Therefore, this study intends to propose a new supercellular storage container model that can maintain the mechanical strength while maximizing the fluid flow structure. To this end, we estimated that the structural change of the storage container effects on the equivalent stress formed around the through-holes of them when exposed to a cryogenic environment using thermal-structural coupled field analysis. As a result of storage experiments in the gas phase tank of the cell-based therapeutic agent using the developed storage container, it was confirmed that the cell growth rate was improved from 66% to 77%, which satisfied the transportation standards of the FDA(Food and Drug Administration) cell-based therapeutic agent.

Prediction of the effective thermal conductivity of microsphere insulation

  • Jin, Lingxue;Park, Jiho;Lee, Cheonkyu;Seo, Mansu;Jeong, Sangkwon
    • 한국초전도ㆍ저온공학회논문지
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    • 제16권1호
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    • pp.36-41
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    • 2014
  • Since glass microsphere has high crush strength, low density and small particle size, it becomes alternative thermal insulation material for cryogenic systems, such as storage and transportation tank for cryogenic fluids. Although many experiments have been performed to verify the effective thermal conductivity of microsphere, prediction by calculation is still inaccurate due to the complicated geometries, including wide range of powder diameter distribution and different pore sizes. The accurate effective thermal conductivity model for microsphere is discussed in this paper. There are four mechanisms which contribute to the heat transfer of the evacuated powder: gaseous conduction ($k_g$), solid conduction ($k_s$), radiation ($k_r$) and thermal contact ($k_c$). Among these components, $k_g$ and $k_s$ were calculated by Zehner and Schlunder model (1970). Other component values for $k_c$ and $k_r$, which were obtained from experimental data under high vacuum conditions were added. In this research paper, the geometry of microsphere was simplified as a homogeneous solid sphere. The calculation results were compared with previous experimental data by R. Wawryk (1988), H. S. Kim (2010) and the experiment of this paper to show good agreement within error of 46%, 4.6% and 17 % for each result.

LNG 지하 저장탱크 벽체의 비선형 열응력 해석 (Nonlinear Thermal Stress Analysis of In-ground LNG Storage Tank)

  • 곽효경;송종영;이광모
    • 한국전산구조공학회:학술대회논문집
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    • 한국전산구조공학회 2000년도 봄 학술발표회논문집
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    • pp.111-118
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    • 2000
  • Concrete cracking due to the temperature gradient across the wall, caused by the difference in temperature between cryogenic liquid natural gas stored and surrounding environment of in-ground LNG storage tank, is investigated in this study. Crack propagation of concrete LNG tank is effectively simulated by using a layered degenerated shell element. In addition, material nonlinearity is taken into consideration on the basis of the nonlinear elastic-orthotropic model. Finally, numerical analysis for a real LNG storage tank is conducted with the objective to verify the efficiency of the introduced model.

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타입 3 극저온 추진제 탱크의 액체질소저장 시험 및 파손 분석 (LN2 storage test and damage analysis for a Type 3 cryogenic propellant tank)

  • 강상국;김명곤;박상욱;공철원;김천곤
    • 한국항공우주학회지
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    • 제35권7호
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    • pp.592-600
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    • 2007
  • 최근에 발사체의 경량화를 위해 추진제 탱크의 재료를 복합재료로 대체하기 위한 연구가 많이 진행되고 있다. 본 연구에서는 극저온용으로 개발된 복합재와 알루미늄 라이너로 구성된 타입 3 추진제 탱크를 제작하고 실제 극저온 상태의 운용환경을 고려한 실험을 수행하였다. 이를 위해 액체 질소를 제작된 타입 3 탱크에 주입하고 기체 질소를 이용하여 가압하였다. 실험수행과정에서 헬리컬 층과 후프 층 사이에서 층간 분리 현상이 관찰되었으며, 이에 대한 원인을 분석하기 위해 해석적 방법과 실험적 방법이 사용되었다. 해석적 방법에서는 점진적 파손 해석을 고려한 열탄성 해석으로부터 파손 지수를 평가하였으며 실험적 방법에서는 타입 3 탱크를 쉽게 모사할 수 있는 복합재/알루미늄 링 시편의 액체질소 담금 시험을 통해 헬리컬 층과 후프 층 사이의 계면을 관찰하였다.

Optimization approach of insulation thickness of non-vacuum cryogenic storage tank

  • MZAD, Hocine;HAOUAM, Abdallah
    • 한국초전도ㆍ저온공학회논문지
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    • 제22권1호
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    • pp.17-23
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    • 2020
  • Cryogenic insulation systems, with proper materials selection and execution, can offer the highest levels of thermal performance. Insulations are listed in order of increasing performance and, generally, in order of increasing cost. The specific insulation to be used for a particular application is determined through a compromise between cost, ease of application and the effectiveness of the insulation. Consequently, materials, representative test conditions, and engineering approach for the particular application are crucial to achieve the optimum result. The present work is based on energy cost balance for optimizing the thickness of insulated chambers, using foamed or multi layered cryogenic shell. The considered insulation is a uniformly applied outer layer whose thickness varies with the initial and boundary conditions of the studied vessel under steady-state radial heat transfer. An expression of the optimal insulation thickness derived from the total cost function and depending on the geometrical parameters of the container is presented.

액체질소의 절연파괴특성 (Characteristics of Dielectric Breakdown in Liquid Nitrogen)

  • 추영배;류경우;류강식;김상현
    • 대한전기학회논문지
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    • 제37권12호
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    • pp.872-878
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    • 1988
  • During the past few years, a great deal of attention has been directed to the application of superconductivity to the electrical systems such as superconducting power transmission lines, superconducting magnet energy storage and so on. Yet in order to develop the practical model of these electrical equiqments utilizing suprconductivety and other phenomena at cryogenic temperautre, it is necessary to know the dielectric behaviour of insulating materials at cryogenic temperature in view of reliability, safety and economy of these machines. Investigation of dielectric properties of cryogenic liquids is very important due to the dual role of those as the dielectric and cooling medium. In this study, we investigated results measured over several kinds of dielectric characteristics of liquid nitrogen taking into consideration for application of high Tc superconductor. Dependence of breakdown voltage of gap width, polarity and pressure is reported in this paper and time delay characteristics of breakdown is also the subject of this discussion.

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On the Leakage Analysis of a Full Containment Tank Using a FEM

  • Kim, Chung-Kyun
    • KSTLE International Journal
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    • 제7권2호
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    • pp.45-50
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    • 2006
  • In this paper, the leakage safety of prestressed concrete structure including the insulation panels has been analyzed using a finite element analysis just after a collapse of 9% nickel inner tank. This FEM study shows that the outer tank may contain the leaked cryogenic liquid for the time being until the primary pump in the inner tank transports stored cryogenic liquids to the nearest LNG storage tank before the outer tank is demolished. This means that the total tank thickness from the insulation panel to the outer tank system safely may retain the leaked cryogenic fluids. The FE computed results indicate that the current structure in a full containment tank is obviously enough to securing the leak-proof safety of the tank system with two primary pumps.

극저온 환경 하 플라이우드의 전단 거동 및 파손 특성 분석 (Analysis of Shear Behavior and Fracture Characteristics of Plywood in Cryogenic Environment)

  • 손영무;김정대;오훈규;김용태;박성보;이제명
    • 한국해양공학회지
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    • 제33권5호
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    • pp.394-399
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    • 2019
  • Plywood is a laminated wood material where alternating layers are perpendicular to each other. It is used in a liquefied natural gas (LNG) carrier for an insulation system because it has excellent durability, a light weight, and high stiffness. An LNG cargo containment system (LNG CCS) is subjected to loads from gravity, sloshing impact, hydrostatic pressure, and thermal expansion. Shear forces are applied to an LNG CCS locally by these loads. For these reasons, the materials in an LNG CCS must have good mechanical performance. This study evaluated the shear behavior of plywood. This evaluation was conducted from room temperature ($25^{\circ}C$) to cryogenic temperature ($-163^{\circ}C$), which is the actual operating environment of an LNG storage tank. Based on the plywood used in an LNG storage tank, a shear test was conducted on specimens with thicknesses of 9 mm and 12 mm. Analyses were performed on how the temperature and thickness of the plywood affected the shear strength. Regardless of the thickness, the strength increased as the temperature decreased. The 9 mm thick plywood had greater strength than the 12 mm thick specimen, and this tendency became clearer as the temperature decreased.

소형 GM 냉동기를 이용한 수소 액화에 관한 시뮬레이션 연구 (A Simulation Study on the Hydrogen Liquefaction through Compact GM Refrigerator)

  • 정하늘;한단비;양원균;백영순
    • 한국수소및신에너지학회논문집
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    • 제33권5호
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    • pp.534-540
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    • 2022
  • Liquid hydrogen has the best storage capacity per unit mass and is economical among storage methods for using hydrogen as fuel. As the demand for hydrogen increases, the need to develop a storage and supply system of liquid hydrogen is emphasizing. In order to liquefy hydrogen, it is necessary to pre-cool it to a maximum inversion temperature of -253℃. The Gifford-McMahon (GM) refrigerator is the most reliable and commercialized refrigerator among small-capacity cryogenic refrigerators, which can extract high-efficiency hydrogen through liquefied hydrogen production and boil of gas re-liquefaction. Therefore, in this study, the optimal conditions for liquefying gas hydrogen were sought using the GM cryocooler. The process was simulated by PRO/II under various cooling capacities of the GM refrigerator. In addition, the flow rate of hydrogen was calculated by comparing with specific refrigerator capacity depending on the pressure and flow rate of a refrigerant medium, helium. Simulations were performed to investigate the optimal values of the liquefaction flow rate and compression pressure, which aim for the peak refrigeration effect. Based on this, a liquefaction system can be selected in consideration of the cycle configuration and the performance of the refrigerator.

극저온용 2단 임펠러 액중펌프 역설계에 관한 연구 (A Study of the Reverse Engineering of a Two-Stage Impeller-Submerged Pump for Cryogenic Fluids)

  • 권병수;이중섭;이치우
    • 한국기계가공학회지
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    • 제16권3호
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    • pp.9-15
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    • 2017
  • This study represents basic research for the development of submerged pump technology applicable to transfer and storage of a cryogenic liquids. Its purpose is to secure baseline design data by applying reverse engineering to the process of developing a submerged cryogenic pump. The two-stage model included in the ARTICK Series LNG Submerged Pump produced by Vanzetti of Italy was selected for analysis for development of a localized product, and was disassembled for reverse engineering. The pump was disassembled after analyzing its processing/assembly characteristics such as shrinkage of fittings. In addition, the materials used in manufacturing of the main components were analyzed, and the ingredients were confirmed. As a result, a design drawing for each component required for product development was secured via foundational design, and a test product was manufactured by maximizing the application of appropriate domestic technologies.