• Journal of Pharmaceutical Investigation
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• 제37권1호
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• pp.57-62
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• 2007

The purpose of the present study was to evaluate the bioequivalence of two donepezil tablets, $Aricept^{TM}$ tablet (Dae Woong Pharm. Co., Ltd., Korea, reference drug) and $Donpezil^{TM}$ tablet (Dong Wha Pharm. Ind. Co., Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four healthy male Korean volunteers received one tablet containing donepezil hydorchloride 10 mg in a $2{\times}2$ crossover study. There was a three-week washout period between the doses. Plasma concentrations of donepezil were monitored by an LC-MS/MS far over a period of 240 hr after the administration. $AUC_t$, (the area under the plasma concentration-time curve from time zero to 240 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$)were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$, No significant sequence effects were found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ and $C_{max}$ were log 0.95${\sim}$log 1.03 and log 0.94${\sim}$log 1.08, respectively. These values were within the acceptable bioequivalence intervals of log 0.80${\sim}$log 1.25. Taken together, our study demonstrated the bioequivalence of $Aricept^{TM}$ and $Donpezil^{TM}$ with respect to the rate and extent of absorption.

• Journal of Pharmaceutical Investigation
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• 제34권4호
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• pp.311-317
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• 2004

A bioequivalence study of $Gomcillin^{TM}$ capsules (DAEWOONG Pharmaceutical Co., Korea) to $Famoxin^{TM}$ capsules (Dong Wha Pharm. Ind. Co., Korea) was conducted according to the guideline of Korea Food and Drug Administration (KFDA). Twenty four healthy male Korean volunteers received each medicine at the amoxicillin dose of 500 mg in a $2{\times}2$ crossover study. There was a one-week wash out period between the doses. Plasma concentrations of amoxicillin were monitored by a high-performance liquid chromatography for over a period of 8 hours after the administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 8 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Gomcillin^{TM}/Famoxin^{TM}$ were $log0.91\;{\sim}\;log1.03$ and $;log0.93\;{\sim}\;log1.10$, respectively. These values were within the acceptable bioequivalence intervals of $log0.80\;{\sim}\;log1.25$. Thus, our study demonstrated the bioequivalence of $Gomcillin^{TM}$ and $Famoxin^{TM}$ with respect to the rate and extent of absorption.

• 공업화학
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• 제8권6호
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• pp.960-966
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• 1997

양이온 촉매(N-Benzylpyrazinium hexafluoroantimonate, BPH)/에폭시 경화계에서 에폭시 수지(DGEBA/DGEBF)의 에폭시 당량 및 촉매함량이 경화 거동, 열적특성 및 유변학적 특성에 미치는 영향을 FT-IR, DSC 및 Dynamic Viscometer를 이용하여 연구하였다. 0.5wt% BPH를 함유하는 DGEBA의 경우 DGEBF/BPH에 비하여 반응 속도가 빠르고 반응 초기에서의 반응 진행(전환율)이 크게 나타나는 것을 등온 DSC 및 FT-IR 결과에서 확인할 수 있었다. 반면 BPH의 함량이 증가함에 따라 반응속도와 전환율이 거의 같은 값을 보여줌을 알 수 있었다. 겔화점(Gel point)으로 정의되는 저장 탄성율(G')과 손실 탄성율(G")의 교차점(G'/G"=1)의 경우 하이드록시기를 포함할 때 도달시간이 빠르게 나타나는데 이는 반응 초기에 하이드록시기의 반응 참여에 의해 반응 초기에 3차원 가교 구조를 형성하는 것으로 생각되었고 또한 DSC 및 FT-IR 결과와 일치하는 결과를 보여주었다. 겔화점에 도달하는 시간을 이용하여 구한 활성화에너지 값은 $31-39kJ.mol^{-1}$의 값을 나타내었다.

• 대한전자공학회논문지TC
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• 제43권12호
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• pp.53-60
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• 2006

WiBro의 핸드오버는 IEEE 802.16e 기반인 하드 핸드오버 방법이고 핸드오버시 주위 neighbor advertisement 메시지에서 주위 cell의 상태와 RAS(Radio Access Station) ID를 확인하여 핸드오버를 한다. 이때 주변 RAS로 HO-notification 메시지를 보낸다. 예상되는 RAS로 HO-notification 메시지를 보냄으로써 불필요한 signal이 많이 발생하게 되고 핸드오버 수행 시 packet 손실이 발생한다. 이로 인하여 서비스의 품질저하가 발생한다. 이러한 문제점을 해결하기 위하여 LPM(Last Packet Marker) 핸드오버 방법이 제안되었다. LPM 핸드오버는 핸드오버 동안 미리 data packet을 저장하기 때문에, seamless 핸드오버를 지원한다. 또한, GPS를 이용하여 PSS(Portable Subscriber Station)의 위치를 파악함으로써, 이동이 예상되는 RAS를 예측하는 방법과 선인증 과정을 이용하여 이동하고자 하는 RAS를 미리 예약하는 방법들이 제안되고 있다. LPM 핸드오버 방법과 선인증 과정을 이용한 방법은 PSS와 RAS에 부담을 주고, 많은 traffic이 발생한다. 본 논문에서는 이러한 문제점을 해결하기 위해 PSS 이동 예측 알고리즘을 제안한다. PSS가 history cache를 가지고 있고 history cache가 가지고 있는 과거의 핸드오버 data와 비교하여 target RAS를 정하고 HO-notification-RSP 메시지를 target RAS로부터 받을 때 crossover node에 target RAS를 알림으로써 serving RAS와 target RAS로 data 패킷을 bicast하고 target RAS는 buffer에 저장하였다가 핸드오버 완료시 전송함으로써 패킷 손실을 막고 불필요한 시그널링 트래픽을 막는 알고리즘을 제안하였다. 시그널링 트래픽은 history cache가 성공시 약 48%의 traffic이 감소되었고 history cache 실패시 약 기존 핸드오버 보다 약 6%의 traffic이 증가되었다.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제10권6호
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• pp.514-528
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• 2004

본 논문에서는 감성에 기반한 장면단위 비디오 검색방법을 제안한다 먼저 특정 줄거리를 담은 장면 비디오 클립에서 급진적/점진적 샷 경계 검출 후. "평균 색상 히스토그램", "평균 자기", "평균 에지 히스토그램", "평균 샷 시간", "점진적 샷 변화율"의 5가지 특징을 추출하고, 이 특징과 사람이 막연하게 가지고 있는 감성공간과의 매핑을 대화형 유전자 알고리즘(IGA, Interactive Genetic Algorithm)을 통하여 실현한다. 제안된 검색 알고리즘은 초기 모집단 비디오들에 대해 찾고자 하는 감성을 내포하고 있는 비디오를 선택하면 선택된 비디오들에서 추출된 특징 벡터를 염색체로 간주하고 이에 대해 교차연산(crossover)을 적용한다. 다음에 새롭게 생성된 염색체들과 특징벡터로 색인된 데이타베이스 비디오들간에 유사도 함수에 의해 가장 유사한 비디오들을 검색하여 다음 세대의 집단으로 제시한다. 이와 같은 과정을 여러 세대에 걸쳐서 실행하여 사용자가 가지고 있는 감성을 내포하는 비디오 집단들을 얻게 된다 제안된 방법의 효과성을 보이기 위해, 300개의 광고 비디오 클립들에 대해 "action", "excitement", "suspense", "quietness", "relaxation", "happiness" 의 감성을 가진 비디오를 검색한 결과 평균 70%의 만족도를 얻을 수 있었다.

• 패션비즈니스
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• 제23권1호
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• pp.116-126
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• 2019

The purpose of this study is to objectify the shape of curvature and average change rate of angular and arched eyebrow makeup. The data for the analysis were the final 336 pieces for the cosmetology students in the whole country. SPSS 20.0 program was used for the collected data, frequency analysis, factor analysis, reliability analysis, and crossover analysis were performed. First, the frequency of the average change rate of eyebrow makeup (angular and arcuate) was analyzed. As a result, the eyebrows suitable for the angled type showed the highest level of 'A-2' and the arched eyebrows had the highest level of 'B-2'. Second, to analyze the important factors of eyebrow makeup, frequency of eyebrows was the most important, followed by the inclination of eyebrows and eyebrow tail. Third, factor analysis and reliability analysis were conducted to examine each dimension of eyebrow makeup perception, and it was derived from three factors including acceptability, aggressiveness, and playability. Fourth, in order to analyze the difference of important factors in the form of the standard eyebrow makeup, the cross - analysis was performed with chi - square test, and it was confirmed that the angular eyebrow makeup showed the most objectivity when the average change rate was 0.29 and the curvature was 0.67. Fifth, arcuate eyebrow makeup showed the most objectivity when the average change rate was 0.57 and curvature was 0.56. The results of this analysis can be used as objective data of aesthetic criteria when designing the eyebrow shape.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2005년도 춘계학술대회
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• pp.227-230
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• 2005

There is a worldwide interest In the development and commercialization of PEMFCs for vehicular and stationary applications. The major problem in the practical use of PEMFCs is the deactivation of the Pt anode electrocatalyst by the adsorption of carbon monoxide. Therefore, intensive work has been devoted to finding electrocatalysts that are tolerant to CO in hydrogen at operating temperatures bellow $100^{\circ}C$. Also, DMFC is considered to be one of the most promising technologies for energy generation. But, the most important problem associated with the DMFC is the slow reaction rate of methanol oxidation and the second major problem is fuel crossover. So, the performance of a state-of-the-art DMFC is considerably lower than that of hydrogen-fuelled PEMFC. In this research, the preparation and characterization of electrode materials will be introduced. Also, some electrochemical techniques for the characterization of PEMFCs will be presented.

• 산업공학
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• 제14권3호
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• pp.227-235
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• 2001

There is a rapidly growing demand for wireless telecommunication. However, the number of usable channel is very limited. Therefore, the problem of channel assignment becomes more and more important to use channels as efficiently as possible. The objective of this paper is to develop an evolution program (EP) to find an efficient dynamic channel assignment method for minimum interference among the channels within reasonable time. The series of specific channel number is used as a representation of chromosome. The only changed chromosomes by crossover and mutation are evaluated in each generation to save computation time and memory for the progress of improved EP. We can easily differentiate the fitness value of each chromosome using proposed evaluation function. We also control the weighting factor of the mutation rate and the used number of elitist chromosomes for the speed of convergence to the optimal solution.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2003년도 신호처리소사이어티 추계학술대회 논문집
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• pp.517-520
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• 2003

Commercial video scope use CCD sensor and frame grabber for image capture and A/D interface but application limited by input resolution and high cost. In this paper we introduce portable video scope using CMOS sensor, USB pen and tuner card (low frame grabber) in place of commercial CCD sensor and frame grabber. Our video scope serves as an essential link between advancing commercial technology and research, providing cost effective solutions for educational, engineering and medical applications across an entire spectrum of needs. The software implementation is done using Direct Show in second version after initial trials using First version VFW (video for window), which gave very low frame rate. Our video scope operates on windows 98, ME, XP, 2000. The drawback of our video scope is crossover problem in output images caused due to interpolation, which has to be rectified for more efficient performance.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1995년도 추계학술발표회논문집(1)
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• pp.123-128
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• 1995

A classical PID controller is designed by applying the GA (Genetic Algorithm) which searches the optimal parameters through three major operators of reproduction, crossover and mutation under the given constraints. The GA could minimize the designer's interference and the whole design process could easily be automated. In contrast with other traditional PID design methods which allows for the system output responses only, the design with the GA can take account of the magnitude or the rate of change of control input together with the output responses, which reflects the more realistic situations. Compared with other PIDs designed by the traditional methods such as Ziegler and analytic, the PID by the GA shows the superior response characteristics to those of others with the least control input energy.