• Title/Summary/Keyword: crossover analysis

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Time Series Analysis of Gamma exposure rates in Gangneung Area (강릉 지역 공간 감마선량률의 시계열 분석)

  • Cha, Hohwan;Kim, Jaehwa
    • Journal of the Korean Society of Radiology
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    • v.7 no.1
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    • pp.25-30
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    • 2013
  • In this work, we investigate the statistical properties of gamma exposure rates using well-known analysis methods, such as Autocorrelation Function Analysis(ACF), Rescaled Range Analysis(R/S Analysis), and Detrended Fluctuation Analysis(DFA). Especially, DFA is an important method to reliably detect long-range correlations in non-stationary time series. Our data are measured by Gangneung regional radiation monitoring station over the period of 1998 to 2011. First, we find a crossover indicating two different governing regimes in fluctuations of gamma exposure rates. Within a year, they show a strong long-ranged memory while this property vanishes over the range of time period longer than one year. Second, our finding is very securely supported by a variety of analysis tools. Those tools yield many relevant exponents which satisfies the well known relation between them.

Design Development for the Ocean & Leasure Industry (해양레저산업 활성화를 위한 아이디어 상품 디자인개발 사례)

  • Kang, Bum-Kyu;Lee, Bo-Bae;Kim, Sung-Hyun
    • The Journal of the Korea Contents Association
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    • v.12 no.10
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    • pp.116-127
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    • 2012
  • With the recent rapid growth in the number of people who enjoy marine and leisure activities in Korea, the marine leisure industry faces good opportunities for development. Korean brands are in between them. In this situation, new and innovative products related to an inflatable tube, which is one of the most popular marine leisure items, will help to increase sales of domestic companies and to pioneer a new market. Research methods are largely divided into 4: investigation, analysis & synthesis, development and evaluation. This paper introduces a "tube cushion" which is an inflatable tube covered by fabrics. It can be functioned at home 365 days a year as a cushion or a children's plaything. Tactile fabrics, neoprene and air-mesh, are used as the cover with a zipper, making it easy to open and close. Moreover, by putting together tubes and connecting them with snap fastener attached straps, the cushion can be transformed into a chair, a table, a tunnel, a train, and so on, serving as a creative plaything for children. With this paper, it is expected that new and innovative items differentiated from others, like this crossover tube cushion, will help to create a 'Blue Ocean' market for the marine leisure industry from the long-term perspective.

Bioequivalence of A-PINE Tablet to SKAD Tablet (Amlodipine Maleate 6.42 mg) (스카드 정(말레인산암로디핀 6.42 mg)에 대한 에이핀 정의 생물학적 동등성)

  • Kim, Sung-Su;Park, Wan-Su;Lee, Heon-Woo;Seo, Ji-Hyung;Kim, Yong-Won;Cho, Sung-Hee;Rew, Jae-Hwan;Lee, Kyung-Tae
    • Journal of Pharmaceutical Investigation
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    • v.36 no.1
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    • pp.59-65
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    • 2006
  • The purpose of this study was to evaluate the bioequivalence of two amlodipine maleate tablets, SKAD tablet (SK Pharma. Co., Ltd., Seoul, Korea, reference drug) and A-PINE tablet (Daewon Pharm. Co., Ltd., Seoul, Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four healthy male volunteers, $22.79\;{\pm}\;1.86$ years in age and $70.08\;{\pm}\;8.68$ kg in body weight, were divided into two groups and a randomized $2\;{\time}\;2$ crossover study was employed. After a tablet containing 6.42 mg of amlodipine maleate was orally administrated, blood was taken at predetermined time intervals over a period of 144 hr and concentrations of amlodipine in plasma were monitored using LC-MS/MS. Pharmacokinetic parameters such as $AUC_t$ (the area under the plasma concentration-time curve from time zero to 144 hr), $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were calculated and analysis of variance (ANOVA) test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$ and $C_{max}$, and untransformed $T_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for A-PINE/SKAD were $log\;0.9429{\sim}log \;1.1476$ and $log\;0.9l46{\sim}log\;1.1488$, respectively. Since these values were within the acceptable bioequivalence intervals of $log\;0.80{\sim}log\;1.25$, recommended by KFDA, it was concluded that A-PINE tablet was bioequivalent to SKAD tablet, in terms of both rate and extent of absorption.

Asymptotic Analysis on the Stagnation-Point Ignition of Hydrogen-Oxygen Mixture at High Pressures (고압하에서 수소-산소의 정체점 점화에 관한 이론적 해석)

  • Lee, Su-Ryong
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.27 no.10
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    • pp.1393-1400
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    • 2003
  • Ignition of hydrogen and oxygen in the "third limit" is theoretically investigated in the stagnation point flow with activation energy asymptotics. With the steady-state approximations of H, OH, O and HO$_2$, a two-step reduced kinetic mechanism is derived for the regime lower than the crossover temperature T$_{c}$ at which the rates of production and consumption of all radicals are equal. Appropriate scaling of Damkohler number successfully provides the explicit relationship between pressure, temperature and strain rate at ignition. It is shown that, compared with those for the counterflow, ignition temperatures for the stagnation point flow are considerably increased with increasing the system pressure. This is because ignition in the "third limit" is characterized by the production of reduction of $H_2O$$_2$, which is reduced by wall effect. Strain rate substantially affects ignition temperature because key reaction rates of $H_2O$$_2$ are comparably with its transport rate, while the mixture temperature and the hydrogen composition do not significantly affect ignition temperature.e.

Effects of Music Therapy on Agitation in Dementia: Systematic Review and Meta-analysis (음악요법이 치매의 초조행동에 미치는 효과: 체계적 문헌고찰 및 메타분석)

  • Kong, Eun-Hi;Park, Myonghwa
    • Korean Journal of Adult Nursing
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    • v.27 no.1
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    • pp.106-116
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    • 2015
  • Purpose: The purpose of this review was to assess the quality and to evaluate the effectiveness of music interventions in reducing agitation in older adults with dementia. Methods: Randomized controlled studies and randomized crossover studies were identified by searching MEDLINE, EMBASE, CINAHL, PsycINFO, AGELINE, Cochrane Central Register of Controlled Trials, Korea Med, Kmbase, RISS, National Assembly Digital Library, KISS, and RICH. Two reviewers independently retrieved articles, extracted data, and assessed the quality of studies. Results: In total, 10 studies were selected from 1095 unique citations. All included studies were conducted in long term care settings. Overall, risk of bias for included studies was low to moderate. The weighted average effect size across studies was -0.39 (95%CI [-0.69, -0.10], p=.009, $I^2=63%$). Music therapy was effective to reduce agitation of the older adults with dementia. Conclusion: Music intervention can be an effective non-pharmacological intervention for the reduction of agitation in dementia. Future studies need to use rigorous research method and to provide description of research methods in greater detail. In addition, future studies are required to explore the effects of music therapy according to severity of agitation and dementia.

Design of a Water Quality Monitoring Network in the Nakdong River using the Genetic Algorithm (유전자 알고리즘을 이용한 낙동강 유역의 수질 측정망 설계에 관한 연구)

  • Park, Su-Young;Wang, Sookyun;Choi, Jung Hyun;Park, Seok Soon
    • Journal of Korean Society on Water Environment
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    • v.23 no.5
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    • pp.697-704
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    • 2007
  • This study proposes an integrated technique of Genetic Algorishim (GA) and Geographic Information System (GIS) for designing the water quality monitoring networks. To develop solution scheme of the integrated system, fitness functions are defined by the linear combination of five criteria which stand for the operation objectives of water quality monitoring stations. The criteria include representativeness of a river system, compliance with water quality standards, supervision of water use, surveillance of pollution sources and examination of water quality changes. The fitness level is obtained through calculations of the fitness functions and input data from GIS. To find the most appropriate parameters for the problems, the sensitivity analysis is performed for four parameters such as number of generations, population sizes, probability of crossover, and probability of mutation. Using the parameters resulted from the sensitivity analysis, the developed system proposed 110 water quality monitoring stations in the Nakdong River. This study demonstrates that the integrated technique of GA and GIS can be utilized as a decision supporting tool in optimized design for a water quality monitoring network.

Examination of useful items for the assessment of fall risk in the Korean community-dwelling elderly (한국 노인의 낙상위험평가 설문항목의 유효성 검토)

  • Shin, Sohee
    • Journal of the Korea Convergence Society
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    • v.9 no.6
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    • pp.271-277
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    • 2018
  • The aim of this study was to select useful items for assessing fall risk in community-dwelling elderly. This study assumed five fall risk factors: Symptoms of falling, physical function, disease and physical symptoms, environment, and behavior and character based on previous studies. The questionnaire consisted of 44 items according to the contents validation, crossover analysis and factor analysis. The Korean version of the Fall Risk Assessment Scale (FRA-K) will be used as a useful tool to improve the fall problems perceived to be serious social problems and to provide important information for prevention of falls.

Application of multi-objective genetic algorithm for waste load allocation in a river basin (오염부하량 할당에 있어서 다목적 유전알고리즘의 적용 방법에 관한 연구)

  • Cho, Jae-Heon
    • Journal of Environmental Impact Assessment
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    • v.22 no.6
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    • pp.713-724
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    • 2013
  • In terms of waste load allocation, inequality of waste load discharge must be considered as well as economic aspects such as minimization of waste load abatement. The inequality of waste load discharge between areas was calculated with Gini coefficient and was included as one of the objective functions of the multi-objective waste load allocation. In the past, multi-objective functions were usually weighted and then transformed into a single objective optimization problem. Recently, however, due to the difficulties of applying weighting factors, multi-objective genetic algorithms (GA) that require only one execution for optimization is being developed. This study analyzes multi-objective waste load allocation using NSGA-II-aJG that applies Pareto-dominance theory and it's adaptation of jumping gene. A sensitivity analysis was conducted for the parameters that have significant influence on the solution of multi-objective GA such as population size, crossover probability, mutation probability, length of chromosome, jumping gene probability. Among the five aforementioned parameters, mutation probability turned out to be the most sensitive parameter towards the objective function of minimization of waste load abatement. Spacing and maximum spread are indexes that show the distribution and range of optimum solution, and these two values were the optimum or near optimal values for the selected parameter values to minimize waste load abatement.

Uncertainty analysis of ROSA/LSTF test by RELAP5 code and PKL counterpart test concerning PWR hot leg break LOCAs

  • Takeda, Takeshi;Ohtsu, Iwao
    • Nuclear Engineering and Technology
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    • v.50 no.6
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    • pp.829-841
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    • 2018
  • An experiment was conducted for the OECD/NEA ROSA-2 Project using the large-scale test facility (LSTF), which simulated a 17% hot leg intermediate-break loss-of-coolant accident in a pressurized water reactor (PWR). In the LSTF test, core uncovery started simultaneously with liquid level drop in crossover leg downflow-side before loop seal clearing, and water remaining occurred on the upper core plate in the upper plenum. Results of the uncertainty analysis with RELAP5/MOD3.3 code clarified the influences of the combination of multiple uncertain parameters on peak cladding temperature within the defined uncertain ranges. For studying the scaling problems to extrapolate thermal-hydraulic phenomena observed in scaled-down facilities, an experiment was performed for the OECD/NEA PKL-3 Project with the Primarkreislaufe Versuchsanlage (PKL), as a counterpart to a previous LSTF test. The LSTF test simulated a PWR 1% hot leg small-break loss-of-coolant accident with steam generator secondary-side depressurization as an accident management measure and nitrogen gas inflow. Some discrepancies appeared between the LSTF and PKL test results for the primary pressure, the core collapsed liquid level, and the cladding surface temperature probably due to effects of differences between the LSTF and the PKL in configuration, geometry, and volumetric size.

Consumer Characteristics in Terms of Pet Food Selection Attributes (펫푸드(반려동물 식품) 선택속성에 대한 소비자 특성 분석)

  • Park, Myeong-Eun;Um, Ji-Bum
    • Journal of Agricultural Extension & Community Development
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    • v.28 no.2
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    • pp.85-98
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    • 2021
  • This study aims to examine consumer types based on pet food selection attributes and to analyze the differences in consumer characteristics by those types. In this study, the researcher uses k-means cluster analysis and crossover analysis to determine market segmention, and then analyzes the resultant characteristics by categorizing consumers. A total of 202 cases are used for this study. First, the selection attributes are classified into the six factors of credibility, quality, design, convenience, information, and price. Second, the clusters are categorized into the four clusters, which are designated pet food lower-involvement type, pet food information- and price-seeking type, pet food convenience-seeking type, and pet food higher-involvement type. Third, these four groups exhibit statistically significant differences in terms of occupational variables, number of pets, and purchase frequency. The results of this study may provide helpful information in establishing customized, market-based marketing strategies based on the characteristics of pet food consumers.