• 자원환경지질
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• 제39권3호
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• pp.269-284
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• 2006

지하수위와 하천수위와의 상호반응과 수리적으로 다른 특성을 가지는 각 층별(실트질 모래층, 자갈모래층, 풍화대층) 반응관계를 알아보기 위하여 시계열 분석에서 많이 사용되어 온 방법인 자기상관분석과 교차상관분석방법을 이용하였다. 만경강 하천부지에 각 층을 대표하는 깊이에서 지하수위를 관측한 결과, 지하수위가 강수량보다는 하천수위변동에 민감하게 반응하고 있었다. 연구지역의 하천수위변동은 만경강 제수문의 조절과 조석의 영향을 받아 주기적인 수위변동이 우세하기 때문에 강수량과의 상관성은 낮다. 다심도 관정에서 각층별 하천수위에 대한 지하수위 반응은 시간지연 없이 서로 같이 변동하는 것으로 나타났으며, 반응시간은 하천과 가까운 관정에서 30-60분 이내로 빠르며 하천에서 거리가 멀어지면서 반응시간은 대체로 늦게 나타났다. 그러나 하천과 멀리 떨어져 있는 관정이더라도 하천수위에 대하여 빠른 반응을 보이는 관정이 있으며, 이는 하천과 대수층과의 높은 수리적 연결성을 나타낸다. 지하수위의 하천에 대한 반응양상이 다르게 나타나는 것은 대수층의 수리적 불균질성에 의한 것으로 사료된다. 연구지역의 하천은 대체로 지하수위가 하천수위보다 높게 관측되고 있기 때문에 지하수가 하천으로 유출되는 이득하천의 성격을 가지고 있다고 판단되나, 하천의 급격한 수위상승에 따라 역으로 하천의 물이 지하수로 공급되는 손실하천의 성격도 보여주었다. 하천수위와 대수층이 연결된 시스템에서 시계열분석으로서의 자기 및 교차상관분석은 수리적 상호관계를 파악하기 위한 유용한 도구로 활용될 수 있다.

• 한국식품영양학회지
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• 제28권5호
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• pp.871-879
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• 2015

24-hour recall is the dietary assessment method most frequently used to evaluate dietary intake; however, accuracy is an issue when using this method, especially in large-scale studies. The purpose of this study was to assess the validity of dietary intake estimation using one serving size. Estimates of energy and nutrients taken in over a 24-hr period based on actual intake amount (24HRAI) and based on estimates of one serving size (24HRSS) were compared. Data were analyzed using a paired t-test, Pearson's correlation coefficients, and a cross-classification method. In male subjects, intake levels of energy, fat, vitamin C, vitamin $B_1$, Zn, and total food measured using 24HRAI were significantly higher than those measured using 24HRSS. In female subjects, intake of carbohydrates, fiber, fat, vitamin A, vitamin C, vitamin B complexes, various minerals, and total food measured using 24HRAI were significantly lower than those measured using 24HRSS. Energy-adjusted Pearson's correlation coefficients revealed that intake of all nutrients showed a significant positive relationship between the two measurement methods in both males and females. Cross-classification analysis revealed that 50.5~67.6% of women and 40.3~71% of men were classified in the same quartile of intake of each nutrient when comparing data from 24HRAI and 24HRSS. We conclude that using one serving size in 24-hr recall analysis was valid and therefore may be used in studies to assess food consumption in the general adult population. Also, this method can be used to classify energy and nutrient intake into quartile, which is useful in examining the association between diet and chronic diseases.

• 통합자연과학논문집
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• 제10권2호
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• pp.78-84
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• 2017

CXC chemokine receptor 2 (CXCR2) is a prominent chemokine receptor on neutrophils. CXCR2 antagonist may reduce the neutrophil chemotaxis and alter the inflammatory response because the neutrophilic inflammation in the lung diseases is found to be largely regulated through CXCR2 receptor. Hence, in the present study, Hologram based Quantitative Structure Activity Relationship Study was performed on a series of CXCR2 antagonist named pyrimidine-5-carbonitrile-6-alkyl derivatives. The best HQSAR model was obtained using atoms, bonds, and chirality as fragment distinction parameter using hologram length 151 and 6 components with fragment size of minimum 4 and maximum 7. Significant cross-validated correlation coefficient ($q^2=0.774$) and non cross-validated correlation coefficients ($r^2=0.977$) were obtained. The model was then used to evaluate the six external test compounds and its $r^2_{pred}$ was found to be 0.614. Contribution map show that presence of cyclopropyl ring and its bulkier substituent's makes big contributions for improving the biological activities of the compounds. We hope that our HQSAR model and analysis will be helpful for future design of novel and structurally related CXCR2 antagonists.

• Structural Engineering and Mechanics
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• 제63권6호
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• pp.761-769
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• 2017

Accurately extracting the axle distribution information of a passing vehicle from bridge dynamic responses experiences a key and challenging step in non-pavement bridge weigh-in-motion (BWIM). In this article, the wavelet transformation is adopted and the wavelet coefficient curve is used as a substitute for dynamic response. The driving frequency is introduced and expanded to multi-axle vehicle, and the wavelet coefficient curve on specific scale corresponding to the driving frequency is confirmed to contain obvious axle information. On this basis, an automatic method for axle distribution information identification is proposed. The specific wavelet scale can be obtained through iterative computing, and the false peaks due to bridge vibration can be eliminated through cross-correlation analysis of the wavelet coefficients of two measure points. The integrand function that corresponds to the maximum value of the cross-correlation function is used to identify the peaks caused by axles. A numerical application of the proposed axle information identification method is carried out. Numerical results demonstrate that this method acquires precise axle information from the responses of an axle-insensitive structure (e.g., girder) and decreases the requirement of sensitivity structure of BWIM. Finally, an experimental study on a full-scale simply supported bridge is also conducted to verify the effectiveness of this method.

• 통합자연과학논문집
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• 제8권1호
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• pp.1-12
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• 2015

CRTh2 receptor is an important mediator of the inflammatory effects and act as beneficial target for the treatment of asthma, COPD, allergic rhinitis and atopic dermatitis. In the present work, Hologram QSAR studies were conducted on a series of 50 training set CRTh2 antagonists (2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl acetic acids). The best HQSAR model was obtained using atoms, bonds, connections and donor/acceptor as fragment distinction parameter using hologram length 257 and 6 components with fragment size of minimum 7 and maximum 10. Significant cross-validated correlation coefficient ($q^2=0.786$) and non cross-validated correlation coefficients ($r^2=0.954$) were obtained. The model was then used to evaluate the 15 external test compounds which are not included in the training set and the predicted values were in good agreement with the experimental results ($r^2_{pred}=0.739$). Contribution map show that presence of C ring and its substituents makes big contributions for activities. The HQSAR model and analysis from the contribution map could be useful for further design of novel structurally related CRTh2 antagonists.

• 대한기계학회논문집B
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• 제26권5호
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• pp.750-756
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• 2002

The effect of equivalence ratio and velocity on the stability of flame in dump combustor was studied in an atmospheric pressure, laboratory scathe dump combustor operating natural gas. Traditionally, peak-to-peak pressure, fluctuation of the heat release rate and Rayleigh index were used to find and control the combustion instability. Cross correlation coefficients, Ci,j which is defined as the normalized value of the integration of the product of two of the mixer pressure, dump plane pressure and heat release rate, are introduced to see whether the flame is stable or not. Ci,j shows more sensitive to combustion status than Rayleigh index in steadily burning flame. Also, the result indicates that the amplitude of Ci,j between heat release and mixer pressure goes up before the flame at the rich de-stabilizing equivalence ratio near $\psi$=0.85. t means Ci:j at this case has a potential to detect the de-stablizing moment in prior to becoming unstable in dump combustor.

• 통합자연과학논문집
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• 제11권2호
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• pp.93-100
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• 2018

Caspases, a family of cysteinyl aspartate-specific proteases plays a central role in the regulation and the execution of apoptotic cell death. Caspase-3 has been proven to be an effective target for reducing the amount of cellular and tissue damage because the activation of caspases-3 stimulates a signalling pathway that ultimately leads to the death of the cell. In this study, Hologram based Quantitative Structure Activity Relationship (HQSAR) models was generated on a series of Caspase-3 inhibitors named 3, 4-dihydropyrimidoindolones derivatives. The best HQSAR model was obtained using atoms, bonds, and hydrogen atoms (A/B/H) as fragment distinction parameter using hologram length 61 and 3 components with fragment size of minimum 5 and maximum 8. Significant cross-validated correlation coefficient ($q^2=0.684$) and non cross-validated correlation coefficients ($r^2=0.754$) were obtained. The model was then used to evaluate the eight external test compounds and its $r^2_{pred}$ was found to be 0.559. Contribution map show that presence of pyrrolidine sulfonamide ring and its bulkier substituent's makes big contributions for improving the biological activities of the compounds.

• 한국콘텐츠학회논문지
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• 제10권3호
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• pp.1-9
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• 2010

본 논문에서는 모바일 환경에서 모션을 추정하기 위하여 특징점을 코너로 선택하고, 기존 코너 검출 알고리즘인 Rosten 알고리즘 보다 모션 추정의 정확성을 높이는 방법을 제안한다. Rosten 알고리즘은 간단한 덧셈과 뺄셈만으로 코너를 검출함에 따라 처리 속도가 빠른 장점이 있지만, 코너를 매칭하면서 모션추정의 성능이 떨어지는 단점을 가지고 있다. 우리는 Normalized Cross Correlation(NCC) 계수를 사용하여 코너를 매칭하고, 두 단계에 걸쳐 부정확한 매칭에 의한 외톨이를 제거한다. 기존의 Rosten 알고리즘과 제안하는 알고리즘을 실제 영상에서 실험을 통하여 성능을 비교하고, 실제 모바일 장치의 응용 프로그램에 적용한다. 제안한 알고리즘이 Rosten 알고리즘 보다 더 정확한 모션을 추정해 냄을 실험 결과 확인하였고, 실제 모바일 환경에서도 실시간으로 동작함을 확인하였다.

• 한국음향학회지
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• 제28권3호
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• pp.285-289
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• 2009

본 논문에서는 음향학적 반향 제거(AES, acoustic echo suppression)를 위해 주파수영역에서 soft decision 기법에 근거한 새로운 동시통화 검출 (DTD, double-talk detection) 알고리즘을 제안한다. 제시된 방법은 효과적인 DTD를 위해 상관계수 (cross-correlation coefficient)에 기반하여 hard decision을 사용하는 기존의 알고리즘 대신 주파수 영역에서 입력 및 원단신호의 VAD (voice activity detection) 결과와 음성 통계모델에 기반한 soft decision 방법을 도입하여 전역 근단화자존 재확률 (GNSPP, global near-end speech presence probability)을 DTD에 적용한다. 제안된 알고리즘은 기존의 방법과 객관적인 실험을 통해 비교 평가한 결과 다양한 배경잡음 환경에서 우수한 성능을 보였다.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2003년도 춘계학술발표대회 논문집
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• pp.95-98
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• 2003

In this work, a closed-form analysis is performed to obtain the stiffness coefficients of thin-walled composites beams with elliptical profiles. The analytical model includes the effects of elastic couplings, shell wall thickness, torsion warping and constrained warping. Reissner's semi-complementary energy functional is used to derive the beam force-displacement relations. The theory is validated against MSC/NASTRAN results for coupled composites beams with single-cell elliptical sections. Very good correlation has been noticed for the test cases considered.