• Journal of Korea Society of Digital Industry and Information Management
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• v.12 no.3
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• pp.11-24
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• 2016

The purpose of this study is to develop a recruiting platform resolving the mismatch between corporate job and job finder's competence in recruitment market. For this, we investigated technological trends and limitation on recruit platform. Based on the findings, this study investigates the trends and directions related to recruiting platform evolution and identified critical success factors and development strategies for successful development of recruiting platform. Two development strategies include employment of online resume and construction of database assessing job finder's competence. We also proposed target system architecture incorporating job database, competency assessment form, capability oriented resume. To analyze user requirement national competency standards and core job capability evaluation model were analyzed. Next, we designed integrated database, user interfaces, and dynamic functionalities using the forms developed in earlier stage. Finally, we assessed the fidelity of form item, integrity of database, and the usability of interface to evaluate the effectiveness of the system.

• Transactions of the Korean Society of Mechanical Engineers
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• v.19 no.6
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• pp.1402-1410
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• 1995

An influence coefficient method with an optimal correction balancing algorithm is developed for balancing a high-speed flexible rotor system. Conventional flexible balancing algorithms such as least square and weighted least square algorithms may not satisfy allowable residual vibration levels in certain speed ranges, while the optimal correction balancing method can be more effective in controlling vibration levels in a target speed. Related analyses were reviewed and applied to a test rig to show the effectiveness of the optimal correction balancing method.

• CELLMED
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• v.8 no.2
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• pp.8.1-8.5
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• 2018

Nitric oxide (NO) is a small diffusible molecule which plays an important role in various physiological activities. NO is a notable molecule, functioning as a cytotoxic agent and cellular messenger. There has been considerable interest in NO production by activated macrophages because this gaseous metabolite plays a fundamental role in the cytotoxic and cytostatic effects of macrophages towards invasive micro-organisms and tumour cells. No is a bioactive free radical that has been implicated in many physiological functions, plays a critical role during inflammation and therefore constitutes a potential target for developing therapeutics for inflammatory diseases. The use of medicinal plants by the population has been an important alternative the resource in the treatment of various diseases. Its growing acceptance in the medical community has been due to the fact that several plants with biological activities have been scientifically investigated and their efficacy and safety have been proven. In this review, discussed suppressive effects of No production by traditional medicines in RAW 264.7 and THP-1 macrophages.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2005.09a
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• pp.23-28
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• 2005

The high-dimensionality and insufficiency of gene expression profiles and proteomic profiles makes feature selection become a critical step in efficiently building accurate models for cancer problems based on such data sets. In this paper, we use a method, called Discrete Function Learning algorithm, to find discriminatory feature vectors based on information theory. The target feature vectors contain all or most information (in terms of entropy) of the class attribute. Two data sets are selected to validate our approach, one leukemia subtype gene expression data set and one ovarian cancer proteomic data set. The experimental results show that the our method generalizes well when applied to these insufficient and high-dimensional data sets. Furthermore, the obtained classifiers are highly understandable and accurate.

• Toxicological Research
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• v.29 no.3
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• pp.165-172
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• 2013

Acetaminophen (APAP) known as paracetamol is the main ingredient in Tylenol, which has analgesic and anti-pyretic properties. Inappropriate use of APAP causes major morbidity and mortality secondary to hepatic failure. Overdose of APAP depletes the hepatic glutathione (GSH) rapidly, and the metabolic intermediate leads to hepatocellular death. This article reviews the mechanisms of hepatotoxicity and provides an overview of current research studies. Pharmacokinetics including metabolism (activation and detoxification), subsequent transport (efflux)-facilitating excretion, and some other aspects related to toxicity are discussed. Nuclear factor erythroid 2-related factor 2 (Nrf2)-regulated gene battery plays a critical role in the multiple steps associated with the mitigation of APAP toxicity. The role of Nrf2 as a protective target is described, and potential natural products inhibiting APAP toxicity are outlined. This review provides an update on the mechanism of APAP toxicity and highlights the beneficial role of Nrf2 and specific natural products in hepatoprotection.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2007.11a
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• pp.612-616
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• 2007

This paper describes a procedure to improve road noise using DPDS estimation. We can estimate a body local stiffness at chassis mounting point where the path of road input vibration by DPDS with experiment and FE simulation. DPDS result from FE model has a good correlation with experiment data. FE model DPDS shows weak points among chassis mounting points. Body panel thickness and shape were changed to meet DPDS target. Improved DPDS of critical points makes a road noise level lower.

• Journal of Korean Society for Quality Management
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• v.38 no.1
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• pp.20-33
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• 2010

This study investigates the relationships of total quality management (TQM), organizational learning (OL) activities and business performance and examines the partial mediation effect of OL activities on business performance in Korean industrial manufacturing setting. Main target sample firms were all manufacturing companies listed in the Korea Composite Stock Price Index (KOSPI) and 206 firms participated. This study theoretically develops a conceptual model with 3 hypotheses regarding how TQM practices influence OL activities and how the OL activities partially mediate between the TQM practices and business performance. To examine these hypotheses, Structural Equation Modeling (SEM) was employed and an alternative model which includes a path between errors of leadership factor and OL construct was developed. The findings are TQM practices cannot directly influence business performance but indirectly impact business performance through OL activities. This study found that OL activities playa role as firms' critical competency to improve business performance.

• Journal of Plant Biotechnology
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• v.4 no.4
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• pp.135-141
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• 2002

Agrobacterium-mediated transformation has been unsuccessful for monocot plants except for a few important crops such as barley, rice, maize and wheat. We discussed here that a successful transformation of monocots demands certain critical conditions. The requirements for an efficient transformation are a selection of target tissues competent for plant regeneration and Agrobacterium-infection, and various factors promoting Agrobacterium-infection. The factors were divided into two to activate Agrobacterium and to increase plant cell's susceptibility against Agrobacterium. Optimization of these factors significantly increased transformation efficiency of zoysia grass and rice plants. A technical improvement in transformation system for monocots will promote improvement of the breed as well as a study of gene functions in monocots.

• Proceedings of the Microbiological Society of Korea Conference
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• 2001.11a
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• pp.97-101
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• 2001

The fusion between viral envelope and target cell membrane is a central step of viral infection, and the fusion proteins located at viral envelope mediate such process. Gp41 of HIV is one of the fusion proteins whose structure and mechanism of membrane fusion had been extensively studied. Functionally important motives of gp41 are the N-terminus fusion peptide, the coiled-coil and the membrane proximal C-peptide regions. The role of these regions during the fusion process had been thoroughly examined. Specially, insertion of the fusion peptide into membrane and conformational change of the coiled-coil and C-peptide regions are assumed to be critical for the fusion mechanism. In addition, the coiled-coil region has been shown to interact with membrane, and the C-peptide region regulates the interaction in a dose dependent manner. Furthermore, fusion defective mutations of the coiled-coil region dramatically changed its binding affinity to membrane. These results suggested that the membrane binding property of the coiled-coil region is important for the fusion activity of gp41, and such property could be modulated by the interaction with the C-peptide region.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.16 no.2
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• pp.84-91
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• 2007

The radial error motion of a machine tool cutter/spindle system is critical to the dimensional accuracy of the parts to be machined. This paper presents an investigation into spindle run-out effects on cutting mark and surface roughness. We experimented the effects of spindle run-out on surface roughness in flat-end milling by cutting AL 7075 workpiece in various cutting conditions. In order to analyze the effects of run-out on the surface roughness, the spindle's radial error motions was measured by mounting a sphere target onto the spindle as a reference. From the experimental results, it was found that spindle un-out makes a directive effects on surface roughness in flat-end milling.