• 제목/요약/키워드: critical target

검색결과 846건 처리시간 0.028초

이동표적에 대한 적중확률 (Hitting Probability on the Moving Target)

  • 오형재
    • 한국국방경영분석학회지
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    • 제1권1호
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    • pp.111-129
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    • 1975
  • U.S. Air Force Regulation 80-1 defines that a weapon system is composed of equipments, skills, and techniques, the composite of which ferns an instrument of combat. The complete weapon system includes all related facilities, equipments, materials, services, and personnels required for the operation of the system, so that the instrument of combat can be considered as a self-sufficient unit of striking power in its intended operational environment. Effectiveness of a weapon system can be expressed as a function of its liability, reliability and performance capability. Among these attributes which influence the weapon effectiveness, performance capability is considered to be the most critical factor for many weapon systems. In order to illustrate the application of the methodology of performance capability, a specific ease study on the effectiveness of Vulcan anti-air craft gun system is presented with special emphasis on hitting probability on moving targets, effects of artificial rounds dispersion, and several principles related to the deployment of the system. This thesis includes the thorough survey of the possibility of calculating the absolute value of hitting probability on moving targets, indicates that the effects of artificial rounds dispersion increase the value of probability only when the total number of rounds fired within fire range exceeds a certain critical number, and suggests that concentrated guns deployment is better than scattered deployment in order to obtain higher probability and lower average amount of rounds if it is assumed that the effects of counter-attack from enemy threats are not serious.

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개심술 환자를 위한 조기 운동프로그램의 개발 및 적용에 관한 연구 (Development and Application of an Early Exercise Program for Open Heart Surgery Patients)

  • 하이경;정연이
    • 중환자간호학회지
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    • 제4권1호
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    • pp.65-73
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    • 2011
  • Purpose: This study was to develop and evaluate stability and effects of an early exercise program for patients with open heart surgery. Methods: The subjects of this study were 30 patients who had either a coronary bypass surgery or a valvular heart surgery at a tertiary hospital in Seoul. The data was collected by observation and measurement from October 1, 2004 to November 15, 2004. Results: The early exercise program developed for this study consisted of range of motion exercise and walking. Intensity of walking was 1~3 METs and increased progressively to daily target distance. During exercise, the subjects were monitored heart rate, blood pressure and RPE (Rating of Perceived Exertion). The mean FIM (Functional Independent Measurements) score of subjects was significantly improved after the early exercise program. However, several complaints such as dizziness or pain were also reported. Most complaints were associated with chest tube and RPE. Conclusion: The early exercise program can help to recover patients' physical activities after surgery, and can be applied to most patients. Patients' RPE, dizziness and pain was possible limitations, therefore, active pain control and prevention of accidents for patients would be needed.

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Development of simulation-based testing environment for safety-critical software

  • Lee, Sang Hun;Lee, Seung Jun;Park, Jinkyun;Lee, Eun-chan;Kang, Hyun Gook
    • Nuclear Engineering and Technology
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    • 제50권4호
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    • pp.570-581
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    • 2018
  • Recently, a software program has been used in nuclear power plants (NPPs) to digitalize many instrumentation and control systems. To guarantee NPP safety, the reliability of the software used in safetycritical instrumentation and control systems must be quantified and verified with proper test cases and test environment. In this study, a software testing method using a simulation-based software test bed is proposed. The test bed is developed by emulating the microprocessor architecture of the programmable logic controller used in NPP safety-critical applications and capturing its behavior at each machine instruction. The effectiveness of the proposed method is demonstrated via a case study. To represent the possible states of software input and the internal variables that contribute to generating a dedicated safety signal, the software test cases are developed in consideration of the digital characteristics of the target system and the plant dynamics. The method provides a practical way to conduct exhaustive software testing, which can prove the software to be error free and minimize the uncertainty in software reliability quantification. Compared with existing testing methods, it can effectively reduce the software testing effort by emulating the programmable logic controller behavior at the machine level.

Inhibition of melanogenesis by tyrosinase siRNA in human melanocytes

  • An, Sang-Mi;Koh, Jae-Sook;Boo, Yong-Chool
    • BMB Reports
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    • 제42권3호
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    • pp.178-183
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    • 2009
  • Tyrosinase (TYR) plays a critical role in cellular melanogenesis and, thus, has been the major target of pharmacological approaches for the control of skin pigmentation. This study examined an alternative molecular approach using TYR-small interfering RNA (siRNA) to control melanogenesis in the human melanocytes. Both the mRNA and protein levels of TYR were significantly lowered by TYR-siRNA treatment, whereas TYR-related protein 1 and TYR-related protein 2 displayed no such changes. TYR-siRNA treatment inhibited the cellular melanin synthesis from the externally supplied TYR substrate L-tyrosine. TYR-siRNA also suppressed melanin synthesis and decreased the viability of cells exposed to ultraviolet radiation, supporting a critical role of melanin in protection against ultraviolet radiation. These results suggest that molecular approaches using siRNA targeted to the enzymes of melanogenic pathway may provide a novel strategy for the control of cell pigmentation.

Regulator of Calcineurin (RCAN): Beyond Down Syndrome Critical Region

  • Lee, Sun-Kyung;Ahnn, Joohong
    • Molecules and Cells
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    • 제43권8호
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    • pp.671-685
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    • 2020
  • The regulator of calcineurin (RCAN) was first reported as a novel gene called DSCR1, encoded in a region termed the Down syndrome critical region (DSCR) of human chromosome 21. Genome sequence comparisons across species using bioinformatics revealed three members of the RCAN gene family, RCAN1, RCAN2, and RCAN3, present in most jawed vertebrates, with one member observed in most invertebrates and fungi. RCAN is most highly expressed in brain and striated muscles, but expression has been reported in many other tissues, as well, including the heart and kidneys. Expression levels of RCAN homologs are responsive to external stressors such as reactive oxygen species, Ca2+, amyloid β, and hormonal changes and upregulated in pathological conditions, including Alzheimer's disease, cardiac hypertrophy, diabetes, and degenerative neuropathy. RCAN binding to calcineurin, a Ca2+/calmodulin-dependent phosphatase, inhibits calcineurin activity, thereby regulating different physiological events via dephosphorylation of important substrates. Novel functions of RCANs have recently emerged, indicating involvement in mitochondria homeostasis, RNA binding, circadian rhythms, obesity, and thermogenesis, some of which are calcineurin-independent. These developments suggest that besides significant contributions to DS pathologies and calcineurin regulation, RCAN is an important participant across physiological systems, suggesting it as a favorable therapeutic target.

The Paradox of Public Diplomacy on the Web: An Empirical Analysis on Interactivity and Narratives of Nation-States' Ministry of Foreign Affairs Web Sites

  • Lee, Hyung Min;Wang, Kevin Y.;Hong, Yejin
    • International Journal of Contents
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    • 제11권3호
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    • pp.24-33
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    • 2015
  • Against the backdrop of Habermas' theory of communicative action, we empirically analyzed the level of interactivity and narratives offered in nation-states' ministry of foreign affairs Web sites. A multiple regression analysis was performed in an attempt to identify factors affecting the level of interactivity in such Web sites. Findings revealed that the level of economic development is the sole significant factor in regards to the level of interactivity. Further, self-interested, goal-directed, and strategic purposes behind the allegedly transparent, engaging, and interactive public diplomacy were evidenced through a critical analysis of the objectives, key issues, and target publics addressed and highlighted in the public diplomacy narratives on the Web. The results suggested a possible digital divide in the interactive adoption of Web public diplomacy as well as strategic motives and interests embedded in the public diplomacy communication on the Web. This study helps increase our understanding of the paradox of public diplomacy in the digital age.

Economic Strategy: Correlation between Macro and Microeconomics on Income Inequality in Indonesia

  • SALIM, Agus;RUSTAM, Andi;HAERUDDIN, Haeruddin;ASRIATI, Asriati;PUTRA, Aditya Halim Perdana Kusuma
    • The Journal of Asian Finance, Economics and Business
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    • 제7권8호
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    • pp.681-693
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    • 2020
  • This study sees a critical gap in the previous body of research, which it seeks to fill; the disclosure of the unemployment ratio correlation has only been measured by the level of economic growth. This study is to add investment variables and government expenditure variables that objectively aim to measure the level of effectiveness in handling the unemployment ratio, which is then a measurement of the effectiveness of unemployment. Economic growth is measured by its impact on income inequality through empirical, conceptual relationships as a critical review and economic strategy for the future. The research uses secondary data on Indonesian macro and microeconomics since 2003-2018, then testing uses a quantitative approach to correlation, regression, and scatterplot. The results of this study show correlations between variables, and volatiles on the graphs show a similar trend. In other words, variables are bound together and support each other. The strategy of prioritizing the scale of government expenditure and investment to reach the target is the primary concern, so that the economic cycle can be optimal and equipped to face the possibility of an economic recession in the future. Many factors cause complex income inequality, though investment does not show a correlation to income inequality.

기사광선 펄스 레이저에 의해 제작된 $YBa_2{Cu_3}O_{7-X}$초전도체 박막의 특성 (Properties of $YBa_2{Cu_3}O_{7-X}$ superconducting thin films prepared by visible light pulsed laser)

  • 신현용
    • E2M - 전기 전자와 첨단 소재
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    • 제7권4호
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    • pp.289-293
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    • 1994
  • Thin films of YB $a_{2}$C $u_{3}$$O_{7-x}$ supercondYB $a_{2}$C $u_{3}$$O_{7-x}$uctor were prepared on (100) SrTi $O_{3}$ substrates by pulsed laser deposition using visible light laser. Q-switched Nd:YAG(532 nm, 30 ns) pulsed laser was used for deposition. The effects of substrate temperature and oxygen pressure during deposition on films were studied. Critical current density of 2.93*10$^{6}$ A/c $m^{2}$ at 77K and Tc(zero)=91.7K were obtained from the film prepared with Tsub=745.deg. C and $P_{02}$=200 mTorr. XRD analysis showed that the grown film has c-axis normal orientation to the substrate surface and has single phase. Surface morphology of the film has been improved by interfering the plume ejected from YB $a_{2}$C $u_{3}$$O_{7-x}$ target.arget.t.

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Buckling analysis of structures under combined loading with acceleration forces

  • Wang, Wenjing;Gu, Randy
    • Structural Engineering and Mechanics
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    • 제52권5호
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    • pp.1051-1067
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    • 2014
  • The structures of concern in this study are subject to two types of forces: dead loads from the acceleration imposed on the structures as well as the installed operation machines and the additional adjustable forces. We wish to determine the critical values of the adjustable forces when buckling of the structures occurs. The mathematical statement of such a problem gives rise to a constrained eigenvalue problem (CEVP) in which the dominant eigenvalue is subject to an equality constraint. A numerical algorithm for solving the CEVP is proposed in which an iterative method is employed to identify an interval embracing the target eigenvalue. The algorithm is applied to four engineering application examples finding the critical loads of a fixed-free beam subject to its own body force, two plane structures and one wide-flange beam using shell elements when acceleration force is present. The accuracy is demonstrated using the first example whose classical solution exists. The significance of the equality constraint in the EVP is shown by comparing the solutions without the constraint on the eigenvalue. Effectiveness and accuracy of the numerical algorithm are presented.

$CeO_{2}/BaTiO_{3}$ 이중완충막을 이용한 YBCO 박막 제작 (Fabrication of YBCO superconducting film with $CeO_{2}/BaTiO_{3}$double buffer layer)

  • 김성민;이상렬
    • 한국전기전자재료학회:학술대회논문집
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    • 한국전기전자재료학회 2000년도 하계학술대회 논문집
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    • pp.790-793
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    • 2000
  • We have fabricated good quality superconducting YBa$_2$Cu$_3$$O_{7-x}$(YBCO) thin films on Hastelloy(Ni-Cr-Mo alloys) metallic substrates with CeO$_2$and BaTiO$_3$buffer layers in-situ by pulsed laser deposition in a multi-target processing chamber. YBCO film with CeO$_2$ single buffer layer shows T$_{c}$ of 71.64 K and the grain size less than 0.1 ${\mu}{\textrm}{m}$. When BaTiO$_3$is used as a single buffer layer, the grain size of YBCO is observed to be larger than that of YBCO/CeO$_2$by 200 times and the transition temperature of the film is enhanced to be about 84 K. CeO$_2$/BaTiO$_3$double buffer layer has been adopted to enhance the superconducting properties, which results in the enhancement of the critical temperature and the critical current density to be about 85 K and 8.4 $\times$ 10$^4$ A/cm$^2$ at 77 K, respectively mainly due to the enlargement of the grain size of YBCO film.ilm.

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