• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3847-3850
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• 2013

The three homologous members of the p160 SRC family (SRC-1, SRC-2 and SRC-3) mediate the transcriptional functions of nuclear receptors and other transcription factors, and are the most studied of all the transcriptional co-activators. Recent work has indicated that the SRC-3 gene is subject to amplification and overexpression in various human cancers. Some of the molecular mechanisms responsible for SRC overexpression, along with the mechanisms by which SRC-3 promotes breast and prostate cancer cell proliferation and survival, have been identified. However, the function of SRC-3 in bladder cancer remains poorly understood. In the present study, our results indicate that overexpression of SRC-3 promotes bladder cancer cell proliferation whereas knockdown of SRC-3 results in inhibition. At the molecular level, we further established that CXCR4 is a transcriptional target of SRC-3. Therefore, our study first identified that SRC-3 plays a critical role in the bladder cancer, which may be a target beneficial for its prevention and treatment.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2002년도 춘계학술대회 및 임시총회
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• pp.252-255
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• 2002

최근 네트워크 취약점 검색 방법을 이용한 침입 공격이 늘어나는 추세이며 이런 공격에 대하여 적절하게 실시간 탐지 및 대응 처리하는 침입탐지시스템 구현은 어렵다. 본 논문에서는 시스템에 허락을 얻지 않는 서비스 거부 공격(Denial of Service Attack) 기술 중 TCP의 신뢰성 및 연결 지향적 전송서비스로 종단간의 통신서비스를 지원하는 3 way handshake를 이용한 SYN flooding 공격에 대하여 침입시도패킷 정보를 수집, 분석 및 침입시도여부를 결정하는 네트워크 기반의 실시간 침입시도탐지(Real Time Scan Detector) 메커니즘을 제안한다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제12권2호
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• pp.710-726
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• 2018

This paper presents an extended particle filter to increase the accuracy and decrease the computation load of vehicle tracking. Particle filter has been the subject of extensive interest in video-based tracking which is capable of solving nonlinear and non-Gaussian problems. However, there still exist problems such as preventing unnecessary particle consumption, reducing the computational burden, and increasing the accuracy. We aim to increase the accuracy without an increase in computation load. In proposed method, we calculate the direction angle of the target vehicle. The angular difference between the direction of the target vehicle and each particle of the particle filter is observed. Particles are filtered and weighted, based on their angular difference. Particles with angular difference greater than a threshold is eliminated and the remaining are stored with greater weights in order to increase their probability for state estimation. Threshold value is very critical for performance. Thus, instead of having a constant threshold value, proposed algorithm updates it online. The first advantage of our algorithm is that it prevents the system from failures caused by insufficient amount of particles. Second advantage is to reduce the risk of using unnecessary number of particles in tracking which causes computation load. Proposed algorithm is compared against camshift, direction-based particle filter and condensation algorithms. Results show that the proposed algorithm outperforms the other methods in terms of accuracy, tracking duration and particle consumption.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제9권4호
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• pp.1359-1375
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• 2015

Energy efficiency is critical for Wireless Sensor Networks (WSNs) since sensor nodes usually have very limited energy supply from battery. Sleep scheduling and nodes cooperation are two of the most efficient methods to achieve energy conservation in WSNs. In this paper, we propose an adaptive energy optimization approach for target tracking applications, called Energy-Efficient Node Coordination (EENC), which is based on the grid structure. EENC provides an unambiguous calculation and analysis for optimal the nodes cooperation theoretically. In EENC, the sleep schedule of sensor nodes is locally synchronized and globally unsynchronized. Locally in each grid, the sleep schedule of all nodes is synchronized by the grid head, while globally the sleep schedule of each grid is independent and is determined by the proposed scheme. For dynamic sleep scheduling in tracking state we propose a multi-level coordination algorithm to find an optimal nodes cooperation of the network to maximize the energy conservation while preserving the tracking performance. Experimental results show that EENC can achieve energy saving of at least 38.2% compared to state-of-the-art approaches.

• IMMUNE NETWORK
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• 제12권6호
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• pp.240-246
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• 2012

Natural killer (NK) cells play a pivotal role in early surveillance against virus infection and cellular transformation, and are also implicated in the control of inflammatory response through their effector functions of direct lysis of target cells and cytokine secretion. NK cell activation toward target cell is determined by the net balance of signals transmitted from diverse activating and inhibitory receptors. A distinct feature of NK cell activation is that stimulation of resting NK cells with single activating receptor on its own cannot mount natural cytotoxicity. Instead, specific pairs of co-activation receptors are required to unleash NK cell activation via synergy- dependent mechanism. Because each co-activation receptor uses distinct signaling modules, NK cell synergy relies on the integration of such disparate signals. This explains why the study of the mechanism underlying NK cell synergy is important and necessary. Recent studies revealed that NK cell synergy depends on the integration of complementary signals converged at a critical checkpoint element but not on simple amplification of the individual signaling to overcome intrinsic activation threshold. This review focuses on the signaling events during NK cells activation and recent advances in the study of NK cell synergy.

• 한국응용곤충학회지
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• 제34권1호
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• pp.20-32
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• 1995

Adult diapause in insects is characterized by suppression of reproductive development. It is induced by environmental cues such as photoperiod, temperature, food availability, and other conditions Diapause-inducing environment is recognized and analyzed by the brain of the insects. The interpreted information is conveyed via endocrine system to target tissues such as ovaries, fat body, and other tissues. From this signal hierarchy of a brain-endocrine-target tissue axis, several factors are involved to express a diapause trait in a quantitative mode, even though the insects show a binomial phenotye between being in diapause or not. Recent works estimated that the number of the factors is relatively small by a series of crossing trials between high and low diapause lines. Heritability of the diapause is quite high (ca. 70%) in some species. Epistasis, sex-linkage, pleiotropism, and other nongenetic components also affect diapause inheritance. Most physiological studies have been focused on control mechanisms of the juvenile hormone (JH) synthesis in corpora allata (CA) because JH level in hemolymph of teneral adults is critical to decide a later developmental mode. Allatostatin, an antagonizer of JH synthesis, has been believed to be a potent brain message to CA for adult diapause induction.

• Ocean Systems Engineering
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• 제8권3호
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• pp.313-327
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• 2018

Meeting the touchdown point (TDP) target box is one of the challenges during catenary riser installation, especially for deep water or ultra-deep water riser systems. TDP location mismatch compared to the design can result in variation of riser configuration, additional hang-off misalignment, and extra bending loads going into the hang-off porch. A good understanding of the key installation parameters can help to minimize this mismatch, and ensure that the riser global response meets the design criteria. This paper focuses on investigating the potential factors that may affect the touchdown point location, and addressing the challenges both in the design stage and during installation campaign. Conventionally, the vessel offset and current are the most critical factors which may affect the TDP movement during installation. With the offshore exploration going deeper and deeper in the sea (up to 10,000ft), other sources such as the seabed slope and seabed soil stiffness are playing an important role as well. The impacts of potential sources are quantified through case studies for steel catenary riser (SCR) and lazy wave steel catenary riser (LWSCR) in deep water application. Investigations through both theoretical study and numerical validation are carried out. Furthermore, design recommendations are provided during execution phase for the TDP mismatch condition to ensure the integrity of the riser system.

• BMB Reports
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• 제36권4호
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• pp.344-348
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• 2003

Protein kinase CKII is composed of two catalytic ($\alpha$ or $\alpha$') subunits and two regulatory ($\beta$) subunits. The $CKII{\beta}$ subunit is thought to mediate the tetramer formation and interact with other target proteins. However, its physiological function remains obscure. In this study, point mutants of $CKII{\beta}$ that are defective for the L41 binding were isolated by using the reverse two-hybrid system. A sequence analysis of the point mutants revealed that Asp-26, Met-52, and Met-78 of $CKII{\beta}$ are critical for L41 binding; Asn-67 (and/or Lys-139) and Met-52 are important for $CKII{\beta}$ homodimerization. Two point mutants, R75 and R83, of $CKII{\beta}$ interacted with L5, topoisomerase $II{\beta}$, and CKBBP1/SAG, but not with the wild-type $CKII{\beta}$. This indicates that $CKII{\beta}$ homodimerization is not a prerequisite for its binding to target proteins. These $CKII{\beta}$ point mutants may be useful in exploring the biochemical physiological functions of $CKII{\beta}$.

• 한국의학물리학회지:의학물리
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• 제29권2호
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• pp.73-80
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• 2018

Accelerated partial breast irradiation (APBI) is a new treatment delivery technique that decreases overall treatment time by using higher fractional doses than conventional fractionation. Here, a quantitative analysis study of CyberKnife-based APBI was performed on 10 patients with left-sided breast cancer who had already finished conventional treatment at the Inha University Hospital. Dosimetric parameters for four kinds of treatment plans (3D-CRT, IMRT, VMAT, and CyberKnife) were analyzed and compared with constraints in the NSABP B39/RTOG 0413 protocol and a published CyberKnife-based APBI study. For the 10 patients recruited in this study, all the dosimetric parameters, including target coverage and doses to normal structures, met the NSABP B39/RTOG 0413 protocol. Compared with other treatment plans, a more conformal dose to the target and better dose sparing of critical structures were observed in CyberKnife plans. Accelerated partial breast irradiation via CyberKnife is a suitable treatment delivery technique for partial breast irradiation and offers improvements over external beam APBI techniques.

• Asian Pacific Journal of Cancer Prevention
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• 제16권10호
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• pp.4147-4156
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• 2015

Lung cancer is a serious health problem and leading cause of death worldwide due to its high incidence and mortality. More than 80% of lung cancers feature a non-small cell histology. Over few decades, systemic chemotherapy and surgery are the only treatment options in this type of tumor but due to their limited efficacy and overall poor survival of patients, there is an urge to develop newer therapeutic strategies which circumvent the problems. Enhanced knowledge of translational science and molecular biology have revealed that lung tumors carry diverse driver gene mutations and adopt different intracellular pathways leading to carcinogenesis. Hence, the development of targeted agents against molecular subgroups harboring critical mutations is an attractive approach for therapeutic treatment. Targeted therapies are clearly more preferred nowadays over systemic therapies because they target tumor specific molecules resulting with enhanced activity and reduced toxicity to normal tissues. Thus, this review encompasses comprehensive updates on targeted therapies for the driver mutations in non-small cell lung cancer (NSCLC) and the potential challenges of acquired drug resistance faced i n the field of targeted therapy along with the imminent newer treatment modalities against lung cancer.