• Tuberculosis and Respiratory Diseases
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• v.67 no.6
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• pp.569-573
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• 2009

Idiopathic pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by surfactant component accumulation in the alveolar space. Idiopathic PAP has recently been recognized as a autoimmune disease of impaired alveolar macrophage function caused by autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF). While whole lung lavage has been the standard treatment, not every patient shows a complete response. Subcutaneous injection or inhalation of GM-CSF is another promising treatment option for PAP. A 45-year-old patient visited our hospital for dyspnea, he was diagnosed as PAP and underwent whole lung lavage. Eighteen months later, the patient had not achieved complete remission in despite of initial response. After then he was administered with GM-CSF (5 ${mu}g/kg/day$, subcutaneous injection) for fivetimes a week during 2 months. Nine months later, the abnormal shadows in high-resolution computed tomography (HRCT) decreased and the patient fully recovered in forced vital capacity. After 60 months, the HRCT scan showed complete remission of PAP.

• Wind and Structures
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• v.24 no.5
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• pp.405-430
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• 2017

The aerodynamic characteristics of vehicles are critical to assess vehicle safety and passenger comfort for vehicles running on long span bridges in a windy environment. However, in previous wind-vehicle-bridge (WVB) system analysis, the aerodynamic interference between the vehicle and the bridge was seldom considered, which will result in changing aerodynamic coefficients. In this study, the aerodynamic coefficients of a high-sided truck on the ground (ground case) and a typical bridge deck (bridge deck case) are determined in a wind tunnel. The effects of existent structures including the bridge deck and bridge accessories on the high-sided vehicle's aerodynamic characteristics are investigated. A three-dimensional analytical framework of a fully coupled WVB system is then established based on the finite element method. By inputting the aerodynamic coefficients of both cases into the WVB system separately, the vehicle safety and passenger comfort are assessed, and the critical accidental wind speed for the truck on the bridge in a windy environment is derived. The differences in the bridge response between the windward case and the leeward case are also compared. The results show that the bridge deck and the accessories play a positive role in ensuring vehicle safety and improving passenger comfort, and the influence of aerodynamic interference on the response of the bridge is weak.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.12
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• pp.1547-1557
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• 2013

A forced vibration model of a rail system was established using the Timoshenko beam theory to determine the dynamic response of a rail under time-varying load considering the damping effect and stiffness of the elastic foundation. By using a Fourier series and a numerical method, the critical velocity and dynamic response of the rail were obtained. The forced vibration model was verified by using FEM and Euler beam theory. The permanent deformation of the rail was predicted based on the forced vibration model. The permanent deformation and wear were observed through the experiment. Parametric studies were then conducted to investigate the effect of five design factors, i.e., rail cross-section shape, rail material density, rail material stiffness, containment stiffness, and damping coefficient between rail and containment, on four performance indices of the rail, i.e., critical velocity, maximum deflection, maximum longitudinal stress, and maximum shear stress.

• Journal of the Korea Institute of Military Science and Technology
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• v.6 no.4
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• pp.100-112
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• 2003

This paper presents the transient response analysis of a rotating blade in resonant frequency range. It is shown that the modeling is considered in elastic foundation and friction damping effect. The equations of motion are derived and transformed into a dimensionless form to investigate general phenomena. Numerical results show that the magnitude of friction damping to reduce maximum transient response in near the critical angular speed. The method can be applied to a number of examples of the practical rotating blade system to minimize transient response in resonant frequency range.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1995.10a
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• pp.569-572
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• 1995

In this study, a hydraulic modulator of solenoid-flow type ABS, the master sylinder, and the wheel cylinder are modeled and simulated for increasing pressure characteristics of the brake. Response can be predicted by external force of the the master sylinder and pulses to the solenoid valve as input. For a demonstration of simulation result, experiment is done under the same condition as simulation condition after experimental apparatus of 1/4 car model is constructed. When factors of flow control valve are changed, the effect of each factor to response, how to improve response, and the most critical factors are considered from simulated result of time constant.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2011.11a
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• pp.415-418
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• 2011

It is critical to assess the characteristics of flame response to pressure perturbations for the understanding of nonlinear combustion instabilities. Previous studies can be grouped into flame response upon perturbed, fresh air and fuel mixture, and flame response directly perturbed from longitudinal waves. The present study presents experimental methodology for the understanding of the flame response exposed to transverse acoustic waves generated by loud speakers.

• Journal of the Korean Society of Combustion
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• v.16 no.1
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• pp.30-35
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• 2011

This study has been mainly motivated to numerically investigate the transient flame response to pressure oscillations in the gaseous hydrogen - liquid oxygen flames at supercritical pressures. The present analysis is based on the real-fluid transient flamlet model and the flame field is acoustically perturbed only by the sinewave oscillations in the frequency range from 1,000 Hz to 5,000 Hz. Based on numerical results, the detailed discussions are made for the flame response characteristics and the transient flamelet response associated with the high-frequency combustion instability in the liquid propellant rocket engines.

• BMB Reports
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• v.41 no.4
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• pp.267-277
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• 2008

Insects mount a robust innate immune response against a wide array of microbial pathogens. The hallmark of the Drosophila humoral immune response is the rapid production of anti-microbial peptides in the fat body and their release into the circulation. Two recognition and signaling cascades regulate expression of these antimicrobial peptide genes. The Toll pathway is activated by fungal and many Gram-positive bacterial infections, whereas the immune deficiency (IMD) pathway responds to Gram-negative bacteria. Recent work has shown that the intensity and duration of the Drosophila immune response is tightly regulated. As in mammals, hyperactivated immune responses are detrimental, and the proper down-modulation of immunity is critical for protective immunity and health. In order to keep the immune response properly modulated, the Toll and IMD pathways are controlled at multiple levels by a series of negative regulators. In this review, we focus on recent advances identifying and characterizing the negative regulators of these pathways.

• Korean Journal of Artificial Intelligence
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• v.12 no.2
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• pp.25-33
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• 2024

This study examines the relationship between customer satisfaction and management response in the hotel industry amid the COVID-19 pandemic. By applying regression analysis and topic modeling to consumer reviews on online platforms, we assess how consumer perceptions and management behaviors have shifted since the onset of the pandemic. The findings reveal a significant decline in customer satisfaction linked to COVID-19. Significantly, while the pandemic has reduced overall customer satisfaction levels, high response rates and high review-response content similarity mitigate the impact of the crises. These results highlight the critical need for hotel managers to continuously monitor online reviews and adapt their engagement strategies to maintain and enhance customer satisfaction during ongoing and future crises. This research not only corroborates existing theories on customer satisfaction but also exposes novel dynamics introduced by the pandemic, offering new insights for effective customer relationship management in turbulent times.

• Journal of the Society of Disaster Information
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• v.19 no.2
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• pp.395-410
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• 2023

Purpose: The purpose of this study was to analyze the current state of drone terrorism response at such critical national facilities and derive improvements, especially to identify problems in laws and systems to effectively utilize the anti-drone system and present directions for improvement. Method: A qualitative research method was used for this study by analyzing a variety of issues not discussed in existing research papers and policy documents through in-depth interviews with subject matter experts. In-depth interviews were conducted based on 12 semi-structured interviews by selecting 16 experts in the field of anti-drone and terrorism in Korea. The interview contents were recorded with the prior consent of the study participants, transcribed back to the Korean file, and problems and improvement measures were derived through coding. For this, the threats and types were analyzed based on the cases of drone terrorism occurring abroad and measures to establish anti-drone system were researched from the perspective of laws and systems by evaluating the possibility of drone terrorism in the Republic of Korea. Result: As a result of the study, improvements to some of the problems that need to be preceded in order to effectively respond to drone terrorism at critical national facilities in the Republic of Korea, have been identified. First, terminologies related to critical national facilities and drone terrorism should be clearly defined and reflected in the Integrated Defense Act and the Terrorism Prevention Act. Second, the current concept of protection of critical national facilities should evolve from the current ground-oriented protection to a three-dimensional protection concept that considers air threats and the Integrated Defense Act should reflect a plan to effectively install the anti-drone system that can materialize the concept. Third, a special law against flying over critical national facilities should be enacted. To this end, legislation should be enacted to expand designated facilities subject to flight restrictions while minimizing the range of no fly zone, but the law should be revised so that the two wings of "drone industry development" and "protection of critical national facilities" can develop in a balanced manner. Fourth, illegal flight response system and related systems should be improved and reestablished. For example, it is necessary to prepare a unified manual for general matters, but thorough preparation should be made by customizing it according to the characteristics of each facility, expanding professional manpower, and enhancing response training. Conclusion: The focus of this study is to present directions for policy and technology development to establish an anti-drone system that can effectively respond to drone terrorism and illegal drones at critical national facilities going forward.