• Title/Summary/Keyword: critical gap

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An Index-Based Search Method for Performance Improvement of Set-Based Similar Sequence Matching (집합 유사 시퀀스 매칭의 성능 향상을 위한 인덱스 기반 검색 방법)

  • Lee, Juwon;Lim, Hyo-Sang
    • KIPS Transactions on Software and Data Engineering
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    • v.6 no.11
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    • pp.507-520
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    • 2017
  • The set-based similar sequence matching method measures similarity not for an individual data item but for a set grouping multiple data items. In the method, the similarity of two sets is represented as the size of intersection between them. However, there is a critical performances issue for the method in twofold: 1) calculating intersection size is a time consuming process, and 2) the number of set pairs that should be calculated the intersection size is quite large. In this paper, we propose an index-based search method for improving performance of set-based similar sequence matching in order to solve these performance issues. Our method consists of two parts. In the first part, we convert the set similarity problem into the intersection size comparison problem, and then, provide an index structure that accelerates the intersection size calculation. Second, we propose an efficient set-based similar sequence matching method which exploits the proposed index structure. Through experiments, we show that the proposed method reduces the execution time by 30 to 50 times then the existing methods. We also show that the proposed method has scalability since the performance gap becomes larger as the number of data sequences increases.

Rheological Behavior of Viscoelastic Semi-Solid Ointment Base (Vaseline) in Oscillatory Shear Flow Fields (진동전단유동장에서 점탄성 반고형 연고기제(바셀린)의 레올로지 거동)

  • Song, Ki-Won;Chang, Gap-Shik
    • Journal of Pharmaceutical Investigation
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    • v.36 no.1
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    • pp.31-38
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    • 2006
  • Using a Rheometries Dynamic Analyzer (RDA II), the dynamic viscoelastic properties of a semi-solid ointment base (vaseline) in large amplitude oscillatory shear flow fields were measured over a temperature range of $25{\sim}45^{\circ}C$ and the linear viscoelastic behavior in small amplitude oscillatory shear flow fields was investigated over a wide range of angular frequencies. In this article, the nonlinear viscoelastic behavior was reported from the experimentally obtained data and the effect of temperature on this behavior was discussed in detail. In addition, the angular frequency and temperature dependencies of a linear viscoelastic behavior were explained. Finally, the applicability of a time-temperature superposition principle originally developed for polymeric materials was examined using a shift factor. Main results obtained from this study can be summarized as follows : (1) At very small strain amplitude region, vaseline shows a linear viscoelastic behavior independent of the imposed deformation magnitudes. Above a critical strain amplitude $({\gamma}_{0}=0.1{\sim}0.2%)$, however, vaseline exhibits a nonlinear viscoelastic behavior ; indicating that both the storage modulus and dynamic viscosity are sharply decreased with increasing deformation magnitude. (2) In large amplitude oscillatory shear flow fields, an elastic behavior (storage modulus) has a stronger strain amplitude dependence and begins to show a nonlinear behavior at a smaller strain amplitude region than does a viscous behavior (dynamic viscosity). (3) In small amplitude oscillatory shear flow fields, the storage modulus as well as the loss modulus are continuously increased as an increase in angular frequency and an elastic nature is always superior to a viscous behavior over a wide range of angular frequencies. (4) A time-temperature superposition principle can successfully be applicable to vaseline. This finding allows us to estimate the dynamic viscoelastic behavior of vaseline over an extraordinarily extended range (11 decades) of angular frequencies inaccessible from the experimentally measured range (4 decades).

Contamination Sources of Several Potentially Hazardous Compounds Found at the Gap Stream and the Miho Stream, Two Major Tributaries of the Geum River (금강 수계 주요지류인 갑천과 미호천에서 잠정유해물질 오염원 확인 연구)

  • Lee, Jun-Bae;Lee, Jay-Jung;Cho, Yoon-Hae;Yoon, Jo-Hee;Hong, Seoun-Hwa;Lee, Dae-Hee;Lee, Dae-Hee;Cho, Young-Hwan;Shin, Ho-Sang
    • Korean Journal of Environmental Agriculture
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    • v.35 no.1
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    • pp.15-23
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    • 2016
  • BACKGROUND: Water quality is of concern to water utility operators, public health officials, and populations using the water. If any contaminant is released from a point of entry, it could be spread rapidly throughout the water stream. So the identification of the location of the points of entry and its release history are critical informations to establish the management strategy.METHODS AND RESULTS: Aniline, nonylphenol, pentachlorophenol and formaldehyde in 39 surface water samples were analysed using Gas chromatography-mass spectrometry (GC-MS) methods. Formaldehyde, aniline and nonylphenol were mainly detected in the near sites where industrial waste water and domestic sewage were discharged into stream. But pentachlorophenol was detected in the downstream samples where pulp manufacturing plants were operated.CONCLUSION: Results indicate that pentachlorophenol found in main stream of Guem river was mainly introduced from pulp manufacture industries. Otherwise, formaldehyde, aniline and nonylphenol were mainly contaminated from the industrial waste water and domestic sewage.

Endothelial Ca2+ signaling-dependent vasodilation through transient receptor potential channels

  • Hong, Kwang-Seok;Lee, Man-Gyoon
    • The Korean Journal of Physiology and Pharmacology
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    • v.24 no.4
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    • pp.287-298
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    • 2020
  • Ca2+ signaling of endothelial cells plays a critical role in controlling blood flow and pressure in small arteries and arterioles. As the impairment of endothelial function is closely associated with cardiovascular diseases (e.g., atherosclerosis, stroke, and hypertension), endothelial Ca2+ signaling mechanisms have received substantial attention. Increases in endothelial intracellular Ca2+ concentrations promote the synthesis and release of endothelial-derived hyperpolarizing factors (EDHFs, e.g., nitric oxide, prostacyclin, or K+ efflux) or directly result in endothelial-dependent hyperpolarization (EDH). These physiological alterations modulate vascular contractility and cause marked vasodilation in resistance arteries. Transient receptor potential (TRP) channels are nonselective cation channels that are present in the endothelium, vascular smooth muscle cells, or perivascular/sensory nerves. TRP channels are activated by diverse stimuli and are considered key biological apparatuses for the Ca2+ influx-dependent regulation of vasomotor reactivity in resistance arteries. Ca2+-permeable TRP channels, which are primarily found at spatially restricted microdomains in endothelial cells (e.g., myoendothelial projections), have a large unitary or binary conductance and contribute to EDHFs or EDH-induced vasodilation in concert with the activation of intermediate/small conductance Ca2+-sensitive K+ channels. It is likely that endothelial TRP channel dysfunction is related to the dysregulation of endothelial Ca2+ signaling and in turn gives rise to vascular-related diseases such as hypertension. Thus, investigations on the role of Ca2+ dynamics via TRP channels in endothelial cells are required to further comprehend how vascular tone or perfusion pressure are regulated in normal and pathophysiological conditions.

Development of Capacity Models Based on the Travel Characteristics at Roundabout (회전교차로의 통행특성에 근거한 용량 모형 개발)

  • Kim, Tae Young;Beak, Tae Hun;Park, Byung Ho
    • Journal of Korean Society of Transportation
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    • v.32 no.6
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    • pp.651-661
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    • 2014
  • Recently, many studies have been undertaken regarding the of introduction at roundabout in Korea. The studies related to roundabout capacity, however, is insufficient. Thus, the goal of this study is to develop a capacity model based on real data. The main results are as follows. First, roundabout capacity in Korea was analyzed using HCM capacity model based on critical gap and following time estimated by Probit model. Entry capacity in Korea was evaluated to be similar to that of the U.S in the case of low circulating flow($Q_c$), but higher in the case of high circulating flow($Q_c$). Second, the basic capacity models in Korea were newly developed based on real traffic data. Third, models that consider geometric structure were developed based on the basic models. Finally, all of the developed models mentioned above were analyzed to be statistically significant.

Effect of Angle and Density of Grooves between Friction Plate Segments on Drag Torque in Wet Clutch of Automatic Transmission (마찰재 그루브에 따른 습식 클러치 드래그 토크 변화 연구)

  • Ryu, Jin Seok;Sung, In-Ha
    • Tribology and Lubricants
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    • v.30 no.2
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    • pp.71-76
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    • 2014
  • As the importance of transmission efficiency to reducing fuel consumption and conserving the environment rapidly increases, reducing the drag torque in an automotive wet clutch is emerging as an important issue in the automotive industry. The drag torque in a clutch occurs from viscous drag generated by automatic transmission fluid in the narrow gap between separate friction plates. In this study, the drag torques in an automotive wet clutch are investigated with respect to the angle and density of the grooves between separate friction plates by three-dimensional finite element simulation of a single set of wet clutch disks considering the two-phase flow of air and oil. The simulation results shows that the drag torque generally increases with the rotational speed to a critical point and then decreases at the high-speed regime. The grooves between the plates plays an important role in reducing the drag peak, and the inclined angle of the grooves affects the oil flow. The grooves with an angle of $50^{\circ}$ shows the lowest drag torques at both low and high speeds. The flow vectors inside the $50^{\circ}$ grooves shows clear evidence that the fluid flows out more easily from the grooves compared with the flow vectors inside grooves with lower angles. The simulation results shows that increasing the number of grooves (density of grooves) decreases the drag torque.

Crossing the Gap between Elementary School Mathematics and Secondary School Mathematics: The Case of Systems of Linear Equations (그림그리기 전략을 통한 초.중등수학의 연립방정식 지도 연결성 강화)

  • Kwon, Seok-Il;Yim, Jae-Hoon
    • Journal of Educational Research in Mathematics
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    • v.17 no.2
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    • pp.91-109
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    • 2007
  • This study deals with the problem of transition from arithmetic to algebra and the relationship between elementary and secondary school mathematics for systems of linear equations. In elementary school, activity for solving word problems related to systems of linear equations in two variables falls broadly into using two strategies: Guess and check and making a table. In secondary school, those problems are solved algebraically, for example, by solving systems of equations using the technique of elimination. The analysis of mathematics textbooks shows that there is no link between strategies of elementary school mathematics and secondary school mathematics. We devised an alternative way to reinforce link between elementary and secondary school mathematics for systems of linear equations. Drawing a diagram can be introduced as a strategy solving word problems related to systems of linear equations in two variables in elementary school. Moreover it is closely related to the idea of the technique of elimination of secondary school mathematics. It may be a critical juncture of elementary-secondary school mathematics in the case of systems of linear equations in two variables.

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An Implementation Analysis of the National Health Insurance Coverage Expansion Policy in Korea: Application of the Winter Implementation Model (건강보험 보장성 확대정책의 집행분석: Winter의 정책집행모형의 적용)

  • You, Sooyeon;Kang, Minah;Kwon, Soonman
    • Health Policy and Management
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    • v.24 no.3
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    • pp.205-218
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    • 2014
  • Background: Most studies on the national health insurance benefit expansion policy have focused on policy tools or decision-making process. Hence there was not enough understanding on how policies are actually implemented within the specific policy context in Korea which has a national mandatory health insurance system with a dominant proportion of private providers. The main objectives of this study is to understand the implementation process of the benefit coverage expansion policy. Unlike other implementation studies, we tried to examine both the process of implementation and decision making and how they interact with each other. Methods: Interviews were conducted with the ex-members of the Health Insurance Policy Review Committee. Medical doctors who implement the policy at the 'street-level' were also interviewed. To figure out major variables and the degree of their influences, the data were analyzed with Winter's Policy Implementation Model which integrates the decision making and implementation phases. Results: As predicted by the Winter model, problems in the decision making phase, such as conflicts among the members of committee, lack of applicable causal theories application of highly symbolic activities, and limited attention of citizen to the issue are key variables that cause the 'implementation failure.' In the implementation phase, hospitals' own financial interests and practitioners' dependence on the hospitals' guidance were barriers to meeting the policy goals of providing a better coverage for patients. Patients, the target group, tend to prefer physicians who prescribe more treatment and medicine. To note, 'fixers' who can link and fill the gap between the decision-makers and implementers were not present. Conclusion: For achieving the policy goal of providing a better and more coverage to patients, the critical roles of medical providers as street-level implementers should be noted. Also decision making process of benefit package expansion policy should incorporate its influence on the implementation phase.

Critical Analysis of Unmet Healthcare Needs Index for Addressing Regional Healthcare Inequality (지역 의료불평등 해소를 위한 미충족 의료지표 활용의 비판적 분석)

  • Park, Yukyung;Kim, Jin-Hwan;Kim, Sun;Kim, Chang-yup;Han, Joo-sung;Kim, Saerom
    • Health Policy and Management
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    • v.30 no.1
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    • pp.37-49
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    • 2020
  • Background: Unmet healthcare needs have many advantages for measuring inequalities in healthcare use. However, the existing indicator is difficult to capture the reality of unmet healthcare needs sufficiently and is not quite appropriate in comparing regional inequality. The purpose of this study is to critically analyze the utilization of the unmet healthcare need indicator for regional healthcare inequalities research. Methods: We used the level of healthcare accessibility and healthcare need to categorize the regions that are known to cause differences in healthcare utilization between regions and verified how existing unmet healthcare need indicator is distributed at the regional level. Results: Four types of regions were classified according to the high and low levels of healthcare needs and accessibility. The hypothesis about the regional type expected to have the highest unmet healthcare need was not proved. The hypothesis about the lowest expected regional type was proved, but the difference in the average rate of unmet healthcare needs among regional types was not significant. The standard deviation of the rate of unmet healthcare needs among regions within the same type was also higher than the overall regional variation, which also disproved the whole frame of hypothesis. Conclusion: Failure to prove the hypothesis means the gap between the supposed meaning of the indicator and the reality. In order to understand the current state of healthcare utilization of people in various regions of Korea and to resolve inequality, fundamental research on the in-depth structure and mechanisms of healthcare utilization is needed.

Triple Helix of University-Industry-Government Relations in Biotechnology Cluster: the Case of Singapore (바이오 클러스터에서의 트리플 힐릭스 관계 연구: 싱가포르 사례를 중심으로)

  • Nam, Jae-Geol
    • Journal of the Economic Geographical Society of Korea
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    • v.17 no.4
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    • pp.801-816
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    • 2014
  • This paper is a theoretically grounded empirical study aimed at shedding light on the Triple Helix of University-Industry-Government (U-I-G) relations in biotechnology cluster of Singapore. It questions the issue about the gap between theoretical consideration of the Triple Helix of U-I-G relations and the actual reality in biotechnology cluster, and the experience of Singapore was investigated. In terms of evolutionary perspective, biotechnology cluster in Singapore has gone through ongoing processes from a certain stage to other, and within the processes the Triple Helix nexus has been found. Analysis of the empirical study reveals significant findings: first, the government policies play a critical role in the operation of U-I-G relations rather than universities; second, therefore, the binding force of U-I-G relationships is based on the government policies being comprehensive including researchers immigration, student scholarship for local students, and tax and non-tax incentives for firms, rather than focusing on a targeted policy; third, the role of government starts from an initial stage, and it's role is ongoing processes by supporting infrastructure, human sources and continuous nourishment enabling the triple helix of U-I-G relations.

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