• BMB Reports
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• 제54권5호
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• pp.233-245
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• 2021

In eukaryotes, the genome is hierarchically packed inside the nucleus, which facilitates physical contact between cis-regulatory elements (CREs), such as enhancers and promoters. Accumulating evidence highlights the critical role of higher-order chromatin structure in precise regulation of spatiotemporal gene expression under diverse biological contexts including lineage commitment and cell activation by external stimulus. Genomics and imaging-based technologies, such as Hi-C and DNA fluorescence in situ hybridization (FISH), have revealed the key principles of genome folding, while newly developed tools focus on improvement in resolution, throughput and modality at single-cell and population levels, and challenge the knowledge obtained through conventional approaches. In this review, we discuss recent advances in our understanding of principles of higher-order chromosome conformation and technologies to investigate 4D chromatin interactions.

• Nuclear Engineering and Technology
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• 제53권5호
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• pp.1464-1478
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• 2021

Selective Production of Exotic Species is an innovative plant for advanced nuclear physic studies. A radioactive beam, generated by using an UCx target-ion source system, is ionized, selected and accelerated for experimental objects. Very high vacuum conditions and appropriate safety systems to storage exhaust gases are required to avoid radiological risk for operators and people. In this paper, Failure Mode, Effects, and Criticality Analysis of a preliminary design of high activity gas recovery system is performed by using a modified Fuzzy Risk Priority Number to rank the most critical components in terms of failures and human errors. Comparisons between fuzzy approach and classic application allow to show that Fuzzy Risk Priority Number is able to enhance the focus of risk assessments and to improve the safety of complex and innovative systems such as those under consideration.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 1997년도 Lecture Notes by Two Distinguished Scholars
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• pp.1.2-22
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• 1997

Anisotropic behaviour in soils and soft rocks may be either fabric of stress related ultra in practice is invariably a combination of both. Theoretical studies in the paper include tile iMluence oil untrained strength of assuming both the critical state and Mo21r-Coulomb concepts to hold, and the influence of elastic anisotropy oil predicted undrained effective stress paths. The predictions stemming from these theoretical concepts are examined in the light of evidence from triaxial compression and extension tests oil laboratory prepared, compacted and natural clays and from triaxial compression tests on clay shales. The experimental studies also show the Buence of sample orientation on untrained snear strength, as wen as the iIBluence of anisotropy old the effective stress angle cishearing resistance and of stress patn on measured stiffness.

• International Journal of Computer Science & Network Security
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• 제23권5호
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• pp.179-192
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• 2023

The widespread use of Cloud Computing, Internet of Things (IoT), and social media in the Information Communication Technology (ICT) field has resulted in continuous and unavoidable cyber-attacks on users and critical infrastructures worldwide. Traditional security measures such as firewalls and encryption systems are not effective in countering these sophisticated cyber-attacks. Therefore, Intrusion Detection and Prevention Systems (IDPS) are necessary to reduce the risk to an absolute minimum. Although IDPSs can detect various types of cyber-attacks with high accuracy, their performance is limited by a high false alarm rate. This study proposes a new technique called Fuzzy Logic - Objective Risk Analysis (FLORA) that can significantly reduce false positive alarm rates and maintain a high level of security against serious cyber-attacks. The FLORA model has a high fuzzy accuracy rate of 90.11% and can predict vulnerabilities with a high level of certainty. It also has a mechanism for monitoring and recording digital forensic evidence which can be used in legal prosecution proceedings in different jurisdictions.

• Tuberculosis and Respiratory Diseases
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• 제86권3호
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• pp.183-195
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• 2023

Bronchiectasis, which is characterized by irreversibly damaged and dilated bronchi, causes significant symptoms, poor quality of life, and increased economic burden and mortality rates. Despite its increasing prevalence and clinical significance, bronchiectasis was previously regarded as an orphan disease, and ideal treatment of this disease has been poorly understood. The European Respiratory Society and British Thoracic Society have recently published guidelines to assist physicians in the clinical field. Guidelines and reports suggest comprehensive management that includes both non-pharmacological and pharmacological treatment. Physiotherapy and pulmonary rehabilitation are two of the most important non-pharmacologic therapies in bronchiectasis patients; long-term inhaled antibiotics and macrolide therapy have gained significant evidence in reducing exacerbation risk in frequent exacerbators. In this review, we summarize recent updates on bronchiectasis treatment to prevent exacerbation and manage clinical deterioration.

• 한국중재학회지:중재연구
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• 제33권3호
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• pp.31-68
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• 2023

In recent years, French courts have decided to adopt an uncompromising stance in the fight against corruption in international arbitration. While French enforcement/annulment courts were originally conducting a limited review of arbitral awards dealing with corruption allegations on international public policy grounds, they now carry a full re-examination of such awards accepting that a corruption plea be raised for the first time before them and admitting new evidence. What is at stake, in terms of international public policy, is to define the happy medium between, on the one hand, the necessity to preserve the enforceability of international arbitral awards, and, the necessity to fight corruption. This paper presents the evolution of French case law in the past years and makes a critical assessment of the French approach by comparison with other jurisdictions.

• 유통과학연구
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• 제22권1호
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• pp.61-67
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• 2024

Purpose: The study has identified factors affecting dynamic capabilities and the distribution of competitive advantage under the impact of dynamic capabilities of Vietnamese fintech businesses. Research design, data, and methods: The method used in this study is a survey analysis of 120 Vietnamese fintech businesses to test the hypothesized relationships of the research model as well as evaluate its effectiveness. The study uses the Cronbach alpha analysis, factor analyses, and structural equation modeling to assess the research's measurement and structural models. Results: Research results show that 3 critical success factors: "Capacity to develop financial service ideas," "Ability to develop a platform," and "Business capacity" have a positive impact on "Dynamic capabilities." In addition, the study also evaluates the effect of "dynamic capabilities" on the "competitive advantage" of fintech businesses. Conclusion: Theoretically, this result contributes to discovering new, specific factors affecting the dynamic capabilities of fintech businesses. In practice, the research results are empirical evidence of the distribution of competitive advantages of Vietnamese Fintech businesses and their impact on dynamic capabilities.

• Korean Circulation Journal
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• 제52권3호
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• pp.198-204
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• 2022

Blood pressure measurement (BPM) is an essential part of medical examination, and therefore accuracy of BPM devices is crucial. Over the past few years, there has been a rise in new BPM techniques using photoplethysmographic (PPG) signals and complex algorithms for blood pressure estimation. Especially the combination of a mobile device or a smartphone with a camera using PPG may potentially revolutionize BPM in the future. The first-ever BPM application to be approved as a medical device was one by the Korean Ministry of Food and Drug Safety in 2020, despite the lack of robust scientific evidence proving its validity. While the prospect of using these novel BPM devices is an opportunity, there are also some critical issues around calibration and utility in different patient groups that need to be resolved before they can be incorporated into daily clinical practice.

• 한방재활의학과학회지
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• 제26권4호
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• pp.77-83
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• 2016

Objectives The aim of this study is to investigate the possibility of making Korean Medicine-Western Medicine collaboration Critical Pathway for Acute Postoperative Pain after Back Surgery. Methods This preliminary Critical Pathway (CP) was composed of 9 Index of vertical axis (assesment, treatment, patient movements, consultation, diet, other, administration, examination, education) and 5 hospitalization periods of horizontal axis through a review of the literature and reference data of medical records. This preliminary CP's Content Validity Index (CVI) survey was carried out by 20 personnel of two different medical institutions from 06, June, 2016 to 15, June, 2016. All data were double-cross checked and analyzed. Results Of those questioned, there were 13 males and 7 females in age, 6 professors, 7 medical residents, 7 nurses in position of 20 personnel. According to the survey, among the 62 contents, 32 contents are above 80 percent agreements, 12 contents were between 70 to 80 percent and 18 contents below 70 percent agreements. Especially, Most contents in treatment index were below fixed validity. Overall Contents Validity in Index, Treatments (72.7%), Diet (100.0%), Other (100.0%), Administration (75.0%) and Examination (100.0%) were in high validity. On the other hands, Assessments (29.4%), Patient movements (0.0%), Consultation (30.0%) and Education (33.3%) were in low position. Conclusions This survey results can be evidence of possibility to develop New Korean Medicine-Western Medicine Collaboration Critical Pathway for Acute Postoperative Pain after Back Surgery.

• Tuberculosis and Respiratory Diseases
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• 제58권6호
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• pp.576-581
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• 2005

배 경 : 기관지 방선균증은 매우 드문 질환이다. 본 연구는 최근 10년간 조직학적으로 진단된 7명의 기관지 방선균증 환자의 임상상과 치료에 대해 살펴보고자 하였다. 대상 및 방법 : 1994년 10월부터 2003년 12월까지 삼성서울병원에 내원하여 기관지 방선균증으로 진단된 7명의 임상적, 방사선학적 특징과 치료에 대해 후향적 분석을 시행하였다. 결 과 : 기침과 가래가 가장 흔한 임상증상이었다. 진단까지의 기간은 중앙값 4개월(범위 1-16개월)이었다. 흉부 방사선 소견은 기관지내 종괴와 동반된 경화 또는 무기폐가 6명에서 관찰되었고 1명에서 기관지내 결절이 관찰되었으며, 이중 5명에서 기관지결석이 동반되었다. 이들 환자의 정주용 항생제 사용기간은 중앙값 3일(범위 0-12일)이었으며, 경구용 항생제 사용 기간은 중앙값 147일(범위 20-412일)이었고, 2명의 환자는 정주용 항생제를 사용하지 않았다. 모든 환자에서 치료 후 임상적, 방사선학적으로 호전의 소견을 보였다. 결 론 : 기관지결석을 동반한 기관지내 병변이 있을 때 기관지 방선균증을 의심하여야 한다. 항생제 치료기간은 병변의 진행 정도, 치료에 대한 반응 등을 고려하여 개별화할 수 있을 것이며, 모든 환자에서 2-6주의 정주용 항생제에 이은 6-12개월의 경구용 항생제의 사용이 필요하지는 않을 것이다.