• 제목/요약/키워드: critical difference

검색결과 1,406건 처리시간 0.028초

Direct Switch from Tiotropium to Indacaterol/Glycopyrronium in Chronic Obstructive Pulmonary Disease Patients in Korea

  • Lee, Sang Haak;Rhee, Chin Kook;Yoo, Kwangha;Park, Jeong Woong;Yong, Suk Joong;Kim, Jusang;Lee, Taehoon;Lim, Seong Yong;Lee, Ji-Hyun;Park, Hye Yun;Moon, Minyoung;Jung, Ki-Suck
    • Tuberculosis and Respiratory Diseases
    • /
    • 제84권2호
    • /
    • pp.96-104
    • /
    • 2021
  • Background: Many chronic obstructive pulmonary disease (COPD) patients receiving monotherapy continue to experience symptoms, exacerbations and poor quality of life. This study aimed to assess the efficacy and safety of direct switch from once-daily tiotropium (TIO) 18 ㎍ to indacaterol/glycopyrronium (IND/GLY) 110/50 ㎍ once daily in COPD patients in Korea. Methods: This was a randomized, open-label, parallel group, 12-week trial in mild-to-moderate COPD patients who received TIO 18 ㎍ once daily for ≥12 weeks prior to study initiation. Patients aged ≥40 years, with predicted post-bronchodilator forced expiratory volume in 1 second (FEV1) ≥50%, post-bronchodilator FEV1/forced vital capacity <0.7 and smoking history of ≥10 pack-years were included. Eligible patients were randomized in a 1:1 ratio to either IND/GLY or TIO. The primary objective was to demonstrate superiority of IND/GLY over TIO in pre-dose trough FEV1 at week 12. Secondary endpoints included transition dyspnea index (TDI) focal score, COPD assessment test (CAT) total score, and rescue medication use following the 12-week treatment, and safety assessment. Results: Of the 442 patients screened, 379 were randomized and 347 completed the study. IND/GLY demonstrated superiority in pre-dose trough FEV1 versus TIO at week 12 (least squares mean treatment difference [Δ], 50 mL; p=0.013). Also, numerical improvements were observed with IND/GLY in the TDI focal score (Δ, 0.31), CAT total score (Δ, -0.81), and rescue medication use (Δ, -0.09 puffs/day). Both treatments were well tolerated by patients. Conclusion: A direct switch from TIO to IND/GLY provided improvements in lung function and other patient-reported outcomes with an acceptable safety profile in patients with mild-to-moderate airflow limitation.

비훈련 성인남여의 무산소성 운동능력 차이 (Gender differences of anaerobic capabilities in untrained adults)

  • 정진원
    • 디지털융복합연구
    • /
    • 제16권5호
    • /
    • pp.463-468
    • /
    • 2018
  • 본 연구의 목적은 윈게이트 검사로부터 측정된 무산소성 운동능력(Anaerobic Capacity, AC)과 임계파워검사로부터 측정된 무산소성 작업능력(Anaerobic Work Capacity, AWC)의 상관관계를 알아보고, 두 가지의 무산소성 능력에서 나타나는 남녀간의 성별 차이를 조사하는데 있었다. 성인 남여 23명을 대상으로 모나크 자전거 에르고미터를 이용하여 두가지 테스트를 수행하였다. 각각의 무산소성 검사에서 AC에서는 남성이 여성보다 높게 나타났으나 AWC에서는 남녀간 차이가 나타나지 않았다. AC와 AWC(J/kg)사이의 상관관계는 여성에서는 통계적으로 유의하였으나(r=0.61, p<0.05), 남성에서는 유의하지 않았다(r=-0.32, p>0.05). 최대 유산소 능력과 체중을 공변인으로 한 공변량분석 결과에 의하면 두 변인이 AC의 남녀간의 차이에는 유의한 영향을 미치지 않았으나 AWC의 남녀간의 차이에는 통계적으로 유의한 영향을 미친 것으로 나타났다. 또한 본 연구결과는 무산소 운동검사로 평가되는 남녀간의 성별 차이에 대한 기초적인 자료를 제공하고 있다.

응급외상 환자 시뮬레이션 적용 효과 (Implementation Effects of Emergency Trauma Patient Simulation)

  • 백미례
    • 한국응급구조학회지
    • /
    • 제15권2호
    • /
    • pp.43-54
    • /
    • 2011
  • Purpose: The purpose of this study was to explore EMT-paramedic students' experience of simulation education and analyze the confidence before and after education, learning attitude and course evaluation. Method: Research survey was conducted on 38 EMT-paramedic students during November, 2011 and EMT-paramedic students' experience of simulation education was analyzed after applying head, spinal, and chest injury scenario. The confidence before and after education, learning attitude and course evaluation in gender were analyzed by Mann-Whitny U test and the difference of confidence before and after education was analyzed by Wilcoxon signed rank test and learning attitude & course evaluation were analyzed by evaluating frequency, percentage, mean, standard deviation by using SPSS WIN 17.0 program. Results: 1. Students experienced various advantages such as increasing interest and self-reflection on learning, critical thinking ability, and EMT-paramedic-role experience and recognition of importance of teamwork. Students also pointed out disadvantages such as gap between real situation and simulation, limit of time and equipments, and burden of demonstration. 2. The confidence between before and after education, learning attitude and course evaluation in gender were not significant different statistically. 3. Confidence mean score elevated from 5.53(before education) to 5.87(after education), but the difference in their confidence did not show significant difference statistically. 4. Total mean score in learning attitude after simulation education was 3.70 out of 5.00, which is considerably very high. 5. Total mean score in course evaluation was 3.89 with score of 3.83 in evaluation in learning environment and 3.99 in evaluation of debriefing. Conclusion: The finding of this study demonstrate that the simulation education can provide a safe and repetitive practice environment, improve problem-solving ability and critical thinking, and increase the confidence in prehospital emergency care; therefore, simulation may be the new effective EMT-paramedic education strategy.

영상처리를 이용한 상업용 전자칠판의 인터페이스 구현 (Implementation of Commercial IWB Interface using Image Processing)

  • 고은상;이양원;이창우
    • 한국산업정보학회논문지
    • /
    • 제17권6호
    • /
    • pp.19-24
    • /
    • 2012
  • 본 논문에서는 상업용 아임센서터치 전자칠판(Interactive Whiteboard System, IWB)을 소개한다. 이 시스템은 손가락이나 펜을 이용하여 접촉식 상호작용이 가능한 화이트보드 스크린을 통해 개인용 컴퓨터를 운용할 수 있도록 도와주는 인터페이스(Interface)이다. 제안된 인터페이스는 윈도우즈 운영체제와 상호작용하며, 온도와 조명의 변화에 적응적으로 동작한다. 제안된 시스템은 카메라에서 입력된 수광부(Optical Receptive Field)의 영상을 참조영상과 비교하여 차이를 계산하고, 그 차이를 이용하여 터치스크린의 좌표값을 계산한다. 계산된 좌표값을 기반으로 윈도우즈 마우스 이벤트를 생성하여 윈도우즈시스템으로 전달한다. 우리는 참조영상을 갱신하기 위해 두 개의 스레드(Thread)을 이용한 임계영역을 구현하고, 차이계산의 신뢰성을 위해 적응적 임계값을 이용한 참조영상의 갱신을 구현한다. 제안된 터치스크린 인터페이스를 장착한 전자칠판 시스템은 향후 국내외 시장의 성장률이 높아 전도유망한 상품이며, 시장성이 밝을 것으로 기대한다.

간호요구도에 따른 중환자간호 분류도구 개발 (Development of Classification System for Critical Care Nursing Based on Nursing Needs)

  • 유정숙;김금순
    • 임상간호연구
    • /
    • 제19권1호
    • /
    • pp.33-44
    • /
    • 2013
  • Purpose: This study was done to develop a valid and reliable Classification System for Critical Care Nursing (CSCCN) to be used in Intensive Care Units (ICUs). Methods: Head nurses and staff nurses of 17 ICUs in 6 hospitals classified 307 patients to verify interrater reliability. To verify construct validity, the staff nurses classified 404 patients according to CSCCN comparing difference in medical department and type of stay in ICU. For conversion index, 78 patients from 4 ICUs of 'S' hospital were classified and nursing time was measured by 107 nurses and 18 nurse aids using stopwatches. Results: The developed CSCCN has 11 categories, 76 nursing activities and 101 criteria. The reliability was verified as having high agreement (r=.946). The construct validity was verified comparing differences in medical department and type of stay in ICU. According to scores, four groups in the CSCCN classification were identified. According to the conversion index, one score on the CSCCN means 7.2 minutes of nursing time. Conclusion: CSCCN can be used to measure diverse and complex nursing demands including psycho-social aspects of ICU patients and convert nursing demands to numbers.

AHP에 의한 조선기업의 작업능률향상을 위한 과업관련기법의 선택 (An AHP Approach to Select the Task Related Technique for Work Efficiency Improvement in Shipbuilding Enterprise)

  • 김태수;이강우
    • 한국품질경영학회:학술대회논문집
    • /
    • 한국품질경영학회 2006년도 추계 학술대회
    • /
    • pp.31-37
    • /
    • 2006
  • The objective of this research is to select the most effective technique from task related techniques(motion & time study, job redesign, physical environment improvement) for improving work efficiency in shipbuilding enterprise. This study consists of several principal steps. The first step is to design critical criteria in evaluating work efficiency in shipbuilding enterprises. The second step is to develop sub-criteria of the critical criteria. The third step is to develop a four level AHP(Analytic Hierarchy Process)structure using the critical criteria, sub-criteria and techniques from task related techniques. The fourth step is to develop the pairwise comparison matrix by each level of AHP structure, which was based on survey data collected at the H heavy industry. And the last step is to select the most effective technique from task related techniques using AHP analysis. The result of AHP analysis has shown clear difference in priority among task related techniques in terms of work efficiency of the shipbuilding enterprise: The reduction of normal time has more importance than the reduction of allowance time, motion & time study techniques are most important for the reduction of normal time, physical environment improvement is most important for the reduction of allowance time as well.

  • PDF

Seismic performances of three- and four-sided box culverts: A comparative study

  • Sun, Qiangqiang;Peng, Da;Dias, Daniel
    • Geomechanics and Engineering
    • /
    • 제22권1호
    • /
    • pp.49-63
    • /
    • 2020
  • Studying the critical response characteristics of box culverts with diverse geometrical configurations under seismic excitations is a necessary step to develop a reasonable design method. In this work, a numerical parametric study is conducted on various soil-culvert systems, aiming to highlight the critical difference in the seismic performances between three- and four-sided culverts. Two-dimensional numerical models consider a variety of burial depths, flexibility ratios and foundation widths, assuming a visco-elastic soil condition, which permits to compare with the analytical solutions and previous studies. The results show that flexible three-sided culverts at a shallow depth considerably amplify the spectral acceleration and Arias intensity. Larger racking deformation and rocking rotation are also predicted for the three-sided culverts, but the bottom slab influence decreases with increasing burial depth and foundation width. The bottom slab combined with the burial depth and structural stiffness also significantly influences the magnitude and distribution of the dynamic earth pressure. The findings of this work shed light on the critical role of the bottom slab in the seismic responses of box culverts and may have a certain reference value for the preliminary seismic design using R-F relation.

Prediction of Microshrinkage Porosity in Thin Al-alloy Permanent Mold Castings

  • Lee, Zin-Hyoung
    • 한국주조공학회지
    • /
    • 제11권1호
    • /
    • pp.44-53
    • /
    • 1991
  • The proper feeding conditions for thin Al-Alloy (AA336, JIS AC8A) castings in permanent mold were investigated to eliminate microshrinkage porosity. 5mm-thick plates (200mm long, 60mm wide) were cast with increasing padding taper from 0 to 5% under different conditions : (1) constant mold temperature of $350^{\circ}C$, (2) continuous production with uniform mold thickness (10mm), (3) continuous production with a negative taper of 2.5% in mold thickness (thickness decreasing in direction to riser). The test casting were machined off to the midplane and the shrinkage porosity was examined visually. The critical padding taper which can just eliminate the shrinkage porosity was determined for each condition, i.e. : (1) 4.5% at the constant mold temperature, (2) 3.5% for continuous production with the uniform mold thickness (3) 1.5% for continuous production with the taper in mold thickness. A computer simulation by a finite difference analysis program was applied to the test casting. The liquid fraction gradient (LFG) and the temperature gradient divided by the square root of the cooling rate (G /SR) were calculated at the end of solidification and compared with the shrinkage porosity area in the castings. For the case of constant mold temperature, LFG is a better parameter to predict shrinkage porosity than G /SR and its critical value is around 11%/cm. But for the case of continuous production, neither LFG nor G /SR could be a reliable parameter. The experimental results about the critical padding taper are of practical interest for designing permanent molds and castings. The computer simulation results stimulate further research to be directed on the prediction of centerline microshrinkage porosity in continuous production.

  • PDF

우리나라 소비자의 은퇴설계실행능력과 영향요인 (Capability of Retirement Planning and Implementing and the Influencing Factor)

  • 김정현;박주영
    • 한국생활과학회지
    • /
    • 제22권1호
    • /
    • pp.117-129
    • /
    • 2013
  • The purpose of this study is to examine the factors affecting on CRPI (capability of retirement planning and implementing) and to identify the critical point of financial factors to increase CRPI. 908 Korean individuals' data were used for descriptive statistics, t-test, F-test, and Generalized Linear Mixed Model Analysis. As a result, CRPI was influenced by attitude toward retirement planning, gender, income, and propensity to save. Some mid-group did not make a significant difference in CRPI compared to the lower-group. Men were more capable at CRPI than women in terms of sense of independence and getting a consulting service. Most consumers appear to have difficulty in calculating their retirement fund. People who have income over 3,000,000 won have dramatically greater CRPI than people who have income under 3,000,000 won. And people who have saving ratio over 23% have significantly greater CRPI than people who have propensity to save under 23%. The monthly income 3,000,000 won and propensity to save 23% were considered as critical points related to CRPI.

T-Commerce 요인에 따른 사용의도 판별에 관한 연구 (A Study on the Discrimination of Use Intention by Critical T-Commerce Factors)

  • 김주안
    • 통상정보연구
    • /
    • 제8권3호
    • /
    • pp.71-95
    • /
    • 2006
  • In recent, T-commerce is widely dispersed as alternative type of commerce. It is forecasted that t-commerce system is used more than e-commerce system. Therefore more and more t-commerce-related industries are also recognizing that t-commerce is a critical business model. It is needed to understand the concept of t-commerce and develop the t-commerce marketing strategy. CEO analyses consumer's behaviors according to the data about buyers and applies the advantage of t-commerce to the communication with customers. This t-commerce system plays an important role in maximizing customer satisfaction and affecting their intention to reuse it. Therefore this paper attempts to identify T-commerce critical success factors and divide between use-intention group and unuse-intention group by taking out a discriminant function by the discriminant analysis. This lays a foundation in developing T-commerce strategy. According to the discriminant function extracted, convenience factor, amusement factor, system quality factor, product perception factor are significant in the sequence of influential degree. However, usefulness factor and speedy connection factor are not significant. In result, the target hitting rate is 77.9% in the first unuse-intention group and it is 95.2% in the second use-intention group. The total discriminant target hitting rate is computed to higher value, 86.55%. The statistic package, SPSS 12.0, is used to survey and analyse data and test the hypothesis. The validity and reliability of variables are verified by both reliability analysis and factor analysis. The discriminant analysis is used to tell the difference between use-intention group and unuse-intention group.

  • PDF