• Title/Summary/Keyword: critical difference

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Direct Switch from Tiotropium to Indacaterol/Glycopyrronium in Chronic Obstructive Pulmonary Disease Patients in Korea

  • Lee, Sang Haak;Rhee, Chin Kook;Yoo, Kwangha;Park, Jeong Woong;Yong, Suk Joong;Kim, Jusang;Lee, Taehoon;Lim, Seong Yong;Lee, Ji-Hyun;Park, Hye Yun;Moon, Minyoung;Jung, Ki-Suck
    • Tuberculosis and Respiratory Diseases
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    • v.84 no.2
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    • pp.96-104
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    • 2021
  • Background: Many chronic obstructive pulmonary disease (COPD) patients receiving monotherapy continue to experience symptoms, exacerbations and poor quality of life. This study aimed to assess the efficacy and safety of direct switch from once-daily tiotropium (TIO) 18 ㎍ to indacaterol/glycopyrronium (IND/GLY) 110/50 ㎍ once daily in COPD patients in Korea. Methods: This was a randomized, open-label, parallel group, 12-week trial in mild-to-moderate COPD patients who received TIO 18 ㎍ once daily for ≥12 weeks prior to study initiation. Patients aged ≥40 years, with predicted post-bronchodilator forced expiratory volume in 1 second (FEV1) ≥50%, post-bronchodilator FEV1/forced vital capacity <0.7 and smoking history of ≥10 pack-years were included. Eligible patients were randomized in a 1:1 ratio to either IND/GLY or TIO. The primary objective was to demonstrate superiority of IND/GLY over TIO in pre-dose trough FEV1 at week 12. Secondary endpoints included transition dyspnea index (TDI) focal score, COPD assessment test (CAT) total score, and rescue medication use following the 12-week treatment, and safety assessment. Results: Of the 442 patients screened, 379 were randomized and 347 completed the study. IND/GLY demonstrated superiority in pre-dose trough FEV1 versus TIO at week 12 (least squares mean treatment difference [Δ], 50 mL; p=0.013). Also, numerical improvements were observed with IND/GLY in the TDI focal score (Δ, 0.31), CAT total score (Δ, -0.81), and rescue medication use (Δ, -0.09 puffs/day). Both treatments were well tolerated by patients. Conclusion: A direct switch from TIO to IND/GLY provided improvements in lung function and other patient-reported outcomes with an acceptable safety profile in patients with mild-to-moderate airflow limitation.

Gender differences of anaerobic capabilities in untrained adults (비훈련 성인남여의 무산소성 운동능력 차이)

  • Jeong, Jinwon
    • Journal of Digital Convergence
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    • v.16 no.5
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    • pp.463-468
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    • 2018
  • The purpose of the study was to investigate the gender differences of anaerobic capabilities between anaerobic capacity(AC) from Wingate test and anaerobic work capacity(AWC) from critical power test in untrained male and female adults. Both tests were carried out to 12 male and 13 female subjects on a Monark cycle ergometer. The results of this study demonstrated that men were higher than women in AC for the Wingate test, but no gender difference(J/kg) in AWC for the Critical Power test. There was a significant relationship between AC(J/kg) and AWC(J/kg) in women(r=0.61, p<0.05), but no significant relationship in men(r=-0.32, p>0.05). ANCOVA analyses using $VO_{2max}$ and body weight as covariates had significant influence on the AWC gender difference. The study provides preliminary data on gender differences of anaerobic capabilities.

Implementation Effects of Emergency Trauma Patient Simulation (응급외상 환자 시뮬레이션 적용 효과)

  • Baek, Mi-Lye
    • The Korean Journal of Emergency Medical Services
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    • v.15 no.2
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    • pp.43-54
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    • 2011
  • Purpose: The purpose of this study was to explore EMT-paramedic students' experience of simulation education and analyze the confidence before and after education, learning attitude and course evaluation. Method: Research survey was conducted on 38 EMT-paramedic students during November, 2011 and EMT-paramedic students' experience of simulation education was analyzed after applying head, spinal, and chest injury scenario. The confidence before and after education, learning attitude and course evaluation in gender were analyzed by Mann-Whitny U test and the difference of confidence before and after education was analyzed by Wilcoxon signed rank test and learning attitude & course evaluation were analyzed by evaluating frequency, percentage, mean, standard deviation by using SPSS WIN 17.0 program. Results: 1. Students experienced various advantages such as increasing interest and self-reflection on learning, critical thinking ability, and EMT-paramedic-role experience and recognition of importance of teamwork. Students also pointed out disadvantages such as gap between real situation and simulation, limit of time and equipments, and burden of demonstration. 2. The confidence between before and after education, learning attitude and course evaluation in gender were not significant different statistically. 3. Confidence mean score elevated from 5.53(before education) to 5.87(after education), but the difference in their confidence did not show significant difference statistically. 4. Total mean score in learning attitude after simulation education was 3.70 out of 5.00, which is considerably very high. 5. Total mean score in course evaluation was 3.89 with score of 3.83 in evaluation in learning environment and 3.99 in evaluation of debriefing. Conclusion: The finding of this study demonstrate that the simulation education can provide a safe and repetitive practice environment, improve problem-solving ability and critical thinking, and increase the confidence in prehospital emergency care; therefore, simulation may be the new effective EMT-paramedic education strategy.

Implementation of Commercial IWB Interface using Image Processing (영상처리를 이용한 상업용 전자칠판의 인터페이스 구현)

  • Ko, Eunsang;Rhee, Yang Won;Lee, Chang Woo
    • Journal of Korea Society of Industrial Information Systems
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    • v.17 no.6
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    • pp.19-24
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    • 2012
  • In this paper we introduce a commercial interactive whiteboard (IWB) system named ImSensorTouch by ImSensor Inc. Using this interface system, we can control our computer through the interactive whiteboard screen just by touching it with your finger or a pen. The interface interacts with Windows operating system (OS) and is adaptable to changes of surroundings especially temperature, and illumination condition. The proposed system calculates the difference between a reference image and a current image captured by a camera in the optical receptive field. And the position making the difference is used to generate the position on Windows screen. Then, we send a mouse event on the position to Windows OS. We have implemented the system using a critical section(CS) with two threads for the reference frame update process in which an adaptive thresholding technique is periodically exploited to get reliable result. We expect the system is competitive and promises a bright future in the IWB market.

Development of Classification System for Critical Care Nursing Based on Nursing Needs (간호요구도에 따른 중환자간호 분류도구 개발)

  • Yoo, Cheong Suk;Kim, Keum Soon
    • Journal of Korean Clinical Nursing Research
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    • v.19 no.1
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    • pp.33-44
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    • 2013
  • Purpose: This study was done to develop a valid and reliable Classification System for Critical Care Nursing (CSCCN) to be used in Intensive Care Units (ICUs). Methods: Head nurses and staff nurses of 17 ICUs in 6 hospitals classified 307 patients to verify interrater reliability. To verify construct validity, the staff nurses classified 404 patients according to CSCCN comparing difference in medical department and type of stay in ICU. For conversion index, 78 patients from 4 ICUs of 'S' hospital were classified and nursing time was measured by 107 nurses and 18 nurse aids using stopwatches. Results: The developed CSCCN has 11 categories, 76 nursing activities and 101 criteria. The reliability was verified as having high agreement (r=.946). The construct validity was verified comparing differences in medical department and type of stay in ICU. According to scores, four groups in the CSCCN classification were identified. According to the conversion index, one score on the CSCCN means 7.2 minutes of nursing time. Conclusion: CSCCN can be used to measure diverse and complex nursing demands including psycho-social aspects of ICU patients and convert nursing demands to numbers.

An AHP Approach to Select the Task Related Technique for Work Efficiency Improvement in Shipbuilding Enterprise (AHP에 의한 조선기업의 작업능률향상을 위한 과업관련기법의 선택)

  • Kim, Tae-Soo;Lee, Kang-Woo
    • Proceedings of the Korean Society for Quality Management Conference
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    • 2006.11a
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    • pp.31-37
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    • 2006
  • The objective of this research is to select the most effective technique from task related techniques(motion & time study, job redesign, physical environment improvement) for improving work efficiency in shipbuilding enterprise. This study consists of several principal steps. The first step is to design critical criteria in evaluating work efficiency in shipbuilding enterprises. The second step is to develop sub-criteria of the critical criteria. The third step is to develop a four level AHP(Analytic Hierarchy Process)structure using the critical criteria, sub-criteria and techniques from task related techniques. The fourth step is to develop the pairwise comparison matrix by each level of AHP structure, which was based on survey data collected at the H heavy industry. And the last step is to select the most effective technique from task related techniques using AHP analysis. The result of AHP analysis has shown clear difference in priority among task related techniques in terms of work efficiency of the shipbuilding enterprise: The reduction of normal time has more importance than the reduction of allowance time, motion & time study techniques are most important for the reduction of normal time, physical environment improvement is most important for the reduction of allowance time as well.

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Seismic performances of three- and four-sided box culverts: A comparative study

  • Sun, Qiangqiang;Peng, Da;Dias, Daniel
    • Geomechanics and Engineering
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    • v.22 no.1
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    • pp.49-63
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    • 2020
  • Studying the critical response characteristics of box culverts with diverse geometrical configurations under seismic excitations is a necessary step to develop a reasonable design method. In this work, a numerical parametric study is conducted on various soil-culvert systems, aiming to highlight the critical difference in the seismic performances between three- and four-sided culverts. Two-dimensional numerical models consider a variety of burial depths, flexibility ratios and foundation widths, assuming a visco-elastic soil condition, which permits to compare with the analytical solutions and previous studies. The results show that flexible three-sided culverts at a shallow depth considerably amplify the spectral acceleration and Arias intensity. Larger racking deformation and rocking rotation are also predicted for the three-sided culverts, but the bottom slab influence decreases with increasing burial depth and foundation width. The bottom slab combined with the burial depth and structural stiffness also significantly influences the magnitude and distribution of the dynamic earth pressure. The findings of this work shed light on the critical role of the bottom slab in the seismic responses of box culverts and may have a certain reference value for the preliminary seismic design using R-F relation.

Prediction of Microshrinkage Porosity in Thin Al-alloy Permanent Mold Castings

  • Lee, Zin-Hyoung
    • Journal of Korea Foundry Society
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    • v.11 no.1
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    • pp.44-53
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    • 1991
  • The proper feeding conditions for thin Al-Alloy (AA336, JIS AC8A) castings in permanent mold were investigated to eliminate microshrinkage porosity. 5mm-thick plates (200mm long, 60mm wide) were cast with increasing padding taper from 0 to 5% under different conditions : (1) constant mold temperature of $350^{\circ}C$, (2) continuous production with uniform mold thickness (10mm), (3) continuous production with a negative taper of 2.5% in mold thickness (thickness decreasing in direction to riser). The test casting were machined off to the midplane and the shrinkage porosity was examined visually. The critical padding taper which can just eliminate the shrinkage porosity was determined for each condition, i.e. : (1) 4.5% at the constant mold temperature, (2) 3.5% for continuous production with the uniform mold thickness (3) 1.5% for continuous production with the taper in mold thickness. A computer simulation by a finite difference analysis program was applied to the test casting. The liquid fraction gradient (LFG) and the temperature gradient divided by the square root of the cooling rate (G /SR) were calculated at the end of solidification and compared with the shrinkage porosity area in the castings. For the case of constant mold temperature, LFG is a better parameter to predict shrinkage porosity than G /SR and its critical value is around 11%/cm. But for the case of continuous production, neither LFG nor G /SR could be a reliable parameter. The experimental results about the critical padding taper are of practical interest for designing permanent molds and castings. The computer simulation results stimulate further research to be directed on the prediction of centerline microshrinkage porosity in continuous production.

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Capability of Retirement Planning and Implementing and the Influencing Factor (우리나라 소비자의 은퇴설계실행능력과 영향요인)

  • Kim, Jung-Hyun;Park, Joo-Yung
    • Korean Journal of Human Ecology
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    • v.22 no.1
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    • pp.117-129
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    • 2013
  • The purpose of this study is to examine the factors affecting on CRPI (capability of retirement planning and implementing) and to identify the critical point of financial factors to increase CRPI. 908 Korean individuals' data were used for descriptive statistics, t-test, F-test, and Generalized Linear Mixed Model Analysis. As a result, CRPI was influenced by attitude toward retirement planning, gender, income, and propensity to save. Some mid-group did not make a significant difference in CRPI compared to the lower-group. Men were more capable at CRPI than women in terms of sense of independence and getting a consulting service. Most consumers appear to have difficulty in calculating their retirement fund. People who have income over 3,000,000 won have dramatically greater CRPI than people who have income under 3,000,000 won. And people who have saving ratio over 23% have significantly greater CRPI than people who have propensity to save under 23%. The monthly income 3,000,000 won and propensity to save 23% were considered as critical points related to CRPI.

A Study on the Discrimination of Use Intention by Critical T-Commerce Factors (T-Commerce 요인에 따른 사용의도 판별에 관한 연구)

  • Kim, Ju-An
    • International Commerce and Information Review
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    • v.8 no.3
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    • pp.71-95
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    • 2006
  • In recent, T-commerce is widely dispersed as alternative type of commerce. It is forecasted that t-commerce system is used more than e-commerce system. Therefore more and more t-commerce-related industries are also recognizing that t-commerce is a critical business model. It is needed to understand the concept of t-commerce and develop the t-commerce marketing strategy. CEO analyses consumer's behaviors according to the data about buyers and applies the advantage of t-commerce to the communication with customers. This t-commerce system plays an important role in maximizing customer satisfaction and affecting their intention to reuse it. Therefore this paper attempts to identify T-commerce critical success factors and divide between use-intention group and unuse-intention group by taking out a discriminant function by the discriminant analysis. This lays a foundation in developing T-commerce strategy. According to the discriminant function extracted, convenience factor, amusement factor, system quality factor, product perception factor are significant in the sequence of influential degree. However, usefulness factor and speedy connection factor are not significant. In result, the target hitting rate is 77.9% in the first unuse-intention group and it is 95.2% in the second use-intention group. The total discriminant target hitting rate is computed to higher value, 86.55%. The statistic package, SPSS 12.0, is used to survey and analyse data and test the hypothesis. The validity and reliability of variables are verified by both reliability analysis and factor analysis. The discriminant analysis is used to tell the difference between use-intention group and unuse-intention group.

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