• Journal of Computational Design and Engineering
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• 제1권1호
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• pp.55-66
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• 2014

A knee joint's longevity depends on the proper integration of structural components in an axial alignment. If just one of the components is abnormally off-axis, the biomechanical system fails, resulting in arthritis. The complexity of various failures in the knee joint has led orthopedic surgeons to select total knee replacement as a primary treatment. In many cases, this means sacrificing much of an other-wise normal joint. Here, we review novel computational approaches to describe knee physiotherapy by introducing a new dimension of foot loading to the knee axis alignment producing an improved functional status of the patient. New physiotherapeutic applications are then possible by aligning foot loading with the functional axis of the knee joint during the treatment of patients with osteoarthritis.

• 대한화학회지
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• 제35권1호
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• pp.78-84
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• 1991

Enkephalin의 작용을 연장하기 위한 연구이 하나로서 수개의 enkephalin aminopeptidase의 저해물을 합성하였다. 이 펩티드성 저해물은 zinc 결합자리로서 3-amino-2-hydroxy amino acid와 기질양상의 곁사슬을 가진다. 펩티드들은 용액 중에서 DCC/HOBt를 축합시약으로 사용하여 C-말단으로부터 사슬 연장법으로 합성하였다. 합성한 펩티드 저해물들은 모두 enkephalin aminopeptidase에 대하여 강한 저해 작용을 나타내었다.

• Earthquakes and Structures
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• 제13권1호
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• pp.9-15
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• 2017

In this paper, the influence of the rotational component, about a vertical axis, of earthquake ground motion on the response of building structures subjected to seismic action is considered. The torsional component of ground motion is generated from the records of translational components. Torsional component of ground motion is then, together with translational components, applied in numerical linear dynamic analysis of different reinforced concrete framed structure of three stories buildings. In total, more than 40 numerical models were created and analyzed. The obtained results show clearly the dependence of the effects of the torsional seismic component on structural system and soil properties. Thus, the current approach in seismic codes of accounting for the effects of accidental torsion due to the torsional ground motion, by shifting the center of mass, should be reevaluated.

• Structural Engineering and Mechanics
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• 제82권2호
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• pp.259-270
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• 2022

The paper investigates the residual stresses arising in a thermoviscoelastic cylinder as a result of layer-by-layer deposition of material on its lateral surface. Internal stresses are caused by incompatible deformations that accumulate in the assembly as a result of joining parts with different temperatures. For the analysis of internal stresses, an analytical solution to the axisymmetric quasi-static problem of thermoelasticity for a growing cylinder is constructed. It is shown that the distribution of residual stresses depends on the scenario of the surfacing process. In this case, the supply of additional heat to the growing body can significantly reduce the unevenness of temperature fields and reduce the intensity of residual stresses. The most effective is uneven heating, which can be realized, by the action of an alternating current with a tunable excitation frequency. The temperature and residual stresses fields on the growing surface is analyzed numerically for Titanium and Copper materials.

• 농약과학회지
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• 제7권1호
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• pp.45-50
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• 2003

Procarbamate계 살충제인 benfuracarb의 산화효소계에 의한 활성화 과정과 이 과정을 통하여 생성되는 독성 대사물의 전환 정도를 확인하고자 수행되었다. Acetylcholinesterase(AChE) 에 대한 henfuracarb의 이 분자속도저해상수$(k_i)$가 $1.1\times10^3\;M^{-1}\;min^{-1}$로 매우 낮은 저해력을 보인 바, 이 약제가 체내에서 독성을 발현하기 위해서는 활성화 과정이 필수적임을 가정할 수 있었다. Benfuracarb의 활성화 과정에 관여하는 cytochrome $P_{450}$의 역할을 in vitro 에서 관찰하기 위하여 AChE/MFO coupling system을 사용하였다. AChE/MFO coupling system에서 AChE에 대한 저해력은 NADPH가 처리된 oxidase system이 NADPH 가 결핍된 대조구에 비하여 약 10배정도 증가하였으며, oxidase+PBO system 에서는 약간의 저해력 감소 경향이 관찰되었다. 생쥐에 henfuracarb을 처리한 후 brain AChE 활성을 조사해 본 결과 henfuracarb만 처리한 benfuracarb 처리구에서의 $I_{50}$은 22.7mg $kg^{-1}$이었으며, PBO를 전처리 한 후 henfuracarb을 처리한 benfuracarb+PBO 처리구에서는 $I_{50}$이 >100mg $kg^{-1}$으로 저해정도가 급격히 경감되어 benfuracarb의 활성화 과정에 cytochrome $P_{450}$이 관련되어 있음을 확인할 수 있었다. Microsomal oxidase system 을 이용하여 henfuracarb이 독성 대사물인 carbofuran으로 전환되는 정도를 관찰하였다. Oxidase system 에서는 처리된 benfuracarb의 58.0%가 carbofuran으로 전환되었지만, oxidase+PBO system에서 1.7%만 생성되어 benfuracarb의 활성화과정에 산화효소인 cytochrome $P_{450}$의 역할이 중요함을 확인할 수 있었다. 본 연구를 통하여 benfuracarb의 독성 발현에 관여하는 주된 독성 대사물은 carbofuran이며, 이 활성화 과정 에 cytochrome $P_{450}$이 중요한 역할을 하는 것으로 확인되었다.

• 대한기계학회논문집
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• 제15권2호
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• pp.463-477
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• 1991

This study proposed a new method to design a robot manipulator control system capable of tracking the trajectories of joint angles in a reasonable accuracy to cover with actual situation of varying payload, uncertain parameters, and time delay. The direct adaptive model following control method has been used to improve existing industrial robot manipulator control system design. The proposed robot manipulator controller is operated by adjusting its gains based on the response of the manipulator in such a way that the manipulator closely matches the reference model trajectories predefined by the designer. The manipulator control system studied has two loops: they are an inner loop on adaptive model following controller to compensate nonlinearity in the manipulator dynamic equation and to decouple the coupling terms and an outer loop of state feedback controller with integral action to guarantee the stability of the adaptive scheme. This adaptation algorithm is based on the hyperstability approach with an improved Lyapunov function. The coupling among joints and the nonlinearity in the dynamic equation are explicitly considered. The designed manipulator controller shows good tracking performance in various cases, load variation, parameter uncertainties. and time delay. Since the proposed adaptive control method requires only a small number of parameters to be estimated, the controller has a relatively simple structure compared to the other adaptive manipulator controllers. Therefore, the method used is expected to be well suited for a high performance robot controller under practical operation environments.

• Structural Engineering and Mechanics
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• 제75권4호
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• pp.487-496
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• 2020

Most of the previous works on numerical analysis of galloping of transmission lines are generally based on the quasisteady theory. However, some wind tunnel tests of the rectangular section or hangers of suspension bridges have shown that the galloping phenomenon has a strong unsteady characteristic and the test results are quite different from the quasi-steady calculation results. Therefore, it is necessary to check the applicability of the quasi-static theory in galloping analysis of the ice-covered transmission line. Although some limited unsteady simulation researches have been conducted on the variation of parameters such as aerodynamic damping, aerodynamic coefficients with wind speed or wind attack angle, there is a need to investigate the numerical simulation of unsteady galloping of two-dimensional iced transmission line with comparison to wind tunnel test results. In this paper, it is proposed to conduct a two dimensional (2-D) unsteady numerical analysis of ice-covered transmission line galloping. First, wind tunnel tests of a typical crescent-shapes iced conductor are conducted firstly to check the subsequent quasisteady and unsteady numerical analysis results. Then, a numerical simulation model consistent with the aeroelastic model in the wind tunnel test is established. The weak coupling methodology is used to consider the fluid-structure interaction in investigating a two-dimension numerical simulation of unsteady galloping of the iced conductor. First, the flow field is simulated to obtain the pressure and velocity distribution of the flow field. The fluid action on the iced conduct at the coupling interface is treated as an external load to the conductor. Then, the movement of the conduct is analyzed separately. The software ANSYS FLUENT is employed and redeveloped to numerically analyze the model responses based on fluid-structure interaction theory. The numerical simulation results of unsteady galloping of the iced conduct are compared with the measured responses of wind tunnel tests and the numerical results by the conventional quasi-steady theory, respectively.

• Ocean Systems Engineering
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• 제8권4호
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• pp.381-407
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• 2018

This paper presents a hybrid numerical approach, which combines a two-phase Navier-Stokes model (NS) and the fully nonlinear potential theory (FNPT), for modelling wave-structure interaction. The former governs the computational domain near the structure, where the viscous and turbulent effects are significant, and is solved by OpenFOAM/InterDyMFoam which utilising the finite volume method (FVM) with a Volume of Fluid (VOF) for the phase identification. The latter covers the rest of the domain, where the fluid may be considered as incompressible, inviscid and irrotational, and solved by using the Quasi Arbitrary Lagrangian-Eulerian finite element method (QALE-FEM). These two models are weakly coupled using a zonal (spatially hierarchical) approach. Considering the inconsistence of the solutions at the boundaries between two different sub-domains governed by two fundamentally different models, a relaxation (transitional) zone is introduced, where the velocity, pressure and surface elevations are taken as the weighted summation of the solutions by two models. In order to tackle the challenges associated and maximise the computational efficiency, further developments of the QALE-FEM have been made. These include the derivation of an arbitrary Lagrangian-Eulerian FNPT and application of a robust gradient calculation scheme for estimating the velocity. The present hybrid model is applied to the numerical simulation of a fixed horizontal cylinder subjected to a unidirectional wave with or without following current. The convergence property, the optimisation of the relaxation zone, the accuracy and the computational efficiency are discussed. Although the idea of the weakly coupling using the zonal approach is not new, the present hybrid model is the first one to couple the QALE-FEM with OpenFOAM solver and/or to be applied to numerical simulate the wave-structure interaction with presence of current.

• International Journal of Contents
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• 제14권3호
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• pp.7-16
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• 2018

The extent and depth of the event plan determines the scope of pedagogical experience in situations and consequently the quality of immersive learning based on our simulated world. In contrast to planning in conventional narrative-based systems mainly pursuing dramatic interests, planning in virtual world-based pedagogical systems strive to provide realistic experiences in immersed situations. Instead of story plot comprising predetermined situations, our inter-event planning method aims at simulating diverse situations that each involve multiple events coupled via their associated agents' conditions and meaningful associations between events occurring in a background world. The specific techniques to realize our planning method include, two-phase planning based on inter-event search and intra-event decomposition (down to the animated action level); autonomous and independent agents to behave proactively with their own belief and planning capability; full-blown background world to be used as the comprehensive stage for all events to occur in; coupling events via realistic association types including deontic associations as well as conventional causality; separation of agents from event roles; temporal scheduling; and parallel and concurrent event progression mechanism. Combining all these techniques, diverse exogenous events can be derived and seamlessly (i.e., semantically meaningfully) integrated with the original event to form a wide scope of situations providing chances of abundant pedagogical experiences. For effective implementation of plan execution, we devise an execution scheme based on multiple priority queues, particularly to realize concurrent progression of many simultaneous events to simulate its corresponding reality. Specific execution mechanisms include modeling an action in terms of its component motions, adjustability of priority for agent across different events, and concurrent and parallel execution method for multiple actions and its expansion for multiple events.

• 대한토목학회논문집
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• 제13권5호
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• pp.99-107
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• 1993

본 논문에서는 콘크리트 균열 사이의 인장강성 효과를 고려한 임의의 기하하적 형상을 갖는 철근 콘크리트 쉘을 해석하기 위하여 재료비선형 유한요소 프로그램을 작성하였다. 본 논문은 연속적인 컴퓨터 해석으로 탄성, 비탄성 및 극한 범위에서의 철근과 콘크리트의 응력은 물론, 하중-변위 응답과 균열전파를 추적할 수 있었다. 골재억물림과 철근의 다울작용을 포함하는 유효전단계수를 평가하기 위하여 균열상태의 전단유지계수를 도입하였다. 콘크리트는 인장에서는 취성으로 압축에서는 탄소성으로 가정하였다. 콘크리트의 소성거동은 Drucker-Prager 항복기준과 결합유동법칙에 따르는 것으로 가정하였다. 철근은 Von Mises 항복기준으로 가정하였으며 등가의 두께를 가지는 철근층으로 모델화 하였다. 수치해석을 위하여는 증분형접선강성도 방법을 사용하였다. 수치예제를 제시하여 본 연구결과를 Hedgren의 실험 결과와 Lin의 수치해석과 비교하였다.