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Green perilla leaf extract ameliorates long-term oxidative stress induced by a high-fat diet in aging mice

  • Edward, Olivet Chiamaka;Thomas, Shalom Sara;Cha, Kyung-Ok;Jung, Hyun-Ah;Han, Anna;Cha, Youn-Soo
    • Nutrition Research and Practice
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    • v.16 no.5
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    • pp.549-564
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    • 2022
  • BACKGROUND/OBJECTIVES: Oxidative stress is caused by an imbalance between harmful free radicals and antioxidants. Long-term oxidative stress can lead to an "exhausted" status of antioxidant defense system triggering development of metabolic syndrome and chronic inflammation. Green perilla (Perilla frutescens) is commonly used in Asian cuisines and traditional medicine in southeast Asia. Green perilla possesses numerous beneficial effects including anti-inflammatory and antioxidant functions. To investigate the potentials of green perilla leaf extract (PE) on oxidative stress, we induced oxidative stress by high-fat diet (HFD) in aging mice. MATERIALS/METHODS: C57BL/6J male mice were fed HFD continuously for 53 weeks. Then, mice were divided into three groups for 12 weeks: a normal diet fed reference group (NDcon), high-fat diet fed group (HDcon), and high-fat diet PE treated group (HDPE, 400 mg/kg of body weight). Biochemical analyses of serum and liver tissues were performed to assess metabolic and inflammatory damage and oxidative status. Hepatic gene expression of oxidative stress and inflammation related enzymes were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR). RESULTS: PE improved hepatopathology. PE also improved the lipid profiles and antioxidant enzymes, including hepatic glutathione peroxidase (GPx) and superoxide dismutase (SOD) and catalase (CAT) in serum and liver. Hepatic gene expressions of antioxidant and anti-inflammatory related enzymes, such as SOD-1, CAT, interleukin 4 (IL-4) and nuclear factor erythroid 2-related factor (Nrf2) were significantly enhanced by PE. PE also reduced the levels of hydrogen peroxide (H2O2) and malondialdehyde (MDA) in the serum and liver; moreover, PE suppressed hepatic gene expression involved in pro-inflammatory response; Cyclooxygenase-2 (COX-2), nitric oxide synthase (NOS), interleukin 1 beta (IL-1β), and interleukin 6 (IL-6). CONCLUSIONS: This research opens opportunities for further investigations of PE as a functional food and possible anti-aging agent due to its attenuative effects against oxidative stress, resulting from HFD and aging in the future.

Effect of Intrinsic Learning Motivation on Korean Language Performance: Moderating Effect of Social Support (내재적 학습동기가 국어수행에 미치는 영향: 사회적 지지의 조절효과)

  • Kim Hey Kyoung;Chung Eun Kyoung
    • The Korean Journal of Coaching Psychology
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    • v.6 no.2
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    • pp.75-92
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    • 2022
  • There are many studies that intrinsic learning motivation and social support play an important role in the study of children and adolescents. However, studies examining the effects of intrinsic learning motivation and social support by measuring the actual academic performance of elementary school students are rare. This study attempted to verify the effect of intrinsic learning motivation on Korean language performance and moderating effect of social support in 5th and 6th graders in elementary school. 122 elementary school students in local county-level areas participated in this study. The Korean language test was conducted about 5 months after intrinsic learning motivation and social support of families and teachers were measured. The results revealed that Korean language performance showed a significant positive correlation with intrinsic learning motivation and social support, and also showed a significant correlation between learning motivation and social support. In the regression analysis with control variables, it was found that intrinsic learning motivation had a significant effect on Korean language performance. The moderating effect of social support was analyzed by dividing it into family support and teacher support. The interaction effect of learning motivation and social support was significant only in teacher support, not in family support. In specific, when teacher support was high, Korean language performance was high regardless of the student's learning motivation level, but when teacher support was low, the student's learning motivation mattered in the performance. Based on the results of this study, implications and limitations were discussed.

Growth-promoting effect on Tricholoma matsutake mycelium by Terrabacteria isolated from pine mushroom habitats in Korea (국내 송이 자생지에서 분리된 Terrabacteria에 의한 송이균사체 생장촉진 효과)

  • Doo-Ho Choi;Jae-Gu Han;Kang-Hyo Lee;Gi-Hong An
    • Journal of Mushroom
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    • v.21 no.3
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    • pp.190-193
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    • 2023
  • To cultivate pine mushroom (Tricholoma matsutake) artificially, co-cultivation with microorganisms has been introduced. Here, experiments were performed to assess the growth-promoting effect of bacteria on T. matsutake mycelia. Bacteria were isolated from soil samples collected in Yangyang County, Korea. Four of the bacterial isolates (Y22_B06, Y22_B11, Y22_B18, and Y22_B22) exhibited a growth-promoting effect on T. matsutake mycelia (154.67%, 125.91%, 134.06%, and 158.28%, respectively). To analyze the characteristics of the bacteria, especially the antifungal activity, 𝛼-amylase and cellulase activity assays were performed. In comparison with the controls, the isolated bacteria exhibited low 𝛼-amylase and cellulase activity. 16S rRNA gene sequencing was performed to identify the four bacterial isolates. The isolates belonged to the Terrabacteria group and were identified as Microbacterium paraoxydans, Paenibacillus castaneae, Peribacillus frigoritolerans, and P. butanolivorans. These bacterial isolates are expected to have contributed to the growth promotion of T. matsutake mycelia and the artificial cultivation of T. matsutake.

Components and Pharmaceutical Effect of Beverage Extracted from Sugar-treated Tartary buckwheat (타타리메밀 당절임 추출음료의 성분 및 약리효능)

  • Park, J.J.;Chang, K.J.;Seo, G.S.;Lee, H.S.;Lee, G.S.;Park, C.H.;Lee, M.H.
    • Journal of Practical Agriculture & Fisheries Research
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    • v.10 no.1
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    • pp.67-75
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    • 2008
  • Tartary buckwheat is one of specialized plants in Pyeongchang county, Korea and contains rutin much more than common buckwheat. Rutin is a kind of flavonoid (polyphenol compound) that has effects on blood vascular disease, strengthen capillary, and anti-inflammatory effect. This study was conducted to determine the possibility of development of beverage extracted from sugar-treated plants and sprouts of tartary buckwheat. By using two types of undiluted solution extracted from plant and sprouts of tartary buckwheat, we analyzed their nutrition components and did experiment on mice to find out pharmaceutical effects. In an experiment on mice, we administered various concentration of buckwheat to induced diabetic mellitus mice for 1 weeks. As a result, the buckwheat effected finely on lowering blood sugar and decreased LDL-cholesterol and total lipid level but increased HDL-cholesterol level.

Estimating Land Assets in North Korea: Framework Development & Exploratory Application (북한지역 토지자산 추정에 관한 연구: 프레임워크 개발 및 탐색적 적용)

  • Lim, Song
    • Economic Analysis
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    • v.27 no.2
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    • pp.71-123
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    • 2021
  • In this study, we present a methodology and model to estimate land prices and the value of land assets in North Korea in the absence of any data about land characteristics from North Korean authorities. Using this framework, we experimentally make market price-based estimates for land assets across the entire urban area of North Korea. First, we estimate the determinants of land prices in South Korea using data on market prices of land from the late 1970s, when it was estimated that the income level gap between South Korea and North Korea wasn't relatively large, and from the early 1980s, when urbanization levels in both of them were similar. Second, we calculate land prices and their relative ratios for each city and urban area in North Korea around 2015 by substituting proxy variables of determinants of land prices derived through a geographic information analysis of North Korea into the function of land prices that we have already estimated. Finally, we estimate the value of land assets in urban areas across North Korea by combining the ratio of housing transaction prices surveyed in several cities in North Korea with the relative prices estimated in this research. As a result, land prices in urban areas in North Korea, looking at the relative ratio of price by city, are estimated to be the highest, at 100.00, in Tongdaewon district of Pyongyang, and to be the lowest, at 1.70, in Phungso county, Ryanggang Province. Meanwhile, the value of land assets in urbanized areas was estimated at $21.6 billion in 2015, which was 1.2 to 1.3 times the GDP of North Korea that year. This ratio is similar to South Korea's in the 1978-1980 period, when the South Korean economy grew at an average rate of 6%. Considering North Korea's growth rate of about 1% in the 2013-2014 period, its ratio of land assets to GDP appears very high.

A study on the Derivation of Improvement Method for the Problems of the Current Land Category System - Focused on Land Category Classification and Conversion Cases - (현행 지목제도의 문제점에 대한 개선방안 도출에 관한 연구 - 지목의 설정과 변경 사례를 중심으로 -)

  • Choi, Dae-Jiup;Shin, Man-Joong
    • Journal of Cadastre & Land InformatiX
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    • v.52 no.2
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    • pp.67-80
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    • 2022
  • This study proposes a legal limit from the administrative and management standpoint of the city hall/county office/gu office, which is the cadastral authority, in relation to the discrepancy between the actual land use status and the cadastral study that has been continuously raised. And also, from the point of view of civil complaints such as landowners, this study tried to evaluate the practical problems of the current land category system from the point of view of civil complaints such as landowners and to derive a solution to these problems. Therefore, this study indicates how the category of land use is classified, and how land use is restricted by the laws of Registration & Management of public cadastre. Also, it shows the reasons why discrepancy between the land use fixed by the law and the current state of actual use of land occurs. Addtionally, This study suggests a plan to reorganize the Land Category system and it includes consolidation and subdivision of land. The study also describes a way to minimize the targets for conversion of land under control of Land Category System as well as to improve the law that protects the people's property rights.

Cultivation of millet in Mahan-Baekje Villages: Archaeobotanical examination of Osan site, Jangheung, Korea (전남 마한백제계 취락의 서속(黍粟) 재배와 농경 체계: 장흥 봉림리 오산유적 자료를 중심으로)

  • RYU Ara;KIM Sebin;OH Byungwook;KIM Minkoo
    • Korean Journal of Heritage: History & Science
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    • v.56 no.2
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    • pp.48-60
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    • 2023
  • Although foxtail and broomcorn millet have been cultivated since the Neolithic Age on the Korean Peninsula, there have been few studies on how the importance of millet cultivation changed over time. The discovery of millet has been rare in the Mahan-Baekje villages in the Jeonnam region, and archaeological discussions on ancient farming have centered around rice farming. However, a large amount of millet was found at the Osan site in Bongrim-ri, Jangheung, showing that the tradition of millet cultivation continued during the AD 3-4 centuries. In contrast to rice farming, which requires low-lying wetlands, hot and humid summers, and a large labor force, millet cultivation has few restrictions in terms of growing environment and labor mobilization. Regarding harvesting seasons, the crops at the Osan site can be divided into fall harvesting (rice, legumes, millet) and summer harvesting (wheat). Regarding field locations, the crops are divided into wetland crops (rice) and dryland crops (wheat, legumes, millet). The operation of the dual agricultural system contributed to subsistence resilience and agricultural production, making it possible to effectively manage social and climatic crises.

Establishment of Optimal Management Plans on Agricultural Groundwater Resources of the Yeosu County (여수시 농어촌지역 지하수자원 적정 관리방안)

  • Seo, Hyo Kyoung;Shin, Hyung Jin;Lee, Byung Sun;Lee, Gyu Sang
    • Proceedings of the Korea Water Resources Association Conference
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    • 2020.06a
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    • pp.282-282
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    • 2020
  • 본 연구는 여수시 농어촌지역에 대하여 지하수 함양특성, 개발가능량 산정 및 오염부하량 등의 조사를 통해서 체계적인 지하수자원의 보전관리(안)을 수립하기 위해 수행되었다. 연구지역은 여수시 화양면, 소라면 2개 면을 포함하는 농어촌 용수구역(여소지구)으로, 여소지구의 총면적은 130.68 ㎢이며, 이 중 임야면적은 81.57 ㎢, 경지면적은 32.98 ㎢ 이고, 경지면적은 논 15.37 ㎢, 밭 17.42 ㎢, 시설재배 0.19 ㎢로 구성되어 있다. 여소지구의 30년 강수평균은 1,454.08 mm/년이며, 지하수 함양량은 국가지하수관리 기본계획(국토교통부, 2019) 및 전라남도 지하수관리계획(전라남도, 2009) 보고서를 참고하여 평균값인 11.28%로 산정한 결과, 21,279 천㎥/년으로 분석되었다. 또한, 지하수연보(국토교통부, 2018)의 세부용도별 이용량을 활용하여 지하수 이용량을 산정한 결과, 2,638.35 천㎥/년이었으며, 강수량, 함양률 및 면적 값을 고려하여 지하수 개발가능량을 산정한 결과, 16,387.57 천㎥/년, 개발가능량 대비 이용량은 16.11%로 확인되었다. 여소지구의 질산성질소 항목은 총 181개소(경지면적 0.2 ㎢당 1점)에 대해 분석한 결과, 전체 평균값은 6.67 mg/L이었으며, 농업용수 수질기준(20 mg/L)을 초과한 관정은 8개소(6%)로 확인되었다. DRASTIC을 이용한 오염취약성 지수는 평균값이 119.57점으로 나타나 오염취약성이 낮은 것으로 분석되었다. 신고·허가된 축사 시설을 기준으로 점오염원 조사결과, 단위면적당 시설수(오염원밀도)는 3.12 개소/㎢로 조사되었으며, 인구, 가축 및 토지이용 등 인자별을 고려하여 오염부하량을 산출한 결과, 단위면적당 오염부하량은 75.30 kg/day/㎢로 확인되었다. 행정구역별로 7가지 지표를 반영하여 관심, 주의, 경계 및 심각 4단계로 기준을 설정하여 지하수관리 필요지역을 선정하였다. 수량 측면은 개발가능량 대비 이용량, 단위면적당 이용량 및 관정밀 3가지 지표를 적용하였고, 수질 측면은 질산성질소 평균, 오염취약성 지수, 오염원밀도 및 단위면적당 오염부하량 4가지 지표를 적용하여 선정하였다. 지하수관리 필요지역을 분석한 결과, 전체 18개 리 중에서 14개 리에서 수량관리 12개리에서 수질관리 필요지역이 나타났다. 수량관리 필요지역은 지하수 취수량 조정 및 관리 확충 등의 대책방안이 마련되어야 하며, 수질관리 필요지역은 주변 오염원관리 및 수질검사 강화 등의 대책방안이 필요할 것으로 판단된다.

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The Effects of a Client-Centered Vocational Rehabilitation Program on the Job Competency of Adolescents with Cerebral Palsy (고객중심 직업재활프로그램이 뇌성마비 청소년의 직무능력에 미치는 효과)

  • Ju, Eun-Sol;Bang, Yo-Soon;Oh, Eun-Ju
    • Journal of Korea Entertainment Industry Association
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    • v.13 no.7
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    • pp.505-519
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    • 2019
  • This study investigated the effects of a client-centered vocational rehabilitation program on vocational basic ability, vocational performance ability, and vocational adjustment ability to improve the job competency of adolescents with cerebral palsy. This study was conducted using a multiple intermittent baseline design between the behaviors of individual research subjects from March 19 to August 27, 2018. The subjects for this study were three adolescents with cerebral palsy who were attending special schools in B County in A Province. The intervention program was performed for 40 minutes every Monday and Wednesday, and the vocational basic ability, vocational performance ability, and vocational adjustment ability of the subjects were measured after each session based on the intervention step. As a result, the client-centered vocational rehabilitation program improved vocational basic ability, vocational performance ability, and vocational adjustment ability required by the targeted job for each subject. Therefore, the client-centered vocational rehabilitation program of this study is proposed as a vocational rehabilitation program because it has had a positive effect on job competency by improving the vocational basic ability, vocational performance ability, and vocational adjustment ability of adolescents with cerebral palsy.

Variables Related with Parental Caregiving Consciousness of Women Immigrants (여성결혼이민자의 부모 부양의식과 관련 변인 연구)

  • Park, Ji Young;Lee, Chang Seek
    • 한국노년학
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    • v.31 no.4
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    • pp.1029-1045
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    • 2011
  • This study was conducted to identify the differences in parental caregiving consciousness according to the characteristics of women immigrants, and the variables affecting parental caregiving consciousness of women immigrants. The participants were 592 women immigrants sampled from a metropolis, three metropolitan cities, two cities and a county across the country. The major results of the study were as follows. First, there were significant differences in physical and economic caregiving consciousness of women immigrants according to residential area, family income, hope to support homeland parents, contact with homeland family, and participation in self-help meeting. And there were significant differences in emotional caregiving consciousness according to residential area, family income, living with parents, hope to support homeland parents, and participation in self-help meeting. Second, as the results of multiple regression analysis, the predictors of physical caregiving consciousness were age, residential area, family income, hope to support homeland parents, and contact with homeland family. But the predictors of economic caregiving consciousness were age, residential area, home country, difference in spouse's age, family income, hope to support homeland parents, and contact with homeland family. Finally, the predictors of emotional caregiving consciousness were residential area, family income, and hope to support homeland parents. The variable of hope to support homeland parents revealed the most influential variable affecting commonly all of the three types of caregiving consciousness.