• The Korean Society of Law and Medicine
• /
• v.23 no.3
• /
• pp.47-87
• /
• 2022

Due to the COVID-19 pandemic, non-face-to-face treatment was temporarily permitted. A lot of consensus has been formed on the need to continuous non-face-to-face treatment. However, the current 「Medical Service Act」 only permits telemedicine between doctors and medical personnel. On the other hand, as a result of legal interpretation, there is an opinion that non-face-to-face treatment is allowed. But considering the overall legal system, non-face-to-face treatment is not allowed. Nevertheless, we have to consider the reality such as the development of science and technology and the outbreak of infectious diseases. Therefore, it is not advisable to allow face-to-face treatment only. Ultimately, it is necessary to find ways to ensure that non-foce-to-face treatment can be performed in a safe and effective manner. And it should be institutionalized. This is strategically necessary and important. Therefore, we must look over ahead legal issues to be discussed. First of all, the scope, the target disease and the subject of implement have to be clear. Also, structurally, the standards of facilities and equipment must be prepared for non-face-to-face treatment to be implemented. Functionally, communication and information exchange between doctors and patients should be well conducted. In addition, the information protection management system that occurs in the process of non-face-to-face treatment should be materialized. Lastly, the issue of responsibility and cost of non-face-to-face treatment should be decided in detail. When these problems materialize, it can be expected that a safe non-face-to-face treatment environment will be established.

• The Journal of the Convergence on Culture Technology
• /
• v.7 no.2
• /
• pp.239-246
• /
• 2021

Unification means the change of the economic system from 'Planned Economy' of the North Korea to 'Market Economy' of the South Korea. Therefore, it may cause confusions and difficulties for North Koreans who have been under planned economy for ages. So, we need to take the perspective of behavioral economics for the effective education. First of all, it is about overall finance, which contains the record of financial transactions, effect of inflation, investors' bounded rationality, and choice difficulty of financial products. Second, it is about borrowings, which includes the credit management, interest rate of difference among financial institutions. Third, it is about investment on financial products, which includes the effect of cost on returns, difference between compound interest and simple interest, trade-off between expected return and risk, market and non-market risks, the importance of diversification, and passive & aggressive investments.

• Microbiology and Biotechnology Letters
• /
• v.49 no.1
• /
• pp.75-87
• /
• 2021

Type I Interferons (IFNα) are known for their role as biological anticancer agents owing to their cell-apoptosis inducing properties. Development of an appropriate, cost-effective host expression system is crucial for meeting the increasing demand for proteins. Therefore, this study aims to develop codon-optimized IFNα-2b in L. lactis NZ3900. These cells express extracellular protein using the NICE system and Usp₄₅ signal peptide. To validate the mature form of the expressed protein, the recombinant IFNα-2b was screened in a human colorectal cancer cell line using the cytotoxicity assay. The IFNα-2b was successfully cloned into the pNZ8148 vector, thereby generating recombinant L. lactis pNZ8148-SP_Usp45-IFNα-2b. The computational analysis of codon-optimized IFNα-2b revealed no mutation and amino acid changes; additionally, the codon-optimized IFNα-2b showed 100% similarity with native human IFNα-2b, in the BLAST analysis. The partial size exclusion chromatography (SEC) of extracellular protein yielded a 19 kDa protein, which was further confirmed by its positive binding to anti-IFNα-2b in the western blot analysis. The crude protein and SEC-purified partial fraction showed IC₅₀ values of 33.22 ㎍/ml and 127.2 ㎍/ml, respectively, which indicated better activity than the metabolites of L. lactis NZ3900 (231.8 ㎍/ml). These values were also comparable with those of the regular anticancer drug tamoxifen (105.5 ㎍/ml). These results demonstrated L. lactis as a promising host system that functions by utilizing the pNZ8148 NICE system. Meanwhile, codon-optimized usage of the inserted gene increased the optimal protein expression levels, which could be beneficial for its large-scale production. Taken together, the recombinant L. lactis IFNα-2b is a potential alternative treatment for colorectal cancer. Furthermore, its activity was analyzed in the WiDr cell line, to assess its colorectal anticancer activities in vivo.

• Journal of the Korea Institute of Building Construction
• /
• v.21 no.3
• /
• pp.203-211
• /
• 2021

Recently, the insulaton design standards for reducing the energy use of buildings have been strengthened. Althoug insulation work is the most cost-effective method for reducing the primary energy consumption per unit area of a building, there are no evaluation criteria for insulation performance at the time of construction and completion inspection. The purpose of this study is to provide objective data by establishing a standard for an analysis method and a method for easily experimenting with the exterior wall thermal transmittance of an apartment house using a thermal transmittance measuring device(TESTO 435). For the exterior wall of the test subject, the specific heat per unit area exceeded 20kJ/(m²·K), and the data at the end point suitable for ISO 9869-1 were analyzed by the average method. The measured values of the thermal transmittance for 3 consecutive days converged within +5% of the desing value, and the standard deviation of the thermal transmittance by day decreased in the order of 1-Day > 3-Day > 2-Day. The standard deviation of the thermal transmittance by time period decreased in the order of 00:00~24:00 < 19:00~07:00 < 00:00~07:00. The measured value of the thermal transmittance for the time perion of 00:00 to 07:00 per day almost coincided with an error of -3% to + 2% compare to the desing value.

• Clean Technology
• /
• v.28 no.4
• /
• pp.323-330
• /
• 2022

Microfluidic paper-based analytical devices (μPADs) have recently been in the spotlight for their applicability in point-of-care diagnostics and environmental material detection. This study presents a double-sided printing method for fabricating 3D-μPADs, providing simple and cost effective metal ion detection. The design of the 3D-μPAD was made into an acryl stamp by laser cutting and then coating it with a thin layer of PDMS using the spin-coating method. This fabricated stamp was used to form the 3D structure of the hydrophobic barrier through a double-sided contact printing method. The fabrication of the 3D hydrophobic barrier within a single sheet was optimized by controlling the spin-coating rate, reagent ratio and contacting time. The optimal conditions were found by analyzing the area change of the PDMS hydrophobic barrier and hydrophilic channel using ink with chromatography paper. Using the fabricated 3D-μPAD under optimized conditions, Ni²⁺, Cu²⁺, Hg²⁺, and pH were detected at different concentrations and displayed with color intensity in grayscale for quantitative analysis using ImageJ. This study demonstrated that a 3D-μPAD biosensor can be applied to detect metal ions without special analysis equipment. This 3D-μPAD provides a highly portable and rapid on-site monitoring platform for detecting multiple heavy metal ions with extremely high repeatability, which is useful for resource-limited areas and developing countries.

• Journal of Mushroom
• /
• v.20 no.4
• /
• pp.274-278
• /
• 2022

The present study aimed at selecting a cost-effective substrate for king oyster mushroom based on the growth characteristics of fruiting body for use as a basic resource to ensure stable production on farms. Compositional analysis of substrates manufactured with different materials in each process revealed that the total carbon content was 42.24-48.22% higher and the total nitrogen content was 1.7-2.29% higher in the processed lot than in the control (i.e., substrate used by the farmhouse; 40.86% and 1.39%, respectively). Meanwhile, the carbon-to-nitrogen ratio was the highest in the control (27.9% vs. 19.12-27.88% in the processed lot). When cultured for 28 days, the mycelium growth was 11.5 and 11.3 mm in substrates 1 and 6, respectively, indicating the fastest growth; meanwhile, the values were 10.1-10.3 mm in the control and substrate 11, showing a similar tendency. Mycelial density did not differ significantly among the processed lots. Yield per bottle was higher in substrates 8 (205.95 g/bottle), 7 (178.51 g/bottle), and 11 (170.63 g/bottle) than in the control (152.2 g/bottle). Fruiting body quality was comparable to controls in all processed lots. Overall, economic effects, such as substrate material prices, should be analyzed, and stability evaluations, such as residual pesticide and harmful microorganisms, should be undertaken along with further detailed examination to ensure safe and stable production on farms.

• Journal of the Korean Applied Science and Technology
• /
• v.39 no.1
• /
• pp.34-41
• /
• 2022

As the use of chemical products increases in daily life, the removal of dye waste has also emerged as an important environmental issue. This dye waste can be decomposed using a photocatalyst, and the photocatalyst can be synthesized very cost-effectively by using the sol-gel technology. The sol-gel technology is not only very useful for nanoscale film formation, but also can simply form multilayer structures. Using a multiple spin coating method, in this study, a ZnO film with a multilayered structure (3 layers, 5 layers) was formed by using zinc oxide (ZnO), which is effective in decomposing various dyes. For performance comparison, a ZnO film having a single layer structure by a single spin coating method was prepared as a control. Structural and elemental analysis of ZnO film was performed using an X-ray diffraction analyzer and an energy dispersive X-ray spectrometer. A nanowire-like surface morphology could be observed through a scanning electron microscope. Additionally, UV-Vis spectrophotometer was used to measure the absorbance of UV light. The ZnO film with a five-layer structure degraded the simulated methylene blue by 49% more than the ZnO film with a single-layer structure. In conclusion, it was found that ZnO having a multilayered structure is useful as a photocatalyst that decomposes methylene blue dye more effectively.

• The Journal of Korean Medicine
• /
• v.42 no.3
• /
• pp.1-8
• /
• 2021

Objectives: A critical pathway defines the optimal care process, sequencing and timing of intervention by multi-disciplinary health care teams for a particular diagnosis and procedure. It plays an important role as a cost-effective health care delivery system and a tool for quality control of medical and dental services by means of standardizing medical practices. The aim of this study is to investigate the satisfaction of patients and medical staff after implementation of a critical pathway for Korean medical treatment of lumbar disc herniation in integrative medical. Methods and Results: The pre-critical pathway group included 3 patients who underwent the implementation procedure from October 2020. All three patients have successfully been applied critical pathways during inpatient and outpatient treatment. Additionally, medical staff members were satisfied with the usefulness of the critical pathway. Conclusions: The implementation of critical pathway for the Korean medical treatment with lumbar disc herniation in integrative medical hospital can appraise possible applicability in actual clinical field.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
• /
• v.40 no.4
• /
• pp.333-342
• /
• 2022

This paper has theoretically and practically reviewed the ISO (International Standard Organization) 17123-8 standard not only to raise the appropriateness for introducing performance criteria of GNSS (Global Navigation Satellite Systems) surveying equipment based on RTK (Real-Time Kinematic) accuracy but also to derive its proper test procedure by introducing the international standard. Field experiments have been performed to appreciate the GNSS-RTK accuracy of five selected receivers via the full testing procedure of the ISO standard, which statistically compares the so-called experimental standard deviations with themselves and with the reference accuracy. A series of statistical tests have revealed that the RTK accuracy of the same class receivers is not identical, whereas that of the different classes can be equivalent. Such a result evidences the urgency of adopting an RTK accuracy-based specification of the GNSS equipment to the performance standard, currently referenced to the static observation technique only. It is believed that this transition helps the maximization of a new generation of cost-effective receivers to legal surveying applications. Finally, this study proposes the ISO full test, comparing an experimental standard deviation with its referenced value, for a potential field verification procedure of the new performance standard.

• KIPS Transactions on Software and Data Engineering
• /
• v.10 no.11
• /
• pp.541-546
• /
• 2021

Recently, there is a trend of developing various identification and prediction models for hypertension using clinical information based on artificial intelligence and machine learning around the world. However, most previous studies on identification or prediction models of hypertension lack the consideration of the ideas of non-invasive and cost-effective variables, race, region, and countries. Therefore, the objective of this study is to present hypertension prediction model that is easily understood using only general and simple sociodemographic variables. Data used in this study was based on the Korea National Health and Nutrition Examination Survey (2018). In men, the model using the naive Bayes with the wrapper-based feature subset selection method showed the highest predictive performance (ROC = 0.790, kappa = 0.396). In women, the model using the naive Bayes with correlation-based feature subset selection method showed the strongest predictive performance (ROC = 0.850, kappa = 0.495). We found that the predictive performance of hypertension based on only sociodemographic variables was higher in women than in men. We think that our models based on machine leaning may be readily used in the field of public health and epidemiology in the future because of the use of simple sociodemographic characteristics.