• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.2
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• pp.235-240
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• 2004

In order to develop new anti-photoaging agents from marine natural products, Zostera marina L. was selected for its antioxidative activity and inhibition of matrix metalloproteinase-1 (MMP-1) expression. Three compounds (compounds 1, 2, and 3) were isolated from the extract, and they were identified as apigenin-7-O-${\beta}$-D-glucoside (1), chrysoeriol (2), and luteolin (3). These compounds have SC$\_$50/ values of 0.18 mM, 0.68 mM, and 0.01 mM against l,l-dipheny1-2-picrylhydrazyl radical and 0.04mM, 0.03mM, and 0.01mM against the superoxide radical in the xanthine/xanthine oxidase system, respectively. Compound 3 suppressed the expression of MMP-1 by up to 44% at 35.0${\mu}$M and inhibited the production of interleukin 6, which is known as a cytokine that induces MMP-1 expression. In addition, the wrinkle improvement effect of the formulation with Z. marina extract was measured. As a result, remarkable reduction was found in the fine wrinkle and skin roughness after application of the cream with 3.0% this extract for 8 weeks. In conclusion, the isolated compounds from Z. marina extract were good antioxidant and suppressor of MMP-1 expression and the formulation with the extract diminished the skin wrinkle. Therefore, the extract can be used as a new anti-aging agent for application in cosmetic.

• Journal of the Korean Chemical Society
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• v.57 no.4
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• pp.520-524
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• 2013

• Bulletin of the Korean Chemical Society
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• v.33 no.1
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• pp.344-346
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• 2012

• Journal of the Society of Cosmetic Scientists of Korea
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• v.40 no.4
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• pp.403-412
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• 2014

To develop an effective skin whitening agent for cosmetics, we isolated cucurbitacin B from Cucumis sativus L. which has been used as traditional skin lighting regimen by the bioactivity-guided fractionation, and investigated the inhibitory effects of cucurbitacin B on melanogenesis. At a non-cytotoxic concentration, cucurbitacin B reduced melanin contents of B16F1 melanoma cells in a dose-dependent manner. Cucurbitacin B did not directly inhibit mushroom tyrosinase activity, but it inhibited intracellular tyrosinase activity in a dose-dependent manner. Its inhibitory mechanism on melanin biosynthesis was further assessed, and we found that cucurbitacin B significantly decreased the protein level of tyrosinase, a major melanogenic enzymes and MITF, a master transcriptional factor of melanogenesis. In addition, cucurbitacin B increased the expression of WW domain-containing oxidoreductase (WWOX) which is known to function as tumor repressor and inhibits $Wnt/{\beta}$-catenin pathway. Collectively, these results suggest that cucuritacin B from C. sativus could be used as an active ingredient for skin whitening.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.6 no.1
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• pp.14-17
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• 1977

• Journal of the Society of Cosmetic Scientists of Korea
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• v.17 no.1
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• pp.48-63
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• 1991

• Journal of the Society of Cosmetic Scientists of Korea
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• v.1 no.1
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• pp.22-24
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• 1970

• Journal of the Society of Cosmetic Scientists of Korea
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• v.1 no.1
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• pp.25-29
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• 1970

• Journal of the Society of Cosmetic Scientists of Korea
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• v.2 no.1
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• pp.3-6
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• 1972

• Journal of the Society of Cosmetic Scientists of Korea
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• v.2 no.1
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• pp.13-18
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• 1972