• The Pure and Applied Mathematics
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• v.6 no.2
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• pp.79-86
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• 1999

A Boolean function generates a binary sequence which is frequently used in a stream cipher. There are number of critical concepts which a Boolean function, as a key stream generator in a stream cipher, satisfies. These are nonlinearity, correlation immunity, balancedness, SAC (strictly avalanche criterion), PC (propagation criterion) and so on. In this paper we construct an algorithm for finding the correlation immune order of a Boolean function, and check how long to find the correlation immune order of a given Boolean function in our algorithm.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.17 no.4
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• pp.89-95
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• 2007

There are various methods constructing correlation immune functions such as Siegenthaler's, Camion et al's and Seberry et al's. In particular, Soberry et al's is a method which directly constructs balanced correlation immune functions of any order using the theory of Hadamard matrices. In this paper, we have studied Seberry et al's method for constructing a correlation immune function on a higher dimensional space by combining known correlation immune functions on a lower dimensional space. Futhermore, we calculated the nonlinearity of functions which are constructed by combining of several correlation immune functions. That is, we have shown that the direct sum of two correlation immune functions and a combination of four correlation immune functions have higher nonlinearity in comparison with each functions. This functions in stream cipher are safe against correlation attacks.

• Journal of the Korean Society of Food Science and Nutrition
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• v.27 no.5
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• pp.920-927
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• 1998

The purpose of this study was to investigate the correlation between serum component and immune function in Korean female college students according to the body mass index. There were significant increased in weight, body fat, LBM, TBW, WHR in subjects as their BMI increase(p<0.001). It was found obese group had higher levels of serum components such as total cholesterol, LDL-cholesterol and Cu levels than those of the normal group. There was a significant positive correlation between HDL-cholesterol level and NK cell number(p<0.01), between A/G ratio and T lympocytes number(p<0.05), between Cu levels and B lympocytes(p<0.01) in normal group. There was a significant positive correlation between TG level and CD4/8 ratio(p<0.001), between and IgG(p<0.001) in obese group.

• Korean Journal of Psychosomatic Medicine
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• v.3 no.1
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• pp.3-10
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• 1995

A comparison was made between the effect of subjective stress and that of objective stress on immune function in male medical college students. Interaction between perceived stress, psychopathology and natural killer-cell(NK) activity was assessed during an exam period, non-exam period, and vacation. No significant difference was found in NK activity among these three periods, but scores of perceived stress related to unusual happenings during an exam period and related to interpersonal relationship during vacation were found to have significantly positive correlation with NK activity, respectively. In psychopathology, only scores of anxiety during an exam period had significantly positive correlation with NK activity. These results suggest that immune function is more likely to be affected by subjective stress than objective stress and that subjective stress such as some perceived stress and subclinical level of anxiety may positively affect immune function.

• Journal of applied mathematics & informatics
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• v.7 no.1
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• pp.269-278
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• 2000

A Boolean function generates a binary sequence which is frequently used in a stream cipher. There are number of critical concepts which a Boolean function, as a key stream generator in a stream cipher, satisfies. These are nonlinearity, correlation immunity, balancedness, SAC(strictly avalanche criterion), PC(propagation criterion) and so on. In this paper, we present the algorithms for generating random nonlinear combining functions satisfying given correlation immune order and nonlinearity. These constructions can be applied for designing the key stream generators. We use Microsoft Visual C++6.0 for our program.

• IMMUNE NETWORK
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• v.23 no.2
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• pp.12.1-12.17
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• 2023

Ssu72, a dual-specificity protein phosphatase, not only participates in transcription biogenesis, but also affects pathophysiological functions in a tissue-specific manner. Recently, it has been shown that Ssu72 is required for T cell differentiation and function by controlling multiple immune receptor-mediated signals, including TCR and several cytokine receptor signaling pathways. Ssu72 deficiency in T cells is associated with impaired fine-tuning of receptor-mediated signaling and a defect in CD4⁺ T cell homeostasis, resulting in immune-mediated diseases. However, the mechanism by which Ssu72 in T cells integrates the pathophysiology of multiple immune-mediated diseases is still poorly elucidated. In this review, we will focus on the immunoregulatory mechanism of Ssu72 phosphatase in CD4⁺ T cell differentiation, activation, and phenotypic function. We will also discuss the current understanding of the correlation between Ssu72 in T cells and pathological functions which suggests that Ssu72 might be a therapeutic target in autoimmune disorders and other diseases.

• The Korean Journal of Physiology and Pharmacology
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• v.18 no.2
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• pp.177-182
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• 2014

This study was to determine the correlation between endothelial function and neuro-endocrine-immune (NEI) network through observing the changes of NEI network under the different endothelial dysfunction models. Three endothelial dysfunction models were established in male Wistar rats after exposure to homocysteine (Hcy), high fat diet (HFD) and Hcy+HFD. The results showed that there was endothelial dysfunction in all three models with varying degrees. However, the expression of NEI network was totally different. Interestingly, treatment with simvastatin was able to improve vascular endothelial function and restored the imbalance of the NEI network, observed in the Hcy+HFD group. The results indicated that NEI network may have a strong association with endothelial function, and this relationship can be used to distinguish different risk factors and evaluate drug effects.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.26 no.3
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• pp.286-292
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• 2016

Objectives: This study aimed to evaluate the effects of chronical exposure to high-level dusts on cellular immune function. Methods: The subjects were 110 male workers, among whom 60 were chronically exposed to high-level dusts in mica, limestone and iron mines. The remaining 50 were office workers. Ambient total, respirable dust and crystalline silica in the workplace were sampled using personal air samplers and analyzed according to NIOSH method 0500. Serum levels of hydrogen peroxide, lipid peroxide and superoxide misutase activity were measured using absorption chromatography. The subpopulations of CD4+, CD8+, natural killer cells (CD16+) and CD3+ T-lymphocytes were examined by two-color staining using monoclonal antibodies. Results: The concentration of hydrogen peroxide was significantly higher in exposed workers and superoxide dismutase activity was significantly higher in control workers. No significant difference in numbers of T-lymphocyte subpopulations were observed between exposed and control workers. A significant correlation in exposed workers was observed among total dusts, respirable dusts and crystalline silica. Hydrogen peroxide was significantly correlated with total dust (r=0.720, p<0.01), respirable dust (r=0.770, p<0.01) and crystalline silica (r=0.678, p<0.01). Concentration of hydrogen peroxide showed a significantly negative correlation with numbers of CD8+ cells (r=-0.274, p<0.01), CD3+ cells (r=-0.222, p<0.01) and natural killer cells (r=-0.556, p<0.01). Conclusions: These results suggest that chronical exposure to high-level dust affects cellular immune function and effects might mediate through reactive oxygen species and inflammatory response.

• Biomedical Science Letters
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• v.28 no.4
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• pp.260-275
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• 2022

Sterile alpha motif (SAM) domains bind to various proteins, lipids, and RNAs. However, these domains have not yet been analyzed as prognostic biomarkers. In this study, SAM domain containing 13 (SAMD13), a member of the SAM domain, was evaluated to identify a novel prognostic biomarker in various human cancers, including hepatocellular carcinoma (HCC). Moreover, we identified a correlation between SAMD13 expression and immune cell infiltration in HCC. We performed bioinformatics analysis using online databases, such as Tumor Immune Estimation Resource, UALCAN, Kaplan-Meier plotter, LinkedOmics, and Gene Expression Profiling Interactive Analysis2. SAMD13 expression in HCC samples was significantly higher than that in normal liver tissue; additionally, SAMD13 was higher in primary tumors, various stages of cancer and grades of tumor, and status of nodal metastasis. Higher SAMD13 expression was also associated with poorer prognosis. SAMD13 expression positively correlated with CD8+ T cells, CD4+ T cells, B cells, neutrophils, macrophages, and dendritic cells. In the analysis of SAMD13 co-expression networks, positively related genes of SAMD13 were associated with a high hazard ratio in different types of cancer, including HCC. In biological function of SAMD13, SAMD13 mainly include spliceosome, ribosome biogenesis in eukaryote, ribosome, etc. These results suggest that SAMD13 may serve as a novel prognostic biomarker for HCC diagnosis and provide novel insights into tumor immunology in HCC.

• Toxicological Research
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• v.17
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• pp.201-203
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• 2001

The Japan Pharmaceutical Manufacturers Association. with the cooperation of the Japan Association of Contract Laboratories for Safety Evaluation. launched a collaborative study with 38 companies aimed at elucidating the correlation between histopathological/hematological findings and immune function. Seven substances were individually administered to Crj : CD (SD)IGS rats for 14 or 28 days. Their immunotoxicity was assessed by histopathology. hematology. plaque-forming cell assay. enzyme-linked immunosorbent assay of serum antibody to sheep red blood cells. and flow cytometry. Appropriate procedures for immunotoxicology evaluation of pharmaceuticals were considered.