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http://dx.doi.org/10.4196/kjpp.2014.18.2.177

Expression Profile of Neuro-Endocrine-Immune Network in Rats with Vascular Endothelial Dysfunction  

Li, Lujin (The Center for Drug Clinical Research, Shanghai University of Chinese Medicine)
Jia, Zhenghua (The Integration of Traditional and Western Medical Research Academy of Hebei Province)
Xu, Ling (The Center for Drug Clinical Research, Shanghai University of Chinese Medicine)
Wu, Yiling (The Integration of Traditional and Western Medical Research Academy of Hebei Province)
Zheng, Qingshan (The Center for Drug Clinical Research, Shanghai University of Chinese Medicine)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.18, no.2, 2014 , pp. 177-182 More about this Journal
Abstract
This study was to determine the correlation between endothelial function and neuro-endocrine-immune (NEI) network through observing the changes of NEI network under the different endothelial dysfunction models. Three endothelial dysfunction models were established in male Wistar rats after exposure to homocysteine (Hcy), high fat diet (HFD) and Hcy+HFD. The results showed that there was endothelial dysfunction in all three models with varying degrees. However, the expression of NEI network was totally different. Interestingly, treatment with simvastatin was able to improve vascular endothelial function and restored the imbalance of the NEI network, observed in the Hcy+HFD group. The results indicated that NEI network may have a strong association with endothelial function, and this relationship can be used to distinguish different risk factors and evaluate drug effects.
Keywords
Endocrine system; Immune system; Nervous system; Vascular endothelial dysfunction;
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1 Besedovsky HO, del Rey A. Introduction: immune-neuroendocrine network. Front Horm Res. 2002;29:1-14.
2 Freimark D, Feinberg MS, Matezky S, Hochberg N, Shechter M. Impact of short-term intermittent intravenous dobutamine therapy on endothelial function in patients with severe chronic heart failure. Am Heart J. 2004;148:878-882.   DOI   ScienceOn
3 Szabó C, Pacher P, Zsengellér Z, Vaslin A, Komjáti K, Benkö R, Chen M, Mabley JG, Kollai M. Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation. Mol Med. 2004;10:28-35.
4 Cabral MD, Teixeira P, Soares D, Leite S, Salles E, Waisman M. Effects of thyroxine replacement on endothelial function and carotid artery intima-media thickness in female patients with mild subclinical hypothyroidism. Clinics (Sao Paulo). 2011;66: 1321-1328.
5 Wilbert-Lampen U, Trapp A, Modrzik M, Fiedler B, Straube F, Plasse A. Effects of corticotropin-releasing hormone (CRH) on endothelin-1 and NO release, mediated by CRH receptor subtype R2: a potential link between stress and endothelial dysfunction? J Psychosom Res. 2006;61:453-460.   DOI   ScienceOn
6 Picchi A, Gao X, Belmadani S, Potter BJ, Focardi M, Chilian WM, Zhang C. Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome. Circ Res. 2006;99:69-77.   DOI   ScienceOn
7 Chen Y, Osika W, Dangardt F, Gan LM, Strandvik B, Friberg P. High levels of soluble intercellular adhesion molecule-1, insulin resistance and saturated fatty acids are associated with endothelial dysfunction in healthy adolescents. Atherosclerosis. 2010;211:638-642.   DOI   ScienceOn
8 Berger MM, Hesse C, Dehnert C, Siedler H, Kleinbongard P, Bardenheuer HJ, Kelm M, Bärtsch P, Haefeli WE. Hypoxia impairs systemic endothelial function in individuals prone to high-altitude pulmonary edema. Am J Respir Crit Care Med. 2005;172:763-767.   DOI   ScienceOn
9 Koh KK. Effects of statins on vascular wall: vasomotor function, inflammation, and plaque stability. Cardiovasc Res. 2000; 47:648-657.   DOI   ScienceOn
10 Muller O, Bartunek J, Hamilos M, Berza CT, Mangiacapra F, Ntalianis A, Vercruysse K, Duby C, Wijns W, De Bruyne B, Heyndrickx GR, Vanderheyden M, Holz JB, Barbato E. von Willebrand factor inhibition improves endothelial function in patients with stable angina. J Cardiovasc Transl Res. 2013;6: 364-370.   DOI
11 Cho YS, Kim CH, Ha TS, Lee SJ, Ahn HY. Ginsenoside rg2 inhibits lipopolysaccharide-induced adhesion molecule expression in human umbilical vein endothelial cell. Korean J Physiol Pharmacol. 2013;17:133-137.   DOI   ScienceOn
12 Durand P, Fortin LJ, Lussier-Cacan S, Davignon J, Blache D. Hyperhomocysteinemia induced by folic acid deficiency and methionine load--applications of a modified HPLC method. Clin Chim Acta. 1996;252:83-93.   DOI   ScienceOn
13 Wagner J, Vitali P, Palfreyman MG, Zraika M, Huot S. Simultaneous determination of 3,4-dihydroxyphenylalanine, 5-hydroxytryptophan, dopamine, 4-hydroxy-3-methoxyphenylalanine, norepinephrine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, serotonin, and 5-hydroxyindoleacetic acid in rat cerebrospinal fluid and brain by high-performance liquid chromatography with electrochemical detection. J Neurochem. 1982;38:1241-1254.   DOI
14 Besedovsky H, Sorkin E. Network of immune-neuroendocrine interactions. Clin Exp Immunol. 1977;27:1-12.
15 Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801-809.   DOI   ScienceOn
16 Puranik R, Celermajer DS. Smoking and endothelial function. Prog Cardiovasc Dis. 2003;45:443-458.   DOI   ScienceOn
17 Ansar S, Koska J, Reaven PD. Postprandial hyperlipidemia, endothelial dysfunction and cardiovascular risk: focus on incretins. Cardiovasc Diabetol. 2011;10:61.   DOI
18 Shimbo D, Muntner P, Mann D, Viera AJ, Homma S, Polak JF, Barr RG, Herrington D, Shea S. Endothelial dysfunction and the risk of hypertension: the multi-ethnic study of atherosclerosis. Hypertension. 2010;55:1210-1216.   DOI   ScienceOn
19 Lee SK, Lee JY, Joo HK, Cho EJ, Kim CS, Lee SD, Park JB, Jeon BH. Tat-mediated P66SHC transduction decreased phosphorylation of endothelial nitric oxide synthase in endothelial cells. Korean J Physiol Pharmacol. 2012;16:199-204.   DOI   ScienceOn
20 del Rey A, Welsh CJ, Schwarz MJ, Besedovsky HO. Neuroimmunomodulation in health and disease. Ann N Y Acad Sci. 2012;1262:vii-viii.   DOI   ScienceOn
21 Nicholson JK, Holmes E, Elliott P. The metabolome-wide association study: a new look at human disease risk factors. J Proteome Res. 2008;7:3637-3638.   DOI   ScienceOn
22 Razvi S, Ingoe L, Keeka G, Oates C, McMillan C, Weaver JU. The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial. J Clin Endocrinol Metab. 2007;92:1715-1723.   DOI   ScienceOn
23 Chapin JK, Nicolelis MA. Principal component analysis of neuronal ensemble activity reveals multidimensional somatosensory representations. J Neurosci Methods. 1999;94:121-140.   DOI   ScienceOn
24 Chen M, Zhao L, Jia W. Metabonomic study on the biochemical profiles of a hydrocortisone-induced animal model. J Proteome Res. 2005;4:2391-2396.   DOI   ScienceOn