• Genomics & Informatics
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• 제6권3호
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• pp.142-146
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• 2008

In order to understand the protein functions that are related to disease, it is important to detect the correlation between amino acid mutations and disease. Many mutation studies about disease-related proteins have been carried out through molecular biology techniques, such as vector design, protein engineering, and protein crystallization. However, experimental protein mutation studies are time-consuming, be it in vivo or in vitro. We therefore performed a bioinformatic analysis of known disease-related mutations and their protein structure changes in order to analyze the correlation between mutation and disease. For this study, we selected 111 diseases that were related to 175 proteins from the PDB database and 710 mutations that were found in the protein structures. The mutations were acquired from the Human Gene Mutation Database (HGMD). We selected point mutations, excluding only insertions or deletions, for detecting structural changes. To detect a structural change by mutation, we analyzed not only the structural properties (distance of pocket and mutation, pocket size, surface size, and stability), but also the physico-chemical properties (weight, instability, isoelectric point (IEP), and GRAVY score) for the 710 mutations. We detected that the distance between the pocket and disease-related mutation lay within $20\;{\AA}$ (98.5%, 700 proteins). We found that there was no significant correlation between structural stability and disease-causing mutations or between hydrophobicity changes and critical mutations. For large-scale mutational analysis of disease-causing mutations, our bioinformatics approach, using 710 structural mutations, called "Structural Mutatomics," can help researchers to detect disease-specific mutations and to understand the biological functions of disease-related proteins.

• 한국통신학회논문지
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• 제37A권12호
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• pp.1023-1030
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• 2012

수중 통신 시스템에서 통신 센서간의 간격을 증가시켜 다이버시티 기법을 적용하면 통신 시스템의 성능이 증가한다. 하지만 이 경우 통신 시스템의 크기가 증가하기 때문에 이를 실제의 수중 채널 환경에서 사용하는데 문제가 있다. 따라서 본 논문에서는 수중 통신 시스템에 빔형성기가 결합된 다이버시티 기법의 적용가능성을 검증하기 위하여 측정을 수행하였으며, 측정된 데이터를 이용하여 수신 신호의 상관계수를 분석해 봄으로써 빔형성기가 결합된 다이버시티 시스템의 성능을 검증하였다. 이를 위해 본 연구에서는 수중 채널 환경에서 측정한 데이터를 이용하여 센서에 수신된 신호의 페이딩 특성을 추정하고, 각 센서에서 추정된 페이딩 특성을 이용하여 센서간의 간격과 빔형성에 의한 상관계수를 분석하였으며, 그 결과 수중 채널 환경에서 서로 다른 다중경로 방향으로 빔형성을 수행하고 빔형성이 수행된 신호를 이용하여 다이버시티를 수행하면 센서간의 간격을 줄이면서도 최적의 다이버시티 이득을 얻을 수 있음을 알 수 있었다.

• The Korean Journal of Physiology and Pharmacology
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• 제11권6호
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• pp.263-267
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• 2007

We have previously demonstrated that the level of leukocytes and neutrophils significantly increased immediately and 30 min after exercise. Interleukin-8 (IL-8) is an inflammatory cytokine that acts as a chemokine on neutrophils. In the present study, we evaluated the correlation between the number of neutrophils and leukocytes, and between the number of neutrophils and plasma IL-8 level. Long-distance trained runners (TRs, n = 10) and untrained sedentary control subjects (SEDs, n = 10) ran for one hour at 70% of heart rate reserve. In the TR, the number of neutrophils correlated significantly with the number of leukocytes in the blood. However, there was no correlation between the number of neutrophils and the plasma IL-8 concentration in both groups. Expressions of IL-8 protein and mRNA were markedly higher in the TRs as compared to the SEDs at three time intervals (pre-exercise, immediately after exercise, and post exercise). In conclusion, our results show that 1) the neutrophil level was dependent on the level of leukocytes 2) there was no correlation between the neutrophils count and plasma IL-8 concentration and 3) a higher plasma IL-8 level in athletes may be a unique characteristic of intensive training.

• 한국안전학회지
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• 제34권5호
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• pp.46-54
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• 2019

Even though the fire performance-based design concept has been introduced for various structures and buildings, which have their own specific fire performance level, the uncertainties of input parameters always exist and, then, could reduce significantly the reliability of the fire modeling. Sensitivity analysis was performed with three limited input parameters, HRRPUA, type of combustible materials, and mesh size, which are significantly important for fire modeling. The output variables are limited to the maximum HRR, the time reaching the reference temperature($60^{\circ}C$), and that to reach limited visible distance(5 m). In addition, correlation coefficient analysis was attempted to analyze qualitatively and quantitatively the degree of relation between input and output variables above. Finally, the relationship among the three variables is also analyzed by the principal component analysis (PCA) to systematically analyze the input data bias. Sensitivity analysis showed that the type of combustible materials is more sensitive to maximum HRR than the ignition source and mesh size. However, the heat release parameter of the ignition source(HRR) is shown to be much more sensitive than the combustible material types and mesh size to both time to reach the reference temperature and that to reach the critical visible distance. Since the derived results can not exclude the possibility that there is a dependency on the fire model applied in this study, it is necessary to generalize and standardize the results of this study for the fire models such as various buildings and structures.

• 대한한의학회지
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• 제42권4호
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• pp.102-119
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• 2021

Objectives: Facial diagnosis is an important part of clinical diagnosis in traditional East Asian Medicine. In this paper, using a fully automated facial shape analysis system, we show that facial morphological features are associated with cold pattern. Methods: The facial morphological features calculated from 68 facial landmarks included the angles, areas, and distances between the landmark points of each part of the face. Cold pattern severity was determined using a questionnaire and the cold pattern scores (CPS) were used for analysis. The association between facial features and CPS was calculated using Pearson's correlation coefficient and partial correlation coefficients. Results: The upper chin width and the lower chin width were negatively associated with CPS. The distance from the center point to the middle jaw and the distance from the center point to the lower jaw were negatively associated with CPS. The angle of the face outline near the ear and the angle of the chin line were positively associated with CPS. The area of the upper part of the face and the area of the face except the sensory organs were negatively associated with CPS. The number of facial morphological features that exhibited a statistically significant correlation with CPS was 37 (unadjusted). Conclusions: In this study of a Korean population, subjects with a high CPS had a more pointed chin, longer face, more angular jaw, higher eyes, and more upward corners of the mouth, and their facial sensory organs were relatively widespread.

• 환경영향평가
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• 제33권2호
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• pp.84-98
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• 2024

본 연구는 인천, 수원, 원주, 양산 지역에서 발파작업 동안 취득한 320개의 발파 진동 및 발파 소음 데이터를 사용하여, 발파 진동 및 발파 소음 추정에 적용가능한 예측식을 개발하였다. 발파진동 예측식은 회귀분석결과, SRSD 및 CRSD에 의한 상관계수가 각각 0.879, 0.890이며 두 경우 모두 R² ≥ 0.7로 나타났다. 발파소음 예측식은 단계적 회귀분석을 수행한 결과, 상관계수는 0.911, R² ≥ 0.7로 유의미하게 높은 상관관계를 보였다. 상수값 결정을 위한 추가 회귀분석 결과 상관계수는 0.881, R² ≥ 0.7로 나타났다. 상기의 결과, 개발된 예측식이 다른 도시지역의 재건축사업이나 공동주택 건설에 따른 환경영향평가나 교육환경평가의 소음·진동분야 보고서 작성 시 정합성이 높은 발파소음·진동 예측값을 도출할 수 있을것으로 기대한다.

• 대한정형도수물리치료학회지
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• 제18권2호
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• pp.41-47
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• 2012

Background: This study was designed to investigate the correlation between electromyography (EMG) activities in the vastus medialis oblique (VMO) vs vastus lateralis (VL) activity ratio and the valgus collapse knee position while stepping down. Methods: Twenty healthy women volunteered to participate in this study. We measured the frontal-plane projections of the knee valgus angle, knee valgus distance, and hip adduction angle by using a digital camcorder. After 3 repetitions of the step down (dominant side) exercise, the findings of the static and dynamic phases were analyzed. EMG activities data of the VMO:VL activity ratio were recorded during the step down exercise and were normalized to the maximal voluntary isometric contraction (MVIC) of the quadriceps. A paired t-test was used to compare the findings of the static and dynamic phases. We analyzed the Spearman's rank order correlation coefficient between the and VMO:VL ratio. Results: Hip adduction angle, knee valgus angle, VMO activity, VL activity, VMO:VL activity ratio were statistically higher in the dynamic phase than in the static phase (p<.05). Frontal-plane projections of knee valgus angle were significantly correlated with hip adduction angle (r=.459, p<.05) and knee valgus distance (r=.505, p<.05). However, the EMG activity ratio of the VMO and the VL did not show a significant change during step down exercise with respect to hip adduction angle (p=.875), knee valgus angle (p=.618), and knee valgus distance (p=.701). Conclusion: The results from this study indicate that frontal-plane projections of knee valgus angle were associated with hip adduction angle and knee valgus distance. On the basis of these results, the knee valgus distance may be used to determine the valgus collapse knee position while stepping down.

• 한국융합학회논문지
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• 제10권7호
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• pp.373-381
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• 2019

2017년 우리나라는 고령사회에 진입하면서 치매환자가 증가하고 있다. 이에 추후, 간호 전문 인력으로 역할을 수행하게 될 간호대학생의 치매노인에 대한 관심이 필요하다. 본 연구의 목적은 간호대학생의 치매노인에 대한 사회적 거리감에 미치는 영향요인을 알아보기 위함이다. 본 연구는 서술적 조사연구 연구로, 자료 수집을 위해 D시의 일개 간호대학 158명을 대상으로 구조화된 설문지를 통해 자료를 수집하여 분석하였다. 각 변수간의 상관관계를 분석한 결과 치매노인에 대한 사회적 거리감과 치매태도(r=.53, p<.001)는 정적인 상관관계를 보였으며, 연령주의(r=-.41, p<.001)는 부적상관관계가 있는 것으로 나타났다. 간호대학생의 치매노인의 사회적 거리감에 미치는 영향요인으로는 치매환자와의 소통경험에서 '전혀 없다' 에 비해 '가끔 있다' 와 (${\beta}=.29$ p=.012), '자주 있다' (${\beta}=.37$ p=.002)가 영향요인으로 나타났고, 치매조기예방에 대한 관심(${\beta}=.32$ p=.002), 연령주의(${\beta}=.36$ p=.002)가 유의한 영향을 미치는 것으로 나타났다. 이러한 영향요인 변수들의 치매노인에 대한 사회적 거리감에 대한 설명력은 41.0% 이었다.

• 한국대기환경학회지
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• 제30권4호
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• pp.378-386
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• 2014

The use of bus stop in the center lane has reduced the emissions of exhaust gas on the road due to the improvement of the traffic speed but has caused a health problem for the citizens who are waiting for the bus in the platform, and thus the air pollution control of bus stop in the center lane is emerging as a more important part. This study was conducted to investigate the air pollution degree for the center lane-bus stops in four regions using mobile air measuring vehicle, and to evaluate the characteristics of air pollution by comparing with the data measured at the urban air monitoring site close to the bus stops. In addition, the correlation analysis was performed to analyze the impact to neighboring region by vehicle exhaust gas. The regional mean concentration of nitrogen dioxide in the center lane-bus stops ranged from 0.025 to 0.043 ppm which shows from 2.5 times to 5.3 times higher than the values of urban air monitoring site selected as a control group. The regional mean concentration of ozone in the center lane-bus stops ranged from 0.023 to 0.034 ppm which shows from 3% to 28% lower than the values of urban air monitoring site selected as a control group. The concentrations of nitrogen dioxide and ozone for the sampling regions did not exceed one hour-air quality environmental standard (0.1 ppm). The mean concentration of particulate matter for four center lane-bus stops was $28{\mu}g/m^3$ which shows about 27% higher than the values of urban air monitoring site selected as a control group, and that of particulate matter did not exceed one day-air quality environmental standard ($100{\mu}g/m^3$). In the results of correlation analysis between data from center lane-bus stops and data from urban air monitoring sites, the correlation coefficient (r) of nitrogen dioxide was relatively low as 0.316 to 0.416, and the correlation coefficient was high as the distance was close and vice versa. However, the correlation coefficient of ozone ranged from 0.167 to 0.658 and the correlation coefficient was high as the distance was far and vice versa.

• 한국안광학회지
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• 제13권3호
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• pp.79-87
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• 2008

목적: 본 연구에서는 첫째, 원, 근거리의 주시시차와 사위를 측정하여 방향과 분포 등을 연구한다. 둘째, 주시시차 곡선의 3가지 변수(일부융합제거사위를 의미하는 X-intercept, 주시시차를 의미하는 Y-intercept, 주시시차 곡선의 기울기)들의 값을 구하여 임상에서 사용되는 주시시차와 사위에 어떠한 영향을 미치는지 연구한다. 셋째, 측정된 항목을 원, 근거리에 따라 비교하여 검사거리에 따라 측정된 검사 값이 유의한지를 연구하였다. 방법: 안질환이 없고 건강한 20대 대학생 51명을 대상으로 원, 근거리에서 사위 및 주시시차를 측정하였다. 원거리의 완전융합제거사위는 원거리용 MIM을 사용하여 측정하였고, 주시시차는 Mallett Far Unit을 사용하여 측정하였다. 근거리의 완전융합제 거사위는 원거리와 마찬가지로 근거리용 MIM을 사용하여 측정하였고, 주시시차는 Wesson fixation disparity card를 이용하여 측정하였다. 결과: 1. 원, 근거리 주시시차 곡선의 유형을 조사한 결과 원거리에서는 제 I유형>제 IV유형 >제 II유형=제 III유형의 순으로 나타났고, 근거리에서는 제 I유형 >제 III유형>제 IV유형>제 II유형의 순으로 나타났다. 2. 원, 근거리 모두 완전융합제거사위, 주시시차(Y-intercept), 일부융합제거사위(X-intercept)는 서로 밀접한 상관관계를 가졌다. 3. 원거리에서 주시시차에 가장 큰 영향을 주는 것은 일부융합제거사위(X-intercept)로 나타났고(p=0.000), 완전융합제거사위에 가장 큰 영향을 주는 것은 주시시차(Y-intercept)이었지만 그 영향력의 유의성은 미미하였다(p=0.342). 4. 근거리에서 주시시차(Y-intercept)에 가장 큰 영향을 주는 것은 일부융합제거사위(Xintercept)로 나타났고(p=0.000), 또한 완전융합제거사위에 가장 큰 영향을 주는 것도 일부융합제거사위(X-intercept)로 나타났다(p=0.009). 5. 원, 근거리에서 측정한 각각의 변수들을 비교해 본 결과 완전융합제거사위(t=7.529 p=0.000), 일부융합제거사위(t=5.860 p=0.000), 주시시차(t=4.640 p=0.000)은 유의한 차이가 있었으나 주시시차 곡선의 기울기는 그 차이가 미미하였다(t=1.336 p=0.188). 결론: 원, 근거리에서 주시시차와 사위의 관계는 상관관계가 있었다.