• Journal of the Optical Society of Korea
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• 제15권1호
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• pp.68-73
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• 2011

This study investigated, using the Orbscan II topography system, the influence of age and sex related changes on the corneal thickness and anterior corneal curvature, more specifically the fine structure of the cornea, in a Korean young population. The Orbscan II topography system is a computer-assisted slit-beam scanning technology that can map the anterior section of the cornea. The mean central corneal thickness of all subjects was $547.532{\pm}44.529\;{\mu}m$. There was no statistical difference (p>0.5) in the mean central corneal thickness between males and females. Sex and age related changes in the mean central corneal thickness had no specific statistical difference (P>0.5). There was a negative correlation between the anterior corneal curvature and the central corneal thickness in all subjects, except for the twenty year olds. However, the thickness relationship between the mean central corneal and the eight paracentral corneal thicknesses had strong statistical differences in all subjects. Also age and sex related changes in the central corneal thickness and the anterior corneal curvature in all subjects had no statistically significant difference, except from 20-26 years old (p>0.05). This information could be a suitable reference basis for future studies in the young population of Asia and for the development of examination tools for corneal refractive surgery.

• 한국임상보건과학회지
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• 제7권1호
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• pp.1205-1214
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• 2019

Purpose: To investigate the effect of color soft contact lenses on the corneal thickness in young Korean population. Methods: The subjects consisted of 112 eyes (7 males, 49 females) with the mean age of $20.987{\pm}1.093years$ (range 20-25 years) in young Korean population during 2018. Test was compared the corneal thickness before and after wearing color soft contact lenses. The thinnest cornea thickness(TCT), central cornea thickness(CCT), pupil centre thickness(PCT), superior corneal thickness(SCT),inferior corneal thickness(ICT), medial corneal thickness(MCT), lateral corneal thickness(LCT) of the cornea was measured using the Pentacam pachymetry. The statistically analysis was perform the Shaparo-Wilk test. Results: The right eye was a statistically significant among the CCT,LCT, MCT and TCT values(p<0.001) in the compared the corneal thickness before and after wearing soft colour contact lenses. Also the left eye was a statistically significant among the LCT and MCT values(p<0.001) in the compared the corneal thickness before and after wearing soft colour contact lenses. However, there was no statistical difference (p>0.5) in the mean PCT between before and after wearing color soft contact lenses. Conclusion: These results suggested that the color soft contact lens wear can the effect the regional thickness of cornea. Therefore, the analysis of corneal topography with Pentacam can provide correct and useful diagnostic information of the morphology of the RGP contact lens fitting and diagnosis of corneal refraction surgery.

• 한국임상보건과학회지
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• 제5권4호
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• pp.1021-1025
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• 2017

Purpose: Changes in corneal thickness after wearing hydrogel lens and silicone-hydrogel lens with different oxygen transmission rates wew syudied. Methods: Experiments were performed on 11 subjects(22 eyes). corneal thickness was measured after wearing contact lenses for 8 hours. Corneal thickness was measured using ORB Scan II(ver. 3.14) Results: In the results of the corneal thickness measurement by direction, in the case of the hydrogel-tor lens, the center thickness was $33.63{\mu}m$, the nasal was $34.29{\mu}m$, the temporal was $27.17{\mu}m$, the inferior was $27.17{\mu}m$, the superior was $18.90{\mu}m$, and change rates were 6.28%, 5.71%, 5.40%, 4.75% and 3.09%, respectively. In the results of the corneal thickness measurement by diameter, in the case of the hydrogel-tor lens, the center was $33.63{\mu}m$, the mid-peripheral was $28.19{\mu}m$, the peripheral was $24.18{\mu}m$, and change rates were 6.28%, 4.76%, and 3.79%, respectively. Conclusions: The hydrogel lenses with relatively low oxygen transmission rates resulted in a significant increase in thickness over the entire cornea compared to silicon-hydrogel lenses with high oxygen transmission rates.

• 한국임상수의학회지
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• 제40권2호
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• pp.152-157
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• 2023

A two-year-old, spayed female, Bichon Frise, was referred for severe corneal edema and corneal ulcer in the left eye (OS). The cornea had gradually swelled over one week after phacoemulsification performed a month prior, and that was refractory to 5% sodium chloride eye drop instillation or temporary partial tarsorrhaphy. A complete ophthalmic examination was performed. Severe corneal edema with intrastromal bullae and moderate anterior chamber flare was found on slit-lamp biomicroscopy in the OS, which obstructed the fundus examination. Corneal thickness was measured using high-resolution ultrasound biomicroscopy. The thickness of the OS cornea was 2.74 mm. The "letter-box" conjunctival flap was planned. Dorsal and ventral superficial keratectomy followed by a hood conjunctival flap was performed. Topical and systemic antibiotics and 5% sodium chloride eye drops were prescribed. Decreased corneal thickness was observed at one week, two weeks, and two months postoperatively (1.53 mm, 1.32 mm, and 0.92 mm, respectively). There were no postoperative complications, such as ocular discomfort or recurrent corneal ulcers. The "letter-box" conjunctival flap, a type of superficial keratectomy and conjunctival advancement hood flap, effectively relieved the severe irreversible corneal edema. This could be a simple but effective surgical intervention for patients with endothelial cell damage especially after phacoemulsification.

• 대한수의학회지
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• 제56권3호
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• pp.155-160
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• 2016

This study was conducted to evaluate three different mixed formulations of sodium hyaluronate (SH) and carboxymethyl cellulose (CMC) using a low-humidity air flow-induced rat dry eye model and determine the most suitable mixture. The total thickness of the cornea, corneal epithelial thickness, corneal stroma thickness, damaged corneal epithelium percentage region, thickness of the bulbar conjunctiva epithelium, number of goblet cells, goblet cell occupation percentage region, and damaged bulbar conjunctiva epithelium percentage region were measured by histomorphological evaluation. After 5 h exposure to drying airflow, the thickness of the cornea and conjunctiva was decreased with desquamation of the corneal and conjunctiva epithelium. However, these dry eye symptoms were markedly inhibited by treatment with the reference and test formulations. More favorable effects on decreased thickness were detected in response to the CMC than the SH. However, SH had a greater protective effect against corneal and conjunctiva epithelial damage. The application of a mixture of 0.1% SH and 0.2% CMC showed more favorable effects on the corneal and conjunctival damage and the stabilization of the ocular surface than SH or CMC alone.

• Applied Microscopy
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• 제44권3호
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• pp.88-95
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• 2014

This study examined the effects of quercetin on corneal opacity caused by corneal edema by suppressing the damage on corneal endothelial cell, which was induced by mitomycin-C (MMC). In the MMC-treated group, the number of keratocytes was noticeably fewer compared to that of other groups. Although this group showed normal amount of fiber in the corneal stroma, the thickness was shown to be very thick and the alignment of the corneal endothelial cells that worked as the barrier against aqueous humor was irregular. According to such results, it was known that corneal opacity induced by MMC is not caused by proliferation of keratocytes, but by corneal edema triggered by the infiltration of aqueous humor. In the MMC+quercetin and quercetin+MMC-treated groups, the number of keratocytes was higher and polymorphonuclear leukocytes infilteration was lower significantly compared to that of the MMC-treated group. Although the amounts of fiber and endothelioid cell arrangement were normal, there was more space observed in the corneal stroma. Nonetheless, these groups showed significantly lower stromal thickness compared to that of the MMC group. In conclusion, quercetin has the effect on the reduction of corneal opacity caused by corneal edema that work MMC-induced damage to the corneal endothelial cells.

• 한국임상보건과학회지
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• 제6권1호
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• pp.1089-1096
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• 2018

Purpose: To investigate the corneal thickness and anterior chamber depth (ACD) of eyes with Keratoconus in the Korean population with the Pentacam. Methods: The subjects consisted of 84 eyes from Keratoconic adults aged 7-59 years during 2010. The thinnest area, apex zone, and pupil centre of the corneal thickness were measured using the Pentacam pachymetry. ACD value was also measured with Pentacam. Results: There was a statistically significant relationship between thickness of the cornea at the apex area and the pupil centre (p=0.0001). However, there was no statistical difference (p>0.5) in the mean thickness of thinnest area, apex zone, pupil centre of cornea between right eye and left eye. Also, correlation between ACD and corneal thickness in all subjects had no statistical differences (p>0.05) in all subjects. Conclusion: These results suggested that the regional thickness of cornea and ACD with Pentacam can provide correct and useful diagnostic information of the morphology of Keratoconus for the RGP contact lens and diagnosis of abnormal corneal refraction surgery.

• 한국임상보건과학회지
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• 제1권2호
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• pp.31-37
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• 2013

Purpose. This study was to investigate the analysis of the central corneal thickness and anterior chamber depth of eyes in Korean Young Population using the Pentacam topography. Methods. The subjects consisted of 126 eyes from normal cornea of Korean aged 7-12($8.857{\pm}1.501$) years during 2009. The thinnest location, pachy apex, and pupil central region of the cornea thickness was measured using the Pentacam pachymetry. The anterior chamber depth of normal corneas was measured with Pentacam. Results. The thinnest location of corneal thickness was $547.413{\pm}37.893$um. The pachy apex of cornea thickness was $552.103{\pm}36.016$um. Also, the pupil center of corneal thickness was measured $552.143{\pm}36.418$um. On the other hand, the mean thickness in the central cornea was a statically significant relationship(t-test, p=0.0002) between pachy apex and thinnest zone. Also the mean thickness of the central cornea was a statically significant correlation(pearson p=0.0001) among the pupil center, pachy apex and thinnest zone. The anterior chamber depth was $3.137{\pm}0.308$mm. The mean depth in the anterior chamber of cornea was a statically relationship(t-test, p>0.05) between OD and OS. Conclusions. The results of this clinical study suggested that the analysis of the central corneal thickness and anterior chamber depth using Pentacam in Korean young population can provide the useful morphological information in diagnosis of cornea for the contact lens fitting and corneal refraction surgery.

• 한국안광학회지
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• 제9권2호
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• pp.281-290
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• 2004

근시안에서 각막 중심부와 주변부의 두께를 측정하여 굴절이상 도에 따른 중심부와 주변부 두께의 상관관계와 각막두께의 변화상에 대하여 알아보고자 하였다. 20세에서 49세까지의 99명 198안을 대상으로 Orbscan Topography System(Orbtex, Inc, USA)을 사용하여 중심부 두께와 좌 우안 중심부를 기준으로 상 하, 이 비측 각 2mm 지점에서 주변부 두께를 측정하여 성별, 연령별, 좌 우안별 그리고 굴절이상도에 따라 분석하였다. 전체 대상자의 각막 중심부 두께는 $530.12{\pm}43.41{\mu}m$때, 주변부 두께는 상측 $591.91{\pm}36.88{\mu}m$, 하측 $561.04{\pm}41.82{\mu}m$, 비측 $584.23{\pm}41.97{\mu}m$, 이측 $567.35{\pm}43.25{\mu}m$로 측정되어 중심부와 주변부 각막두께의 차이는 유의한 차이를 보였다. 그러나 굴절이상도, 연령, 성별 그리고 좌 우안에 따른 각막두께는 통계적으로 유의한 차이는 없었다.

• 한국안광학회지
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• 제14권3호
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• pp.7-15
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• 2009

목적: 각막굴절교정렌즈를 장기간 착용한 어린이에서 렌즈 착용 중지 후 나타나는 각막복귀현상을 분석하였다. 방법: 각막굴절교정렌즈를 평균 8개월 이상 착용하고 굴절교정효과를 보인 착용자 중 렌즈 착용을 중지한 25명을 대상으로 각막굴절교정렌즈 착용 전과 착용 중지 후 1개월 동안 나안시력, 굴절이상도, 각막곡률(Sim K), 각막중심 두께 및 각막이심율을 측정하여 분석하였다. 결과: 나안시력과 각막형상은 각막굴절교정렌즈 착용 후 유의한 변화를 보였고, 렌즈 착용 중지 후 1개원 동안 대부분 복귀되었다. 나안시력과 굴절이상도는 착용 중지 2주 후에 완전히 복귀되었고, 각막중심두께 변화와 상관성이 있었다. 그러나 각막형상은 서서히 복귀되어 각막중심두께와 각막이 심율은 착용 중지 1개월 후에 복귀되었고 각막곡률은 1개월까지 착용 전 상태로 복귀되지 않았다. 결론: 각막굴절 교정렌즈 장기 착용자의 경우 렌즈 착용 중지 후 굴절력은 빠르게 복귀되나 각막곡률과 중심두께는 서서히 복귀되므로 콘택트렌즈를 재피팅할 경우 주의가 필요할 것으로 사료된다.