• 한국임상수의학회지
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• 제38권2호
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• pp.98-102
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• 2021

Three dogs with different extents of corneal edema were presented to the Dana Animal Hospital Eye Center. The dogs (3 eyes) were diagnosed with corneal endothelial degeneration with clinical signs of corneal edema, conjunctival hyperemia, and mild blepharospasm through a full ophthalmic examination. For the treatment of corneal edema, superficial keratectomy using a crescent microsurgical knife was performed, and a conjunctival advancement hood flap was applied to the stromal defects. In two cases where corneal edema and opacity were observed only in a part of the cornea, corneal edema was reduced and did not progress to other parts of the cornea and corneal transparency and vision were also well-maintained during the follow-up on days 349 and 231 after the surgery. In a case where the whole cornea was edematous and cloudy, corneal edema and opacity had not clearly improved at the last follow-up on day 275 after the surgery. In conclusion, SKCAHF relieved corneal edema and improved vision, and the prognosis tended to be better when there was less corneal edema caused by CED.

• 한국임상수의학회지
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• 제40권2호
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• pp.152-157
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• 2023

A two-year-old, spayed female, Bichon Frise, was referred for severe corneal edema and corneal ulcer in the left eye (OS). The cornea had gradually swelled over one week after phacoemulsification performed a month prior, and that was refractory to 5% sodium chloride eye drop instillation or temporary partial tarsorrhaphy. A complete ophthalmic examination was performed. Severe corneal edema with intrastromal bullae and moderate anterior chamber flare was found on slit-lamp biomicroscopy in the OS, which obstructed the fundus examination. Corneal thickness was measured using high-resolution ultrasound biomicroscopy. The thickness of the OS cornea was 2.74 mm. The "letter-box" conjunctival flap was planned. Dorsal and ventral superficial keratectomy followed by a hood conjunctival flap was performed. Topical and systemic antibiotics and 5% sodium chloride eye drops were prescribed. Decreased corneal thickness was observed at one week, two weeks, and two months postoperatively (1.53 mm, 1.32 mm, and 0.92 mm, respectively). There were no postoperative complications, such as ocular discomfort or recurrent corneal ulcers. The "letter-box" conjunctival flap, a type of superficial keratectomy and conjunctival advancement hood flap, effectively relieved the severe irreversible corneal edema. This could be a simple but effective surgical intervention for patients with endothelial cell damage especially after phacoemulsification.

• Applied Microscopy
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• 제44권3호
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• pp.88-95
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• 2014

This study examined the effects of quercetin on corneal opacity caused by corneal edema by suppressing the damage on corneal endothelial cell, which was induced by mitomycin-C (MMC). In the MMC-treated group, the number of keratocytes was noticeably fewer compared to that of other groups. Although this group showed normal amount of fiber in the corneal stroma, the thickness was shown to be very thick and the alignment of the corneal endothelial cells that worked as the barrier against aqueous humor was irregular. According to such results, it was known that corneal opacity induced by MMC is not caused by proliferation of keratocytes, but by corneal edema triggered by the infiltration of aqueous humor. In the MMC+quercetin and quercetin+MMC-treated groups, the number of keratocytes was higher and polymorphonuclear leukocytes infilteration was lower significantly compared to that of the MMC-treated group. Although the amounts of fiber and endothelioid cell arrangement were normal, there was more space observed in the corneal stroma. Nonetheless, these groups showed significantly lower stromal thickness compared to that of the MMC group. In conclusion, quercetin has the effect on the reduction of corneal opacity caused by corneal edema that work MMC-induced damage to the corneal endothelial cells.

• 한국안광학회지
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• 제20권2호
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• pp.151-156
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• 2015

목적: 콘택트렌즈를 권장착용시간 동안 착용한 후에 렌즈의 재질에 따라 발생하는 각막부종의 정도를 비교해 보고자 한다. 방법: 안질환이나 약물사용이 없는 성인남녀 43명 77안을 대상으로 하였다. Narafilcon A, HEMA, 실리콘 하이드로젤 재질의 정기교체형 렌즈 3종의 렌즈를 사용하였다. 중심각막두께는 Pentacam을 사용하여 렌즈 착용 전과 8시간 착용 후를 측정하였다. 착용 전과 후의 차이 값으로 각막부종의 정도를 판단하였다. 결과: Narafilcon A, HEMA 재질의 렌즈, 실리콘 하이드로젤 재질의 정기교체형 렌즈의 평균 각막부종은 각각 $2.36{\pm}6.15{\mu}m(Mean{\pm}SD)$, $23.61{\pm}10.71{\mu}m$, $18.25{\pm}8.64{\mu}m$였다. Narafilcon A를 착용한 뒤 측정된 중심각막두께는 착용 전 측정한 중심각막두께와 통계적으로 유의한 차이가 없었다. HEMA와 실리콘 하이드로젤 재질의 렌즈에서 착용 후에 유발된 각막부종은 그 정도에 있어 narafilcon A와 통계적으로 유의한 차이가 있었다. 결론: 정기교체형 실리콘 하이드로젤 재질 렌즈에서 유발된 각막부종의 양은 HEMA 재질의 렌즈에서 유발된 각막부종의 양과 통계적으로 유의한 차이가 없었지만 narafilcon A와는 유의한 차이가 있었다. 따라서 콘택트렌즈 재료의 조성에 따라 권장착용시간을 초과하지 않도록 주의해야 할 것으로 판단된다.

• 대한두개안면성형외과학회지
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• 제23권4호
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• pp.183-186
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• 2022

Plastic surgery around the eyes is usually performed under local anesthesia, using a mixture of lidocaine and epinephrine. Blindness is a rare but devastating complication after the injection of local anesthesia in this region. Most cases reported to date have been caused by occlusion of the ophthalmic artery or central retinal artery. In this case report, however, we present a highly unusual case of blindness caused by corneal edema after a local anesthetic injection. A patient visited the emergency room with a laceration on the eyebrow, and local anesthesia was injected before suturing. Immediately after the injection, severe corneal edema developed, making it impossible to observe the structures in the anterior chamber in detail or check the light reflex and visual acuity of the naked eye. An antibiotic (moxifloxacin hydrochloride) and high-concentration steroid eyedrops were promptly applied. High-concentration steroids were also administered orally. On day 13 post-injury, the visual acuity of the naked eye improved to 1.0, and no recurrence of corneal lesions was observed. Although the cause of corneal edema after the local injection could not be conclusively identified, we hope that this report will help raise clinicians' awareness of this complication and appropriate treatment methods.

• Journal of Yeungnam Medical Science
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• 제41권4호
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• pp.300-305
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• 2024

Cytomegalovirus (CMV) retinitis is a rare disease, and overlapping manifestations involving the anterior segment are extremely uncommon. We report a patient who initially presented with persistent corneal edema and was later diagnosed with CMV retinitis. A 72-year-old man with uncontrolled intraocular pressure (IOP) in his right eye visited a tertiary hospital. At initial presentation, the IOP was 36 mmHg and the fundus was not clear due to corneal edema. Spectral domain optical coherence tomography revealed paracentral acute middle maculopathy (PAMM). Panretinal obstructive vasculopathy was observed on ultra-widefield fluorescein angiography. Three weeks later, trabeculectomy was performed to resolve the persistently high IOP. Once corneal edema improved, a white patch-like peripheral lesion and silver wire-like retinal vasculature were observed. Polymerase chain reaction of the aqueous humor was positive for CMV. Oral valganciclovir and intravitreal ganciclovir were administered as antiviral therapies. Despite treatment for 4 months, the final visual acuity was no light perception, with persistent corneal edema and neovascularization of the iris. We describe a rare case of the simultaneous occurrence of hypertensive uveitis and CMV retinitis. The presence of PAMM could be an initial identifiable sign of CMV retinitis, even in the presence of media opacity.

• 한국임상수의학회지
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• 제34권3호
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• pp.204-207
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• 2017

We report the successful treatment of feline acute bullous keratopathy (FABK) and corneal perforation with a conjunctival hood graft. Two cats with FABK and corneal perforation had severe corneal edema with large central bullae. Their corneas were thinned and perforated. Conjunctival hood grafts were performed. All corneas recovered after 3-4 weeks. The grafts were then removed from the cornea using superficial keratectomy and no ocular irritation was observed. One month later, the corneas had recovered, although there was very mild fibrosis. The cats had normal vision without any corneal problems at this time. Conjunctival hood graft was thus useful for the treatment of severe FABK and allowed the cats to maintain vision.

• 한국임상수의학회지
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• 제40권4호
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• pp.303-307
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• 2023

A 4-year-old female Munchkin cat presented with a 2-day history of a large mass in the left eye. On the first presentation, slit lamp biomicroscopy revealed a large corneal bulla occupying around 40% of the corneal surface along the visual axis. Based on the results, a diagnosis of feline acute bullous keratopathy was made. Due to the location of the extensive corneal bulla, autologous lamellar keratoplasty was performed based on prior studies, to both minimize postoperative complications that may affect axial vision and address any cosmetic concerns the owner had. The autologous lamellar keratoplasty successfully resolved the corneal bulla with no signs of corneal opacities postoperatively. Therefore, autologous lamellar keratoplasty may be a useful surgical treatment for feline acute bullous keratopathy from both the tectonic and optical points of view.

• 대한안과학회지
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• 제59권11호
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• pp.1077-1081
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• 2018

목적: 기화된 아민에 의한 각막부종 2예를 보고하고자 한다. 증례요약: 28세 남자 환자가 시력저하를 주소로 내원하였다. 폴리우레탄 액체를 고체화시키는 작업을 했으며 폴리우레탄과 직접적인 접촉은 없어도 작업 시 열기와 기체를 직접 접하게 된다고 했다. 우안 나안시력 0.5, 좌안 0.6, 세극등현미경검사에서 상피하 소낭포 소견이 관찰되었고, 경면현미경에서 각막두께는 우안 $698{\mu}m$ 좌안 $672{\mu}m$로 증가해 있었다. 0.5% moxifloxacin과 1% fluorometholone을 점안하며 3일 후 나안시력 우안 0.5, 좌안 1.0, 각막두께는 우안 $644{\mu}m$, 좌안 $651{\mu}m$로 감소, 좌안 소낭포도 감소했다. 34세 여자 환자가 자동차 의자 충전재를 다루는 공장에서 일하며 시력감소로 내원하였다. 우안 시력 0.8, 좌안 시력 1.0, 중심각막두께는 우안 $537{\mu}m$, 좌안 $541{\mu}m$를 보였다. 세극등현미경검사에서 양안 각막에 상피하 부종이 관찰되었다. 환자는 초진 이후 내원하지 않았다. 결론: 폴리우레탄 폼 생산과 같이 아민을 취급하는 작업 시 간접적인 증기 노출로도 가역적인 각막 독성을 유발할 수 있으므로 산업장에서 아민류 농도에 관한 고려가 필요하다.

• 한국임상수의학회지
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• 제25권4호
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• pp.292-294
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• 2008

The purpose of this study was to evaluate the cause of lens luxation and to determine the frequency of vision loss, glaucoma, cataract, and corneal edema before and after intracapsular lens extraction (ICLE). The medical records of 8 dogs underwent ICLE for the correction of anterior lens luxation at the Veterinary Medical Teaching Hospital of Seoul National University from August 2005 to September 2007 were reviewed. The most frequently affected breed was Miniature Poodle (n = 3). The mean age was $10.8{\pm}2.1$ years. Preoperatively, 5 eyes (67.5%) with anterior luxation had secondary glaucoma, 7 eyes (87.5%) had vision loss, and all eyes (100.0%) had corneal edema. Four weeks after ICLE, 6 eyes (75.0%) had normal intraocular pressure (IOP), and 4 eyes (50.0%) regained vision. Corneal edema was reduced after ICLE in all eyes, but still remained in 4 eyes. It was considered that ICLE was beneficial in the management of anterior lens luxation, but the eyes without glaucoma before ICLE had more favorable prognosis than eyes with.