• Journal of the Optical Society of Korea
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• v.15 no.1
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• pp.68-73
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• 2011

This study investigated, using the Orbscan II topography system, the influence of age and sex related changes on the corneal thickness and anterior corneal curvature, more specifically the fine structure of the cornea, in a Korean young population. The Orbscan II topography system is a computer-assisted slit-beam scanning technology that can map the anterior section of the cornea. The mean central corneal thickness of all subjects was $547.532{\pm}44.529\;{\mu}m$. There was no statistical difference (p>0.5) in the mean central corneal thickness between males and females. Sex and age related changes in the mean central corneal thickness had no specific statistical difference (P>0.5). There was a negative correlation between the anterior corneal curvature and the central corneal thickness in all subjects, except for the twenty year olds. However, the thickness relationship between the mean central corneal and the eight paracentral corneal thicknesses had strong statistical differences in all subjects. Also age and sex related changes in the central corneal thickness and the anterior corneal curvature in all subjects had no statistically significant difference, except from 20-26 years old (p>0.05). This information could be a suitable reference basis for future studies in the young population of Asia and for the development of examination tools for corneal refractive surgery.

• Applied Microscopy
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• v.44 no.3
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• pp.88-95
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• 2014

This study examined the effects of quercetin on corneal opacity caused by corneal edema by suppressing the damage on corneal endothelial cell, which was induced by mitomycin-C (MMC). In the MMC-treated group, the number of keratocytes was noticeably fewer compared to that of other groups. Although this group showed normal amount of fiber in the corneal stroma, the thickness was shown to be very thick and the alignment of the corneal endothelial cells that worked as the barrier against aqueous humor was irregular. According to such results, it was known that corneal opacity induced by MMC is not caused by proliferation of keratocytes, but by corneal edema triggered by the infiltration of aqueous humor. In the MMC+quercetin and quercetin+MMC-treated groups, the number of keratocytes was higher and polymorphonuclear leukocytes infilteration was lower significantly compared to that of the MMC-treated group. Although the amounts of fiber and endothelioid cell arrangement were normal, there was more space observed in the corneal stroma. Nonetheless, these groups showed significantly lower stromal thickness compared to that of the MMC group. In conclusion, quercetin has the effect on the reduction of corneal opacity caused by corneal edema that work MMC-induced damage to the corneal endothelial cells.

• Journal of Veterinary Clinics
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• v.37 no.4
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• pp.213-216
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• 2020

Two cats were presented to the Dana Animal Hospital Eye Center and were diagnosed with corneal sequestrum through full ophthalmic examination. After lamellar keratectomy using a reusable corneal trephine blade and a crescent microsurgical knife, porcine urinary bladder submucosa extracellular matrix (UBM, ACeLL Vet^® corneal disc) was applied to the corneal defects. In both cases, no corneal sequestrum recurrences were observed until 119 days and 253 days after the surgery, respectively. Porcine UBM could be recommended as a surgical scaffold for treatment of corneal sequestrum in cats.

• Journal of Veterinary Clinics
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• v.38 no.2
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• pp.98-102
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• 2021

Three dogs with different extents of corneal edema were presented to the Dana Animal Hospital Eye Center. The dogs (3 eyes) were diagnosed with corneal endothelial degeneration with clinical signs of corneal edema, conjunctival hyperemia, and mild blepharospasm through a full ophthalmic examination. For the treatment of corneal edema, superficial keratectomy using a crescent microsurgical knife was performed, and a conjunctival advancement hood flap was applied to the stromal defects. In two cases where corneal edema and opacity were observed only in a part of the cornea, corneal edema was reduced and did not progress to other parts of the cornea and corneal transparency and vision were also well-maintained during the follow-up on days 349 and 231 after the surgery. In a case where the whole cornea was edematous and cloudy, corneal edema and opacity had not clearly improved at the last follow-up on day 275 after the surgery. In conclusion, SKCAHF relieved corneal edema and improved vision, and the prognosis tended to be better when there was less corneal edema caused by CED.

• Journal of Korean Clinical Health Science
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• v.7 no.1
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• pp.1205-1214
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• 2019

Purpose: To investigate the effect of color soft contact lenses on the corneal thickness in young Korean population. Methods: The subjects consisted of 112 eyes (7 males, 49 females) with the mean age of $20.987{\pm}1.093years$ (range 20-25 years) in young Korean population during 2018. Test was compared the corneal thickness before and after wearing color soft contact lenses. The thinnest cornea thickness(TCT), central cornea thickness(CCT), pupil centre thickness(PCT), superior corneal thickness(SCT),inferior corneal thickness(ICT), medial corneal thickness(MCT), lateral corneal thickness(LCT) of the cornea was measured using the Pentacam pachymetry. The statistically analysis was perform the Shaparo-Wilk test. Results: The right eye was a statistically significant among the CCT,LCT, MCT and TCT values(p<0.001) in the compared the corneal thickness before and after wearing soft colour contact lenses. Also the left eye was a statistically significant among the LCT and MCT values(p<0.001) in the compared the corneal thickness before and after wearing soft colour contact lenses. However, there was no statistical difference (p>0.5) in the mean PCT between before and after wearing color soft contact lenses. Conclusion: These results suggested that the color soft contact lens wear can the effect the regional thickness of cornea. Therefore, the analysis of corneal topography with Pentacam can provide correct and useful diagnostic information of the morphology of the RGP contact lens fitting and diagnosis of corneal refraction surgery.

• Current Optics and Photonics
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• v.3 no.1
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• pp.72-77
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• 2019

This study was performed to analyze the optical aberrations of the cornea induced by myopic refractive surgery. Corneal total higher-order aberrations, spherical aberration and coma for 4-mm and 6-mm pupils were measured using a wave-front analyzer. The amount of aberrations of the oblate corneal optics by the achieved correction was found to be larger than for the prolate corneal shape with complete eye, in an emmetropia control group. The change in corneal shape acts as an optical factor that degrades the quality of the retinal image; it seems to be one of the important factors related to quality of vision.

• Journal of Veterinary Clinics
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• v.35 no.6
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• pp.311-314
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• 2018

Squamous cell carcinoma (SCC) is a form of neoplasm that origins from the epithelial surface of many organs. Ocular occurrence in small animals is rare, especially in the central cornea without the involvement of limbus or conjunctiva. In the current case, a 10-year-old, spayed female Shih-Tzu was presented with a central corneal mass. Through an ophthalmic examination the sign of corneal scarring around the mass was found. Pink fleshy lesion that protruded outward was removed through superficial keratectomy. The mass with the size of $8.5{\times}6.5$ millimeter was histopathologically diagnosed as corneal SCC infiltrating not only the epithelium, but also the superficial corneal stroma with surrounding superficial lymphoplasmacytic and neutrophilic chronic keratitis. Also, the adjacent, non-affected corneal epithelium was markedly hyperplastic and keratinized; the adjacent stroma was moderately vascularized and fibrotic. The pulse-dose therapy using 1% topical 5-flourouracil were applied for five cycles. The tumor has not recurred through nine months of follow-up time.

• Journal of Korean Ophthalmic Optics Society
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• v.14 no.2
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• pp.35-39
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• 2009

Purpose: In this study a program was developed to determine corneal aberrations using corneal shape of topographer and represented a wavefront and corneal aberrations using zernike polynomial. Methods: When the pupil size was 6 mm, we calculated new corneal shape data with zernike polynomials using corneal shape data of ORBSCAN topographer. We programmed the wavefront construction using ray tracing for corneal shape, then represented corneal aberrations having zernike polynomial with 6th order and 28 terms. Conclusions: We developed programs to determine a wavefront and corneal aberrations using corneal shape of ORBSCAN topographer. Theses results will be applied to a development of new topographer and prescription of contact lens and OK lens.

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.3
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• pp.377-382
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• 2014

Purpose: To investigate the effect of anterior, posterior corneal astigmatism and total corneal astigmatism on posterior corneal astigmatism by analyzing correlation. Methods: Participants were 31 patients (31 eyes) without corneal disease at the age range of 22 to 28 who had visited hospital to receive corneal refractive surgery. The total corneal astigmatism and anterior and posterior corneal astigmatism were measured using a rotating scheimpflug camera before surgery. The magnitude of astigmatism was calculated with the difference between the meridian of the steep refractive power and the flat, and With-The-Rule and inverse astigmatism were divided according to the direction of the meridian that was the steepest. Results: The averages of total corneal astigmatism and anterior and posterior astigmatism were found to be $1.13{\pm}0.76D$, $1.51{\pm}0.84D$, and $-0.59{\pm}0.17D$. The magnitude of posterior corneal astigmatism was distributed between -1.0 D and -0.25 D in all the subjects, and when the magnitude of total corneal astigmatism was set as 100, the magnitude of anterior corneal astigmatism was $142.9{\pm}29.9%$. Total corneal astigmatism indicated the highest correlation with the magnitude of anterior astigmatism (y = 0.871x-0.184, $R^2=0.982$) and high negative correlation with posterior astigmatism (y = -2.974x-0.184, $R^2=0.698$). All the subjects' anterior and posterior corneal astigmatism was classified into With-The-Rule. Conclusions: Anterior and posterior corneal astigmatism in the subjects in their 20's showed the magnitude of -3.8 D in 0.2 D and -0.25 D in -1.0 D separately, and both anterior and posterior astigmatism indicated a high percentage of With-The-Rule.

• Journal of Veterinary Clinics
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• v.40 no.2
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• pp.152-157
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• 2023

A two-year-old, spayed female, Bichon Frise, was referred for severe corneal edema and corneal ulcer in the left eye (OS). The cornea had gradually swelled over one week after phacoemulsification performed a month prior, and that was refractory to 5% sodium chloride eye drop instillation or temporary partial tarsorrhaphy. A complete ophthalmic examination was performed. Severe corneal edema with intrastromal bullae and moderate anterior chamber flare was found on slit-lamp biomicroscopy in the OS, which obstructed the fundus examination. Corneal thickness was measured using high-resolution ultrasound biomicroscopy. The thickness of the OS cornea was 2.74 mm. The "letter-box" conjunctival flap was planned. Dorsal and ventral superficial keratectomy followed by a hood conjunctival flap was performed. Topical and systemic antibiotics and 5% sodium chloride eye drops were prescribed. Decreased corneal thickness was observed at one week, two weeks, and two months postoperatively (1.53 mm, 1.32 mm, and 0.92 mm, respectively). There were no postoperative complications, such as ocular discomfort or recurrent corneal ulcers. The "letter-box" conjunctival flap, a type of superficial keratectomy and conjunctival advancement hood flap, effectively relieved the severe irreversible corneal edema. This could be a simple but effective surgical intervention for patients with endothelial cell damage especially after phacoemulsification.