• 제목/요약/키워드: core stability

검색결과 657건 처리시간 0.025초

T-cell Epitope을 운반할 수 있는 재조합소아마비바이러스 벡터의 제조 및 특성연구 (Construction and Characterization of Recombinant Poliovirus that Delivers T-cell epitope)

  • 조성필;이범용;정수일;민미경
    • 대한바이러스학회지
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    • 제28권2호
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    • pp.139-146
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    • 1998
  • Recombinant polioviruses have been developed by many research groups for use as vaccine vector because poliovirus induces mucosal immunity as well as humoral immunity through oral uptake. We assessed the potential use of poliovirus as a T-cell epitope carrier. Recombinant poliovirus V129 5L was constructed to have a substituted T-helper epitope from the core protein of Hepatitis B virus at neutralization antigenic site 1 on its VP1 capsid protein. The recombinant virus replicated less efficiently than type 1 poliovirus Mahoney strain. The V129 5L formed a little smaller plaques than the Mahoney strain and showed some 1.25 log unit lower titer at the peak in the one-step growth kinetics though it had similar growth profile to that of the Mahoney strain. Since V129 5L recombinant virus was genetically stable even after 24 successive passages in HeLa cells, the antigenic site 1 on VP1 capsid protein was confirmed for its ability of carrying T cell epitope. The genetic stability of V129 5L also indicated that recombinant poliovirus can be successfully utilized for the development of the multivalent vaccines.

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Design of HTS power cable with fault current limiting function

  • Kim, Dongmin;Kim, Sungkyu;Cho, Jeonwook;Kim, Seokho
    • 한국초전도ㆍ저온공학회논문지
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    • 제22권1호
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    • pp.7-11
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    • 2020
  • As demand for electricity in urban areas increases, it is necessary to improve electric power stability by interconnecting neighboring substations and high temperature superconductor (HTS) power cables are considered as a promising option due to its large power capacity. However, the interconnection of substations reduces grid impedance and expected fault current is over 45 kA, which exceeds the capacity of a circuit breaker in Korean grid. To reduce the fault current below 45 kA, a HTS power cable having a fault current limiting (FCL) function is considered by as a feasible solution for the interconnection of substations. In this study, a FCL HTS power cable of 600 MVA/154 kV, transmission level class, is considered to reduce the fault current from 63 kA to less than 45 kA by generating an impedance over 1 Ωwhen the fault current is induced. For the thermal design of FCL HTS power cable, a parametric study is conducted to meet a required temperature limit and impedance by modifying the cable core from usual HTS power cables which are designed to bypass the fault current through cable former. The analysis results give a minimum cable length and an area of stainless steel former to suppress the temperature of cable below a design limit.

Numerical buckling temperature prediction of graded sandwich panel using higher order shear deformation theory under variable temperature loading

  • Sahoo, Brundaban;Sahoo, Bamadev;Sharma, Nitin;Mehar, Kulmani;Panda, Subrata Kumar
    • Smart Structures and Systems
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    • 제26권5호
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    • pp.641-656
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    • 2020
  • The finite element solutions of thermal buckling load values of the graded sandwich curved shell structure are reported in this research using a higher-order kinematic model including the shear deformation effect. The numerical buckling temperature has been computed using an in-house specialized code (MATLAB environment) prepared in the framework of the current mathematical formulation. In addition, the mathematical model includes the excess structural distortion under the influence of elevated environment via Green-Lagrange nonlinear strain. The corresponding eigenvalue equation has been solved to predict the critical buckling temperature of the graded sandwich structure. The numerical stability and the accuracy of the current solution have been confirmed by comparing with the available published results. Thereafter, the model is extended to bring out the influences of structural parameters i.e. the curvature ratio, core-face thickness ratio, support conditions, power-law indices and sandwich types on the thermal buckling behavior of graded sandwich curved shell panels.

임상간호사에서 의료급여관리사로의 역할 전이 과정: '척박한 땅에 뿌리내리기' (Role Transition from Clinical Nurse to Case Manager for Medical-aid Beneficiaries: Taking Root in a Barren Land)

  • 박은준;김춘미;임승주
    • 대한간호학회지
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    • 제42권2호
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    • pp.149-160
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    • 2012
  • Purpose: The purpose of this study was to explain the role transition process to nurse case managers (NCMs) for Medical-aid beneficiaries in Korea. Methods: Fourteen NCMs were interviewed regarding their experiences of becoming proficient in the new role of case manger. Data were analyzed through the application of grounded theory. Results: 'Taking root in a barren land' was the core category explaining the role transition process of NCMs. They engaged in four stages: launching, trial and error, proficiency, and wait-and-see stages. NCMs showed not only fear but also passion for case management practice. Despite their passion and effort, NCMs went through a period of trial and error. After becoming skilled, NCMs went through a stage of wait-and-see often because of job insecurity related to temporary position or few opportunities for promotion. Factors influencing NCMs' role transition process included their understanding of client characteristics, belief in case management, and support from their colleagues and families. Conclusion: NCMs experience many challenges in the process of becoming proficient NCMs. To help with their role transition, there is a need for education programs, preceptorship programs, research on their roles and functions, and regulation for securing NCMs' employment and career stability.

미래 한국 국가전략 : 대륙인가 해양인가? (Some Future Issues of Republic of Korea's National Strategy: Land-oriented or Maritime-oriented Character?)

  • 최재선;김민수
    • Strategy21
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    • 통권36호
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    • pp.121-149
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    • 2015
  • This paper will examine some past and current issues concerning the Republic of Korea's national strategy, focusing predominantly upon how the ROK should respond to the urgent maritime-oriented strategy highlighted by the recent developments and achievements of national prosperity achieved during last three decades and identify some of successful cases in East Asia. Some consideration will also be given to more general emergent issues of trends and developments of East Asian countries which might affect to define the ROK's future national strategy in the context of its national grand strategy to enhance national interests and prosperity. ROK is especially dependent upon open Sea Lanes of Communication (SLOC) and its national security emphasizes the sea as the medium of geopolitical and geo-economic development, given the sea known as core geographic option remains that ROK is an important maritime power, ranking the world-level nation in term of GDP, sea-borne trade, container processing capability, shipbuilding capacity and so on. It should be apparent, therefore, that ROK's national strategic development depends upon the relationship between its peninsula geography and its national development based on sea-borne economic growth and its maritime-oriented future national strategy will be the best option to maintain its national development and economic prosperity.

Hybrid Sensor-less Control of Permanent Magnet Synchronous Motor in Low-speed Region

  • Yamamoto, Yasuhiro;Funato, Hirohito;Ogasawara, Satoshi
    • Journal of Power Electronics
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    • 제8권4호
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    • pp.301-308
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    • 2008
  • This paper proposes a method of improving the stability in sensor-less control of permanent magnet synchronous motors. The control method for low-speed region is divided into two: One is a high frequency method, which involves a problem of reverse rotation once misdetection of the permanent magnet polarity should occur, and another one is a current drive method, which has a problem that phase and speed oscillations are caused by quick speed changes. Hence, authors propose adoption of the current drive method for the basic control system with added compensation of stabilization by means of the high frequency method. This combination secures stable control with no risk of reversal and less vibration. In addition, authors have also considered a frequency separation filter of a shorter delay time so that current control performance will not lower even when high frequencies are introduced. This filter has achieved simplified compensation using repetitive characteristic through the utilization of the periodicity of high frequency current. Simulation and experiment have been conducted to verify that the stable performance of this system is improved.

Vignetting Analysis of GOCI Optical System

  • Yeon, Jeoung-Heum;Youn, Heong-Sik
    • 대한원격탐사학회:학술대회논문집
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    • 대한원격탐사학회 2007년도 Proceedings of ISRS 2007
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    • pp.195-198
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    • 2007
  • GOCI(Geostationary Ocean Color Imager) is the core paryload of the geostationary satellite COMS(Communication, Ocean and Meteological Satellite) for ocean monitoring. It is scheduled to be launched at the end of 2008. GOCI observes ocean color around the Korean Peninsula over $2500km{\times}2500km$ area. Whole field of view is divided into 16 solts and scan mechanism enables to point each slot position. Tilted two-axis scan method is used to observe entire field of view with great pointing stability. Vignetting of the optical system appears when the partial obscuration by intermediate optical components occurs. It leads to the variation of the illumination in the image and gradual fading near the edge of the field. It should be prohibited for the stable radiometric performances. In this work, vignetting analysis of GOCI optical system is performed. For the systematic approach, GOCI optical system is divided into scan mechanism part and telescope part. Vignetting analysis of each part is performed and each result is combined for the overall vignetting performances. The analyzed results can be applied to the selection of slot acquisition angle of scan mechanism to minimize vignetting effects.

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Neighbor Cooperation Based In-Network Caching for Content-Centric Networking

  • Luo, Xi;An, Ying
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • 제11권5호
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    • pp.2398-2415
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    • 2017
  • Content-Centric Networking (CCN) is a new Internet architecture with routing and caching centered on contents. Through its receiver-driven and connectionless communication model, CCN natively supports the seamless mobility of nodes and scalable content acquisition. In-network caching is one of the core technologies in CCN, and the research of efficient caching scheme becomes increasingly attractive. To address the problem of unbalanced cache load distribution in some existing caching strategies, this paper presents a neighbor cooperation based in-network caching scheme. In this scheme, the node with the highest betweenness centrality in the content delivery path is selected as the central caching node and the area of its ego network is selected as the caching area. When the caching node has no sufficient resource, part of its cached contents will be picked out and transferred to the appropriate neighbor by comprehensively considering the factors, such as available node cache, cache replacement rate and link stability between nodes. Simulation results show that our scheme can effectively enhance the utilization of cache resources and improve cache hit rate and average access cost.

Recognition of Radar Emitter Signals Based on SVD and AF Main Ridge Slice

  • Guo, Qiang;Nan, Pulong;Zhang, Xiaoyu;Zhao, Yuning;Wan, Jian
    • Journal of Communications and Networks
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    • 제17권5호
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    • pp.491-498
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    • 2015
  • Recognition of radar emitter signals is one of core elements in radar reconnaissance systems. A novel method based on singular value decomposition (SVD) and the main ridge slice of ambiguity function (AF) is presented for attaining a higher correct recognition rate of radar emitter signals in case of low signal-to-noise ratio. This method calculates the AF of the sorted signal and ascertains the main ridge slice envelope. To improve the recognition performance, SVD is employed to eliminate the influence of noise on the main ridge slice envelope. The rotation angle and symmetric Holder coefficients of the main ridge slice envelope are extracted as the elements of the feature vector. And kernel fuzzy c-means clustering is adopted to analyze the feature vector and classify different types of radar signals. Simulation results indicate that the feature vector extracted by the proposed method has satisfactory aggregation within class, separability between classes, and stability. Compared to existing methods, the proposed feature recognition method can achieve a higher correct recognition rate.

전광파이버형 광파이버 자이로 (All-Fiber Optic Gyroscope)

  • 김인수;김요희
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 1998년도 하계학술대회 논문집 E
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    • pp.1840-1842
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    • 1998
  • Gyroscope is a very important core sensor, as a rotation sensor in inertial space, in inertial guidance and navigation system on aeronautics, plane, vessel and so on for civilian and millitary applications. Mechnical gyroscopes, adopting a principle of spinning a top, have been used in many application system. These mechnical gyroscopes need high power consumption, long warming time and complicated peripheral devices. But fiber-optic gyroscopes, based on the Sagnac effect, have novel advantages as small volume. simple scheme, low power consumption and high reliability. So we have developed a Intermediate grade All-fiber Optic Gyroscope, which has open-loop and minimum reciprocal configuration scheme. We have designed feedback circuits for stability of amplitude and phase using four lock-in amplifier(LIA) circuits and also used for noise limitation. This paper describes the scheme of optical part and electronic part and also test results of this all-fiber optic gyroscope. The performance have been achieved as long-term bias drift of $9.54^{\circ}/h$, random walk of $0.0317^{\circ}/\sqrt{h}$ and dynamic range of ${\pm}150\;deg/s$.

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