• Toxicological Research
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• 제24권4호
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• pp.273-280
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• 2008

The single intratracheal instillation (ITI) of bleomycin (BLM) is a widely used method for inducing experimental pulmonary fibrosis in rat model. In the present study, pulmonary function tests (PFTs) of tidal volume ($V_T$), minute volume ($V_M$), and respiratory frequency ($F_R$) have been applied to study their possibility as a tool to monitor the progress of BLM-induced lung injury in rat model. Rats were treated with a single ITI of BLM (2.5 mg/kg) or saline (control). Animals were euthanized at 3, 7, 14, 21, and 28 days post-ITI. Lung toxicity effects were evaluated by inflammatory cell count, lactate dehydrogenase (LDH) activity in the bronchoalveolar lavage fluid (BALF), and light microscopic examination of lung injury. The PFT parameters were measured immediately before the animals were sacrificed. BLM treatment induced significant cellular changes in BALF-increase in number of total cells, neutrophils, and lymphocytes along with sustained increase in number of macrophages compared to the controls at days 3, 7, and 14. BALF LDH level was significantly increased compared to that in the controls up to day 14. On day 3, infiltration of neutrophils was observed in the alveolar spaces. These changes developed into marked peribronchiolar and interstitial infiltration by inflammatory cells, and extensive thickening of the interalveolar septa on day 7. At 14, 21, and 28 days, mild peribronchiolar fibrosis was observed along with inflammatory cell infiltration. The results of PFT show significant consistencies compared to the results of other toxicity tests. These data demonstrate that the most suitable time point for assessing lung fibrosis in this model is 14 days post-ITI of BLM based on the observation of fibrosis at 14, 21, and 28 days. Further, the progress of lung injury can be traced by monitoring the PFT parameters of $F_R$, $V_T$, and $V_M$.

• 한국진공학회:학술대회논문집
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• 한국진공학회 1999년도 제17회 학술발표회 논문개요집
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• pp.211-211
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• 1999

Titanium nitride (TiN) thin films have useful properties including high hardness, good electrical conductivity, high melting point, and chemical inertness. The applications have included wear-resistant hard coatings on machine tools and bearings, decorative coating making use of the golden color, thermal control coatings for widows, and erosion resistant coatings for spacecraft plasma probes. For all these applications as feature sizes shrink and aspect ratios grow, the issue of good step coverage becomes increasingly important. It is therefore essential to manufacture conformal coatings of TiN. The growth of TiN thin films by chemical vapor deposition (CVD) is of great interest for achieving conformal deposition. The most widely used precursor for TiN is TiCl4 and NH3. However, chlorine impurity in the as-grown films and relatively high deposition temperature (>$600^{\circ}C$) are considered major drawbacks from actual device fabrication. To overcome these problems, recently, MOCVD processes including plasma assisted have been suggested. In this study, therefore, we have doposited Ti(C, N) thin films on Si(100) and D2 steel substrates in the temperature range of 150-30$0^{\circ}C$ using tetrakis diethylamido titanium (TDEAT) and titanium isopropoxide (TIP) by pulsed DC plamsa enhanced metal-organic chemical vapor deposition (PEMOCVD) method. Polycrystalline Ti(C, N) thin films were successfully grown on either D2 steel or Si(100) surfaces at temperature as low as 15$0^{\circ}C$. Compositions of the as-grown films were determined with XPS and RBS. From XPS analysis, thin films of Ti(C, N) with low oxygen concentration were obtained. RBS data were also confirmed the changes of stoichiometry and microhardness of our films. Radical formation and ionization behaviors in plasma are analyzed by optical emission spectroscopy (OES) at various pulsed bias and gases conditions. H2 and He+H2 gases are used as carrier gases to compare plasma parameter and the effect of N2 and NH3 gases as reactive gas is also evaluated in reduction of C content of the films. In this study, we fond that He and H2 mixture gas is very effective in enhancing ionization of radicals, especially N resulting is high hardness. The higher hardness of film is obtained to be ca. 1700 HK 0.01 but it depends on gas species and bias voltage. The proper process is evident for H and N2 gas atmosphere and bias voltage of 600V. However, NH3 gas highly reduces formation of CN radical, thereby decreasing C content of Ti(C, N) thin films in a great deal. Compared to PVD TiN films, the Ti(C, N) film grown by PEMOCVD has very good conformability; the step coverage exceeds 85% with an aspect ratio of more than 3.

• 대한감각통합치료학회지
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• 제7권1호
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• pp.47-57
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• 2009

목적: 본 논문에서는 감각통합치료프로그램이 발달장애아동의 신체도식과 실행능력에 어떠한 영향을 미치는가에 대하여 알아보았다. 연구방법: 30명의 발달장애아를 대상으로 6주 동안 Ayres의 감각통합이론을 근거로 변형된 발달장애아 감각통합 치료프로그램을 적용하여 실시하였다. 연구 대상자의 실행능력의 평가는 신체도식 검사(한점 모방 검사, 신체 6퍼즐 맞추기 검사), 실행검사(언어지시실행, 구강실행, 순서실행) 및 감각통합실행검사(SIPT)를 통하여 데이터를 수집하였으며 치료 전과 치료 후의 변화를 알아보기 위하여 대응표본 t-검정으로 통계처리 하였다. 결과: 1. 감각통합치료프로그램이 발달장애아의 신체도식능력, 즉 한 점 모방과 신체 6 퍼즐 맞추기 능력에서 치료 전 후에서 유의한 차이를 나타내었다(p<0.01). 2. 감각통합치료프로그램이 발달장애아의 실행능력, 즉 언어지시실행, 구강실행 과 순서실행 모두에서 치료 전 후에서 유의한 차이를 나타내었다(p<0.01). 3. 감각통합치료프로그램이 발달장애아의 감각통합실행능력(SIPT)에서 유의한 치료 효과를 나타내었다(p<0.01).

• 유통과학연구
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• 제14권3호
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• pp.85-91
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• 2016

Purpose - Prior research has suggested that consumers typically prefer to have a larger number of options. However, preference of assortment size may depend on how depleted resources in consumers' mind are. Reduced capacity for self-regulation by resource depletion makes people rely on more intuitive and less effortful decision processing. When they are mentally depleted, people are likely to focus on the choice difficulty from large assortment, which leads to preference for the small assortment when they make a decision. It could be an important question potentially how being in a depleted mode through effortful self-regulation will influence on the evaluation of assortment size. To answer this questioner, we hypothesized that being engaged in self-regulation, as compared with not being engaged in self-regulation, will influence on the evaluation of product assortment size such as attractiveness, difficulty of choice, and anticipated regret. Research design, data, and methodology - In this study, we first manipulated self-regulatory resource availability using a self-regulation task (i.e., instructing participants to solve Sudoku puzzle vs. to solve diagram cube by filling any diagrams that they prefer into cube instead of number) and asked to indicate the difficulty of the tasks available to them ("How much difficulty did you feel when you complete the task?") Next, participants were asked to imagine that they were planning to buy a laptop at one of the two stores (small assortment: 6 options vs. large assortment: 30 options), both offering good quality of products. After reading the product descriptions, participants were instructed to consider all the information and choose a store that they would like to shop. Finally we measured the choice difficulty, evaluation of product assortments, and anticipated regret on a 7-point scale. We conducted two-way ANOVA in testing the main hypothesis that depleted consumers will show poorer subsequent self-control than non-depleted consumers when they make a decision in large assortment. Results - Compared with non-depleted participants, depleted participants showed the bigger difference from the degree of choice difficulty and product attractiveness between large and small assortments, but the result revealed only a significant interaction effect of resource depletion and assortment size on choice difficulty. Also depleted participants showed the smaller difference from the degree of anticipated regret between large and small assortments than non-depleted participants. Conclusion - Depleted individuals by a prior task are relatively effortless and intuitive form of choosing products so that they try to avoid making effortful trade-offs among choice difficulty such as large assortment, compare with non-depleted individuals. However, for anticipated regret, non-depleted individuals in small assortment anticipate more regret by excluding or at least restricting the possibility of buying attractive items or another kind of potential items than depleted individuals, regardless less choice difficulty in small option. To sum up, it is important to note that individuals are influenced by self-regulatory resources and their self-regulatory conditions contribute to the overall positive or negative impact of product assortment on choice.

• 유통과학연구
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• 제13권6호
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• pp.97-104
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• 2015

Purpose - The distribution of agricultural products is changing due to recent shifts in environmental free trade. Specifically, the competitiveness of domestic agricultural products has weakened as a result of the Korea-China Financial Trade Agreement. Agricultural producers are faced with increasing difficulties and organized production centers are growing in importance daily. To overcome this crisis, agricultural producer organizations are vying for environment-friendly agricultural certifications, Good Agriculture Practices (GAP) and Hazard Analysis and Critical Control Point (HACCP). In particular, as consumer demand for higher safety grows, farmers are increasing their certification rates. Therefore, this certification system is expected to help strengthen the competitiveness of agricultural producer organizations. Research design/data/methodology - Organized production centers are classified by certification. A survey was conducted with 91 organizations using factor analysis and logistic regression analysis for the examination. The factor analysis results are as follows. Raw material procurement, education·specialization, marketing, joint business, organizing ability, business management, effectiveness, certification, and larger organizations were classified as the nine types of factors. These factors affect the organized production centers and are used in the logistic regression analysis. The purpose of such research and analysis is to suggest a direction for future production center policies. Results - The basic statistical results are as follows: analysis of the producer organizations of 91 sites, average number of members per site of 1,624, and average sales of 25,961 million won. Additionally, the average income per farmer is 175 million won, and the pooling system rate is 53.5%. The factor analysis results are as follows. Factor 1 consists of contract cultivation, ongoing shipment, selection subdivision, traceability, and major retailer management. Factor 2 consists of manual cultivation, specialty selection, education program, and R&D. Factor 3 consists of advertising, various dealers, various sales strategies, and a unified sales counter. Factor 4 consists of agricultural materials co-purchase, policy support, co-shipment, and incentives. Factor 5 consists of the co-selection and pooling system. Factor 6 consists of co-branding and operating by the organization's article. Factor 7 consists of the buy-sell ratio and rate of operation of the agriculture promotion center. Factor 8 consists of bargaining power in volume and participation rate of farmer certification. Factor 9 consists of increasing new subscribers. The logistic regression analysis results are as follows. Considering the results by type of certification, the environment-friendly agricultural certification type and the GAP certification type have a (+) influence. GAP and HACCP certification types affecting the education·specialization factor have a (+) influence. Considering the results for each type of certification, the environment-friendly agricultural certification types on the effectiveness factor have (-) influence; the HACCP certification types on the organizing ability and effectiveness factor have a (-) influence. Conclusions - Agricultural producer organizations should develop plans as follows: The organizations need to secure education for agricultural production; increase the pooling system ratio for sustainable organizational development; and, finally, expand the number of agricultural producer organizations.

• 대한수학교육학회지:수학교육학연구
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• 제17권4호
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• pp.395-418
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• 2007

수학교육에서 수학적 의사소통을 강화하는 것은 교사에게 많은 것을 의존하는 교실 상황을 학생들이 그들 자신의 생각을 책임지는 상황으로 바꾸는데 도움을 준다. 이 연구는 수학적 의사소통에서 중요한 역할을 할 것으로 예상되는 수학적 과제가 수학적 의사소통에 미치는 영향에 대하여 탐구하였다. 이를 위해 인지적 요구수준에 따라 수학적 과제를 암기형, 절차형, 개념원리형, 탐구형으로 나누고, 각 과제 유형에 따라 학생들의 수학적 의사소통 참여, 수학적 정당화 유형, 수학적 합의과정이 어떻게 달라지는지 양적 분석방법과 질적 분석방법을 병행하여 살펴보았다. 수학적 과제는 학생들의 수학적 의사소통과 밀접한 연관성을 갖고 있으며, 어떤 과제로 학습하느냐에 따라 학습 효과는 달라진다. 따라서 해결방법이 다양하고 인지적 요구수준이 높은 수학적 과제를 제공하는 것은 학생들의 수학적 의사소통 능력을 향상시키는데 중요하다.

• 한국식품위생안전성학회지
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• 제22권1호
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• pp.63-75
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• 2007

전라북도내 사업체, 병원, 학교, 사회복지시설 등 집단급식소 설치 신고를 한 집단급식소 98개 업소를 대상으로 설문조사를 실시하여 집단급식소의 위생관리 실태에 대하여 조사하였다. 식기 기구 및 용품의 소독 방법은 식기, 수저, 행주의 경우 열탕 소독이, 주방기기, 냉장고, 냉동고, 도마, 칼의 경우 소독제 방법이 많이 사용되었다. 위생복(34.4%), 위생모(34.4%), 냉장고(32.6%), 냉동고(31.8%)의 순으로 소독을 하지 않는 경우가 많았다. 위생교육 횟수는 월 1회가 56.1%로 가장 많았고, 월 2-3회 12.2%, 주 1회 11.3%순 이었다. 집단급식소의 일지 작성율은 해동일지(73.8%), 창고 및 화장실 점검일지(60.5%), 기구 등의 세척 및 살균 일지(54.5%),등의 순으로 많이 작성되었고, 조리장 위생관리 점검표(9.5%), 조리 종사자 위생점검 일지(10.8%), 위생교육 일지(8.4%) 등은 작성율이 낮았다. HACCP 제조 도입시 급식시설과 설비의 부족(54.1%)과 HACCP 제도에 대한 이해 부족(17.3%)이 주요 장애 요인이었다. 주방기기 및 기구 취급, 개인위생, 급 배수 시설 및 쓰레기 처리, 건물의 구조, 배치 및 시설관리에 대한 위생관리는 잘 이루어지고 있지 않았다. 집단급식소의 영양사들은 종사자의 개인위생과 급 배수 시설 및 쓰레기 처리에 대한 위생관리에 대해서는 잘 인식하고 있었으나 주방기기 및 기구 취급과 건물의 배치 및 시설의 위생 관리에 대해서는 인식이 부족하였다. 따라서 발생률이 계속 증가하는 식중독의 발생을 감소시키기 위해서는 위생관리 체계의 도입과 위생관리에 대한 영양사 인식의 전환이 필요하였다.

• 한방재활의학과학회지
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• 제30권1호
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• pp.79-93
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• 2020

Objectives While sciatic neuropathy is one of the common symptoms which have the lifetime incidence of 13~40%, still there is no consensus about the standardized and the most effective conservative treatment. In addition, the importance of systematic review and meta-analysis of preclinical are growing as they could suggest possible effective treatment strategy for future studies. Therefore, we conducted systematic review and meta-analysis to estimate analgesic effect of acupuncture on sciatica in rat models. Methods Systematic search was conducted for all controlled comparative preclinical trials which assessed analgesic effect of acupuncture in sciatica rat models. Database of PubMed, EMBASE, Web of Science, CNKI and 6 Korean databases were used. The primary outcome was pain, which is evaluated by stimulus behavior tests in rat models. We assessed the methodological quality with Systematic Review Centre for Laboratory Animal Experimentation's risk of bias tool. RevMan 5.3 was used for meta-analysis and subgroup analysis was conducted according to treatment site, acupuncture point, treatment period and frequency used in electroacupuncture. Results 14 studies were finally included following our inclusion criteria. The data from meta-analysis indicated that the acupuncture significantly improved the result values of behavior tests for pain evaluation, compared to no-treatment control group in animal models (standardized mean difference=4.43, 95% confidence interval 3.16 to 5.69, Z=6.84, p<0.00001; χ²=68.02, p<0.00001; I²=82%). The results of subgroup analysis indicate that acupuncture treatment of unilateral site, distal acupoints, longer treatment period and applying 2/100 Hz frequency in electroacupuncture could be more effective. Conclusions Systematic review and meta-analysis of animal studies are getting important for the future clinical studies and the improvement of heatlh care. Therefore the results of the study would provide evidence and better design for the forthcoming studies.

• Tuberculosis and Respiratory Diseases
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• 제59권5호
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• pp.480-486
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• 2005

Since the year 2000, lung cancer has become the leading cause of cancer death in South Korea as in many other parts of the world. The current multidisciplinary approach for lung cancer includes a wide range of modalities, not only surgery, radiotherapy, medical drug therapy but also pain control, as well as social and psychological support. Therefore, thoracic surgeons, radiologists, nuclear medicine specialists, anesthetists, psychologist, nurses and social workers as well as medical doctors care for lung cancer patients. Sharing a common treatment protocol and optimal communication are vital aspects of shared care both from a medical and cost-effectiveness point of view. We developed a shared electronic medical record (SEMR) for treating patients with lung cancer in a university hospital to facilitate the sharing protocols and communications between doctors involved in a lung cancer clinic. A SEMR system was developed within a order communication system(OCS) for a lung cancer clinic. The records of radiological, laboratory and pathological studies as well as the records of surgery, chemotherapy, and radiotherapy were stored and presented to all doctors who treat the same patient. Every doctor was allowed to change his/her own records. They could review other doctor s records but could not alter them. With the SEMR, it was expected that the time to complete the medical records for one patient could be reduced because it was easy to review all the data from the other doctors who share the same patient. In addition, the confidence of the doctors who share a common treatment protocol would be higher. Therefore, a shared electronic medical record is expected to improve the quality of patient care.

• 농업과학연구
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• 제25권2호
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• pp.260-270
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• 1998

본 연구는 합리적인 침하계측관리의 수립을 위하여 현재 시공중인 사업부지를 선정하여 연약지반에 성토시 안정성에 미치는 영향을 현장계측결과를 기초로 기존의 안정평가 방법등과 비교분석하여 성토에 따른 지반의 복합적인 거동을 구명하고 연약지반의 안정평가 기법을 제시하고자 한 것으로 연구결과를 요약하면 다음과 같다. 1. 물리적 성질이 심도별로 최대치를 나타내며 변곡점이 형성되는 부분에서 수평변위가 급증하여 위험가능성이 있으므로 안정관리분석시 기초자료로 이용할 수 있고, 수평변위량의 차가 가장 큰 부분에서 전단변형이 발생되었다. 2. 단계성토에 따른 계측자료를 이용하여 성토체의 안정성을 비교분석 한 결과, 파괴기준선을 초과하여 위험치에 접근하는 부분도 있었으나 성토체는 안정한 것으로 확인되어 안정관리상 파괴기준선으로 안정성을 판단하는 것보다는 곡선의 기울기로 판단하는 것이 합리적이라고 판단된다. 3. 처리지반에서의 수평변위와 상대침하량은 거의 같은 비율을 유지하면서 증가하며, 무처리 지반에서 Terzaghi 수정지지력을 사용할 경우의 전단변형은 성토하중과 비배수 전단강도와의 관계를 고려하고 안전율은 1.2보다 큰 값을 사용하여야 할 것으로 판단된다. 4. 과잉간극수압은 성토시공높이에 따라 상승되고 방치기간에 따라서 감소되며, 성토높이가 관리기준치를 초과하면 과잉간극수압은 급격하게 증가되어 불안정한 상태가 되고 과잉간극수압과 수평변위량의 움직임은 거의 일치하고 있으므로 성토의 시공속도를 조절하는데 판단기준으로 이용할 수 있다.