• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.11
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• pp.155-167
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• 2016

Technology valuation is necessary for determining the feasibility of technology commercialization. However, existing methods focus only on technology evaluation, with limitation in sufficiently reflecting buyer viewpoint. In addition, it causes a gap between estimated value and market value. Therefore, this research suggests a new technology valuation method which focuses on the perspectives of buyers. Technology factors, buyer factors and market factors are first determined and their relationships are analyzed. Second, based on the relationships, profit projections are calculated using the discount cash flow method. Finally, profit projections for each year are discounted. The proposed method was applied using the ubiquitous home network system and audio service and illumination control method and results compared with the value of a technology valuation guide distributed by the Ministry of Trade, Industry and Energy. The technology valuation approach used in this research is quantitative and systematic and can be used as a decision making support tool in technology transfer, reflecting various perspectives of stakeholders.

• The KIPS Transactions:PartB
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• v.18B no.5
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• pp.249-254
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• 2011

FGS (fine granularity scalability) supporting scalability in MPEG-4 Part 2 is a scalable video coding scheme that provides bit-rate adaptation to varying network bandwidth thereby achieving of its optimal video quality. In this paper, we proposed FGS coding scheme which performs one more bit-plane coding for residue signal occured in the enhancement-layer of the basic FGS coding scheme. The experiment evaluated in terms of video quality scalability of the proposed FGS coding scheme by comparing with FGS coding scheme of the MPEG-4 verification model (VM-FGS). The comparison was conducted by analysis of PSNR values of three tested video sequences. The results showed that when using rate control algorithm VM5+, the proposed FGS coding scheme obtained Y, U, V PSNR of 0.4 dB, 9.4 dB, 9 dB averagely higher and when using fixed QP value 17, obtained Y, U, V PSNR of 4.61 dB, 20.21 dB, 16.56 dB averagely higher than the existing VM-FGS. From results, we found that the proposed FGS coding scheme has higher video quality scalability to be able to achieve video quality from minimum to maximum than VM-FGS.

• Proceedings of the KWS Conference
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• 2002.10a
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• pp.250-254
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• 2002

Intergranular corrosion of austenitic stainless steels is a conventional and momentous problem during welding and high temperature use. One of the major reasons for such intergranular corrosion is so-called sensitization, i.e., chromium depletion due to chromium carbide precipitation at grain boundaries. Conventional methods for preventing sensitization of austenitic stainless steels include reduction of carbon content in the material, stabilization of carbon atoms as non-chromium carbides by the addition of titanium, niobium or zirconium, local solution-heat-treatment by laser beam, etc. These methods, however, are not without drawbacks. Recent grain boundary structure studies have demonstrated that grain boundary phenomena strongly depend on the crystallographic nature and atomic structure of the grain boundary, and that grain boundaries with coincidence site lattices are immune to intergranular corrosion. The concept of "grain boundary design and control", which involves a desirable grain boundary character distribution, has been developed as grain boundary engineering. The feasibility of grain boundary engineering has been demonstrated mainly by thermomechanical treatments. In the present study, a thermomechanical treatment was tried to improve the resistance to the sensitization by grain boundary engineering. A type 304 austenitic stainless steel was pre-strained and heat-treated, and then sensitized, varying the parameters (pre-strain, temperature, time, etc.) during the thermomechanical treatment. The grain boundary character distribution was examined by orientation imaging microscopy. The intergranular corrosion resistance was evaluated by electrochemical potentiokinetic reactivation and ferric sulfate-sulfuric acid tests. The sensitivity to intergranular corrosion was reduced by the thermomechanical treatment and indicated a minimum at a small roll-reduction. The frequency of coincidence-site-lattice boundaries indicated a maximum at a small strain. The ferric sulfate-sulfuric acid test showed much smaller corrosion rate in the thermomechanically-treated specimen than in the base material. An excellent intergranular corrosion resistance was obtained by a small strain annealing at a relatively low temperature for long time. The optimum parameters created a uniform distribution of a high frequency of coincidence site lattice boundaries in the specimen where corrosive random boundaries were isolated. The results suggest that the thermomechanical treatment can introduce low energy segments in the grain boundary network by annealing twins and can arrest the percolation of intergranular corrosion from the surface.

• Journal of Korea Water Resources Association
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• v.53 no.4
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• pp.313-322
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• 2020

There is always a risk of water disasters due to sudden storms in mountainous regions in Korea, which is more than 70% of the country's land. In this study, a radar-based risk prediction technique for sudden downpour is applied in the mountainous region and is evaluated for its applicability using Mt. Biseul rain radar. Eight local heavy rain events in mountain regions are selected and the information was calculated such as early detection of cumulonimbus convective cells, automatic detection of convective cells, and risk index of detected convective cells using the three-dimensional radar reflectivity, rainfall intensity, and doppler wind speed. As a result, it was possible to confirm the initial detection timing and location of convective cells that may develop as a localized heavy rain, and the magnitude and location of the risk determined according to whether or not vortices were generated. In particular, it was confirmed that the ground rain gauge network has limitations in detecting heavy rains that develop locally in a narrow area. Besides, it is possible to secure a time of at least 10 minutes to a maximum of 65 minutes until the maximum rainfall intensity occurs at the time of obtaining the risk information. Therefore, it would be useful as information to prevent flash flooding disaster and marooned accidents caused by heavy rain in the mountainous area using this technique.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.8
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• pp.3971-3977
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• 2016

Background: Breast cancer, the commonest cancer among women in the world, ranks top in India with an incidence rate of 1,45,000 new cases and mortality rate of 70,000 women every year. Chemotherapy outcome for breast cancer is hampered due to poor response and irreversible dose-dependent cardiotoxicity which is determined by genetic variations in drug metabolizing enzymes and transporters. Pregnane X receptor (PXR), a member of the nuclear receptor superfamily, induces expression of drug metabolizing enzymes (DMEs) and transporters leading to regulation of xenobiotic metabolism. Materials and Methods: A genomic region spanning PXR 3' UTR was amplified and sequenced using genomic DNA isolated from 96 South Indian breast cancer patients. Genetic variants observed in our study subjects were queried in miRSNP to establish SNPs that alter miRNA binding sites in PXR 3' UTR. In addition, enrichment analysis was carried out to understand the network of miRNAs and PXR in drug metabolism using DIANA miRpath and miRwalk pathway prediction tools. Results: In this study, we identified SNPs rs3732359, rs3732360, rs1054190, rs1054191 and rs6438550 in the PXR 3; UTR region. The SNPs rs3732360, rs1054190 and rs1054191 were located in the binding site of miR-500a-3p, miR-532-3p and miR-374a-3p resulting in the altered PXR level due to the deregulation of post-transcriptional control and this leads to poor treatment response and toxicity. Conclusions: Genetic variants identified in PXR 3' UTR and their effects on PXR levels through post-transcriptional regulation provide a genetic basis for interindividual variability in treatment response and toxicity associated with chemotherapy.

• IMMUNE NETWORK
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• v.6 no.4
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• pp.185-191
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• 2006

Background: Based on outstanding progresses in animal experiments, vaccines for some human tumors have been developed. However, clinical effects of these vaccines have been far below than expected. This discrepancy might come from differences between animal models and human patients with respect to immunocompetency. The immune status of mice after tumor inoculation has not been well studied, which make us cautious in interpreting and applying the results from mice to human. We evaluated cell-mediated immune responses in mice after tumor cell inoculation. Methods: Mice were inoculated with TA3Ha, CT26, or 4T1. Delayed-type hypersensitivity (DTH) responses were induced 2-4 weeks after inoculation using 2,4-dinitro-1-fluorobenzene as an antigen. The relationships between the severity of DTH responses and the duration of tumor inoculation or the size of tumor mass were analyzed. Results: In T A3Ha groups, DTH response was elevated 2 weeks after inoculation, but depressed after 4 weeks, compared to the control group. When analyzed based on the sizes of tumor masses elicited, DTH responses were inversely related to the mass size, especially in those greater than 10 mm in diameter. In CT26 groups, while the duration after inoculation did not affect the severity of DTH responses, those with large mass showed depressed responses regardless the duration of inoculation. 4T1 cells grew so slowly that the size of tumor mass was small even 4 weeks after inoculation, and this group showed much higher DTH responses compared to that of tumor-free group. Conclusion: At least in an experimental setting where tumor model was induced by inoculating tumor cell lines into immunologically competent mice, the host immune response was elevated in early stage, and then depressed in late stage when the mass grew over a critical size.

• IMMUNE NETWORK
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• v.3 no.3
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• pp.211-218
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• 2003

Background: Vitamin C is an essential nutrient, taken as a daily supplement by many people. Recently, high-dose vitamin C is considered as a therapeutic regimen in some clinical situations. Until now, few studies have been done with the effects of high-dose vitamin C on the immune response. Methods: In this experiment, the effects of high-dose vitamin C on cell-mediated immune response in immunologically competent mice were evaluated. After intraperitoneal injection of 2.5, 5, or 10 mg/day of vitamin C for 10 days, delayed type hypersensitivity (DTH) was provoked against DNFB in the pinnae as a model for cell-mediated immune response. Severity of DTH reaction was evaluated as the thickness of pinnae, and the vitamin C levels were measured in the serum, liver, kidney, lung, pinnae, and splenocytes. Results: After challenge, the thickness increased at its peak on the $2^{nd}$ day in all groups. On the first day, the pinnae were thicker in the injected groups than in the control. On the contrary, the increment of the pinnae thickness was attenuated and the number of cells infiltrated in the site of DTH decreased proportionately to the amount of vitamin C administered from the second day on. With vitamin C exogenously given, the serum level peaked at 30 min after injection, and returned abruptly to its basal level without accumulation. However, it accumulated in the liver, kidney, and especially in the pinnae inflamed and splenopcytes, proportionately to the amount administered. Conclusion: Based on these results, it is suggested that, in one hand, exogenously administered high-dose vitamin C accumulated in the splenocytes and presumably changed the function of them resulting in the augmented cell-mediated immune response, as was revealed in the first day of DTH reaction. On the other hand, it seems likely that the vitamin C also showed anti-inflammatory effects.

• IMMUNE NETWORK
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• v.3 no.3
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• pp.201-210
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• 2003

Objective: The role of prostaglandin $E_2$ (PGE2) in the etiopathogenesis of immune and inflammatory diseases has become the subject of recent debate. To determine the role of PGE2 in rheumatoid arthritis (RA), we tested the effect of exogenous PGE2 on the production of cyclooxygenase-2 (COX-2) by rheumatoid synoviocytes. Methods: Fibroblast-like synoviocytes (FLS) were prepared from the synovial tissues of RA patients, and cultured in the presence of PGE2. The COX-2 mRNA and protein expression levels were determined by RT-PCR and Western blot analysis, respectively. The PGE2 receptor subtypes in the FLS were analyzed by RT-PCR. Electrophoretic mobility shift assay (EMSA) was used to measure the NF-${\kappa}B$ binding activity for COX-2 transcription. The in vivoeffect of PGE2 on the development of arthritis was also tested in collagen induced arthritis (CIA) animals. Results: PGE2 ($10^{-11}$ to $10^{-5}M$) dose-dependently inhibited the expression of COX-2 mRNA and the COX-2 protein stimulated with IL-$1{\beta}$, but not COX-1 mRNA. NS-398, a selective COX-2 inhibitor, displayed an additive effect on PGE2-induced COX-2 downregulation. The FLS predominantly expressed the PGE2 receptor (EP) 2 and EP4, which mediated the COX-2 suppression by PGE2. Treatment with anti-IL-10 monoclonal antibodies partially reversed the PGE2-induced suppression of COX-2 mRNA, suggesting that IL-10 may be involved in modulating COX-2 by PGE2. Experiments using an inducer and an inhibitor of cyclic AMP (cAMP) suggest that cAMP is the major intracellular signal that mediates the regulatory effect of PGE2 on COX-2 expression. EMSA revealed that PGE2 inhibited the binding of NF-${\kappa}B$ in the COX-2 promoter via a cAMP dependent pathway. In addition, a subcutaneous injection of PGE2 twice daily for 2 weeks significantly reduced the incidence and severity of CIA as well as the production of IgG antibodies to type II collagen. Conclusion: Our data suggest that overproduced PGE2 in the RA joints may function as an autocrine regulator of its own synthesis by inhibiting COX-2 production and may, in part, play an anti-inflammatory role in the arthritic joints.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.9 no.3
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• pp.12-19
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• 2010

In road network, especially in urban area, inefficiency of travel time is caused by signal control and turn maneuver at intersection and this inefficiency has substantial effects on travel time. When searching for the shortest path, this inefficiency which is caused by turn maneuver must be considered. Therefore, travel time, vehicle volume and delay for each link were calculated by using simulation package, PARAMICS V5.2 for adaptation of turn penalty at 16 intersections of Gangnam-gu. Turn penalty was calculated respectively for each intersection. Within the same intersection, turn penalty differs by each approaching road and turn direction so the delay was calculated for each approaching road and turn direction. Shortest path dealing with 16 intersections searched by Dijkstra algorithm using travel time as cost, considering random turn penalty, and algorithm considering calculated turn penalty was compared and analyzed. The result shows that by considering turn penalty searching the shortest path can decrease the travel time can be decreased. Also, searching the shortest path which considers turn penalty can represent reality appropriately and the shortest path considering turn penalty can be utilized as an alternative.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.17 no.4
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• pp.86-98
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• 2018

Since 2015, the Korea Expressway Corporation has provided predicted travel time information, which is reproduced from DSRC systems over the extended expressway network in Korea. When it is open for public information, it helps travelers decide optimal routes while minimizing traffic congestions and travel cost. Although, sutiable evaluations to investigate the reliability of travel time forecast information have not been conducted so far. First of all, this study seeks to find out a measure of effectiveness to evaluate the reliability of travel time forecast via various literatures. Secondly, using the performance measurement, this study evaluates concurrent travel time forecast information in highway quantitatively and examines the forecast error by exploratory data analysis. It appears that most of highway lines provided reliable forecast information. However, we found significant over/under-forecast on a few links within several long lines and it turns out that such minor errors reduce overall reliability in travel time forecast of the corresponding highway lines. This study would help to build a priority for quality control of the travel time forecast information system, and highlight the importance of performing periodic and sustainable management for travel time forecast information.