• KSBB Journal
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• 제16권1호
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• pp.11-14
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• 2001

Techniques for protein refolding from inclusion body are discussed in view of its engineering application to large scale protein purification. Among the techniques, dilution and dialysis are mainly utilized due to simple operation. Membrane reactor, gel filtration chromatography, and continuous tank operation are emerging tools for their process-scale possibility in refolding. Reaction engineering approaches could be used to analyze the kinetic behaviour in the process scale refolding reactor. The kinetic analysis is helpful in the optimization of refolding yield in the refolding reactor.

• Journal of Chest Surgery
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• 제32권11호
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• pp.1057-1059
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• 1999

Lymphangioleiomyomatosis(LAM) is defined as an abnormal proliferation of smooth muscles in the lung tissue throughout lymphatics, vascular and bronchial structure. A 52-year-old postmenopausal woman was admitted to our hospital for recurrent pneumothorax. She was treated for medroxyprogesterone by LAM 1 month ago. We performed operation of pulmonary partial resection and pleurodesis. The patient is receiving continuous medroxyprogesterone and Leuplin administration, and currently, 6 months after the operation, is still showing good results.

• 대한수학회논문집
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• 제28권3호
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• pp.635-642
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• 2013

There are many results on the extended operations of two fuzzy numbers based on the Zadeh's extension principle. For the calculation, we have to use existing operations between two ${\alpha}$-cuts. In this paper, we define parametric operations between two ${\alpha}$-cuts which are different from the existing operations. But we have the same results as the extended operations of Zadeh's principle.

• KSBB Journal
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• 제6권3호
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• pp.249-254
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• 1991

Permeabilization of Zymomonas mobilis with CTAB(Cetyltrimethylammoniumbromide) was investigated in order to obtain stable process for sorbitol production in the immobilized system. The optimum conditions for sorbitol formation were obtained in the case of using cells treated with 0.2% CTAB at$ 4^{\circ}C$ for 10 min. Permeabilized cells were treated with glutaraldehyde to cross-link the internal enzyme for the improvement of the enzyme stability. In this way, no significant loss of enzyme activity was apparent during 30-day operation in a continuous process. The productivity of the continuous process at dilution rate 0.2h-1 was 6.51g/1/h for sorbitol. The CTAB permeabilized cells could be used to produce sorbitol in the long term continuous process.

• Industrial Engineering and Management Systems
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• 제15권2호
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• pp.148-155
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• 2016

Existing power plants may consume significant amounts of fuel and require high operating costs, partly because of poor electrical power output estimates. This paper suggests a continuous conditional random field (C-CRF) model to predict more precisely the full-load electrical power output of a base load operated combined cycle power plant. We introduce three feature functions to model association potential and one feature function to model interaction potential. Together, these functions compose the C-CRF model, and the model is transformed into a multivariate Gaussian distribution with which the operation parameters can be modeled more efficiently. The performance of our model in estimating power output was evaluated by means of a real dataset and our model outperformed existing methods. Moreover, our model can be used to estimate confidence intervals of the predicted output and calculate several probabilities.

• 한국미생물·생명공학회지
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• 제23권6호
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• pp.717-722
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• 1995

Using a flocculating Saccharomyes cerevisiae CA-1, an air-lift reactor equipped with a modified settler was used for ethanol fermentation. The effects of conditions such as aeration rate, initial glucose concentration, and dilution rate were studied using the air-lift reactor. In batch fermentation, optimum aeration rate was 0.5 vvm. In continuous fermentation, aeration rate and initial pH were fixed 0.5 vvm and 4.5, substrate concentration and dillution rate were changed 10-15% and 0.1-1.3. The maximum ethanol productivity was shown to be 20.4 g/l$\cdot $h in 10% glucose and 0.7 h$^{-1}$ dilution rate., and optimum operation condition considering the ethanol productivity and glucose utilization ratio was 0.5 h$^{-1}$ dilution rate in 10% glucose concentration.

• 전자공학회논문지B
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• 제32B권12호
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• pp.1545-1551
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• 1995

As the modern industrial processes become more complex, it is getting more difficult to model and control the processes. Naturally, an advanced type of DCS(Distributed Control System) with higher level functions is being sought. Advanced DCS is a DCS with advanced functions such as fault diagnosis, GPC(Generalized Predictive Control), NN(Neural Network), and Fuzzy Control. In this thesis, we have studied a fuzzy control algorithm for realizing an advanced DCS. Its algorithm is implemented in a form of function code which is a process control language, being used by the industrial engineers. To verify the realized function code of the fuzzy control, the function code is applied to a continuous casting process of the Pohang Iron & Steel Works in Kwangyang. The rules of the fuzzy control were collected via interviews of the field operators and their operation documents. Finally under a real-time operating system environment, usability of the function code of the fuzzy control is shown via simulation for the continuous casting process.

• KSBB Journal
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• 제5권3호
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• pp.223-227
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• 1990

Ethanol을 주로 생산하는 균주인 Z. mobilis의 cell wall 투과성을 높인 후 고정화하여 sorbitol 생산에 이용 하였다. 그러나, toluene으로 투과성을 높은 cell은 oxidoreductase의 유출, 손실로 인하여 sorbitol conversion efficency가 급격히 저하되었다. 따라서, 이와같은 enzymcd의 유출을 방지 하기 위하여, 투과성을 향상시킨 cell을 0.25% glutaraldehyd로 처리한 후 alginate와 chitin에 고정화하여 회석율 $0.2h^{-1}$에서 연속배양을 한 결과 210시간동안 효소활성도의 저하는 거의 일어나지 않았다. 이와같은 연속배양에서 얻어진 sorbitol productivity는 3.5g / l-h로 측정 되었다.

• 대한전기학회논문지:전기기기및에너지변환시스템부문B
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• 제49권10호
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• pp.701-707
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• 2000

This paper proposes a tension control to compensate friction loss using on-line friction torque observer for a continuous strip processing line. Friction loss of roller results in significant deviation of strip tension, accordingly it has an influence on the operation of other adjacent rolls. To avoid tension variation of the strip, a friction torque observer is designed in adjacent roll, which operates in speed control mode. The observed torque is added to the torque limit reference of the pay-off reel for on-line compensation of both friction loss and acceleration/deceleration torque at the same time. The simulation and experimental results show improvement of tension control performance by the proposed friction compensation method.

• 한국안전학회지
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• 제8권4호
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• pp.127-132
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• 1993

Porphyrin-catalyzed reduction of TNT to triaminotoluene was performed in both batch reactions and a continuous process. Packed-bed reactors were used to study porphyrin-catalyzed reduction in a continuous process. A reactor was packed with DEAD(diethylaminoethyl)-substituted glass beads on which $Co^{+3}$_centered deuteroporpgyrin Ⅸ, -2, 4-disulfonic acid was immobilized, and another containing only DEAE glass beads was used as a control. The porphyrin exhibited catalytic activity in its immobilized state up to 100 hours of operation. Based on the successful abatement of nitrobodies by porphyrin-catalyzed reduction in both batch and continuous process, this process is recommended to be used as a pretreatment for biological treatment or carbon adsorption treatment of TNT wastes.