• Biomolecules & Therapeutics
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• v.20 no.5
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• pp.470-476
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• 2012

Resveratrol, a chemopreventive agent, is rapidly metabolized in the intestine and liver via glucuronidation. Thus, the pharmacokinetics of resveratrol limits its efficacy. To improve efficacy, the activity of resveratrol was investigated in the context of sphingolipid metabolism in human gastric cancer cells. Diverse sphingolipid metabolites, including dihydroceramides (DHCer), were tested for their ability to induce resveratrol cytotoxicity. Exposure to resveratrol ($100{\mu}M$) for 24 hr induced cell death and cell cycle arrest in gastric cancer cells. Exposure to the combination of resveratrol and dimethylsphingosine (DMS) increased cytotoxicity, demonstrating that sphingolipid metabolites intensify resveratrol activity. Specifically, DHCer accumulated in a resveratrol concentration-dependent manner in SNU-1 and HT-29 cells, but not in SNU-668 cells. LC-MS/MS analysis showed that specific DHCer species containing C24:0, C16:0, C24:1, and C22:0 fatty acids chain were increased by up to 30-fold by resveratrol, indicating that resveratrol may partially inhibit DHCer desaturase. Indeed, resveratrol mildly inhibited DHCer desaturase activity compared to the specific inhibitor GT-11 or to retinamide (4-HPR); however, in SNU-1 cells resveratrol alone exhibited a typical cell cycle arrest pattern, which GT-11 did not alter, indicating that inhibition of DHCer desaturase is not essential to the cytotoxicity induced by the combination of resveratrol and sphingolipid metabolites. Resveratrol-induced p53 expression strongly correlated with the enhancement of cytotoxicity observed upon combination of resveratrol with DMS or 4-HPR. Taken together, these results show that DHCer accumulation is a novel lipid biomarker of resveratrol-induced cytotoxicity in human gastric cancer cells.

• Journal of Society of Preventive Korean Medicine
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• v.1 no.1
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• pp.1-13
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• 1997

Cho, Tak(曺倬)'s Yi-Yang-Pyun(二養編), first published in the 12 year of Kwang-Hae-Kun(光海君) era(1620), is composed of two parts. The first part is an edition of various Confucian scriptures that is used to control and restrain the mind. The second pan, considering mostly of contents borrowed from medical works, anthologies and books on yang-saeng(養生), is used to maintain the well-being of the body. Yi-Yang-Pyun shows several distinct characteristics of Yang-saeng ideas. first, it follows the teachings of Yi, Hwang(李滉) which denotes the state of body and mind according to the Kyung(敬) philosophy. 'Kyung' is a state of being that does not require bondage as it automatically reveres the mind. Therefore, actively fostering the body and mind is to maintain this respective state of being. Second, it has summarized and arranged certain medical contents from the Dong-Eui-Bo-Kam(東醫寶鑑) for the purpose of discovering the truth underlying one's body in an effort to pursue the logics of universal nature. Third, although it was based on the contents of Confucianism related books, it widely encompassed the regimen of Taoism. Fundamentally, the Confucian had regarded the Taoism as a heretic, but accepted it in e influence of Zhu xi(朱熹) who interpretated Can-Tong-Qi(參同契) with Confucian perspectives and put in practice the regimen of Taoism. In this context, Yi-Yang-Pyun also used jointly Taoism-related books with Confucian scriptures. Although Taoist regimen was accepted, elixir(外丹), conjury of Taoist hermit(神仙方術) and issues which run counter to morality like sexual practices(房中術) were not. Most of regimens used were related to disease-prevention and health-enhancement like breathing(服氣法), gym-nastics(導引), Diet(服餌) etc. Ideas of Yi-Yang-Pyun, written from Confucian perspectives, latter heavily influenced on scholars of inner elixir(內丹).

• Journal of Family Resource Management and Policy Review
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• v.19 no.1
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• pp.139-161
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• 2015

The number of Healthy Family Support Centers has increased and the services for enhancement of family strength have extended during the past ten years since the Framework Act on Healthy Families was enacted. It is time to pay attention to the empowerment for Healthy Family Specialist because their capability is directly linked to improve the quality of services, which means the satisfaction of family services and the quality of family policy. In this context, this study investigate organizational experience of Healthy Family Specialists and suggest the empowerment plan to enhance their capability. We conducted in-depth interviews for 9 Healthy Family Specialists who is currently working at Healthy Family Support Centers as a manager status during June 2014. We analyzed organizational experiences through job commitment and job satisfaction and empowerment plans through their strength and weakness. Our findings revealed that job commitment and job satisfaction of Healthy Family Specialist are relatively low due to a poor working condition and a low brand awareness. Also, the capability of Healthy Family Specialists is an important factor to determine their job commitment and job satisfaction, and it can impact on the long service. These results suggest that the payroll system, increment of salary, career recognition, employee benefit, systematic operation, and motivation are needed to improve their job satisfaction. There are various ways to improve professional capability of Healthy Family Specialists besides education program. This study contributes to make the plan of empowerment for Healthy Family Specialists and it also contributes to improve the service quality of family policy.

• Journal of Korean Medicine for Obesity Research
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• v.4 no.1
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• pp.161-183
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• 2004

Context : Oriental medicine deals with mind cardinally and effectiveness of CBT on weight control is well-known. but there is no well-structured psychotherapy for weight control like CBT in Oriental medicine so far. Therefore It is necessary to develop new cognitive program based on the theory of Oriental medical. Objective: This study examined whether Yangsung program based on new cognitive weight regulation model is effective on weight loss, self esteem and self control. Design and setting: 44 women were assigned randomly to 2 groups; experimental group(n=24) and control group(n=10). experimental group had 11 sessions consisted of cognitive therapy, meditation, general diet and exercise education. Control group had personal interview with general diet and exercise education and ear acupuncture once a week for two months. All subjects were weighed and evaluated with Rosenberg self esteem scale, and three factor eating questionnaires at the beginning of the program and at the end of the program. Result: Experimental group reported significant changes of weight, self esteem, restraint eating, disinhibition and hunger(p<0.01). Compared with control group, more significant(p<0.05) Weight reduction and self-esteem enhancement were reported in experimental group than control group. There is no significant difference between two groups in changes of restraint eating, disinhibition and hunger.

• Journal of the Korean housing association
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• v.21 no.4
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• pp.1-9
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• 2010

Since the active enhancement of large-scale apartment development in 1970, apartment complexes in Korea have shown considerable changes throughout, with respect to its planning and design. Depending on the government legislations, and economical and social issues of its time, apartments have been designed to respond to varying demands of the society; from minimal unit design to overall masterplan. As existing researches regarding development of apartment planning are conducted in individual and distinct manner, not only is it difficult to find cases of an overall critical analysis of apartment complexes, it is also rare to look for research that deals with a greater urban context, nor the geographical location of the site. With specific focus on apartments in the metropolitan, the focus of this research lies in critically analyzing the qualities of outdoor spaces within an apartment complex, its generational change and interpreting the value it holds for the society. With regards to analyzing its outdoor features, the core of this study deals with applying space syntax, based on the configurational properties of spatial constituents. The results of this research have some implications that the accessibility change of apartment outdoor spaces was examined through quantitative analysis, and the changes of it by time were clarified in detail. And objective and quantitative approaches were employed for an alternative to the methods used in existing related researches.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.10a
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• pp.759-762
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• 2015

As a result of the popularization of smart devices, smart phones or the tablets have become necessities in modern society. In this current of the times, the bring-your-own-device environment, in which personally owned smart devices are utilized in life, is attracting attention. In this context, this paper designed a Wi-Fi remote ordering system focused on the BYOD environment. If the Wi-Fi remote ordering system based on the BYOD environment is popularized, positive effects can be expected such as the enhancement of efficiency and the increase of customer benefits. As a typical example, real-time customer requests via smart devices enable the provision of fast services. This paper designed a mobile app for customers' remote ordering and web pages on which member stores can inquire details of orders, manage a menu, and register statistical data on sales. If the Wi-Fi remote ordering system designed by this paper is widely distributed internationally, it is expected that the system will be used usefully by many people.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.45 no.6
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• pp.117-124
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• 2008

The approaches to overcome the limited spatial resolution and the limited dynamic range of image sensors have been studied independently. A high resolution image is reconstructed from multiple low resolution observations and a wide dynamic range image is reconstructed from differently exposed multiple low dynamic range in es based on signal processing approach. In practical situations, it is reasonable to address them in a unified context because the recorded image suffers from limitations of both spatial resolution and dynamic range. In this paper, the image acquisition process including limited spatial resolution and limited dynamic range is modelled. With the image acquisition model, the response function of the imaging system is estimated and the single image of which spatial resolution and dynamic range are simultaneously enhanced is obtained. Experimental results indicate that the proposed algorithm outperforms the conventional approaches that perform the high resolution and wide dynamic range reconstruction sequentially with respect to both objective and subjective criteria.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.13 no.5
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• pp.106-122
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• 2010

With the introduction of the 40 hours workweek system, an intensive discussion was made among relevant departments. Building facilities does not necessarily guarantee more leisure activities and higher satisfaction for the public. It is essential to draft at the trend of leisure policy in Japan and learn from the experiences to set the policy direction best fitting future changes in Korea, as Japan has gone through comprehensive changes ahead of us. With this understanding, this study analyzed key leisure policies of Japan and examined the trend of changes of time. The followings are the findings of the research. First, Japan's leisure policies could be categorized into five stages and six terms. Second, leisure policies in Japan are being established as a local welfare system, not in the context of industrial perspective, to help people in local community. This is to make voluntary move by eliminating the factors that restrict social demand with an effort to expand leisure time and to secure and enhance access to leisure space. Third, Neighborhood leisure space has taken the center stage, in an effort to seek solutions to the issues of improving space utilization, restoring local community and encouraging participation of local residents. The conclusion drawn from the research is as follows. It is required to recommend the use of the specific term 'leisure' for leisure policies in Korea and for leisure space policies in Korea that are now facing sociocultural challenges similar to the ones emerging in Japan, measures are required to improve physiological access of local residents including information promotion, lifetime education and relationships enhancement along with the establishment of neighborhood leisure space.

• STI Policy Review
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• v.8 no.2
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• pp.23-48
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• 2017

This article advocates for a Mode 3 science policy. Compared to the university research-based Mode 1 knowledge production system and the knowledge application-centric Mode 2 innovation system, Mode 3 can be defined as a system that integrates both Mode 1 and Mode 2-type knowledge production models. In this article, based on the major characteristics of the Mode 3 scientific knowledge production system, I agree with the advocates of Mode 3 that constructing a knowledge society requires an inclusive form of knowledge production and innovation system through the democratization of knowledge production as well as the promotion of social values. Moreover, the mechanisms for creating accountable innovation in the Mode 3 system should be given more attention from the science research and policy communities to make public policy for scientific and technological innovation more reflective of social changes. Similar to the ways that the Mode 1 and Mode 2 scientific knowledge production approaches have influenced the development of science policy models, the Mode 3 scientific knowledge production approach, or Mode 3 science, also has the potential to shape a new science policy model. I will refer to this as Mode 3 science policy. In an effort to conceptualize the democracy- and society-centric Mode 3 science policy model, I will articulate science policy strategies in four science policy domains in South Korea from the context of the Mode 3 science approach. These include (1) evaluation of publicly-funded research activities, (2) valorization of scientific knowledge (that is, enhancement of the value of scientific knowledge through governmental action), (3) development of a science policy decision-making support system, and (4) anticipatory foresight of science, technology and society. When adopting and implementing a Mode 3 science framework, one progressive change is to increase socially desirable innovation such as responsible innovation.

• International Journal of Computer Science & Network Security
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• v.21 no.9
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• pp.323-331
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• 2021

The relevance of the study implies the need to explain the main determinants of environmental policy, allowing countries to converge on a common working basis. The purpose of the research is to explore ways in which the environmental aspects of EU regions and territories can be shaped to apply to domestic environmental policy. A total of 997 representatives from the Ukrainian UTCs, who are involved in local environmental policy, participated in the survey. Results of the research. A hierarchy of regional environmental policy objectives has been identified. Three key principles of eco-policy development have been distinguished. The means of the innovative approach strategy implementation have been outlined (formation of the regional market of environmental services; organization of interaction between environmental agencies and market structures; establishment of environmental funds which finance environmental activities; implementation of the "collateral return" system; formation of a system of benefits and loans to enterprises that successfully implement the environmental policy). The means of the prognostic approach implementation strategy to the development of the region's environmental policy have been determined (the use of an orderly and successful long-term strategy of economic development of the region; obligatory consideration in the mechanisms strategy aimed at improvement of environmental management system of the region, interbranch impact of the projects implemented on the region's ecological situation; taking into consideration the economic and geographical peculiarities of the region, the necessary infrastructure, issues of the territorial location of the large enterprises in the region and their impact on the environment). The means of the traditional approach strategy implementation have been outlined (activity programs focused on solution of specific problems, rather than on the implementation of measures for environmental restoration and enhancement; nature conservation problems have interbranch, interdepartmental character due to unity of the region's ecosystem; tracking complexity of changing conditions (water basins, woodlands, air-mass transport), regional boundaries generally do not coincide with natural ecosystems boundaries). The practical significance of the study lies in providing recommendations for the implementation of certain aspects of Ukrainian UTC's environmental policy.