• 제목/요약/키워드: contact interface

검색결과 990건 처리시간 0.029초

생체응용을 위한 휴대용 단일빔 음향집게시스템 개발 (Development of portable single-beam acoustic tweezers for biomedical applications)

  • 이준수;박연성;김미지;윤창한
    • 한국음향학회지
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    • 제39권5호
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    • pp.435-440
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    • 2020
  • 음향집게는 마이크론 단위의 미세입자를 비접촉 방식으로 조작할 수 있어 다양한 생체공학 응용에 사용되고 있다. 현재까지 음향집게는 in vitro 실험을 목적으로 개발되어 임의파형 발생기와 전력 증폭기와 같은 부피가 큰 고가의 장비를 사용하여 구현하였다. 따라서 이러한 시스템은 이동이 불편하여 한정된 공간에서만 사용이 가능하기 때문에 향후 in vivo 및 임상 실험에 적합하지 않은 구조를 가진다. 따라서 본 논문에서는 이동이 가능한 휴대용 음향집게를 개발하고 그 성능을 평가하였다. 개발한 휴대용 음향집게 시스템은 하나의 Field Programmable Gate Array(FPGA)와 2 개의 펄서로 구현되었으며, Universal Serial Bus(USB) 통신을 이용하여 Personal Computer(PC)에서 송신 주파수 및 펄스 길이 등을 실시간으로 조절이 가능하도록 설계하였다. 개발한 시스템은 최대 20 MHz의 중심 주파수 까지 송신이 가능하며, 미세입자 및 세포를 포획할 수 있는 충분한 힘을 생성할 수 있었다. 개발한 시스템의 성능을 평가하기 위하여 40 ㎛와 90 ㎛ 크기의 폴리스티렌 입자를 포획 및 조정하였다.

Crystal Structure of GRIP1 PDZ6-peptide complex reveals the structural basis for class II PDZ target recognition and PDZ domain-mediated multimerization

  • Im, Young-Jun;Park, Seong-Ho;Park, Seong-Hwan;Lee, Jun-Hyuck;Kang, Gil-Bu;Morgan Sheng;Kim, Eunjoon;Eom, Soo-Hyun
    • 한국결정학회:학술대회논문집
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    • 한국결정학회 2002년도 정기총회 및 추계학술연구발표회
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    • pp.4-4
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    • 2002
  • PDZ domains bind to short segments within target proteins in a sequence-specific fashion. GRIP/ABP family proteins contain six to seven PDZ domains and interact via its sixth PDZ domain (class Ⅱ) with the C-termini of various proteins, including liprin-α. In addition the PDZ456 domain mediates the formation of homo- and heteromultimers of GRIP proteins. To better understand the structural basis of peptide recognition by a class Ⅱ PDZ domain and DZ-mediated multimerization, we determined the crystal structures of the GRIPI PDZ6 domain, alone and in complex with a synthetic C-terminal octapeptide of human liprin-α, at resolutions of 1.5 Å and 1.8 Å, respectively. Remarkably, unlike other class Ⅱ PDZ domains, Ile736 at αB5 rather than conserved Leu732 at αB1 makes a direct hydrophobic contact with the side chain of the Tyr at the -2 position of the ligand. Moreover, the peptide-bound structure of PDZ6 shows a slight reorientation of helix αB, indicating that the second hydrophobic pocket undergoes a conformational adaptation to accommodate the bulkiness of the Tyr's side chain, and forms an antiparallel dimer through an interface located at a site distal to the peptide-binding groove. This configuration may enable formation of GRIP multimers and efficient clustering of GRIP-binding proteins.

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전기방전가공법을 이용한 임플랜트 보철물의 적합도 연구 (A STUDY ON THE FIT OF IMPLANT-RETAINED PROSTHESES USING ELECTRIC DISCHARGE MACHINING)

  • 한의택;김영수;김창회;양재호
    • 대한치과보철학회지
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    • 제39권1호
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    • pp.1-13
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    • 2001
  • An absolutely passive fit at the interface with the superstructure and the abutment cylinders is need for implant longevity. In this study, a method of cast framework correction using spark erosion technology was evaluated. Electric discharge machining(EDM) is a process that uses electrical discharges, or sparks, to machine metal, The surface being machined is bombared with high-intensity electrical energy pulses that gradually melt away the stock until the desired configuration is obtained. Master model was fabricated by using metal block impression analogue, which fired 5 Branemark squared impression coping in an arc shaped metal block. Then framework using 4mm standard gold cylinder and type IV gold alloy was fabricated. In order to measure the fit of the framework we used both contact and noncontact coordinate measurement machine and data was processed by computer program. After superimposition of gold framework and master model numeric image data the distances between gold cylinder bearing surfaces and abutment replica bearing surfaces, and the angle deviations between gold cylinder and abutment replica centroid points were calculated. The results were as follows 1 The total mean distance (p<0.01) and standard deviation (p<0.001) between the gold cylinders and abutment bearing surfaces were significantly decreased after EDM 2. The total mean of maximum distances was significantly decreased after EDM (p<0.05). 3. After EDM, the mean angle deviation between centroid points was decreased.

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Cell response to a newly developed Ti-10Ta-10Nb alloy and its sputtered nanoscale coating

  • Kim, Young-Min;Vang, Mong-Sook;Yang, Hong-So;Park, Sang-Won;Lim, Hyun-Pil
    • The Journal of Advanced Prosthodontics
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    • 제1권1호
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    • pp.56-61
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    • 2009
  • STATEMENT OF PROBLEM. The success of titanium implants is due to osseointegration or the direct contact of the implant surface and bone without a fibrous connective tissue interface. PURPOSE. The purpose of this study was to evaluate the osteoblast precursor response to titanium-10 tantalum-10 niobium(Ti-Ta-Nb) alloy and its sputtered coating. MATERIAL AND METHODS. Ti-Ta-Nb coatings were sputtered onto the Ti-Ta-Nb disks. Ti6-Al-4V alloy disks were used as controls. An osteoblast precursor cell line, were used to evaluate the cell responses to the 3 groups. Cell attachment was measured using coulter counter and the cell morphology during attachment period was observed using fluorescent microscopy. Cell culture was performed at 4, 8, 12 and 16 days. RESULTS. The sputtered Ti-Ta-Nb coatings consisted of dense nanoscale grains in the range of 30 to 100 nm with alpha-Ti crystal structure. The Ti-Ta-Nb disks and its sputtered nanoscale coatings exhibited greater hydrophilicity and rougher surfaces compared to the Ti-6Al-4V disks. The sputtered nanoscale Ti-Ta-Nb coatings exhibited significantly greater cell attachment compared to Ti-6Al-4V and Ti-Ta-Nb disks. Nanoscale Ti-Ta-Nb coatings exhibited significantly greater ALP specific activity and total protein production compared to the other 2 groups CONCLUSIONS. It was concluded that nanoscale Ti-Ta-Nb coatings enhance cell adhesion. In addition, Ti-Ta-Nb alloy and its nanoscale coatings enhanced osteoblast differentiation, but did not support osteoblast precursor proliferation compared to Ti-6Al-4V. These results indicate that the new developed Ti-Ta-Nb alloy and its nanoscale Ti-Ta-Nb coatings may be useful as an implant material.

냉난방 가동 모사에 따른 콘크리트 에너지파일의 열응력 해석에 대한 연구 (Study on Thermal Stress Occurred in Concrete Energy Pile During Heating and Cooling Buildings)

  • 성치훈;박상우;김병연;정경식;최항석
    • 한국지열·수열에너지학회논문집
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    • 제11권2호
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    • pp.12-18
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    • 2015
  • The energy pile, used for both structural foundations and heat exchangers, brings about heat exchange with the ground formation by circulating a working fluid for heating and cooling buildings. As heat exchange occurs in the energy pile, thermal stress and strain is generated in the pile body and surrounding ground formation. In order to investigate the thermo-mechanical behavior of an energy pile, a comprehensive experimental program was conducted, monitoring the thermal stress of a cast-in place energy pile equipped with five pairs of U-type heat exchanger pipes. The heating and cooling simulation both continued for 30 days. The thermal strain in the longitudinal direction of the energy pile was monitored for a 15 operation days and another 15 days monitoring followed, without the application of heat exchange. In addition, a finite element model was developed to simulate the thermo-mechanical behavior of the energy pile. A non-linear contact model was adopted to interpret the interaction at the pile-soil interface, and thermal-induced structure mechanics was considered to handle the thermo-mechanical coupled multi-field problem.

모바일 RFID 응용 컨텐츠 표현 언어 설계 (A Design of Language for Mobile RFID Application Contents Expression)

  • 연동희;김용운;유상근;이준섭;김형준;정회경
    • 한국정보통신학회:학술대회논문집
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    • 한국해양정보통신학회 2005년도 추계종합학술대회
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    • pp.975-978
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    • 2005
  • RFID(Radio Frequency Identification) 기술은 인식 대상에 태그를 부착하여 물리적인 접촉 없이 정보를 읽을 수 있는 비접촉식 인식 시스템으로 산업 전반에 여러 가지 응용이 가능함에 따라 많은 연구가 진행되고 있다. 최근 휴대폰에 RFID 리더를 장착하고 이동통신 산업과 연계하여 단말기 사용자에게 서비스를 제공하는 모바일 RFID 서비스가 등장하였으며, 이를 위한 응용 서비스 모델들이 제시되고 있다. 이러한 모바일 RFID 기술 기반의 응용 서비스는 제공할 데이터의 형식을 모델링하는 스키마를 필요로 한다. 이에 본 논문에서는 모바일 환경에서 서비스될 모바일 RFID 응용 서비스 모델과 프로토콜의 기능요소 및 인터패이스를 분석하여 이들 응용 서비스 모델에서 데이터를 처리하고 컨텐츠를 표현하기위한 언어를 설계하였다.

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4H-SiC기판 위에 Aerosol Deposition으로 증착된 Al2O3박막의 후열처리 효과 (Post Annealing Effect on the Characteristics of Al2O3 Thin Films Deposited by Aerosol Deposition on 4H-SiC)

  • 유수산나;강민석;김홍기;이영희;구상모
    • 한국전기전자재료학회논문지
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    • 제27권8호
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    • pp.486-490
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    • 2014
  • $Al_2O_3$ films on silicon carbide were fabricated by Aerosol deposition with annealing temperature at $800^{\circ}C$ and $1,000^{\circ}C$. The effect of thermal treatment on physical properties of $Al_2O_3$ thin films has been investigated by XRD (X-ray diffraction), AFM (atomic force microscope), SEM (scanning electron microscope), and AES (auger electron spectroscopy). Also electrical properties have been investigated by Keithley 4,200 semiconductor parameter analyzer to explain the interface trapped charge density ($D_{it}$), flatband voltage ($V_{FB}$) and leakage current ($I_o$). $Al_2O_3$ films become crystallized with increasing temperature by calculating full width at half maximum (FWHM) of diffraction peaks, also surface morphology is observed by topography measurement in non-contact mode AFM. $D_{it}$ was $2.26{\times}10^{-12}eV^{-1}.cm^{-2}$ at $800^{\circ}C$ annealed sample, which is the lowest value in all samples. Also the sample annealed at $800^{\circ}C$ has the lowest leakage current of $4.89{\times}10^{-13}A$.

WPF/E를 활용한 효율적인 콘텐츠 제작 방법 연구 (Study on Effective contents Implementation Method that Make use of WPF/E)

  • 오경숙;류남훈;한재정;김응곤
    • 한국콘텐츠학회:학술대회논문집
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    • 한국콘텐츠학회 2008년도 춘계 종합학술대회 논문집
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    • pp.658-662
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    • 2008
  • 기존에는 다양한 경로를 통해 얻은 데이터의 분석이 숫자, 문자의 표현이나 2차원 형태로도 충분했었다. 그러나 오늘날의 사용자들은 컴퓨터 그래픽스 기술의 발달로 인해 다양한 형태의 사용자 인터페이스를 접하게 되었고, 이로 인해 요구사항은 갈수록 증가하고 있는 추세이다. 초기의 프로그램은 데이터 분석을 위한 기능적인 측면에 중점을 두었으나 오늘날의 사용자들은 시각적, 감성적 느낌을 충족시킬 수 있으며, 즉각적인 분석이 가능한 화면을 요구하고 있다. 본 논문에서는 2차원, 3차원 형태의 그래프, 소리, 애니메이션 등 다양한 형태의 멀티미디어 데이터 구현이 가능한 WPF/E에 대해 알아보고, 이를 활용한 효율적인 콘텐츠 제작 방법을 제시하고자 한다.

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현대건축에서 나타나는 복합적 외피의 표현적 특성에 관한 연구 - 헤르조그 & 드 뮤론의 건축물을 중심으로 - (The Study on the Expressive Characteristics of Complex Surface in Contemporary Architecture - focused on of Herzog & de Meuron's Architecture -)

  • 김정곤
    • 한국실내디자인학회논문집
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    • 제21권5호
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    • pp.3-11
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    • 2012
  • The first visual contact in architecture happens in surface, and it could be significant object as well as the starting point to recognize the essence and perceive the buildings. Architecture surface could not get out of the restriction of structures and materials that support buildings for a long time in the past. Architecture surface in the past should fulfill the structural role to form are appearance of buildings and support buildings at the same time, so it was difficult to get out of logic for material and thickness of walls, arrangements and sizes of windows. However, since the modern age, architecture surface came to be freer according to the development of building technology, and development of technology changes shows tendencies to express role of new design factor as an architectural element emphasized expression and autonomy,s which was escaped from the subordinate relationship that the surface of building must do the structural function. In this study, it would be examined the expressive characteristics of various epidermis that are expressed in architecture of Herzog & de Meuron since the end of 20thcentury focused on comprehended and analyzed results of changes and characteristics of contemporary society. Through this, it would be comprehended the epidermis of architecture that has particular character expressed in modern buildings of Herzog & de Meuron, and it would be composed a certain linkage between this and characteristics of contemporary society and it would be investigated that the establishing process of inner spaces. Identification through case analysis for this would perform a role of catalyst for the new possibility and development of contemporary architecture's surface expression in the future.

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내열성 불소수지 코팅막의 열 안정성에 관한 연구 (Investigation into the Thermal Stability of Fluoropolymer Coating for Heat-Resistant Application)

  • 조혜진;류주환;변두진;최길영
    • 폴리머
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    • 제29권1호
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    • pp.96-101
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    • 2005
  • PTFE 및 PFA 등의 불소수지는 최대 연속 사용 온도가 260$^{\circ}C$에 달하는 고온 내열성 고분자 소재로서, 본 연구에서 수행된 280 $^{\circ}C$, 7주 간의 열노화에 의해서도 충분한 열적 안정성이 유지됨을 관측하였다. 그러나 기계적 강도, 융점 및 열분해 개시 온도 등의 소재적 물성이 유지됨을 의미하는 상기한 열적 안정성은 본 연구에서 수행된 코팅막으로서의 표면접촉각, 미세 모폴로지, 내스크래치성 분석에 의한 방법을 기준하면 충분하지 못하다는 것이 확인 되었다. 공기 치환율이 제어되는 기어식 노화시험기로 진행된 불소수지 코팅막의 280 $^{\circ}C$ 열노화에 대한 분석의 결과는 심각한 표면 모폴로지의 손상과 금속기재에 대한 접착력의 손실을 지적하고 있다.