• Journal of Periodontal and Implant Science
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• 제49권6호
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• pp.382-396
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• 2019

Purpose: The purpose of this study was to elucidate the efficacy and safety of carbonate apatite (CO₃Ap) granules in 2-stage sinus floor augmentation through the radiographic and histomorphometric assessment of bone biopsy specimens. Methods: Two-stage sinus floor augmentation was performed on 13 patients with a total of 17 implants. Radiographic assessment using panoramic radiographs was performed immediately after augmentation and was also performed 2 additional times, at 7±2 months and 18±2 months post-augmentation, respectively. Bone biopsy specimens taken from planned implant placement sites underwent micro-computed tomography, after which histological sections were prepared. Results: Postoperative healing of the sinus floor augmentation was uneventful in all cases. The mean preoperative residual bone height was 3.5±1.3 mm, and this was increased to 13.3±1.7 mm by augmentation with the CO₃Ap granules. The mean height of the augmented site had decreased to 10.7±1.9 mm by 7±2 months after augmentation; however, implants with lengths in the range of 6.5 to 11.5 mm could still be placed. The mean height of the augmented site had decreased to 9.6±1.4 mm by 18±2 months post-augmentation. No implant failure or complications were observed. Few inflammatory cells or foreign body giant cells were observed in the bone biopsy specimens. Although there were individual differences in the amount of new bone detected, new bone was observed to be in direct contact with the CO₃Ap granules in all cases, without an intermediate layer of fibrous tissue. The amounts of bone and residual CO₃Ap were 33.8%±15.1% and 15.3%±11.9%, respectively. Conclusions: In this first demonstration, low-crystalline CO₃Ap granules showed excellent biocompatibility, and bone biopsy showed them to be replaced with bone in humans. CO₃Ap granules are a useful and safe bone substitute for two-stage sinus floor augmentation.

• Composites Research
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• 제29권6호
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• pp.408-413
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• 2016

흔히 사용되는 고분자는 다양한 형태로 제조되고 있다. 더 나아가, 나일론, 아라미드와 같은 연속적인 고분자 섬유가 최근에 제조되고 있다. 이번 실험에서 에폭시를 이용하여 고분자 섬유를 제조하였다. 비스페놀-A 타입의 에폭시가 사용되었고, 아민계 및 산 무수물계 경화제가 사용되었다. 에폭시 형상을 유지하기 위해 단계적 승온방식을 이용하여 에폭시 섬유를 경화했다. 계면접착력을 확인하기 위하여 두 섬유에 대한 상대적인 표면에너지를 수정된 정적 접촉각 방식으로 확인하였다. 인장실험을 통하여 기계적인 실험을 실시하였다. 인장실험 후에 파단형태가 경화제에 따라 달라지는 것을 확인하였다. 아민계 경화제를 사용한 에폭시 섬유의 경우 인장강도가 183 MPa로 70 MPa인 산 무수물계 경화제를 사용한 에폭시를 사용한 에폭시 섬유보다 더 좋은 것을 확인하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6491-6496
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• 2012

Background: The influence of parental socio-economic status on childhood cancer treatment outcome in low-income countries has not been sufficiently investigated. Our study examined this influence and explored parental experiences during cancer treatment of their children in an Indonesian academic hospital. Materials and Methods: Medical charts of 145 children diagnosed with cancer between 1999 and 2009 were reviewed retrospectively. From October 2011 until January 2012, 40 caretakers were interviewed using semi-structured questionnaires. Results: Of all patients, 48% abandoned treatment, 34% experienced death, 9% had progressive/relapsed disease, and 9% overall event-free survival. Prosperous patients had better treatment outcome than poor patients (P<0.0001). Odds-ratio for treatment abandonment was 3.3 (95%CI: 1.4-8.1, p=0.006) for poor versus prosperous patients. Parents often believed that their child's health was beyond doctor control and determined by luck, fate or God (55%). Causes of cancer were thought to be destiny (35%) or God's punishment (23%). Alternative treatment could (18%) or might (50%) cure cancer. Most parents (95%) would like more information about cancer and treatment. More contact with doctors was desired (98%). Income decreased during treatment (55%). Parents lost employment (48% fathers, 10% mothers), most of whom stated this loss was caused by their child's cancer (84% fathers, 100% mothers). Loss of income led to financial difficulties (63%) and debts (55%). Conclusions: Treatment abandonment was most important reason for treatment failure. Treatment outcome was determined by parental socio-economic status. Childhood cancer survival could improve if financial constraints and provision of information and guidance are better addressed.

• Journal of Periodontal and Implant Science
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• 제32권3호
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• pp.615-630
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• 2002

Various long-term studies have shown that titanium implants as abutments for different types of prostheses have become a predictable adjunct in the treatment of partially or fully edentulous patients. The continuous exposure of dental implants to the oral cavity with all its possible contaminants creates a problem. A lack of attachment, together with or caused by bacterial insult, may lead to peri-implantitis and eventual implant failure. Removal of plaque and calculus deposits from dental titanium implants with procedures and instruments originally made for cleaning natural teeth or roots may cause major alterations of the delicate titanium oxide layer. Therefore, the ultimate goal of a cleaning procedure should be to remove the contaminants and restore the elemental composition of the surface oxide without changing the surface topography and harming the surrounding tissues. Among many chemical and mechanical procedure, air-powder abrasive have been known to be most effective for cleaning and detoxification of implant surface. Most of published studies show that the dental laser may be useful in the treatment of pen-implantitis. $CO_2$ laser and Soft Diode laser were reported to kill bacteria of implant surface. The purpose of this study was to obtain clinical guide by application these laser to implant surface by means of Non-contact Surface profilometer and X-ray photoelectron spectroscopy(XPS) with respect to surface roughness and atomic composition. Experimental rough pure titanium cylinder models were fabricated. All of them was air-powder abraded for 1 minute and they were named control group. And then, the $CO_2$ laser treatment under dry, hydrogen peroxide and wet condition or the Soft Diode laser treatment under Toluidine blue O solution condition was performed on the each of the control models. The results were as follows: 1. Mean Surface roughness(Ra) of all experimental group was decreased than that of control group. But it wasn't statistically significant. 2. XPS analysis showed that in the all experimental group, titanium level were decreased, when compared with control group. 3. XPS analysis showed that the level of oxygen in the experimental group 1, 3($CO_2$ laser treatment under dry and wet condition) and 4(Soft Diode laser was used under toluidine blue O solution) were decreased, when compared with control group. 4. XPS analysis showed that the atomic composition of experimental group 2($CO_2$ laser treatment under hydrogen peroxide) was to be closest to that of control group than the other experimental group. From the result of this study, this may be concluded. Following air-powder abrasive treatment, the $CO_2$ laser in safe d-pulse mode and the Soft Diode laser used with photosensitizer would not change rough titanium surface roughness. Especially, $CO_2$ laser treatment under hydrogen peroxide gave the best results from elemental points of view, and can be used safely to treat peri-implantitis.

• 대한토목학회논문집
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• 제37권5호
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• pp.787-799
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• 2017

저수지 제체 내 수로 구조물과 흙 접촉면의 장기적인 누수가 제체 파괴의 주원인 중의 하나 임에도 불구하고 이에 대한 연구는 미미한 실정이다. 배수통관과 같은 구조물이 부분 파손되어 누수가 발생하는 경우 외형적으로 관측하기 곤란하고 파이핑 등에 의한 제체 손상 우려가 있어 이에 대한 연구가 필요하다. 본 연구는 저수지 제체를 관통하는 배수 통관이 부등침하 등으로 인해 통관 일부가 파손되어 누수가 발생하는 경우 저수지의 제체 형태를 코어형 단면과 균일형 단면으로 구분하여 수위변화에 따른 2차원 침투해석을 수행하였다. 연구결과 저수지 등의 제체를 관통하는 배수 통관으로의 누수가 발생 할 경우 통관 하부보다는 상부가 파손되어 누수가 되는 경우가 파이핑 발생 가능성이 크며, 특히 제체 하류측에서 누수가 발생하는 경우 제체 중심 코어부의 존재는 제체 안정 유지에 도움을 주고 있다고 판단된다. 또한 저수지 제체 내부 간극수압의 급격한 감소가 관측되면 파이핑 발생 우려에 대한 심도 있는 고려가 필요할 것으로 사료된다.

• Clinics in Shoulder and Elbow
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• 제9권1호
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• pp.89-95
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• 2006

Purpose: Arthroscopic repair of rotator cuff tears are many techniques that have been developed to improve the initial postoperative strength of the repair. There was a doubt that current arthroscopic cuff repairs using a single row of suture anchors reproduce insufficient area of the anatomic cuff insertion, and concerns about failure of fixation often lead surgeons to limit early motion. Newer technique of double-row repair in arthroscopic treatment may provide initial stronger fixation and more contact with bone at the repair site than single-row repair did. We studied the comparison between clinical outcomes of arthroscopic single- and double-row repair in cuff tears at 1year postoperatively. Materials and methods: We retrospectively analyzed 40 shoulders with single-row repair and 38 shoulders with double-row repair of full-thickness rotator cuff tears between May 2002 and October 2004. Out of total 78 shoulders, 42 (54%) were male patients and 36 (46%) were female patients and the mean age at surgery was 56 years. All patients were diagnosed by physical examination and MRI. At 1year' follow-up after operation, we evaluated with the ASES and the Constant scoring system, and measured muscle power of abduction, internal and external rotation of the affected shoulder then compared with each other. Results: Mean ASES scores and Constant scores in double-row repair group improved more than single-row repair group significantly at 1year postoperatively. Muscle power of abduction and internal rotation, especially abduction power, improved more significantly in double-row repair group than in single-row repair. Conclusion: Arthroscopic double-row repair for the full thickness rotator cuff tear may be a superior technique, which showed better clinical outcomes and restoration of muscle power compared with single-row repair at relatively short period of postoperative follow-up. Restoration of footprint close to normal anatomy by double-row repair seems to play an important role in the recovery of muscle strength.

• 공업화학
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• 제23권3호
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• pp.313-319
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• 2012

본 연구에서는 Polyacrylonitrile (PAN)계 탄소섬유 표면에 구리도금 표면처리가 탄소섬유 강화 복합재료의 기계적 계면 특성에 미치는 영향에 관하여 관찰하였다. 탄소섬유 표면특성은 주사전자현미경, X-선 광전자 분광법, X-선 회절분석기, 접촉각 측정기로 측정하였고, 탄소섬유 강화 복합재료의 기계적 계면 물성은 층간전단강도(interlaminar shear strength, ILSS)와 파괴인성(critical stress intensity factor, $K_{IC}$)측정을 통하여 알아보았다. 실험결과로부터, 기계적 계면물성은 탄소섬유 표면에 COOH group과 도금된 구리함량이 증가됨에 따라 순차적으로 증가되는 것이 확인되었으나, 도금시간을 길게 하여 과량의 구리가 도입되었을 경우 기계적 계면 물성을 도리어 감소시키는 것으로 확인되었다. 결론적으로 구리함량이 탄소섬유 복합재료의 기계적 계면물성을 결정하는 중요 요소라 판단되나, 최적의 함량이상에서는 계면분리에 의한 물성저하의 원인이 될 수 있다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제29권5호
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• pp.383-393
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• 2007

The aim of the present study is to investigate the effect of anodized surface of osseointegration implants by using of resonance frequency analysis (RFA) and histomorphometric analysis. A total of 96 screw-shaped implants were devided into 4 groups. Seventy-two implants were prepared by electrochemical oxidation with 3 different ways; Group 1 (n=24) were prepared at galvanostatic mode in 0.25M sulfuric acid and phosphoric acid, Group 2 (n=24) were prepared at galvanostatic mode in calcium glycerophosphate and calcium acetate, and Group 3 (n=24) were prepared at galvanostatic mode in 0.25M sulfuric acid and phosphoric acid followed by Calcium metaphosphate(CMP) coating. Control group (n=24) were the RBM surfaced implants. The implants were placed in the mandibles of 12 mini pigs. Bone tissue responses were evaluated by resonance frequency analysis(RFA) and histomorphometric analysis that were undertaken at 2, 4 and 6weeks after implant placement. The following result were obtained. 1. Twenty-two of 96 implants (4 in control group, 5 in group 1, 7 in group 2, and 6 in group 3) were failed due to faliure of osseoitegration. The failure rate of osseointegration was 22.9%. 2. The mean values of RFA in control, group 2 and groups 3 showed the similar values, but there was no significant difference among groups. 3. Histomorphometric evaluation demonstrated significantly higher bone-to-implant contact ratio in group 2 at 3 and 4 weeks after implant placement than other groups (p<0.05), but there was no significant difference among groups at 6weeks after implant placement.

• 콘크리트학회논문집
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• 제20권2호
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• pp.147-156
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• 2008

콘크리트의 일축압축실험에서 축하중이 발생함에 따라 새로운 균열이 발생하고 이 균열의 확장이 파괴의 주된 원인이 되는 경우가 대부분인데 이는 입자 결합 모델에서 입자간의 결합이 파괴되어 해석 대상체의 균열 모사와 유사하게 해석될 수 있어 콘크리트의 표준 공시체에 대하여 일축압축실험의 모사 가능성을 연구하였다. 그러나 입자 결합 모델은 해석 대상체를 입자간의 집합체로 모사하기 때문에 입자간의 결합을 결정하는 미시변수에 의해서 해석 대상의 거시물성이 변하게 되어 이들 변수간의 정량적인 관계를 파악하는 것이 중요하다. 본 연구에서 사용된 접촉 결합 모델에서는 총 8개의 미시변수가 있어 이들 변수와 일축압축실험결과 나오는 거시물성-탄성계수, 일축압축강도, 포아송비-와 콘크리트의 압축파괴거동에 관련이 있는 균열 개시 응력과 일축압축강도와의 비로서 5개의 거시물성에 대하여 부분배치법 및 회귀분석을 통하여 이들 간의 정량적인 관계를 도출하였고 그 결과 일축압축강도를 가정한 가상시료 및 조사 자료로부터 얻은 일축압축강도를 비교적 잘 모사할 수 있었다. 또한 해석을 수행한 공시체의 응력-변형률 곡선이나 응력 수준별 균열 발생의 빈도 및 파괴거동을 관찰한 결과 일반적인 콘크리트의 일축압축하중 하에서의 파괴거동과 상당부분 유사함을 보여 입자 결합 모델을 이용하여 콘크리트 공시체에 대한 일축압축실험을 잘 모사할 수 있다고 본다.

• Archives of Plastic Surgery
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• 제36권5호
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• pp.578-582
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• 2009

Purpose: In extensive deep burn of the lower limb, due to less amount of soft tissue, bone is easily exposed. When it happens, natural healing or reconstruction with skin graft only is not easy. Local flap is difficult to success, because adjacent skins are burnt or skin grafted tissues. Muscle flap or free flap are also limited and has high failure rate due to deep tissue damage. The authors acquired good outcome by performing one - stage operation on bone exposed soft tissue defect with AlloDerm$^{(R)}$(LifeCell, USA), an acellular dermal matrix producted from cadaveric skin. Methods: We studied 14 bone exposed soft tissue defect patients from March 2002 to March 2009. Average age, sex, cause of burn, location of wound, duration of admission period, and postoperative complications were studied. We removed bony cortex with burring, until conforming pinpoint bone bleeding. Then rehydrated AlloDerm$^{(R)}$(25 / 1000 inches, meshed type) was applicated on wound, and thin split thickness(6 ~ 8 / 1000 inches) skin graft was done at the immediately same operative time. Results: Average age of patients was 53.6 years(25 years ~ 80 years, SD = 16.8), and 13 patients were male(male : female = 13 : 1). Flame burn was the largest number. (Flame burn 6, electric burn 3, contact burn 4, and scalding burn 1). Tibia(8) was the most affected site. (tibia 8, toe 4, malleolus 1, and metatarsal bone 1). Thin STSC with AlloDerm$^{(R)}$ took without additional surgery in 12 of 14 patients. Partial graft loss was shown on four cases. Two cases were small in size under $1{\times}1cm$, easily healed with simple dressing, and other two cases needed additional surgery. But in case of additional surgery, granulation tissue has easily formed, and simple patch graft on AlloDerm$^{(R)}$ was enough. Average duration of admission period of patients without additional surgery was 15 days(13 ~ 19 days). Conclusion: AlloDerm$^{(R)}$ and thin split thickness skin graft give us an advantage in short surgery time and less limitations in donor site than flap surgery. Postoperative scar is less than in conventional skin graft because of more firm restoration of dermal structure with AlloDerm$^{(R)}$. We propose that AlloDerm$^{(R)}$ and thin split thickness skin graft could be a solution to bone exposured soft tissue defects in extensive deep burned patients on lower extremities, especially when adjacent tissue cannot be used for flap due to extensive burn.