• 사상체질의학회지
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• 제24권4호
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• pp.75-83
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• 2012

Objectives : Although Yeoldahanso-tang (YDHST) has been widely used for treatment of obesity and its related diseases such as hyperinsulinemia and hypertension for Taeeumin, no scientific evidence has reported yet to support its ability to work against these metabolic disorders. Our study was aimed to investigate the anti-obesity effect of YDHST extract on the cellular differentiation of 3T3-L1 preadipocytes into adipocytes. Methods : 3T3-L1 preadipocytes were differentiated into adipocytes by adding insulin, dexamethasone and 3-isobutyl-1-methylxanthine (IBMX) for 8 days in the absence or presence of YDHST extract. Anti-obesity effects of YDHST extract were evaluated by Oil Red O staining, glycerol-3-phosphate dehydrogenase (GPDH) activity, triglyceride contents, and leptin production. Results : YDHST extract remarkably prevented lipid accumulation with no cytotoxicity in the differentiated 3T3-L1 cells. In addition, YDHST extract decreased contents of triglyceride 3T3-L1 adipocytes. Consistently, YDHST extract caused a significant inhibition of GPDH activity and leptin production in a dose-dependent manner. Conclusions : Our findings suggest that Sasang constitutional herbal formula YDHST for Tae-eumin has anti-obesity activity by regulation of the adipogenesis process in vitro. Additional study will be required to further confirm the inhibitory effect on adipocyte differentiation by using in vivo animal model.

• 사상체질의학회지
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• 제9권1호
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• pp.213-243
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• 1997

After studying about the formative process and theory concerning So-Yang In(少陽人)'s prescriptions, Some principles were founded. Those were summarized as follows. 1. Lee Jae Ma(李濟馬) established the theory and remedy about the So Yang In's diseases, and the formation of So Yang In's prescriptions was based on those theories and remedies 2. As the emprical prescription of So Yang In's diseases, ten pre-scriptions of Discussion of Cold-Induced Disorder(傷寒論) and nine of Won Myung dynasty period(元明時代) were described in Dong Eui Su-Se Bo Won(東醫壽世保元), and I could confirm that the formation of So Yang In's presciptions was based on those emprical prescriptions. 3. The pathological characteristics of emprical prescriptions of So-Yang In's diseases in Discussion of Cold-Induced Disorder(傷寒論) were completely corresponded with the principle of So Yang In's diseases, and we could know that emprical presciptions of diseases that were the base of So Yang In's prescriptions were selected by the principle of So Yang In's diseases. 4. In the serious cases of So Yang In's diseases, So Yang In's pre-scriptions were mostly made up of tonifying and nourishing yin medicine(補陰藥物) that dirrectly rufill the damaged Eum Chung Zi Ki(陰淸之氣). According to the above results, it could be concluded that Lee Jae-Ma(李濟馬) made So Yang In's prescriptions with emprical pre scri-ptions that were based on the theory of So Yang In's diseases and concluded that So Yang In's prescriptions were made up of tonifying and nourishing yin medicine(補陰藥物) in the serious cases of diseases.

• 사상체질의학회지
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• 제19권2호
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• pp.11-21
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• 2007

1. Objectives The object of this thesis is to find the basis on why Jejo was assigned as a Taeumin medicine, and to understand Taeumin edema. 2. Methods ${\ulcorner}$Dongyisusebowon${\lrcorner}$ 'Shinchukbon', 'Gabobon', 'Chobonkwun', other related Sasang Constitutional Medicine(SCM) books, herbal medicine books such as ${\ulcorner}$Bonchokangmok${\lrcorner}$, and etc. were compared and researched. 3. Results & Conclusions (1) In Sasang Constitutional Medicine, edema is seen as a critical condition. The first cause of edema in Taeumin is fatigue, a condition where the flow of Qi and Fluid Qi is stagnated. Secondly, edema is caused as Taeeumin is mentally stressed(勞心焦思) and he/she is unable to accomplish his/her plans over many trials or as when they find pleasure in striving for greed. When Lungs which is Incline & Small Viscera(偏小之臟) in Taeumin decreases, it diminishes Real Count of Longevity(命脈實數) which leads to edema formation. (2) Perspective of Human Nature & Character(心性學) and Regimen(養生法) became included gradually in the treatment methods and prescription of edema in Taeumin as ${\ulcorner}$Dongyisusebowon${\lrcorner}$ was revised over time. The revisions also lead to more diversity in prescriptions. (3) Jejo didn't appear In ${\ulcorner}$Dongyisusebowon${\lrcorner}$ 'Chobonkwun' and 'Gabobon'. It was first presented in 'Shinchukbon' as a medicine to treat edema in Taeumin. (4) Jejo have effects of easing clumps. Also it has a strong radiating ability(發散力) which induces perspiration to treat diseases. Finally Jejo is used to remove Takki(濁氣) by utilizing powerful Exhale Gathering Qi contained in it.

• 사상체질의학회지
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• 제13권2호
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• pp.194-204
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• 2001

Purpose: In general, Acute Pyelonephritis is effectively treated with the use of antibiotics. However, some antibiotics are reported to cause side effects, and the abuse of antibiotics results in the increase of the disease's tolerance to antibiotics. Recently, I have effectively treated five cases of Acute Pyelonephritis by using only Constitution - Acupuncture and Herb, and therefore I would like to report about these cases. Methods: I diagnosed Acute Pyelonephritis of these five patients by confirming symptoms and employing a urine analysis with reagent strip(Multi $stix{\circledR}$). I used Kuon's method of constitutional diagnosis for the purpose of the diagnosis of the constitutional 8 morbidities. I relied on Sungjeong(性情) and Chehyungkisang(體刑氣像) in diagnosing Sasang Constitutions(四象人). I performed acupuncture on the left and right sides, depending on 8 constitutions, by employing Chang - temperament Inflammation Formula(臟系炎症方) that is used for the treatment of all kinds of chang-temperament inflammation diseases, as well as Bactericidal Formula(殺菌方) that is used for the treatment of all kinds of bacterially caused diseases. I prescribed by consulting the appearance of disease and general symptoms of each case with Dongyi Soose Bowon(東醫壽世保元)'s prescription symptoms. Result: Two of them showing severe symptoms were hospitalized, while three others took OPD treatment. The patient who was PANCREOTONIA and Soyangin improved through hospitalization for three days, another patient who was PULMOTONIA and Taeyangin with severe symptoms, improved through hospitalization for seven days, and completely recovered through OPD treatment later. The three others took only OPD treatment, and improved within 5-7 days. Conclusion: I confirmed that each of 8-constituions and Sasang Constitutions were all treated effectively without antibiotics.

• 사상체질의학회지
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• 제16권2호
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• pp.84-98
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• 2004

1. Objectives Yangkyuksanhwa-tang is used mush in pruritus and dermatopathy of Soyangin. It is suggested this prescription is effective on atopy dermatitis. 2. Methods For observation of Yangkyuksanhwa-tang effected to atopic dermatitis, extract of Yangkyuksanhwa-tang has been dispensed to the stratum corneum of epithelium in dermatome of murine after making damage to its defense mechanism against fat and causing atopic dermatitis artificially. After that, the change in outer dermatome and minute mechanism of epidermis, the change of eosinophil, the change in distribution of soybean agglutinin, the change in distribution of fat and ceramide in stratum corneum, the change in inflammation in dermatome, the change of cell accrementition and apoptosis, and the effect on anaphylaxis and Staphylococcus aureus was observed. 3. Results After administration of Yangkyuksanhwa-tang, severe skin damage such as eczema and psoriasis, that was observed in the case of atopy dermatitis, was decreased and the increase of eosinophil in serum was suppressed. Lipid lamella was recovered, so epidermal demage was relieved. The distribution of HSP70 in the outer skin was decreased. Yangkyuksanhwa-tang suppressed activation of $NF-_{\kappa}B$ p50, induced CD11/18b not to be generated, and suppressed inflammatory response of skin. Anaphylaxis and groth of Staphylococcus aureus was suppressed. 4. Conclusions Yangkyuksanhwa-tang decreased skin damage of atopy dermatitis. It has antibiosis about Staphylococcus aureus, it can be medicinal substances on atopy dermatitis. In addition, it is possible that it can be medicinal substances on regional skin allergy.

• 사상체질의학회지
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• 제14권2호
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• pp.1-9
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• 2002

I think that the study on the ${\ulcorner}$DongMuSunSaSaSangYakSungSangHumGoGa${\lrcorner}$ of ${\ulcorner}$DongMuYooGo${\lrcorner}$ is basic material explaining the character of sasang-herb and prescription. Through the study on the ${\ulcorner}$DongMuSunSaSaSangYakSungSangHumGoGa${\lrcorner}$'s origin and meaning, I can take the result as follows. The first, that is composed of total 237 herbs of 90 spleen-herb (Soeumin-herb), 61 kidney-herb (Soyangin-herb), 67 lung-herb (Taeeumin-herb) and 19 liver-herb (Taeyangin-herb). The second, the origin of that is ${\ulcorner}$JeJungSinPyun${\lrcorner}$, ${\ulcorner}$BangYakHapPyun${\lrcorner}$ and ${\ulcorner}$EuiHakIpMum${\lrcorner}$. And DongMu classified traditional YakSungGa as spleen-herb, kidney-herb, lung-herb and liver-herb which is suitable to Sasangin, not created that. So we can know that the first understanding for DongMu' s herb is focused on the traditional YakSungGa. The third, DongMu's unique terminology of spleen-herb, kidney-herb, lung-herb and liver herb show his sight of symptom, disease and pharmacology, that is focused on small JangBu. The forth, through herb-nature gathered from traditional YakSungGa, that purposed to classfying each constitutional herb. So we can know his idea that the choice of herb is not in general efficacy but in personal constitution. As mentioned abovet, that can refer to an herbal argument of DongMu and ${\ulcorner}$DongMuYooGoYakSungGa${\lrcorner}$ that make known to be common can refer to an prescriptional argument of DongMu.

• 사상체질의학회지
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• 제11권1호
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• pp.63-77
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• 1999

1. 연구목적 : '연변조선족민족의약연구회(延邊朝鮮族民族醫藥硏究會)'에서 1984년에 영인한 "동의수세보원사상초본권(東醫壽世保元四象草本卷)"의 필사본(筆寫本)은 여러 정황과 글의 내용으로 보아 동무(東武) 이제마(李濟馬)의 글로 추정되며 "동의수세보원(東醫壽世保元)"저술 이전의 초기 저작과 같은 글임을 확인할 수 있어 이를 밝히고자 하였다. 이 논고는 문헌의 내용을 언급하기 이전에 반드시 선행이 되어야 할 서지학적(書誌學的)인 고찰과 문헌 연구의 일환이다. 2. 연구방법 : 문헌 제공자인 손영석(孫永錫)의 진술 내용과 문염(文厭)의 내용을 중심으로 "동의수세보원사상초본권(東醫壽世保元四象草本卷)"이 "동의수세보원(東醫壽世保元)" 내용으로 발전 과정과 개념 및 병증약리(病證藥理)의 변화를 문헌적 고찰을 통해 살펴보았다. 또한 동무공의 기타 저술과 비교하여 저술 시기를 추정해 보았다. 3. 연구 결과 및 결론 : 이상의 연구에서 얻은 결론은 아래와 같다. 1) "동의수세보원사상초본권(東醫壽世保元四象草本卷)"은 함흥의 최겸강(崔謙鋼)이 소장하던 것을 김구익(金九翌)이 수초(手抄)하여 1984년 필사본(筆寫本)이 영인(影印)되었고 1985년 10월 연변조선족자치주민족의약연구소(延邊朝鮮族自治州民族醫藥硏究所)에서 발간한 "조의학(朝醫學)" 제1편(第一冊) 사상의학론(四象醫學論)에서 부록으로 '사상의학초본권(四象醫學草本卷)'이라는 제목으로 출판되었다. 2) "동의수세보원사상초본권(東醫壽世保元四象草本卷)"은 그 편제에서 "동의수세보원(東醫壽世保元)"의 내용이 각 편마다 함축되어 있고 권지삼(卷之三)의 태양인약방(太陽人藥方)에서 동무공(東武公) 자신이 태양인(太陽人)임과 태양인(太陽人)의 병증약리(病證藥理)를 성립하게 되는 과정을 서술하고 있어 동무공(束武公)의 저술임을 확인할 수 있다. 3) "권지삼약방(卷之三藥方)"에서 "동의수세보원(東醫壽世保元)" 신정방(新定方)의 기원이 되는 처방을 확인할 수 있으며 대표적으로 "소음약방(少陰藥方)"의 반강탕(半薑湯)은 계지반하생강탕(桂枝半夏生薑湯)으로 "태음약방(太陰藥方)"의 구미천문동탕(九味天門冬湯)은 청심운자탕(淸心運子湯)으로 발전한 것으로 추정된다. 4) "권지삼약방(卷之三藥方)"을 통해 태소음양인(太小陰陽人)의 병증약리(病證藥理)의 성립 과정을 알 수 있으며 소양인(少陽人)의 병증약리(病證藥理)가 비교적 초기에 완성되고 태음인(太陰人) 병증약리(病證藥理)가 완성되고 소음인(少陰人)의 병증약리(病證藥理)는 증치의학(證治醫學)의 처방을 이용하다 비교적 후기에 완성되었음을 확인할 수 있다. 5) "동의수세보원사상초본권(東醫壽世保元四象草本卷)" 권지일(卷之一)의 지(知)와 행(行)에 대한 인식은 "성명론(性命論)"의 사고와는 달리 비교적 정제되지 않은 상태이며 "격치고(格致藁)" "유약(儒略)"과 "반성잠(反誠箴)"의 사고와 유사함을 볼 수 있다. 6) "동의수세보원사상초본권(東醫壽世保元四象草本卷)"의 저술시기는 "동무유고(東武遺稿)" 약성가(藥性歌)나 39세 망음증(亡陰證) 치험례 이후이며 저술로 "격치고(格致藁)" "유약(儒略)" "반성잠(反誠箴)" 저술 전이나 저술 당시로 추정되어 40대 후반과 50대 초반 사이의 저술로 추정된다.

• 사상체질의학회지
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• 제12권2호
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• pp.162-170
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• 2000

Purpose : Studies on the Regulatory Effect of Cytokine Production in Taumin Patients with Cerebral Infarction by Cheongsimyeonjatang Method : ELISA(enzyme-linked immuno-sorbent assay) Result : Chungsimyeunjatang(CYT) is a prescription for the cerebral infarction (CI) patients of Taeumin according to Sasang constitution philosophy. Taeumin patients with CI were treated with CYT during the acute stage. Clinical signs of CI disappeared markedly in about two to four weeks after oral administration of CYT in all patients. The mean interleukin (IL)-2 plasma levels were slightly lower in the patients with CI than in the normal groups, whereas the mean IL-4, IL-6 and IgE levels were significantly higher in the patients. There were no significant differences in $interferon-{\gamma}$ $(IFN-{\gamma})$ levels between the groups. Serum $IFN-{\gamma}$ and IL-2 levels derived from T helper (Th)1 cells were elevated significantly in the patients with CI by CYT administration. Significant reduced plasma levels of IL-4 and IL-6 derived from Th2 cells and IgE were observed in the patients treated with CYT. During the period of CYT administration, there were no other adverse effects. The data indicate that CYT has a good CI treatment effect, and that its action may be due to regulation of cytokine Production.

• 사상체질의학회지
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• 제12권2호
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• pp.153-161
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• 2000

1. Purpose This studies the regulatory effect of cytokine production in Soyangin patients with cerebral infarction by Yangkyuksanhwatang. 2 Method ELISA 3. Result & Conclusion Yangkyuksanhwatang(YST) is a prescription for the cerebral infarction (CI) patients of Soyangin according to Sasang constitution philosophy. Soyangin patients with CI were treated with YST during the acute stage. Clinical signs of CI disappeared markedly in about 2 to 4 weeks after oral administration of YST in all patients. The mean interleukin (IL)-2 plasma levels were slightly lower in the patients with CI than in the normal groups, whereas the mean IL-4, IL-6 and IgE levels were significantly higher in the patients. There were no significant differences in interferon- ${\gamma}$ (IFN- ${\gamma}$ ) levels between the groups. Serum IFN- ${\gamma}$ and IL-2 levels derived from T helper (Th)1 cells were elevated significantly in the patients with CI by YST administration. Significant reduced plasma levels of IL-4 and IL-6 derived from Th2 cells and IgE were observed in the patients treated with YST. During the period of YST administration, there were no other adverse effects. The data indicate that YST has a good CI treatment effect, and that its action may be due to regulation of cytokine production.

• 사상체질의학회지
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• 제25권4호
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• pp.343-358
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• 2013

Objectives This study aimed to observe the effect of Hyangsayangwi-tang on the cisplatin-induced gastrointestinal dysfunctions in rats. Methods Four groups(each of 8 rats per group) were used in this study. Saline and distilled water treated control rats are Intact vehicle control group. Delayed gatrointestinal mortility was induced by intraperitoneal treatment of cisplatin 2mg/kg, once a week for 5 weeks(Cisplatin control group). Hyangsayangwi-tang aqueous extracts(HY) were orally administered in a volume of 5ml/kg, once a day for 14 days from 4th ciplatin treatmernt(HY group). Ondansetron 1mg/kg was subcutaneously treated, in a volume of 1ml/kg, as same as HY(ondansetron group). We measured the body weights, intestinal charcoal transit ratio, fecal parameters, fundus MDA, GSH contents and SOD, CAT activities, TPH and MAO activities, pyloric gastrin and serotonin contents with their immunoraective cells, colonic serotonin-immunoreactive cells, the histopathology of pylorus, fundus mucosa and colon. Results and Conclusions (1) The body weight gains, the small intestinal charcoal transfer rates, the fecal parameters(numbers, weights and water contents) were increased in HY, ondansetron group. (2) The inhibit of fundus antioxidant defense systems by cisplatin were decreased in HY, ondansetron group. (3) The pyloric TPH activities were increased and the pyloric MAO activities were decreased in HY group. (4) The pyloric gastric contents and the gastrin-immunoreactive cells were increased in HY group. And the pyloric serotonin contents and the pyloric and colonic serotonin-immunoreactive cells were decreased in HY group. (5) The pyloru atrophic changes and the gastric surface erosive damage regions by cisplatin were favorably inhibited by treatment of HY. HY, a representative Soeumin prescription improve GI dysfunctions and constipation retarded by cisplatin through modulations of GI enterochromaffin cells, serotonin and gastrin-producing cells and antioxidative systems. Especially HY showed the highest favorable effects more than those of ondansetron.