Journal of Sasang Constitutional Medicine (사상체질의학회지)

The Society Of Sasang Constitutional Medicine (사상체질의학회)
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Studies on the Regulatory Effect of Cytokine Production in Taumin Patients with Cerebral Infarction by Cheongsimyeonjatang

청심연자탕(淸心蓮子湯)이 태음인(太陰人) 뇌경색증(腦硬塞症) 환자(患者)의 세포활성물질(細胞活性物質) 생성조절(生成調節)에 미치는 영향(影響)

  • Kim, Kyung-Yo (Dept. of Oriental Medicine, Graduate School of Wonkwang University) ;
  • Noh, Hyun-Soo (Dept. of Oriental Medicine, Graduate School of Wonkwang University)
  • 김경요 (원광대학교 한의과대학 사상의학교실) ;
  • 노현수 (원광대학교 한의과대학 사상의학교실)
  • Published : 2000.12.31
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Abstract

Purpose : Studies on the Regulatory Effect of Cytokine Production in Taumin Patients with Cerebral Infarction by Cheongsimyeonjatang Method : ELISA(enzyme-linked immuno-sorbent assay) Result : Chungsimyeunjatang(CYT) is a prescription for the cerebral infarction (CI) patients of Taeumin according to Sasang constitution philosophy. Taeumin patients with CI were treated with CYT during the acute stage. Clinical signs of CI disappeared markedly in about two to four weeks after oral administration of CYT in all patients. The mean interleukin (IL)-2 plasma levels were slightly lower in the patients with CI than in the normal groups, whereas the mean IL-4, IL-6 and IgE levels were significantly higher in the patients. There were no significant differences in $interferon-{\gamma}$ $(IFN-{\gamma})$ levels between the groups. Serum $IFN-{\gamma}$ and IL-2 levels derived from T helper (Th)1 cells were elevated significantly in the patients with CI by CYT administration. Significant reduced plasma levels of IL-4 and IL-6 derived from Th2 cells and IgE were observed in the patients treated with CYT. During the period of CYT administration, there were no other adverse effects. The data indicate that CYT has a good CI treatment effect, and that its action may be due to regulation of cytokine Production.

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References

  1. 동의수세보원 v.4 이제마
  2. 동의사상신편 원지상
  3. 사상의학회지 v.7 no.2 난치병과 면역 그 사상의학적 접근 김경요
  4. 사상의학회지 v.9 no.1 태음인 갈근해기탕과 원지상의 갈근해기탕이 면역반응에 미치는 영향 박성식
  5. 사상의학회지 v.4 소음인 십전대보탕이 면역 반응에 미치는 영향 박성호
  6. 사상의학회지 v.10 no.2 방풍통성산 전탕액의 면역 조절 작용 이창규;송정모
  7. 사상의학원론 홍순용;이을호
  8. 사상요람 이도경
  9. 동의수세보원주석 한동석
  10. 사상의학 성리임상학 김주
  11. 사상의학회지 v.10 no.1 청심연자탕 활용에 대한 임상적 고찰 박성식
  12. 청심연자탕이 심근허혈에 미치는 영향 김남선
  13. 태음인 청심연자탕과 청폐사간탕의 면역반응과 항알러지 효과에 관한 실험적 연구 김달래
  14. 사상의학회지 v.7 no.2 태음인 청심연자탕의 항스트레스 효과에 관한 실험적 연구 홍석철;고병희;송일병
  15. 태음인 청심연자탕이 hydrogen peroxide에 손상된 백서의 대뇌 신경세포에 미치는 영향 옥윤영
  16. Immunology Letters v.61 IL-6 antisense oligonucleotides inhibit IgE production in IL-4 and anti-CD40-stimulated human B-lymphocytes Bjorck, P.;Larsson, S.;Andang, M.;Ahrlund-Richter, L.;Paulie, S.
  17. European Journal of Immunology v.20 Regulation of human IgE synthesis. I. Human IgE synthesis in vitro is determined by the reciprocal antagonistic effects of interleukin 4 and interferon-gamma Chretien, I.;Pene, J.;Briere, F.;De Waal Malefijt, R.;Rousset, F.;De Vries, J.E.
  18. Current Opinion in Immunology v.2 IgE synthesis Delespesse, G.;Sarfati, M.;Heusser, C.
  19. Journal of Immunology v.140 IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants Del Prete, G.;Maggi, E.;Parronchi, P.;Chretien, I.;Tiri, A.;Macchia, D.;Ricci, M.;Banchereau, J.;De Vries, J.;Romagnani, S.
  20. Journal of Clinical Investigation v.88 Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production Del Prete, G.F.;De Carli, M.;Mastromauro, C.;Biagiotti, R.;Macchia, D.;Falagiani, P.;Ricci, M.;Romagnani, S.
  21. Current Opinion in Immunology v.3 Regulation of IgE synthesis by cytokines de Vries, J.E.;Gauchat, J.F.;Aversa, G.G.;Punnonen, J.;Gascan, H.;Yssel, H.
  22. Annual Review of Immunolgy v.8 Lymphokine control of in vivo immunoglobulin isotype selection Finkelman, F.D.;Holmes, J.;Katona, I.M.;Urban, J.F. Jr.;Beckmann, M.P.;Park, L.S.;Schooley, K.A.;Coffman, R.L.;Mosmann, T.R.;Paul, W.E.
  23. Journal of Experimental Medicine v.168 Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients Frei, K.;Leist, T.P.;Meager, A.;Gallo, P.;Leppert, D.;Zinkernagel, R.M.;Fontana, A.
  24. Journal of Immunology v.140 Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones Gajewski, T.F.;Fitch, F.W.
  25. Clinical and Experimental Allergy v.21 no.Suppl 1 Regulation of human IgE synthesis Gascan, H.;Gauchat, J.F.;de Waal Malefyt, R.;Schneider, P.;Yssel, H.;de Vries, J.E.
  26. Proceedings of the National Academy Sciences of the United States of America v.84 Interferon Beta 2/B cell stimulatory factor type 2 shares identity with monocyte derived hepatocyte stimulating factor and regulates the major acute phase protein response in liver cells Gauldie, J.;Richards, C.;Harnish, D.;Lansdorp, P.;Baumann, H.
  27. Proceedings of the National Academy Sciences of the United States of America v.82 Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2) Hirano, T.;Taga, T.;Nakano, N.;Yasukawa, K.;Kashiwamura, S.;Shimizu, K.;Nakajima, K.;Pyun, K.H.;Kishimoto, T.
  28. Clinical and Experimental Immunology v.71 Elevated levels of the 26K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system Houssiau, F.A.;Bukasa, K.;Sindic, C.J.;Van Damme, J.;Van Snick, J.
  29. Journal of Immunology v.144 IL-4 inhibits the synthesis of IFN-gamma and induces the synthesis of IgE in human mixed lymphocyte cultures Vercelli, D.;Jabara, H.H.;Lauener, R.P.;Geha, R.S.
  30. Cell Mol Neurobiol Dec v.18 no.6 Cytokines in brain ischemia-the role of TNF alpha Feuerstein, G.;Wang, X.;Barone, F.C.
  31. J Clin Immunol Jul v.19 no.4 Intracerebral produccion of tumor necrosis factor-alpha, a local neuroprotective agent in Alzheimer disease and vascular dementia Tarkowski, E.;Blennow, K.;Tarkowski, A.
  32. Neurol Res v.21 no.3 Time course of IL-6 expression in experimental CNS ischemia Clark, W.M.;Rinker, L.G.;Lessov, N.S.;Eckenstein, F.
  33. Proceedings of the National Academy Sciences of the United States of America v.86 Regulation of immunoglobulin production in hyper immunoglobulinE recurrent-infection syndrome by interferon gamma King, C.L.;Gallin, J.I.;Malech, H.L.;Abramson, S.L.;Nutman, T.B.
  34. Journal of Neuroimmunology v.24 Brain tumors: detection of B-cell stimulatory factor-2 interleukin-6 in the absence of oligoclonal bands of immunoglobulins Leppert, D.;Frei, K.;Gallo, P.;Yasargil, M.G.;Hess, K.;Baumgartner, G.;Fontana, A.
  35. Clinical and Experimental Immunology v.85 Serum levels of soluble IL-2 receptor, IL-4 and IgE-binding factors in childhood allergic diseases Matsumoto, T.;Miike, T.;Yamaguch, K.;Murakami, M.;Kawabe, T.;Yodoi, J.
  36. Journal of Immunology v.136 Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins Mosmann, T.R.;Cherwinski, H.;Bond, M.W.;Giedlin, M.A.;Coffman, R.L.
  37. Journal of Experimental Medicine v.170 Recombinant interleukin-4 suppresses the production of interferon gamma by human mononuclear cells Peleman, R.;Wu, J.;Fargeas, C.;Delespesse, G.
  38. Immunology Today v.11 Regulation and deregulation of human IgE synthesis Romagnani, S.
  39. Lancet v.1 Reduced interferon-gamma secretion in neonates and subsequent atopy Tang, M.L.;Kemp, A.S.;Thorburn, J.;Hill, D.J.
  40. Proceedings of the National Academy Sciences of the United States of America v.86 IgE secretion by Epstein Barr virus infected purified human B lymphocytes is stim ulated by interleukin 4 and suppressed by interferon gamma Thyphronitis, G.;Tsokos, G.C.;June, C.H.;Levine, A.D.;Finkelman, F.D.
  41. Journal of Experimental Medicine v.169 Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor /CD3 complex and MHC class 11 antigens Vercelli, D.;Jabara, H.H.;Arai, K.;Geha, R.S.