• Korean Journal of Clinical Pharmacy
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• v.16 no.1
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• pp.57-62
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• 2006

The purpose of this study was to investigate the effect of naringenin, one of flavonoids, on the pharmacokinetics and bioavailability of diltiazem (15 mg/kg) after oral administration of diltiazem with or without naringenin (2.0, 10 and 20 mg/kg) in rabbits. Coadministration of naringenin increased the absorption rate constant $(K_a)$, the area under the plasma concentration-time curve (AUC) and peak concentration $(C_{max})$ of diltiazem compared to the control group, but only significantly (p<0.05) by 10mg/kg of naringenin coadministration. The absolute bioavailability (AB%) of diltiazem by coadministration ranges from 7.8% to 10.3%, increased more than control (7.2%), and relative bioavailability (RB%) of diltiazem is increased from 1.08- to 1.43-fold. Coadministration caused on significant changes in the terminal half-lives $(t_{1/2})$ and the time to reach the peak concentration $(T_{max})$ of diltiazem. On the other hand, coadministration of naringenin increased the AUC desacetyldiltiazem, significantly at the dose of 10mg/kg. But the metabolite ratio (MR) was decreased, significantly at 10mg/kg of naringenin. Based on these results, we can make a conclusion that the increased bioavailability and the significant changes of these pharmacokinetic parameters might be due to naringenin, which possess the potency to inhibit the metabolizing enzyme (CYP3A4) in the liver and intestinal mucosa, and also inhibit the P-glycoprotein efflux pump in the intestinal mucosa.

• Proceedings of the Korean Geotechical Society Conference
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• 2009.09a
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• pp.1141-1146
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• 2009

The compressibility of clay has been expressed e-log p' graph. In natural clay, e-log p' graph are changed by deposition condition and chemical cementation as well as Atterberg limits, whereas in reconstituted clay, it is generally known that e-log p’ curve is varied with Atterberg limits. However, e-log p' graph is possible to change according to the reconstituting methods and test conditions. In this study, consolidation tests are performed as various test condition for reconstituted Busan clay. Test results show that the relationship e/$e_L$ and log p' is almost constant with $e_L$. And the compression index obtained from slurry method sample is larger than one obtained from kneading method sample. Intrinsic compression line (ICL) of Busan clay is identical with ICL suggested by Burland.

• Journal of The Korean Society of Agricultural Engineers
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• v.66 no.2
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• pp.1-12
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• 2024

In order to integrate two consolidation theories of Terzaghi's consolidation theory and Mesri's secondary compression theory and to identify a model suitable for analyzing stress-strain behavior over time, numerical analysis on consolidation tests were conducted using a modified cam-clay model and a soft soil creep model and the following conclusions were obtained. The results of numerical analysis applying the theory that a linear proportional relationship is established between the void ratio at logarithmic scale and the permeability coefficient at logarithmic scale is better agreement with the result of oedometer test than the results of applying constant hydraulic conductivity. The modified cam-clay model is a model that does not include secondary compression, but the slope of the normal consolidation line corresponding to the compression index of the standard consolidation test includes secondary compression, so the actual settlement curve over time is lower than the predicted value through numerical analysis. It always gets smaller. Other previous studies that applied Terzaghi's consolidation theory to consolidation test analysis showed the same results and were cross-confirmed. The soft soil creep model, which includes secondary compression in the theory, showed good agreement in all sections including secondary compression in the consolidation test results. It was judged appropriate to use a soft soil creep model when performing numerical analysis of soft clay ground.

• Earthquakes and Structures
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• v.26 no.6
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• pp.449-461
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• 2024

The vertical reinforcement connection between the precast reinforced concrete shear wall and the cast-in-place reinforced concrete member is vital to the performance of shear walls under seismic loading. This paper investigated the structural behavior of three precast reinforced concrete shear walls, with different levels of connection (i.e., full connection, partial connection, and no connection), subjected to quasi-static lateral loading. The specimens were subjected to a constant vertical load, resulting in an axial load ratio of 0.4. The crack pattern, failure modes, load-displacement relationships, ductility, and energy dissipation characteristics are presented and discussed. The resultant seismic performances of the three tested specimens were compared in terms of skeleton curve, load-bearing capacity, stiffness, ductility, energy dissipation capacity, and viscous damping. The seismic performance of the partially connected shear wall was found to be comparable to that of the fully connected shear wall, exhibiting 1.7% and 3.5% higher yield and peak load capacities, 9.2% higher deformability, and similar variation in stiffness, energy dissipation capacity and viscous damping at increasing load levels. In comparison, the seismic performance of the non-connected shear wall was inferior, exhibiting 12.8% and 16.4% lower loads at the yield and peak load stages, 3.6% lower deformability, and significantly lower energy dissipation capacity at lower displacement and lower viscous damping.

• Journal of the Korean Geotechnical Society
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• v.27 no.2
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• pp.91-101
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• 2011

In this study, a new design method of Pile-Bent structure considering plastic hinge was proposed on the basis of the beam-column model. To obtain the detailed informations, the optimized cross-section ratio between column and pile was analyzed to induce the plastic hinge at the joint section between the pile and column. Base on this study, the optimized diameter ratio of pile and column can be obtained below the inflection point of the bi-linear curve depending on the relations between column-pile diameter ratio ($D_c/D_p$) and normalized lateral cracking load ratio ($F/F_{Dc=Dp}$). Moreover, through comparisons with field cases to find out in-depth limit in which minimum concrete-steel ratio could be applied, in-depth limits ($L_{As=0.4%}$) normalized by the pile length ($L_p$) proportionally decrease as the pile length ($L_p/D_p$)increases up to $L_p/D_p=17.5$, and beyond that in-depth limit converges to a constant value (${\simeq}0.3$).

• Magazine of the Korean Society of Agricultural Engineers
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• v.25 no.4
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• pp.50-60
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• 1983

305 samples of alluvial deposit in inland and harbour districts were selected and consolidation charateristics of the alluvium were put in order statiscally. The correlations between them were as follows. 1. The relationships between LL(liguid limit) and Cc (compression index) were explained as Cc=0. 03(LL-21. 7) in case of inland district soil and as Cc=0. 019(LL-19) in case of harbour district soil. As compared with formular proposed by Skernpton, the gradient of this linear line was slight steep. 2. The relationships between PI(plastic index) and Cc were explained as Cc=0. 063 PI-0. 52 in case of inland district soil and Cc=0. 043 PI-0. 31 in case of harbour district soil. 3. As void ratio and natural moisture content were increased, Cc was increased, and as wet density was increased, Cc was decreased with a gentle curve. 4. As LL and P1 increased, mv(coefficient of volume compressibility) was increased but if LL and P1 was increased beyond a certain extend, mv has a tendency of constant value, that is, mv show a tendency to take constant value in the very soft clay. and mv in P=2. 5kg/cm$^2$ was about l${\times}$ l0-$^1$cm$^2$/kg in case of land district soil and 6x 10-$^1$crn$^2$/kg in case of harbour district soil lower than that in P=0. 25kg/crn2. 5. Cv(coefficient of consolidation) was a tendency to decrease with a gentle curve as LL was increased, and Cv in P=0. 25kg/crn2 was about 3x l0-$^1$crn$^2$/min larger than that in P=2. 5kg/crn$^2$. 6. Relationships between Py(pre-consolidation pressure) which is included over consolidation soil and ∑r1h(effective over-burden pressure) were explained as Py=l. 12 ∑r'h in case of land district soil and as Py=l. l5∑r'h in case of harbour district soil. 7. Some of the properties show good correlations between them, practical and effective applications of these correlations are expected in the planning and excution of soil investigation and also in the evaluation of the results.

• Journal of the Korean Electrochemical Society
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• v.10 no.4
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• pp.301-305
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• 2007

The performance of polymer electrolyte membrane fuel cell could be decreased due to coolant leaked from connection part. Micro pump was used to put small amount of coolant and investigate the effect on fuel cell. The stoichiometric ratio of hydrogen/air was 1.5/2.0, both side of gas was fully humidified, and current density of $400mA/cm^2$ was used as standard condition in this experiment. Constant current method was used to check performance recovery from coolant effect in 3 cell stack. The performance was recovered when coolant was injected in cathode side. On the other hand, the performance was not recovered when coolant was injected in anode side. Ethylene glycol could be converted to CO in oxidation process and cause poisoning effect on platinum catalyst or be adhered on GDL and cause gas diffusion block effect resulting performance decrease. Water with nitrogen gas was supplied in anode side to check performance recovery. Polarization curve, cyclic voltammetry, electrochemical impedance spectroscopy was used to check performance, and gas chromatography was used to check coolant concentration. Constant current method was not enough in full recovery of performance. However, water injection method was proved good method in full recovery of performance.

• The Transactions of the Korean Institute of Power Electronics
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• v.19 no.4
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• pp.320-326
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• 2014

In this paper, the new smart dimming algorithm which is mixed with PWM and PAM control method is proposed for reducing the power consumption of LED TV Backlight. The proposed technique is using the curve characteristics of LED forward voltage and current which is proportionally changing LED forward voltage as changing LED forward current. Therefore, each PWM and PAM control method has different LED forward voltage and current in the same brightness condition. The PWM control method adjusts the brightness of LED TV Backlight by only varying the duty ratio of PWM and constantly sustaining the amplitude of LED forward current and voltage. So, the level of LED forward current and voltage in the PWM control method is relatively high and constant regardless of duty ratio of PWM. On the other hand, the PAM control method adjusts the brightness of LED TV Backlight by directly varying the level of LED forward current. So, the level of LED forward current and voltage in the PAM control method is lowered according to the brightness level. For the above-mentioned reason, the PAM control method has the advantage of reducing the total power consumption of LED TV Backlight at the brightness condition of below 100%, compared with PWM control method. By implementing this characteristic to LED driver circuit with control algorithm in MCU, the power consumption of LED TV Backlight can expect to be reduced. The effectiveness of the proposed method, new smart dimming algorithm, CPWAM(=Conditional Pulse Width Amplitude Modulation), has been verified by experimental results.

• Journal of the Korea Concrete Institute
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• v.22 no.3
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• pp.389-397
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• 2010

Concrete has excellent mechanical properties, high durability, and economical advantages over other construction materials. Nevertheless, it is not an easy task to apply concrete to long span bridges. That's because concrete has a low strength to weight ratio. Ultra high performance concrete (UHPC) has a very high strength and hence it allows use of relatively small section for the same design load. Thus UHPC is a promising material to be utilized in the construction of long span bridges. However, there is a possibility of crack generation during the curing process due to the high binder ratio of UHPC and a consequent large amount of hydration heat. In this study, adiabatic temperature rise and mechanical properties were modeled for the stress analysis due to hydration heat. Adiabatic temperature rise curve of UHPC was modeled superposing 2-parameter model and S-shaped function, and the Arrhenius constant was determined using the concept of equivalent time. The results are verified by the mock-up test measuring the temperature development due to the hydration of UHPC. In addition, models for mechanical properties such as elastic modulus, tensile strength and compressive strength were developed based on the test results from conventional load test and ultrasonic pulse velocity measurement.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.25 no.2
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• pp.56-61
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• 2015

The effects of the growth temperature on the properties of a-plane GaN epi-layer on r-plane sapphire by HVPE were studied, when the constant V/III ratio and the flow rate of HCl for the Ga source channel was fixed at 10 and 700 sccm, respectively. Additionally the effects of V/III ratios for source gasses were studied when growth temperature and the flow rate of HCl for the Ga source channel was fixed at $1000^{\circ}C$ and 700 sccm, respectively. As the growth temperature was increased, the values of Full Width Half Maximum (FWHM) for Rocking curve (RC) of a-plane GaN (11-20) epi-layer were decreased and thickness of a-plane GaN epi-layer were increased. As V/III ratios were increased at $1000^{\circ}C$, the values of FWHM for RC of a-plane GaN (11-20) were declined and thickness of a-plane GaN epi-layer were increased. The a-plane GaN (11-20) epi-layer grown at $1000^{\circ}C$ and V/III ratio = 10 showed the lowest value FWHM for RC of a-plane GaN (11-20) for 734 arcsec and the smallest dependence of Azimuth angle for FWHM of (11-20) RCs.