• Nutrition Research and Practice
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• 제5권4호
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• pp.313-321
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• 2011

The Korea Food and Drug Administration (KFDA) revised the Health Functional Food Act in 2008 and extended the form of health functional foods to general food types. Therefore, this study was performed to investigate consumers' perceptions of the expanded form of health functional food and to predict consumption patterns. For this study, 1,006 male and female adults aged 19 years and older were selected nationwide by multi-stage stratified random sampling and were surveyed in 1:1 interviews. The questionnaire survey was conducted by Korea Gallup. The subjects consisted of 497 (49.4%) males and 509 (50.6%) females. About 57.9% of the subjects recognized the KFDA's permission procedures for health functional foods. Regarding the health functional foods that the subjects had consumed, red ginseng products were the highest (45.3%), followed by nutritional supplements (34.9%), ginseng products (27.9%), lactobacillus-containing products (21.0%), aloe products (20.3%), and Japanese apricot extract products (18.4%). Opinions on expanding the form of health functional foods to general food types scored 4.7 points on a 7-point scale, showing positive responses. In terms of the effects of medicine-type health functional foods versus generic health functional foods, the highest response was 'same effects if the same ingredients are contained' at a rate of 34.7%. For intake frequency by food type, the response of 'daily consistent intake' was 31.7% for capsules, tablets, and pills, and 21.7% for extracts. For general food types, 'daily consistent intake' was 44.5% for rice and 22.8% for beverages, which were higher rates than those for medicine types. From the above results, consumers had positive opinions of the expansion of health functional foods to generic forms but are not expected to maintain accurate intake frequencies or amounts. Thus, continuous promotion and education are needed for proper intake of generic health functional foods.

• 한국지반공학회논문집
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• 제22권9호
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• pp.45-59
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• 2006

탄소성 구성방정식은 주로 미분방적식(rate equation)으로 이루어져 있기 때문에 유한요소법 등을 이용한 지반구조물 해석시 미분방정식들에 대한 수치적분을 수행할 수 있는 방법이 필요하다. 구조물의 거동을 해석할시 미분방정식들을 위한 적분방법은 해석결과의 정확성과 유한요소법 모델링의 안전성에 큰 영향을 미치고 있다. 본 논문에서는 최근에 개발되어 사용되고 있는 흙에 관한 구성모델인 "Two-surface soil plasticity model (Manzari and Dafalias 1997)"을 Implicit return-mapping 수치적분방법을 이용하여 실행하는 과정을 제시한다. 본 연구에서 사용된 수치적분방법은 Closest-Point-Projection Method(CPPM) 방법으로 탄성 예측자-소성 교정자(elastic predictor-plastic corrector) 개념을 Implicit Backward Euler방법으로 체계화 시킨 알고리듬이다. 본 연구에서 수행한 "Two-surface soil plasticity model"은 조립토의 비선형거동을 해석하며, Bounding surface 개념 및 비선형 등방경화와 이동경화법칙을 사용하는 모델이다. 본 연구는 CPPM 방법이 정확하고 안정되며 유용한 수치적분을 수행할 수 있는 알고리듬이라는 것을 제시한다. 또한, CPPM 알고리듬은 구성방정식의 해를 반복적으로 해석하는 동안 "Consistent tangent operator $d{\sigma}/d{\varepsilon}$"를 제공하므로, 비선형 유한요소 해석이 2차(quadratic convergence rate)의 수렴 조건을 만족하는데 기여한다는 것을 보여준다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권1호
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• pp.261-267
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• 2012

Purpose: The relationship between thymidylate synthase (TS) expression and outcomes in gastric cancer (GC) patients remains controversial, although most studies reported poor survival and reduced response to fluoropyrimidine were related to high TS in tumors. We carried out a systematic review of the literature with meta-analysis to estimate the predictive value of TS expression from published studies. Methods: We indentified 24 studies analysing the outcome data in gastric cancer stratified by TS expression. Effect measures of outcome were hazard ratios (HRs) for overall survival (OS) and event-free survival (EFS), or the odds ratio (OR) for overall response rate (ORR). HRs and ORs from these eligible studies were pooled using random-effects meta-analysis. Results: Fifteen studies investigated outcomes in a total of 844 patients with advanced GC, and nine studies investigated outcomes in a total of 1,235 patients with localized GC undergoing adjuvant therapy. Meta-analysis of estimates showed high TS expression was significantly associated with poor OS in the advanced setting (HR: 1.43, 95%CI: 1.08 - 1.90), and poor EFS in the adjuvant setting (HR: 1.53, 95%CI: 1.01 - 2.32). Subgroup analysis demonstrated TS expression to haves even greater value in predicting OS, EFS and ORR in advanced GC patients treated with fluoropyrimidine monotherapy (HR for OS: 2.32, 95%CI: 1.53 - 3.50; HR for EFS: 1.76, 95%CI: 1.19 - 2.60; OR for ORR: 0.32, 95%CI: 0.11 - 0.95). Conclusion: High levels of TS expression were asssociated with a poorer OS for advanced GC patients compared with low levels. In the adjuvant setting, high TS expression was also associated with a worse EFS. Additional studies with consistent methodology are needed to define the precise predictive value of TS.

• Geomechanics and Engineering
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• 제16권4호
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• pp.399-413
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• 2018

This paper addresses the issue of field measurement of excavation damage zone (EDZ) and its numerical simulation method considering both excavation unloading and blasting load effects. Firstly, a 2000 m-deep rock cavern in China is focused. A detailed analysis is conducted on the field measurement data regarding the mechanical response of rock masses subjected to excavation and blasting operation. The extent of EDZ is revealed 3.6 m-4.0 m, accounting for 28.6% of the cavern span, so it is significantly larger than rock caverns at conventional overburden depth. The rock mass mechanical response subjected to excavation and blasting is time-independent. Afterwards, based on findings of the field measurement data, a numerical evaluation method for EDZ determination considering both excavation unloading and blasting load effects is presented. The basic idea and general procedures are illustrated. It features a calibration operation of damage constant, which is defined in an elasto-plastic damage constitutive model, and a regression process of blasting load using field blasting vibration monitoring data. The numerical simulation results are basically consistent with the field measurement results. Further, some issues regarding the blasting loads, applicability of proposed numerical method, and some other factors are discussed. In conclusion, the field measurement data collected from the 2000 m-deep rock cavern and the corresponding findings will broaden the understanding of tunnel behavior subjected to excavation and blasting at great depth. Meanwhile, the presented numerical simulation method for EDZ determination considering both excavation unloading and blasting load effects can be used to evaluate rock caverns with similar characteristics.

• 한국작물학회지
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• 제48권6호
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• pp.460-464
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• 2003

본 연구는 벼 종자의 파종 후 발아, 유묘출현 및 생육 초기에 가하여지는 광질처리가 유묘 출현, 생장, 형태, 엽록소 함량 및 광합성율에 미치는 영향을 조사하여 벼의 육묘에 이용되고 있는 부직포의 색상을 전환할 필요가 있는가를 검토하고자 실시하였으며 그 결과를 요약하면 다음과 같다. 1. 파종 직후에 가하여지는 광질처리에서 유묘출현율은 조사일 모두 일미벼에서는 광질처리간 차이가 없었다. 그러나 동진벼와 대산벼에서는 원적색광 처리에서 가장 낮았으며, 청색광과 적색광간에는 차이가 거의 없었다. 2. 파종 직후에 가하여지는 광질처리로 인하여 원적색광 처리에서 초장과 엽장이 가장 짧았던 반면, 적색광은 뿌리수를 증대시켰다. 3. 파종 직후에 가하여지는 광질처리로부터 지상부 건물중은 청색광 처리에서, 뿌리의 건물중은 적색광 처리에서 가장 많았던 반면, 지상부 및 뿌리 건물중 모두 원적색광에서 가장 적었다. 4. 엽록소 함량과 광합성율 모두 품종간에는 일정한 경향이 없었으나, 광질처리에서는 이들 모두 적색광에서 가장 높고, 청색광, 원적색광 순으로 감소하였다.

• 한국어병학회지
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• 제24권3호
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• pp.279-287
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• 2011

Transcriptional response patterns of mud loach (Misgurnus mizolepis; Cypriniformes) hepcidin, a potential ortholog to human hamp1, in response to experimental challenges with non-pathogenic and pathogenic bacterial species were analyzed based on the semi-quantitative reverse transcription-PCR assay. Mud loach hepcidin transcripts were much more preferentially induced by pathogenic bacterial species (Edwardsiella tarda and Vibrio anguillarum) causing apparent pathological symptoms than by non-pathogenic species (Escherichia coli and Bacillus thuringiensis) displaying neither clinical signs nor mortality. However in overall, the induced amounts of hepcidin transcripts were positively related with the number of bacterial cells delivered in both pathogenic and non-pathogenic bacterial species. Inducibility of hepcidin transcripts were variable among three tissues examined (liver, kidney and spleen) in which kidney and spleen were more responsive to the bacterial challenge than liver. Time course expression patterns of hepcidin mRNAs after challenge were different between groups challenged with pathogenic and non-pathogenic species, although the overall pattern of hepcidin expression was in accordance with that generally observed in battery genes appeared during early phase of inflammation. Fish challenged with E. coli (non-pathogenic) showed the significant induction of hepcidin transcripts within 24 hr post injection (hpi) but the level was rapidly declined to the basal level either at 48 or 96 hpi. On the other hand, hepcidin transcript levels in E. tarda (pathogenic)-challenged fish were continuously elevated until 48 hpi, then downregulated at 96 hpi, although the level at 96 hpi was still significantly higher than control level observed in non-challenged fish. This expression pattern was consistent in all the three tissues examined. Taken together, our data indicate that hepcidin is tightly in relation with pathological and/or inflammation status during bacterial challenge, consequently providing useful basis to extend knowledge on the host defensive roles of hepcidin under infectious conditions in bony fish.

• 대한예방의학회:학술대회논문집
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• 대한예방의학회 1994년도 교수 연수회(환경)
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• pp.431-438
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• 1994

As currently conducted, standard rodent bioassays do not provide sufficient information to assess carcinogenic risk to humans at doses thousands of times below the maximum tolerated dose. Recent analyses indicate that measures of carcinogenic potency from these tests are restricted to a narrow range about the maximum tolerated dose and that information on shape of the dose-response is limited in experiments with only two doses and a control. Extrapolation from high to low doses should be based on an understanding of the mechanisms of carcinogenesis. We have postulated that administration of the maximum tolerated dose can increase mitogenesis which, in turn. increases rates of mutagenesis and, thus, carcinogenesis. The animal data are consistent with this mechanism, because about half of all chemicals tested are indeed rodent carcinogens, and about 40% of the positives are not detectably mutagenic. Thus, at low doses where cell killing does not occur, the hazards to humans of rodent carcinogens may be much lower than commonly assumed. In contrast, for high-dose exposures in the workplace, assessment of hazard requires comparatively little extrapolation. Nevertheless. permitted workplace exposures are sometimes close to the tumorigenic dose-rate in animal tests. Regulatory policy to prevent human cancer has primarily addressed synthetic chemicals, yet similar proportions of natural chemicals and synthetic chemicals test positive in rodent studies as expected from an understanding of toxicological defenses, and the vast proportion of human exposures are to natural chemicals. Thus, human exposures to rodent carcinogens are common. The natural chemicals are the control to evaluate regulatory strategies, and the possible hazards from synthetic chemicals should be compared to the possible hazards from natural chemicals. Qualitative extrapolation of the carcinogenic response between species has been investigated by comparing two closely related species: rats and mice. Overall predictive values provide moderate confidence in interspecies extrapolation; however, knowing that a chemical is positive at any site in one species gives only about a 50% chance that it will be positive at the same site in the other species.

• 한국강구조학회 논문집
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• 제9권2호통권31호
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• pp.181-191
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• 1997

케이블이 가설되기 전까지 외팔보 형태로 지지되는 현수교의 주탑에 불규칙적인 변동 공기력이 작용할 때 발생하는 버페팅은 구조물의 기본 고유진동수와 일치하는 풍속이 존재하고 이에 따른 주탑의 공진에 의해 큰 응답을 유발할 수 있다. 버페팅 하중에 의한 동적 응답을 감소시키기 위해서 제진장치의 일종인 TMD(Tuned Mass Damper)를 부착한 주탑의 거동특성에 관한 연구를 유한요소법에 의하여 시간영역에서 수행하였다. 버페팅 하중을 구하기 위하여 주파수 영역의 속도스펙트럼을 시간영역의 무작위변량으로 변환시켰으며, peak factor를 이용하여 일정기간동안 일어날 수 있는 구조물의 최대 변위의 기대치를 구하였다. 최적의 TMD 부착위치와 제원을 변수별 수치해석을 통하여 결정하였으며, 최적의 제원을 갖는 TMD에 의한 풍속별 진동제어 효과를 검토하였다.

• 한국강구조학회 논문집
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• 제18권4호
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• pp.481-490
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• 2006

지진의 피해를 입은 후 건물의 실제 성능은 많은 요인에 영향을 받는다. 신축 구조물이나 기존 구조물의 지진 성능 예측은 복잡하다. 그 이유는 고려되어져야 하는 많은 요소와 지진 반응의 복잡성뿐만 아니라 이러한 예측과 관련된 타고난 불확실성 과 가변성 때문이다. 본 연구의 목적은 구조물의 능력 평가와 반응 요구에서의 불확실성과 가변성의 적절한 취급과 결합이다. 일관된 방법으로 demand와 capacity에서의 불확실성과 가변성을 설명하기 위하여 신뢰성 이론에 기초한 성능평가의 접근 방법이 초고층 철골 건축물의 내진성능평가 법으로 채택되어져 오고 있다. 신뢰성 이론에 근거한 내진성능평가에 대한 기본 체계와 통계적 연구에 대한 핵심 요소를 요약하였다. dema nd 요소와 capacity 요소의 통계적인 분석을 위하여 국내 기준에 맞는 전형적인 초고층 철골 건축물을 36개 설계하였다. global drift capacity 산정을 위해 철골 모멘트 골조 건물을 증분동해석 하였다.

• The Korean Journal of Physiology
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• 제29권2호
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• pp.233-241
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• 1995

The nonapeptide bradykinin has been shown to exhibit an array of biological activities including relaxation/contraction of various smooth muscles. In order to investigate the effects of bradykinin on the contractility and the electrical activity of antral circular muscle of guinea-pig stomach, the isometric contraction and membrane potential were recorded. Also, using standard patch clamp technique, the $Ca^{2+}-activated$ K currents were recorded to observe the change in cytosolic $Ca^{2+}$ concentration. $0.4 {\mu}M$ bradykinin induced a triphasic contractile response (transient contraction-transient relaxation-sustained contraction) and this response was unaffected by pretreatment with neural blockers (tetrodotoxin, atropine and guanethidine) or with apamin. Bradykinin induced hyperpolarization of resting membrane potential and enhanced the amplitude of slow waves and spike potentials. The enhancement of spike potentials was blocked by neural blockers. Both the bradykinin-induced contractions and changes in membrane potential were reversed by the selective $B_2$-receptor antagonist $(N{\alpha}-adamantaneacetyl-_{D}-Arg-[Hyp, Thy,_{D}-Phe]-bradykinin)$. In whole-cell patch clamp experiment, we held the membrane potential at -20 mV and spontaneous and transient changes of Ca-activated K currents were recorded. Bradykinin induced a large transient outward current, consistent with a calcium-releasing action of bradykinin front the intracellular calcium pool, because such change was blocked by pretreatment with caffeine. Bradykinin-induced contraction was also blocked by pretreatment with caffeine. From these results, it is suggested that bradykinin induces a calciumrelease and contraction through the $B_{2}$ receptor of guinea-pig gastric smooth muscle. Enhancement of slow wave activity is an indirect action of bradykinin through enteric nerve cells embedded in muscle strip.