• 산업경영시스템학회지
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• 제43권1호
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• pp.110-122
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• 2020

Many companies make considerable efforts in implementing supply chain management systems to increase their competitiveness. In particular, there are significant investments in their ICT (Information and Communication Technology) and supply chain. However, considerable diversity exists in how well firms have been able to assimilate ICT and leverage the business value of it. In addition, studies on supply chains, particularly Real Time Enterprise (RTE) competence, which is cited for rapid information sharing and dynamic capabilities for each role in the supply chain, are insufficient. The purpose of this paper is to explore and evaluate effect of ICT utilization capabilities, including 'ICT internal cooperative capabilities' and 'ICT operational flexibility capabilities', on RTE capabilities (flexibility, visibility and prediction) and supply chain performance. To validate the research model proposed in the study, survey was conducted on companies using ICT along the supply chain of manufacturing industries. 216 data were used, SPSS and AMOS were used for the analysis methods. Study results showed that ICT internal collaboration capabilities affect agility, one of RTE capabilities, but not visibility and prediction, and ICT operational flexibility capabilities have affected all three RTE capacities. And, RTE capabilities had a huge impact on supply chain performance as expected. In this paper, it has been found that the ICT capabilities in manufacturing are an important factor in improving RTE capabilities that are important in the supply chain and improving the performance of the supply chain.

• Korean Journal of Radiology
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• 제20권1호
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• pp.148-157
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• 2019

Objective: To evaluate the current status of managing adverse reactions to iodinated contrast media (ICM) for computed tomography in referral hospitals in South Korea compared with hospitals in other countries. Materials and Methods: This survey investigation involved 59 Korean and 15 overseas hospitals using guideline-based questionnaires consisting of 24 items in 7 main categories related to managing adverse reactions to ICM. Results: Informed written consent with risk factor evaluation was appropriately performed in most of the Korean hospitals. There was considerable variability in assessing renal function across the hospitals; serum creatinine level was used as a reference in 76.4% of Korean hospitals. The Korean hospitals preferred a more stringent approach to determining normal renal function (p = 0.01), withholding metformin (p = 0.01), and fasting before ICM exposure (p < 0.001) compared with overseas hospitals. All the Korean hospitals had an emergency protocol and in-hospital system for adverse reactions to ICM. The Korean (87.7%) and overseas hospitals (100%) were similarly equipped with epinephrine (p = 0.332), but only 38.6% of Korean hospitals were equipped with a bronchodilator (p = 0.004). For patients with a previous hypersensitivity reaction to ICM, 62.3% of Korean hospitals pre-medicated with anti-histamine and corticosteroid according to the severity of the previous reaction, and changed the culprit ICM in 52.8%, while skin test was performed in 17%. Conclusion: In general, Korean referral hospitals were well-prepared regarding informed consent, protocol, and an in-hospital system for managing adverse reactions to ICM. Nevertheless, there was considerable variability in details and management, thus requiring standardization by reflecting current guidelines.

• 통합자연과학논문집
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• 제16권4호
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• pp.123-131
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• 2023

Breast cancer continues to pose a substantial worldwide health challenge, thereby requiring the development of innovative strategies to discover new therapeutic interventions. Signal Transducer and Activator of Transcription 3 (STAT-3) has been identified as a significant factor in the development of several types of cancer, including breast cancer. This is primarily attributed to its diverse functions in promoting tumour formation and conferring resistance to therapeutic interventions. This study presents an in silico drug repositioning approach that focuses on identifying specific inhibitors of STAT-3 for the purpose of treating breast cancer. We initially examined the structural and functional attributes of STAT-3, thereby elucidating its crucial involvement in cellular signalling cascades. A comprehensive virtual screening was performed on a diverse collection of drugs that have been approved by the FDA from zinc15 database. Various computational techniques, including molecular docking, cross docking, and cDFT analysis, were utilised in order to prioritise potential candidates. This prioritisation was based on their predicted binding energies and outer molecular orbital reactivity. The findings of our study have unveiled a Dihydroergotamine and Paritaprevir that have been approved by the FDA and exhibit considerable promise as selective inhibitors of STAT-3. In conclusion, the utilisation of our in silico drug repositioning approach presents a prompt and economically efficient method for the identification of potential compounds that warrant subsequent experimental validation as selective STAT-3 inhibitors in the context of breast cancer. The present study highlights the considerable potential of employing computational strategies to expedite the drug discovery process. Moreover, it provides valuable insights into novel avenues for targeted therapeutic interventions in the context of breast cancer treatment.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제5권11호
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• pp.1959-1975
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• 2011

Adaptive Bit Loading (ABL) in Multiple-Input Multiple-Output Orthogonal Frequency-Division Multiplexing (MIMO-OFDM) is often used to achieve the desired Bit Error Rate (BER) performance in wireless systems. In this paper, we discuss some of the bit loading algorithms, compare them in terms of the BER performance, and present an effective and concise Adaptive Grouped Loading (AGL) algorithm. Furthermore, we propose a "weight factor" for loading algorithm to converge rapidly to the final solution for various data rate with variable Signal to Noise Ratio (SNR) gaps. In particular, we consider the bit loading in near optimal Singular Value Decomposition (SVD) based MIMO-OFDM system. While using SVD based system, the system requires perfect Channel State Information (CSI) of channel transfer function at the transmitter. This scenario of SVD based system is taken as an ideal case for the comparison of loading algorithms and to show the actual enhancement achievable by our AGL algorithm. Irrespective of the CSI requirement imposed by the mode of the system itself, ABL demands high level of feedback. Grouped Loading (GL) would reduce the feedback requirement depending upon the group size. However, this also leads to considerable degradation in BER performance. In our AGL algorithm, groups are formed with a number of consecutive sub-channels belonging to the same transmit antenna, with individual gains satisfying predefined criteria. Simulation results show that the proposed "weight factor" leads a loading algorithm to rapid convergence for various data rates with variable SNR gap values and AGL requires much lesser CSI compared to GL for the same BER performance.

• Asian Pacific Journal of Cancer Prevention
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• 제13권6호
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• pp.2503-2509
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• 2012

Considerable research has been conducted concerning galectin-9 and carcinomas, but little information is available about any relation with the hepatocellular carcinoma. In this study, we employed a small interfering RNA (siRNA) targeting galectin-9 to down-regulate the expression in HepG2 cells. As a result, after galectin-9 expression was reduced, cell aggregation was suppressed, while other behaviour such as the proliferation, adhesion and invasion to ECM, cell-endothelial adhesion and transendothelial invasion of the cells were markedly enhanced. When tumors of 200 patients with hepatocellular carcinoma were tested for galectin-9 expression by immunohistochemistry, binding levels demonstrated intimate correlations with the histopathologic grade, lymph node metastasis, vascular invasion and intrahepatic metastasis (P<0.05). Moreover, survival analysis indicated that patients with galectin-9 expression had much longer survival time than those with negative lesions, and the Log-rank test indicated that this difference was statistical significant (P<0.0001). The Cox proportional hazards model suggested that negative galectin-9 expression in hepatocellular carcinoma represented a significant risk factor for patient survival. We propose that galectin-9 might be a new prognostic factor with antimetastatic potential in patients with hepatocellular carcinoma.

• KDI Journal of Economic Policy
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• 제32권4호
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• pp.75-114
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• 2010

본 연구는 우리나라에서 정보통신자본의 활용이 경제 전반의 생산성을 높이는데 기여하고 있는지를 1970~2005년 기간의 산업별 자료를 이용하여 분석하였다. 특히 정보통신자본의 축적과 생산성 향상 사이에 상당한 시차가 존재할 가능성을 고려하였다. 생산성 향상을 유발할 수 있을 만큼 정보통신자본이 충분히 축적되었는지를 평가하기 위해 선진국과 비교한 결과, 경제 전체로서는 선진국과의 격차를 줄이고 있으나, 이는 주로 정보통신자본의 집적도가 높은 산업의 비중이 증가한 데 기인하며, 개별 산업에서는 선진국에 비해 낮은 수준이 지속되고 있는 것으로 나타났다. 한편, 산업별 성장회계 결과는 정보통신 고이용부문의 총요소생산성 증가세가 2000년 이후 개선되었으나, 사업서비스 등 일부 산업을 제외하면 정보통신자본의 축적이 생산성 향상을 초래하였을 가능성은 높지 않은 것으로 나타났다. 회귀분석 결과는 정보통신 생산부문을 제외하면 정보통신자본의 축적이 생산성 향상으로 이어지기까지 상당한 시간이 소요되고 있을 가능성을 시사하였다. 따라서 정보통신기술의 생산성 파급효과를 강화하기 위해서는 정보통신자본의 축적을 저해하는 제도적 요인을 점검하는 한편, 정보통신기술 활용을 위한 보완적 혁신이 용이하게 이루어질 수 있도록 제도적 환경을 개선하는 것이 중요하다고 생각된다.

• 대한기계학회논문집A
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• 제38권12호
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• pp.1317-1323
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• 2014

본 연구의 목적은 마찰교반용접된 Al7075-T651의 피로균열전파 거동에 미치는 시험편의 채취방향의 영향을 고찰하기 위한 것이다. 피로균열전파 실험은 마찰교반용접된 공시재로부터 모재와 용접재에 대하여 CT 시험편을 채취하여 일정응력확대계수범위 제어하에서 수행되었다. 균열이 용접선에 수직하여 전파하는 것(TL 시험편으로 명명)과 균열이 용접선과 나란히 전파하는 시험편(LT 시험편으로 명명)에 대하여 3가지 다른 응력확대계수범위에서 실험이 수행되었다. 시험편의 채취 방향에 따라 피로균열전파거동에 주요한 영향을 미침을 알 수 있었다. Paris 법칙에 적합시킨 결과 지수 m값은 WM-LT 시험편이 3.56으로 가장 높게 나타났다.

• 대한기계학회논문집
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• 제10권6호
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• pp.916-922
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• 1986

본 논문에서는 여러 연구자들이 반타원형 표면균열에 대한 응력확대계수의 수 정계수(correction factor)을 이론해석, 수치해석 및 실험해석 등을 통하여 구했는데, 그 결과는 서로가 5∼100%의 차이를 나타내고 있는 것이다. 이 때문에 표면균열에 대한 연구보고는 다른 분야에 비하여 비교적 적은 편이며, 현재까지 펴면균열의 피로 성장거동에 대한 정열이 설정되어 있지 못한 실정인 것이다. 이에 저자들은 표면균 열의 피로성장거동에 대한 다각적인 연구계획을 추진하고 있는 중이며, 본 보고서는 그 제1단계 연구로서, 초기 표면균열의 크기가 피로균열성장거동에 미치는 영향을 규 명하기 위한 실험적인 연구결과이다.

• 한국건설관리학회논문집
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• 제9권5호
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• pp.214-226
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• 2008

Construction delay caused considerable losses to project parties. Avoiding construction delays is important to save costs for project stakeholders. The main objective of this paper is to identify major causes of construction delays of apartment construction projects in Vietnam. Sixteen causes of delay were identified through a questionnaire survey of 166 professionals. Factor analysis was employed to categorize these causes. The results of the survey revealed the main causes of delay of apartment projects in Vietnam are: (1) owner's and contractor'S financial difficulties; (2) lack of experienced contractors; (3) late delivery of materials; (4) late construction site handover; (5) owner's late payments for completed works; (6) low bid prices; (7) inappropriate construction method; and (8) defective works and unnecessary reworks. Factor analysis uncovered that causes of delay can be grouped under five categories labeled the five INs: incompetence, ineffectiveness, inadequateness, inapplicableness and inconceivableness. Comparative analysis between the Vietnam construction industry (VCI) and the Korea construction industry (KCI) has been performed to infer valuable lessons for researchers and practitioners in the VCI and the KCI. Comparative analysis indicated that main causes of delay in the VCI somewhat differ from main causes of delay in the KCI. However, "contractor'S financial difficulties", "late construction site handover", "unnecessary rework", "incapable designers", "site clearance difficulties" are common causes of delay in the VCI as well as the KCI. The findings of this research can be used as a guideline to overcome problems in the VCI as well as in other construction industries. Since Korea has emerged as the first largest foreign investor in Vietnam, the results of this study may be useful not only to practitioners and researchers in Vietnam but also to participants in Korea.

• Structural Engineering and Mechanics
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• 제4권5호
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• pp.513-527
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• 1996

In this paper, both an approximate expression and an exact expression for the contribution factor of an element to the natural frequency of the finite element discretized system of a structure in general and a membrane in particular have been derived from the energy conservation principle and the finite element formulation of structural eigenvalue problems. The approximate expression for the contribution factor of an element is used to predict and determine the elements to be removed in an iteration since it depends only on the quantities associated with the old system in the iteration. The exact expression for the contribution factor of an element makes it possible to check whether the element is correctly removed at the end of an iteration because it depends on both the old system and the new system in the iteration. Thus, the combined use of the approximate expression and the exact expression allows a considerable number of elements to be removed in a single iteration so that the efficiency of the evolutionary structural optimization method can be greatly improved for solving the natural frequency optimization problem of a structure. A square membrane with different boundary supports has been chosen to investigate the general evolutionary path for the fundamental natural frequency of the structure. The related results indicated that if the objective of a structural optimization is to raise the fundamental natural frequency of the structure to an optimal value, the general evolutionary path during its optimization is that the elements are gradually removed along the direction from the area surrounded by the contour of the highest value to that surrounded by the contour of the lowest value.