• Asian Pacific Journal of Cancer Prevention
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• 제17권10호
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• pp.4577-4581
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• 2016

Objective: The aim of this study was to assess thyroid function in breast cancer patients exposed to therapeutic external beam radiation. The focus was on possible progressive changes and any relationships between the incidence of primary hypothyroidism, the time required to become hypothyroid, and factors such as chemotherapy, hormonotherapy and immunotherapy. Materials and Methods: Seventy females undergoing 3D conformal and IMRT radiation therapy for breast cancers were enrolled in a non-randomized prospective study. The patients was divided into two groups: those after mastectomy or breast conserving surgery (BCS) were irradiated to a scar of the chest wall/breast and the ipsilateral supraclavicular and the axillary areas (supraclavicular radiotherapy group - SC-RT group - 32 patients) and the control group receiving adjuvant chest wall/breast RT only (BCT group - 38 patients).The total doses were 50.0 to 70 Gy in 5 to 7 weeks. The median follow-up term was 24 months (range, 1-40 months). Thyroid function was evaluated by measuring thyroid stimulating hormone (TSH), free thyroxine (fT4), and free triiodothyronine (fT3) levels. The minimum, maximum and mean thyroid gland doses for 20 Gy (V20) were calculated for all patients. Results: Statistically significant results were obtained for the SC-RT group. Two yearsa fter the end of RT the chance of an event was increased in 6% of the population (p=0.009) in the SC-RT group. In the BCT group no significance was noted. No statistically significant differences were found for V20, chemio-, immunotherapy and hormonotherapy or Ki67 values (p=0.12). No significant results were obtained for development of hypothyroidism and clinical factors (age, thyroid volume, treatment modalities). Conclusion: Radiotherapy is associated with a higher incidence of thyroid toxicity in breast cancer patients. Routine thyroid function monitoring should be recommended in such cases.

• Radiation Oncology Journal
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• 제33권3호
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• pp.242-249
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• 2015

Purpose: The purpose of this study is to compare the dosimetry of electron beam (EB) plans and three-dimensional helical tomotherapy (3DHT) plans for the patients with left-sided breast cancer, who underwent breast conserving surgery. Materials and Methods: We selected total of 15 patients based on the location of tumor, as following subsite: subareolar, upper outer, upper inner, lower lateral, and lower medial quadrants. The clinical target volume (CTV) was defined as the area of architectural distortion surrounded by surgical clip plus 1 cm margin. The conformity index (CI), homogeneity index (HI), quality of coverage (QC) and dose-volume parameters for the CTV, and organ at risk (OAR) were calculated. The following treatment techniques were assessed: single conformal EB plans; 3DHT plans with directional block of left anterior descending artery (LAD); and 3DHT plans with complete block of LAD. Results: 3DHT plans, regardless of type of LAD block, showed significantly better CI, HI, and QC for the CTVs, compared with the EB plans. However, 3DHT plans showed increase in the $V_{1Gy}$ at skin, left lung, and left breast. In terms of LAD, 3DHT plans with complete block of LAD showed extremely low dose, while dose increase in other OARs were observed, when compared with other plans. EB plans showed the worst conformity at upper outer quadrants of tumor bed site. Conclusion: 3DHT plans offer more favorable dose distributions to LAD, as well as improved target coverage in comparison with EB plans.

• Radiation Oncology Journal
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• 제36권1호
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• pp.63-70
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• 2018

Purpose: The objective of this study was to compare dosimetric characteristics of three-dimensional conformal radiotherapy (3D-CRT) and two types of intensity-modulated radiotherapy (IMRT) which are step-and-shoot intensity modulated radiotherapy (s-IMRT) and modulated arc therapy (mARC) for thoracic esophageal cancer and analyze whether IMRT could reduce organ-at-risk (OAR) dose. Materials and Methods: We performed 3D-CRT, s-IMRT, and mARC planning for ten patients with thoracic esophageal cancer. The dose-volume histogram for each plan was extracted and the mean dose and clinically significant parameters were analyzed. Results: Analysis of target coverage showed that the conformity index (CI) and conformation number (CN) in mARC were superior to the other two plans (CI, p = 0.050; CN, p = 0.042). For the comparison of OAR, lung V5 was lowest in s-IMRT, followed by 3D-CRT, and mARC (p = 0.033). s-IMRT and mARC had lower values than 3D-CRT for heart $V_{30}$ (p = 0.039), $V_{40}$ (p = 0.040), and $V_{50}$ (p = 0.032). Conclusion: Effective conservation of the lung and heart in thoracic esophageal cancer could be expected when using s-IMRT. The mARC was lower in lung $V_{10}$, $V_{20}$, and $V_{30}$ than in 3D-CRT, but could not be proven superior in lung $V_5$. In conclusion, low-dose exposure to the lung and heart were expected to be lower in s-IMRT, reducing complications such as radiation pneumonitis or heart-related toxicities.

• Radiation Oncology Journal
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• 제37권4호
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• pp.254-258
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• 2019

Purpose: Deep inspiration breath hold (DIBH) is a well-established technique that enables efficient cardiac sparing in patients with left-sided breast cancer. The aim of the current study was to determine if DIBH is effective for reducing radiation exposure of of liver and other organs at risk in right breast radiotherapy (RT). Materials and Methods: Twenty patients with right-sided breast cancer were enrolled in this study. Three-dimensional conformal RT plans were generated for each patient, with two different computed tomography scans of free breathing (FB) and DIBH. Nodes were contoured according to the Radiation Therapy Oncology Group contouring guidelines. Dose-volume histograms for the target volume coverage and organs at risk were evaluated and analyzed. Results: DIBH plans showed significant reduction in mean liver dose (5.59 ± 2.07 Gy vs. 2.54 ± 1.40 Gy; p = 0.0003), V_20Gy (148.38 ± 73.05 vs. 64.19 ± 51.07 mL; p = 0.0003) and V_10Gy (195.34 ± 93.57 vs. 89.81 ± 57.28 mL; p = 0.0003) volumes compared with FB plans. Right lung doses were also significantly reduced in DIBH plans. Heart and left lung doses showed small but statistically significant improvement with application of the DIBH technique. Conclusion: We report that the use of DIBH for right-sided breast cancer significantly reduces the radiation doses to the liver, lungs, and heart.

• 대한수학회보
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• 제55권3호
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• pp.957-965
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• 2018

We study the class $C{\mathcal{V}} ({\Omega})$ of analytic functions f in the unit disk ${\mathbb{D}}=\{z{\in}{\mathbb{C}}$ : ${\mid}z{\mid}$ < 1} of the form $f(z)=z+{\sum}_{n=2}^{\infty}a_nz^n$ satisfying $$1+\frac{zf^{{\prime}{\prime}}(z)}{f^{\prime}(z)}{\in}{\Omega},\;z{\in}{\mathbb{D}}$$, where ${\Omega}$ is a convex and proper subdomain of $\mathbb{C}$ with $1{\in}{\Omega}$. Let ${\phi}_{\Omega}$ be the unique conformal mapping of $\mathbb{D}$ onto ${\Omega}$ with ${\phi}_{\Omega}(0)=1$ and ${\phi}^{\prime}_{\Omega}(0)$ > 0 and $$k_{\Omega}(z)={\displaystyle\smashmargin{2}{\int\nolimits_{0}}^z}{\exp}\({\displaystyle\smashmargin{2}{\int\nolimits_{0}}^t}{\zeta}^{-1}({\phi}_{\Omega}({\zeta})-1)d{\zeta}\)dt$$. Let $z_0,z_1{\in}{\mathbb{D}}$ with $z_0{\neq}z_1$. As the first result in this paper we show that the region of variability $\{{\log}\;f^{\prime}(z_1)-{\log}\;f^{\prime}(z_0)\;:\;f{\in}C{\mathcal{V}}({\Omega})\}$ coincides wth the set $\{{\log}\;k^{\prime}_{\Omega}(z_1z)-{\log}\;k^{\prime}_{\Omega}(z_0z)\;:\;{\mid}z{\mid}{\leq}1\}$. The second result deals with the case when ${\Omega}$ is the right half plane ${\mathbb{H}}=\{{\omega}{\in}{\mathbb{C}}$ : Re ${\omega}$ > 0}. In this case $CV({\Omega})$ is identical with the usual normalized class of convex univalent functions on $\mathbb{D}$. And we derive the sharp upper bound for ${\mid}{\log}\;f^{\prime}(z_1)-{\log}\;f^{\prime}(z_0){\mid}$, $f{\in}C{\mathcal{V}}(\mathbb{H})$. The third result concerns how far two functions in $C{\mathcal{V}}({\Omega})$ are from each other. Furthermore we determine all extremal functions explicitly.

• Korean Chemical Engineering Research
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• 제43권1호
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• pp.98-102
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• 2005

본 연구에서는 유기금속 전구체인(HFAC)Cu(DMB)을 이용하여 구리를 제조하고, 기판온도 및 요오드 화합물이 증착 구리막의 표면 형상 및 충진 특성에 미치는 영향을 살펴보았다. 증착 온도가 높을수록 표면 형상이 거칠어지고 충진 특성이 악화되었으며, 요오드를 사용하여 증착할 경우 표면 거칠기와 충진 특성이 개선됨을 알 수 있었다. 이때 요오드 화합물과 전구체를 동시에 반응기에 유입할 경우보다 구리의 씨앗층을 증착하고 요오드 화화물을 반응기에 유입한 후 다시 구리 증착을 진행하는 경우가 좀 더 효과가 컸다.

• 한국통신학회논문지
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• 제15권9호
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• pp.785-795
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• 1990

임의의 반경을 갖는 원통의 내곡면 및 외곡면 표면에 밀착하여 호형(弧形, arc array)으로 배열된 마이크로스트립 어레이 안테나의 원거리 복사패턴에 관하여 Fourier Transform을 이용하는 근사법을 제시한다. 실효개구면을 호의 끝점을 잇는 평면으로 정의하면, 곡면 안테나는 실효개구면 평면위에 위상이 다른 비주기 배열로 근사화될 수 있음을 보였으며, 평면형에 대하여 표준화된 실효개구면비가 1.0-0.9인 범위에서 근사법에 의한 해석이 타당함을 확인하였다. 실효개구면 배열에서 위상 변화는 곡면과 개구면 사이의 비선형적 경로차에 기인하는 것으로 해석하였으며, 특히 곡률 반경이 호의 길이보다 5배 이상일 때는 Fourier Transform Method에서 scale factor의 변화만으로 해석이 가능하였다. 근사법에 의한 계산 결과는 -40dB의 측정범위에서 좌표변화법 및 실험결과와 잘 일치하였으며, 근사법과 좌표변환법에 의한 계산에서 반전력각(half power angle)의 차이는 실효개구면비가 0.9이상에서 5'미만이었다.

• 대한기계학회논문집A
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• 제38권9호
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• pp.953-958
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• 2014

형상적응형 냉각회로를 구비한 사출금형 및 히트 싱크를 가지는 절삭공구 (혹은 냉각 장치) 등과 같은 많은 응용 분야에서 기능성 경사 복합재(FGM)를 사용하여 필요한 강성을 약화시키지 않으면서 열전도 특성을 향상 시킬 수 있을 것으로 기대된다. 본 논문에서는 M2 공구강과 Cu 간의 FGM 히트 싱크를 가지는 절삭 공구 제작을 위한 기초연구로, M2 와 Cu 를 각각 100:0, 80:20, 60:40, 40:60, 20:80, 0:100 wt% 비율로 사전에 혼합한 금속분말을 분말야금법으로 가압성형 및 소결 제작 하였다. 각 시편의 단면을 광학현미경으로 관찰하여 소결 상태를 분석하였으며, 열전도도, 비열 및 열팽창계수 등 열전달 관련물성을 측정하고 분석하였다.

• 대한방사선치료학회지
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• 제11권1호
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• pp.100-105
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• 1999

Purpose : When the value of X,Y,Z coordination of the isocenter are reallocated from an arbitrary point using DRR (Digitally Reconstructed Radiographs) image in CT Simulation, conventional simulation is normally performed to verify the accuracy of this reallocation of the isocenter through the fluroscopy. The purpose of our experiment is to determine whether repeated test of the verification is necessary or not, and to analyze errors of reallocation with respect to the body region and the beam projection, if necessary, Material and Method : For 200 simulation patient, an arbitrary point is marked on each body and axial scaning is performed using CT, and treatment planing is done by drawing tumor and target volume on each slice. Using the planing data and the reallocated point of the isocenter, DRR image can be obtained and the final isocenter are marked on the patient's skin. In order to verify this reallocation of X,Y.Z coordination from CT simulation, We measure and evaluate the errors of these value on the fluoroscopy monitor and systematize them by classifying according to each body region (Brain, Neck and SCL, Lung, Esophagus, abdomen, Breast and Pelvis) and each beam projection {AP(PA), Supine, Prone and conformal : etc. } Conclusion : Isocenters are shifted by 3-5 mm in the case of Neck & SCL, Breast. at Abdomen, while noticeable differences are not found in other regions. Also, there are not correlations between the errors and the body regions or beam projections. However, our experiment intends to decide whether the procedure of verification is necessary on the vase of time and economy. It is regretful that we could not fully analyze the geometrical errors of DRR image and visual errors from the divergence. In conclusion, according to how much doctor consider tumor margin in drawing tumor and target volume, the meaning of analysis on the reallocation of isocenter should be reinterpreted, (which depends on the experience and capability of doctors)

• 한국위성정보통신학회논문지
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• 제2권2호
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• pp.10-15
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• 2007

위성방송수신 및 위성 양방향 인터넷, VSAT 등의 위성통신서비스를 차량 이동 시에도 이용할 수 있기 위해서는 차량에 탑재하기 용이하도록 소형이며 높이가 낮은 안테나 구조가 요구된다. 또한 중위도 지역에서 평면 안테나 상태로 45도 빔틸트 특성을 갖고, Ku 밴드의 위성통신용으로 충분한 고이득을 얻기 위해, 빔폭이 좁고 사이드로브가 적으며 저손실 구조의 배열안테나 개발이 필요하다. 본 논문에서는 이러한 성능을 만족시키기 위해, 진행파형 누설파 모드를 기초로 한 수직 편파로 동작하는 도파관 종방향 슬롯 배열안테나를 제안하였다. 16개 누설파 소자의 배열안테나 이득은 30 dBi 이었으며, 빔폭은 4.9도, 사이드로브 레벨은 -20 dB 이하, 중심주파수에서 빔틸트 각도는 45도를 얻었다. 급전선로는 도파관의 병렬급전 방식으로 설계하여 광대역, 저손실 특성을 얻을 수 있었다.