• Knowledge Management Research
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• v.21 no.3
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• pp.105-121
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• 2020

With regard to the development of new drugs, what is most important for a Korean Biotech, where no global sales network has been established, is decision-making related to out-licensing of new drugs. The probability of success for each clinical phase is different, and the licensing amount and its royalty vary depending on which clinical phase the licensing contract is made. Due to the nature of such a licensing contract and Biotech's weak financial status, it is a very important decision-making issue for a Biotech to determine when to license out to a Big Pharma. This study defined a model called 'optimal timing for out-licensing of new drugs' and the results were derived from the decision tree analysis. As a case study, we applied to a Biotech in Korea, which is conducting FDA global clinical trials for a first-in-class new drug. Assuming that the market size and expected market penetration rate of the target disease are known, it has been shown that out-licensing after phase 1 or phase 2 of clinical trials is a best alternative that maximizes Biotech's profits. This study can provide a conceptual framework for the use of management science methodologies in pharmaceutical fields, thus laying the foundation for knowledge and research on out-licensing of new drugs.

• The Journal of the Korea Contents Association
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• v.15 no.6
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• pp.326-336
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• 2015

This study intended to identify the factors of breast and cervical cancer screening behaviors in married female immigrants and provide information for the development of intervention programs to promote the behaviors. Pender's Health Promotion Model was the conceptual framework of this study. The subjects of this study were 157 female immigrants living in Daegu and Gyeongbuk area. It was found that 33.1% of subjects had mammography, 22.9% of them did breast self-examination, and 51% of them had cervical cancer screening test. The breast cancer screening behavior increased 1.25 times as the score of social support increased one point, 1.13 times as the score of perceived benefit increased one point, 3.58 times when the subjects had experiences of breast and cervical cancer education, and 1.24 times as the score of action plan increased one point. The cervical cancer screening behavior increased 2.89 times when the subjects had experiences of breast and cervical cancer education, and 1.23 times as the score of social support increased one point. However, the cervical cancer screening behavior decreased 0.82 times as the score of perceived barriers increased one point.

• Economic and Environmental Geology
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• v.41 no.6
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• pp.719-729
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• 2008

In this study, the speciation, adsorption, and transport of uranium in groundwater environments were simulated using geochemical models. The retarded transport of uranium by adsortption was effectively simulated using 3-D groundwater flow and reactive transport models. The results showed that most uranium was adsorbed(up to 99.5%) in a neutral pH(5.5$pCO_2(10^{-3.6}atm)$ condition. Under the higher $pCO_2(10^{-2.5}atm)$ condition, however, the pH range where most uranium was absorbed was narrow from 6 to 7. Under very low $pCO_2(10^{-4.5}atm)$ condition, uranium was mostly absorbed in the relatively wide pH range between 5.5 and 8.5. In the model including anion complexes, the uranium adsorption decreased by fluoride complex below the pH of 6. The results of this study showed that uranium transport is strongly affected by hydrochemical conditions such as pH, $pCO_2$, and the kinds and concentrations of anions($Cl^-$, ${SO_4}^{2-}$, $F^-$). Therefore, geochemical models should be used as an important tool to predict the environmental impacts of uranium and other hazardous compounds in many site investigations.

• Journal of Engineering Education Research
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• v.11 no.1
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• pp.64-75
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• 2008

A new product development and product realization process (PRP) is a circulating and feedback process by generating ideas through creative problem solving process. The early stages of PRP correspond to conceptual design and product development, in which a large portion of product life cycle cost can be saved. The optimal design method for this stage is a robust design suggested by Taguchi. Quality must be 'engineered in' since it can not be 'inspected out.' A robust design is an engineering methodology to improve the quality of a product by minimizing the efforts of variations without eliminating the causes. The objective of this study is to propose a scheme and a case study of robust design for exploring design parameters, and introduce a creative problem solving process. Major research subjects include a creative problem solving process, robust design procedure and their implementation. For the experiment of Taguchi method, a toy catapult is adopted. For the creativity development, a short project is assigned to devise a similar tool with the toy catapult. A reference model is suggested to compare and evaluate their ideas.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.26 no.3
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• pp.227-239
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• 2008

Processing LiDAR (Light Detection And Ranging) data obtained from ALS (Airborne Laser Scanning) systems mainly involves organization and segmentation of the data for 3D object modeling and mapping purposes. The ALS systems are viable and becoming more mature technology in various applications. ALS technology requires complex integration of optics, opto-mechanics and electronics in the multi-sensor components, Le. data captured from GPS, INS and laser scanner. In this study, digital image processing techniques mainly were implemented to gray level coded image of the LiDAR data for building extraction and superstructures segmentation. One of the advantages to use gray level image is easy to apply various existing digital image processing algorithms. Gridding and quantization of the raw LiDAR data into limited gray level might introduce smoothing effect and loss of the detail information. However, smoothed surface data that are more suitable for surface patch segmentation and modeling could be obtained by the quantization of the height values. The building boundaries were precisely extracted by the robust edge detection operator and regularized with shape constraints. As for segmentation of the roof structures, basically region growing based and gap filling segmentation methods were implemented. The results present that various image processing methods are applicable to extract buildings and to segment surface patches of the superstructures on the roofs. Finally, conceptual methodology for extracting characteristic information to reconstruct roof shapes was proposed. Statistical and geometric properties were utilized to segment and model superstructures. The simulation results show that segmentation of the roof surface patches and modeling were possible with the proposed method.

• Journal of Digital Convergence
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• v.13 no.7
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• pp.9-21
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• 2015

Nowadays, within the paradigm shift of e-learning, MOOCs service has been expanded among a number of global leading universities and this has affected our domestic universities' e-learning to look for different possibilities and new challenges. In consideration of our domestic educational condition, it is required to contemplate how university e-learning can be changed and developed with focus on MOOCs from the perspective of convergence development. This study suggests plans for convergence development in university e-learning based on MOOCs with conceptual model. We conducted the studies on relevant literature of university e-learning and MOOCs, expert consultation, SWOT analysis, survey for those involved of e-learning centers, etc. Through this process, we developed a final plan which integrates 'open advanced education course service', 'teaching and learning curation service', 'teaching and learning practice service', 'creative teaching and instruction method development and sharing service', and 'cloud based educational platform support service', etc with the perspective of convergence development. Also we designed convergence development plan based on MOOCs. It is assumed that the result of this research provides advanced plans for development of university e-learning and the base for further discussion of introduction and application of MOOCs service in domestic university.

• Journal of the Korean Association of Geographic Information Studies
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• v.20 no.4
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• pp.24-38
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• 2017

The awareness and demand for technological elements in the field of cloud computing and their application models have increased. Cloud-based service information systems are being expanded for use in many applications. Advancements in information technology are directly related to spatial information. PaaS is an important platform for implementing a substantial cloud ecosystem to develop geo-based application services. For this reason, it is necessary to analyze the PaaS cloud technology prior to the development of SaaS. The PaaS cloud supports sharing of related extensions, database operations and management, and application development and deployment. The development of geo-spatial information systems or services based on PaaS in ranging the domestic and overseas range is in the initial stages of both research and application. In this study, state-of-the-art cloud computing is reviewed and a conceptual design for geo-based applications is presented. The proposed model is based on container methods, which are the core elements of PaaS cloud technology based on open source. It is thought that these technologies contribute to the applicability and scalability of the geo-spatial information industry that addresses cloud computing. It is expected that the results of this study will provide a technological base for practical service implementation and experimentation for geo-based applications.

• The Journal of Society for e-Business Studies
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• v.15 no.4
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• pp.123-142
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• 2010

Generally speaking, user behavior in the post-adoption period is different from that in the pre-adoption period. Users come to make on their experiences of IT use whether they will continue to use it or not. Most theories about the user behaviors in the pre-adoption period are limited in describing them after adoption since they do not consider user's experiences of using the adopted IT and the beliefs formed by those experiences. Therefore, in this study, we explore user's experiences and beliefs such as familiarity, satisfaction and habits in the post-adoption period and examine how they affect user's intention to continue in using Mobile Social Network Service. Through literature reviews, we proposed the conceptual model to explain the role of users' habits in continuance of IT post-adoption stage. Then, we examine the impact of the constructs to affect the intention to continue using the Mobile SNS. The results show that the intention to continue to use Mobile SNS is strongly influenced by users' habits, satisfaction and familiarity; users' habits is strongly influenced by satisfaction and familiarity; satisfaction is strongly influenced by familiarity.

• Research in Community and Public Health Nursing
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• v.16 no.4
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• pp.498-507
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• 2005

Purpose: The purpose of this study is to survey health requirements of middle-aged women and their families and to provide guidelines for developing nursing interventions by describing the process of family health maintenance experienced by middle-aged women and its conceptual system. Methods: To get saturated data, each of four researchers conducted two or three times of in-depth interview with eight middle-aged women aged between 40-64 years old and living in Seoul and Chuncheon from the 10th to the 30th of October 2004 and each interview was continued one or two hours. The Grounded theory adopted by Strauss & Corbin (1998) is a substantive theory that can explain the experiencing process of middle-aged women. Results: We found that the casual condition of family health maintaining by middle-aged women was 'confidence of health belief', and 'pouring by body moving' was found to be its phenomenon. A textual condition that might respond to the phenomenon was 'fatal roles acceptance', and intervening conditions that promote their family health were 'retracing' and 'gathering health information'. These intervening conditions impacted middle-aged women's confidence in family health and led them to take actions/interactions such as 'being a model of health', 'adapting to circumstances', 'do-it-myself', 'taking-care' 'harmonious mind' and 'the pursuit of cleanness'. These actions/interactions produced results such as 'being stronger', 'being unmanageable' and 'being fruitful'. Conclusions: Health confidence and practical health behaviors were observed in the process that the middle-aged female participants experienced unmanageable circumstances but they accepted their roles and responsibilities and recognized that they must be get stronger. The behaviors of health-together-with were divided into enthusiastic type, adaptation type and self-sacrificing type. Therefore middle-aged woman with the understanding of family health maintaining process as well as the theoretical system and practical principals needs to implement the intervention in acceptable level of family health process of preventing psychological and physical problems.

• Child Health Nursing Research
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• v.7 no.1
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• pp.21-34
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• 2001

The impact of childhood experience has lifelong significance on subsequent health and development. Especially, the experience of infant is mostly affected by the quality of parental care and rearing environment. But the new mothers usually do not know what to do because of the lack of experience in these days. Therefore, an educational program regarding maternal role would be necessary. This study was conducted to evaluate the effectiveness of the maternal role education program for mother-infant interaction, child-rearing environment, and infant development. Non-equivalent control group time-series design was used, and Barnard's mother-infant interaction model was used as a conceptual framework of this study. The subjects were the healthy infants weighing over 2,500gm at birth, whose gestational age was more than 37 weeks, and their mothers. The final sample consisted of 19 mother-infant dyads for intervention group and 18 dyads for control group. Data were collected from March 15th to September 3rd in 1999. For the intervention group, programmed education which focused on mother-infant interaction, breast feeding, and infant care was provided before discharge. Telephone counselling was provided within one week after discharge. Home visiting for maternal role education was provided twice, one month and three months postpartum. For the control group, home visiting was also conducted but only for data collection. The data were analyzed using chi-square test and t-test to test the equivalence of two groups, and the effectiveness of intervention program was determined with repeated measure ANCOVA and t-test. The results were as follows: 1. Significant differences were found in mother-infant interaction between two groups(p=.000). It indicates that intervention program was effective in improving mother- infant interaction. In subscale analysis, four out of six subscale showed significant differences between the groups: sensitivity to cues (p=.000), social-emotional growth fostering (p=.000), cognitive growth fostering(p=.000) in mothers, and responsiveness to caregiver (p=.019) in infants. 2. The difference in the mean score of childrearing environment (HOME) between the intervention group and control group was significant(p=.003). When each subscale of HOME was examined individually, intervention group showed significantly higher scores in the diversity of stimulation(p=.000), and mother's involvement(p=.001). 3. Three-month-Infants of the intervention group showed higher GQ in the Griffiths mental development scale(p=.026). In subscale analysis, significant differences were found in the personal-social(p=.005), and the hearing and speech(p=.003). In conclusion, the maternal role education program proved to be effective in promoting the mother-infant interaction, organizing the childrearing environment, and fostering the infant development. These results are very meaningful that we found maternal role education necessary for normal infants' mothers, and that nurses can make a great contribution in promoting health of infants and mothers.