• 한방재활의학과학회지
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• 제33권1호
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• pp.77-85
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• 2023

Objectives This study is designed to evaluate the safety of palmul-tang soft extract in healthy male volunteers. Methods Twelve healthy male volunteers were recruited. And this study was conducted in a single center. As a result of the laboratory test, the safety was evaluated by collecting vital signs of volunteers. Twelve subjects were assigned by serial number according to the registration order. For safety evaluation, blood samples were collected and vital signs were checked four times throughout the test period, including screening, pre-administration, post-administration (after 48 hours) and post-administration (after 7 days). The difference in variables was summarized as the mean±standard deviation. The normality was performed using Kolmogorov-Smirnov and Shapiro-Wilk test. If normality is satisfied, a paired t-test is applied. Otherwise, the Wilcoxon sign rank test, which is a nonparametric method, is applied. The significance was p<0.05. The incidence of all side effects is expressed as a percentage. Results In the case of red blood cell, hemoglobin, and hematocrit values, the result of normality test of variables for the difference value before and after administration is significant level p<0.05. However, all laboratory test values before and after administration did not deviate from the normal range. Also the deviations in the normal range could not be seen as significance related to this clinical trial. And no side effects related to clinical trial drugs were observed. Conclusions The soft extract of palmul-tang was considered safe for healthy male volunteers.

• 국제학술발표논문집
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• The 3th International Conference on Construction Engineering and Project Management
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• pp.1300-1306
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• 2009

If a brief direction and plan for a remodeling project are decided, it may moves to a concrete design step of which to select the most suitable alternative out of applicable compounding devices to reveal dynamic drifting performance. However, the volume of knowledge baseed utility which can refer to systematic evaluation regarding remodeling element technology and the accumulation of realistic cases are not only sufficient, but also short including its system for expression and consistency. Therefore, it may necessary to deliver the main frame which make enables the Owner, designer and builder to get performance technology for applying advanced remodeling element and knowledge based utility. There is a necessity to provide an information with latest made by virtue of modeling in the 3D/4D based on construction-based knowledge etc. which we can use for life cycle of a project, as a prominent way of knowledge based utility. Then, it is sure that remodeling can become more activative by sharing of knowledge based utility formed in electronic 3D/4D which is a systematic and expressed consistently to a performance and applicability in preservation of savings. It is expected for modeling of the 3D/4D in knowledge based utility enables to verify the practicability of each technology on effective application, and the use of technology might be spread widely due its obvious and oriented expressions. Further, this knowledge based utility formed in electronic 3D/4D may applicable for VE process in addition to remodeling design fields.

• 대한토목학회논문집
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• 제26권1A호
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• pp.21-33
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• 2006

사장교 구조물을 대상으로 확률유한요소법을 신뢰성이론에 적합하도록 정식화하여 신뢰성해석을 보다 효율적으로 수행하고자 한다. 사장교의 초기평형해석을 수행한 후, 섭동법을 이용하여 선형 비선형 확률유한요소해석을 수행할 수 있으며, 확률변수의 상관성에 따른 신뢰성해석을 수행할 수 있는 프로그램을 작성하였다. 작성된 프로그램을 이용하여 사장교의 응답해석을 검토한 결과, 확률변수의 상호간 상관성에 따른 절점변위, 부재력 및 케이블긴장력에 대한 분산특성을 정량적으로 평가할 수 있었다. 또한 신뢰성지수 및 파괴확률을 검토하여 사장교 구조물의 안전성을 명확하게 파악하였다.

• 폴리머
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• 제39권3호
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• pp.382-387
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• 2015

본 연구에서는 탄산칼슘($CaCO_3$)의 폴리프로필렌에 분산과 탄산칼슘 입자의 크기가 폴리프로필렌의 결정성에 미치는 영향을 연구하였다. 무기물로 충전된 고분자복합재료는 일반적으로 취성(brittleness)의 문제를 가지고 있으며, 이러한 문제는 주로 무기물입자의 크기와 분산에 의해서 영향을 받는다. 따라서 탄산칼슘의 분산성을 향상시키기 위한 방법으로 sodium lignosulfonate(SLS)의 함량을 달리하면서 탄산칼슘을 전처리하고 이에 따른 분산효과를 고찰하였다. 그 결과 3 wt%의 SLS로 처리된 탄산칼슘은 미처리 탄산칼슘에 비해 우수한 분산성을 보였으며, 열분석에서도 빠른 결정형성능을 보였다. 이러한 결정형성능은 탄산칼슘 입자의 크기에 의해서도 영향을 받았으며, 입자의 크기가 커지면 용융과 결정화 과정에서의 엔탈피 출입이 줄어드는 것으로 관찰되었다. 이러한 결과들은 무기물 고분자복합재료의 취성을 해결할 수 있는 단서를 제공한다고 할 수 있겠다.

• 한국산학기술학회논문지
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• 제18권9호
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• pp.146-156
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• 2017

본 연구에서는 FTA 이행에 따른 시장개방화 속에서 농산물 수입 변화에 영향을 미치는 요인들을 살펴보았고, 실증분석을 통해 농산물 수입 변화와 이러한 요인들 간의 인과관계를 규명하였으며, 각각의 요인이 농산물 수입 변화에 미치는 영향의 크기를 비교하였다. 분석결과, FTA 요인을 대표하는 수입자유화율은 물론 국내 소비패턴 변화에 영향을 미치는 1인당 GDP, 수출국 농산물 수급여건 및 환율 변화를 나타내는 수입가격이 농산물 수입 변화에 영향을 미치는 것으로 나타났다. 단, 농산물 부류별 수입 변화에 영향을 미치는 요인과 각 요인별 영향의 크기는 상이한 것으로 나타났다. 이를 통해 FTA 요인과 함께 다양한 요인이 농산물 수입 변화에 복합적으로 작용하고 있음을 입증하였다. 앞으로 FTA 이행에 따른 관세율 하락으로 시장개방 폭이 더욱 커지고 있으며, 정부는 추가 FTA를 추진하여 FTA 경제영토는 더욱 확대될 것으로 예상되는 가운데, 이러한 농산물 수입 변화는 국내 농업부문의 피해로 이어질 것이므로 이에 대한 대응방안이 시급하다. 예를 들어, 품목별 경쟁력 제고를 위한 생산성과 품질 제고와 생산기반 확충, 농식품 소비패턴 변화에 기초한 소비자 지향적 생산 유통부문 전략 수립, 신규 FTA 협상 혹은 기 체결 FTA 개선협상 시 비관세조치 관련 사항에 대한 신중한 대처, 수출국의 농산물 수급동향에 대한 지속적인 모니터링과 국내 농산물 수급안정 노력 등이 필요하다.

• 한국수학교육학회지시리즈A:수학교육
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• 제44권3호
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• pp.457-475
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• 2005

We have inquired on what the statistical classes of the secondary schools had been aiming to, say the epistermlogical objects. And we now appreciate that the main obstacle to the systematic articulation is the lack of anticipation on what the statistical concepts are. This study focuses on the ingredients of the statistical concepts. Those are to be the ground of the systematic articulation of statistic courses, especially of the one for the school kids. Thus we required that those ingredients must satisfy the followings. i) directly related to the contents of statistics ii) psychologically developing iii) mutually exclusive each other as much as possible iv) exhaustive enough to cover all statistical concepts We examined what and how statisticians had been doing and the various previous views on these. After all we suggest the following three concepts are the core of conceptual developments of statistic, say the concept of distributions, the summarizing ability and the concept of samples. By the concepts of distributions we mean the frequency views on each random categories and that is developing from the count through the probability along ages. Summarizing ability is another important resources to embed his probe with the data set. It is not only viewed as a number but also to be anticipated as one reflecting a random phenomena. Inductive generalization is one of the most hazardous thing. Statistical induction is a scientific way of challenging this and this starts from distinguishing the chance with the inevitable consequences. One's inductive logic grows up along with one's deductive arguments, nevertheless they are different. The concept of samples reflects' one's view on the sample data and the way of compounding one's logic with the data within one's hypothesis. With these three in mind we observed Korean Statistic Curriculum from K to 12. Distributional concepts are dealt with throughout but not sequenced well. The way of summarization has been introduced in the 1 st, 5th, 7th and the 10th grade as a numerical value only. One activity on the concept of sample is given at the 6th grade. And it jumps into the statistical reasoning at the selective courses of ' Mathematics I ' or of ' Probability and Statistics ' in the grades of 11-12. We want to suggest further studies on the developing stages of these three conceptual features so as to obtain a firm basis of successive statistical articulation.

• 한국식생활문화학회지
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• 제18권5호
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• pp.443-456
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• 2003

The lyophilization of the solution extracted from 60 percent of acetone applied to persimmon leaves, the compounding process in accordance with the solution's concentration, and the gel filteration through Sephadex G-50 of biologically activated substances obstructing enzyme activity, such as tyrosinase, xanthine oxidase, and angiotesin converting enzyme (ACE) led to the assumption that polyphenol was the compound serving as biologically activated substances obstructing enzyme activity. Xanthine oxidase involved in pruine metabolism oxidizes hypoxanthine to xanthine and xanthine to uric acid. In the continuous study for natural compound, nine flavan-3-ols have been isolated from the persimmon leaves. The structures of (+)-catechin, (+)-gallocatechin, procyanidin B-1, pyrocyanidin C-1, prodelphinidin B-3, gallocatechin-$(4{\alpha}{\rightarrow}8)$-catechin, procyanidin B-7-3-O-gallate, procyanidin C-1-3'-3'-3'-O-trigallate and (-)-epigallocatechin-$(4{\alpha}{\rightarrow}8)$-epigallocatechin-$(4{\alpha}{\rightarrow}8)$-catechin were established by NMR and their inhibitory effect on xanthine oxidase activity was investigated. Procyanidin B-7-3-O-gallate, (-)-epigallocatechin-$(4{\alpha}{\rightarrow}8)$-epigallocatechin-$(4{\alpha}{\rightarrow}8)$-catechin and procyanidin C-1-3'-3'-3'-O-trigallate showed 94%, 90.69%, 80.90% inhibition at $100\;({\mu})M$ and inhibited on the angiotensin converting enzyme respectively. Procyanidin B-7-3-O-gallate and procyanidin C-1-3'-3'-3'-O-trigallate showed 66%, 63% inhibition at $100\;({\mu})M$ and inhibited on the xanthine oxidase competitively. Procyanidin C-1-3'-3'-3'-O-trigallate showed 70% inhibition at $100\;({\mu})M$ and inhibited on the tyrosinase competitively.

• 한국세라믹학회지
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• 제39권11호
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• pp.1090-1096
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• 2002

몬모릴로나이트군의 벤토나이트(BEN)와 첨가제로서 풀림제 및 음이온 계면활성제를 배합하여 6종의 수팽윤성 BEN 유동성 개질제(WSB-1~WSB-6)를 제조하였다. 제조한 WSB의 평균입경, 입자형태, 용액점도, 수팽윤성 및 첨가제에 따른 점도를 각각 측정하였고, WSB의 유동학적 거동을 레오메타를 이용하여 조사하였다. WSB-1의 점도는 pH가 낮을수록 BEN의 평균입경이 작을수록 각각 증가하였고, 풀림제로서 $Na_2CO_3$를 처리한 WSB-2의 점도가 가장 높게 나타났다. 이 결과는 WSB에 포함된 BEN 입자가 edge-to-face의 구조로 재배열이 일어나기 때문으로 해석할 수 있다. 또한 WSB에 풀림제 및 음이온 계면활성제가 포함된 WSB-4, WSB-5 및 WSB-6은 전단력에 따라 점도의 변화가 거의 없는 졸(sol)상으로 존재하지만, 음이온 계면활성제로서 Tetrasodium Pyrophosphate(TSPP)를 첨가한 WSB-3의 경우는 전단력에 따른 점도가 1000배의 차이가 남으로서 요변성(thixotropy)을 나타내었고, 이 결과로부터 TSPP의 음이온이 WSB-3에 포함된 BEN 입자의 edge에 배열된다고 설명할 수 있다.

• 대한약침학회지
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• 제22권4호
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• pp.260-268
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• 2019

Objectives: The Clinical Decision Support System (CDSS), which analyzes and uses electronic health records (EHR) for medical care, pursues patient-centered medical care. It is necessary to establish the CDSS in Korean medical services for objectification and standardization. For this purpose, analyses were performed on the points to be followed for CDSS implementation with a focus on herbal medicine prescription. Methods: To establish the CDSS in the prescription of Traditional Korean Medicine, the current prescription practices of Traditional Korean Medicine doctors were analyzed. We also analyzed whether the prescription support function of the electronic chart was implemented. A questionnaire survey was conducted querying Traditional Korean Medicine doctors working at Traditional Korean Medicine clinics and hospitals, to investigate their desired CDSS functions, and their perceived effects on herbal medicine prescription. The implementation of the CDSS among the audit software developers used by the Korean medical doctors was examined. Results: On average, 41.2% of Traditional Korean Medicine doctors working in Traditional Korean Medicine clinics manipulated 1 to 4 herbs, and 31.2% adjusted 4 to 7 herbs. On average, 52.5% of Traditional Korean Medicine doctors working in Traditional Korean Medicine hospitals adjusted 1 to 4 herbs, and 35.5% adjusted 4 to 7 herbs. Questioning the desired prescription support function in the electronic medical record system, the Traditional Korean Medicine doctors working at Korean medicine clinics desired information on 'medicine name, meridian entry, flavor of medicinals, nature of medicinals, efficacy,' 'herb combination information' and 'search engine by efficacy of prescription.' The doctors also desired compounding contraindications (eighteen antagonisms, nineteen incompatibilities) and other contraindicatory prescriptions, 'medicine information' and 'prescription analysis information through basic constitution analyses.' The implementation of prescription support function varied by clinics and hospitals. Conclusion: In order to implement and utilize the CDSS in a medical service, clinical information must be generated and managed in a standardized form. For this purpose, standardization of terminology, coding of prescriptions using a combination of herbal medicines, and unification such as the preparation method and the weights and measures should be integrated.

• 정보처리학회논문지C
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• 제14C권4호
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• pp.331-340
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• 2007

모바일 네트워크 환경은 언제 어디서나 네트워크를 사용하는 모바일 서비스를 편리하게 사용할 수 있도록 해준다. 그러나 언제 어디서나 서비스를 제공받을 수 있다는 것은 언제 어디서든지 정보가 누출되거나 왜곡될 위험성 또한 존재하기 마련이다. 특히, 프라이버시 문제가 해결되지 않고서는 우리 일상생활과 융합되어 편리함을 제공해주는 모바일 네트워크 환경이 오히려 모바일 네트워크 감시 체제를 구축하는 심각한 역기능을 초래하게 될 것이다. 모바일 단말기들은 크기와 모양이 다양하고 컴퓨팅 연산 능력이 적은 저성능 휴대 장치들이 많기 때문에, 컴퓨팅 연산이 많이 요구되는 공개키 암호 기술을 저성능 모바일 단말기에 적용하기는 힘든 상황이다. 이에 본 논문에서는 프라이버시 문제를 해결하면서, 컴퓨팅 연산 능력이 적은 저성능 모바일 단말기에 적용할 수 있는 자바 기반의 암호 모듈 및 PKI 기반의 사용자 인증을 제안하고자 한다. 국내 표준 암호 알고리즘(SEED, KCDSA, HAS160)과 인증서를 기반으로 세션키와 공개키를 조합함으로서 최소한의 암복호화 연산을 통해 인증 및 전자 서명을 제공하며, 이를 대표적인 모바일 단말기인 PDA 환경에서 세션키 분배 및 사용자 인증이 안전하게 이루어짐을 확인할 수 있었다.