• Natural Product Sciences
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• 제15권1호
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• pp.22-26
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• 2009

Phytochemical investigation of the roots of Echiochilon fruticosum resulted in the isolation of two naphthoquinone derivatives. Compound 1 was identified as anhydroalkanin while compound 2 was identified as a new derivative 5-hydroxy 8-methoxy 2-(4-methylpent-1,3-dienyl) naphthalene-1,4-dione named as echiochiloquinone. In addition, caffeic acid 3, caffeic acid methyl ester 4 were isolated. The structures were determined by physical, chemical and spectral methods. The anti-inflammatory activity of the root extracts and compound 2 was evaluated utilizing both cotton pellet-induced and carragenin-induced rat paw edema. The ulcerogenic effect was also studied.

• Fisheries and Aquatic Sciences
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• 제9권4호
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• pp.175-178
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• 2006

An acidic ent-cyclic peroxide was isolated from a sponge, Plakotis sp., and showed activity against leishmaniasis and pathogenic fungi. To improve the activity of this compound, we coupled the acidic ent-cyclic at the C1 position of ircinol A. Compound 3 exhibited significant activity against Leishmania mexican a and fungi with $IC_{50}$ values of 0.7 and $0.3-34{\mu}g/mL$, respectively. The yield of compound 3 was 98%.

• The Korean Journal of Ceramics
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• 제2권2호
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• pp.111-113
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• 1996

Dielectric properties at microwave frequency region of the five-layered compound $Ba_5Nb_4O_{15}$ prepared by the conventional solid state reaction method were investigated. $Ba_5Nb_4O_{15}$ has excellent microwave dielectric characteristics; ${\varepsilon}_r$=38, Q=7500 at 10 GHz, and ${\tau}_l$=+50 ppm/K. Since this compound has a high dielectric constant, high Q and sufficiently stable characteristics, it is useful for the applications at microwave frequencies.

• 한국토양비료학회지
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• 제11권1호
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• pp.37-42
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• 1978

수도추비용시제복합비료(水稻追肥用試製複合肥料) (조선비료공업주식회사(朝鮮肥料工業株式會社) 제품(製品)) 17-0-17과 17-0-14의 비효를 밝히기 위(爲)하여 수도(水稻)아끼바레를 표식작물(標識作物)로 포장시험(圃場試驗)을 한 결과(結果)는 다음과 같다. 1. 정조(正租)의 수량(收量)과 질소(窒素) 및 가리(加里)의 흡수량(吸收量)으로 보아 시제복합비료(試製複合肥料)의 비효는 단비요소(單肥尿素) 염화가리(鹽和加里)에 뒤떨어지지 않는다. 2. 복합비료(複合肥料) 17-0-17 입제(粒製)는 비효가 완만하여 수비용(穗肥用)보다는 유효분벽기비용으로 가(可)할 것 같다. 3. N K 복비(複肥)의 추비(追肥)는 수량(收量)과 양분(養分)의 흡수량(吸收量)을 증가(增加)하고 시험후(試驗後) 토양(土壤)의 치환성가중함량(置煥性加里含量)을 증가(增加)한다는 점(點)으로 보아 시제복비(試製複肥)와 같은 비료(肥料)의 개발(開發)에 관(關)하여 적극적(積極的)인 고려(考慮)가 필요(必要)한 것으로 생각된다.

• 한국토양비료학회지
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• 제49권4호
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• pp.393-400
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• 2016

Fusarium graminearum is the main cause of substantial economic loss in wheat production. The aim of this study is to investigate biocontrol potential of Lysobacter antibioticus HS124 against F. graminearum and to purify an antifungal compound. In preliminary study, n-butanol crude extract revealed destructive alterations in the hyphal morphology of F. graminearum and almost degraded with $1,000{\mu}g\;mL^{-1}$ concentration. For further study, the antifungal compound extracted from the n-butanol crude extract of L. antibioticus HS124 was identified as N-Butyl-tetrahydro-5-oxofuran-2-carboxamide ($C_9H_{16}NO_3$) using NMR ($^1H-NMR$, $^{13}C-NMR$, $^1H-^1H\;COSY$, HMBC, and HMQC), and HR-ESI-MS analysis. To our knowledge, N-Butyl-tetrahydro-5-oxofuran-2-carboxamide may be a novel compound with molecular weight of 186.1130. The minimum inhibitory concentration value of antifungal compound was $62.5{\mu}g\;mL^{-1}$ against F. graminearum. In an in vivo pot experiment, crown rot disease from F. graminearum was inhibited when wheat seeds were treated with both HS124 culture and F. graminearum. Growth of wheat seedling was enhanced by treatment of HS124 compared to control. Our results suggest that L. antibioticus HS124 characterized in this study could be successfully used to control F. graminearum and could be used as an alternative to chemical fungicides in modern agriculture.

• 생물환경조절학회지
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• 제15권4호
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• pp.317-321
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• 2006

본 실험은 딸기의 고설수경재배에 이용 가능한 적정한 배지를 조사하기 위하여 수행하였다. 코코피트 배지에서 엽수가 가장 많았으며, 원예용 상토배지에서 엽장과 엽폭이 가장 우수했다. 과중은 통계적인 유의성은 없었지만 원예용 상토배지에서 25.8g으로 가장 높게 나타났고 과장, 과경, 당도 등도 처리 간에 유의한 차이는 없었지만 원예용 상토배지에서 가장 좋은 결과를 나타내었다. 주당 수확과수는 원예용 상토와 코코피트 배지 모두 왕겨 혼합배지보다 유의하게 높은 수치를 나타내었다. 주당 수량은 원예용 상토배지가 545.9g으로 가장 많았으며, 그 다음으로 코코피트 배지에서 높았으며 왕겨 혼합배지에서 가장 낮았다. 본 연구에서는 딸기의 수경재배에 적합한 고형배지로서 생산자가 구입과 작업이 편리하고 물리성이 좋은 원예용 상토의 우수성을 입증하여, 딸기 재배농가에게 유용한 정보로 활용될 수 있을 것으로 기대되며 타 작물의 고형배지 재배에서도 유용하게 이용될 것으로 생각된다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3759-3765
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• 2015

Background: Approaches in disruption of MDM2-p53 interactions have now emerged as an important therapeutic strategy in resurrecting wild type p53 functional status. The present study highlights virtual screening strategies in identification of high affinity small molecule non-peptidic inhibitors. Nutlin3A and RG7112 belonging to compound class of Cis-imidazoline, MI219 of Spiro-oxindole class and Benzodiazepine derived TDP 665759 served as query small molecules for similarity search with a threshold of 95%. The query molecules and the similar molecules corresponding to each query were docked at the transactivation binding cleft of MDM2 protein. Aided by MolDock algorithm, high affinity compound against MDM2 was retrieved. Patch Dock supervised Protein-Protein interactions were established between MDM2 and ligand (query and similar) bound and free states of p53. Compounds with PubCid 68870345, 77819398, 71132874, and 11952782 respectively structurally similar to Nutlin3A, RG7112, Mi219 and TDP 665759 demonstrated higher affinity to MDM2 in comparison to their parent compounds. Evident from the protein-protein interaction studies, all the similar compounds except for 77819398 (similar to RG 7112) showed appreciable inhibitory potential. Of particular relevance, compound 68870345 akin to Nutlin 3A had highest inhibitory potential that respectively showed 1.3, 1.2, 1.16 and 1.26 folds higher inhibitory potential than Nutilin 3A, MI 219, RG 7112 and TDP 1665759. Compound 68870345 was further mapped for structure based pharamacophoric features. In the study, we report Cis-imidazoline derivative compound; Pubcid: 68870345 to have highest inhibitory potential in blocking MDM2-p53 interactions hitherto discovered.

• Elastomers and Composites
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• 제44권4호
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• pp.416-422
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• 2009

Benzyl 4-Hydroxybenzoate와 1,6-Dibromohexane을 반응시켜 4-(6-bromohexyloxy)benzoic acid를 합성하였다. 이것을 하이드로퀴논과 반응시켜 브롬 그룹을 갖는 새로운 mesogenic ester를 합성하였다. Mesogenic ester를 자외선에 민감한 coumarin과 반응시켜 새로운 형태의 광응답성 coumarin 화합물을 합성 하였다. 합성된 화합물의 구조는 FT-IR 및 $^1H$-NMR에 의해 확인 하였으며, 그들의 열적 상전이온도 및 안정성들은 DSC, 편광현미경 및 X-선 회절에 의해 조사 하였다. 한편 합성된 새로운 화합물은 광학 편광 현미경 관찰에 의해 스멕틱 및 네마틱 구조를 갖는 쌍방성 액정성을 보였다.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2005년도 하계학술대회 논문집 Vol.6
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• pp.414-415
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• 2005

A solar cell is an element to transform the solar light energy into the electric energy in a moment. The single crystal element of high quality on which many studies were conducted in the past has a high efficiency of energy transformation, but its price competitiveness is so poor that it has failed to be popularized However, recently, in terms of an environment-friendly alternative energy, studies on applicability of the polycrystal solar cell have been actively under way. Among subject substances for such solar cell, $CuInSe_2$ has several good physical properties so that the greatest attention is paid to it as an optical absorption layer material for a low-cost solar cell of high efficiency. In order to manufacture the $CuInSe_2$ compound thin film, the unit element was deposited by using the sputtering method and the evaporation method and the heat treatment process was used in an electric furnace. Thereby, we intended to get a single-phase $CuInSe_2$ compound thin film.

• 한국약용작물학회지
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• 제15권1호
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• pp.6-11
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• 2007

작약의 지상부인 잎과 줄기에서 물질을 분리 동정하기 위해 MeOH 추출 및 column chromatograpy하여 단일 물질 5종을 분리하였으며, 분리한 물질에 대하여 IR, UV, Mass, NMR 등을 이용하여 화학구조를 동정하였다. 그 결과 oleanolic acid, kaempferol, methyl gallate, astragalin, paeoniflorin의 구조가 확인되었으며 이들 화합물은 작약의 지상부인 잎과 줄기에서는 처음으로 분리되었다.