• Herbal Formula Science
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• v.19 no.1
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• pp.79-90
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• 2011

Objectives : This study was performed to analysis the composition of herbal formulations about a series of Wolgug-Hwan(WGH, formed by Gukchur-won and Sagung-san) in Dongeuibogam written by Heo Jun. Methods : The series of WGH in Dongeuibogam were selected by 'Prescription Lineage Graph' (http://164.125.206.43/PrescriptionLineageGraph.aspx) established by prof. Lee at Pusan National University. In the analysis of a series of WGH, we used some formulation books including classics. Results : Gaeuldogi-tang(GDT) is formed by WGH, Yeonggangchulgam-tang(YGT), Yugil-san (YIS) and Gungchul-san. Cheongul-san(CUS) is formed by WGH, Ijin-tang(IJT), YGT and Haegeum -hwan(HGH). Sosikcheongul-san(SCS) is formed by CUS and IJT. Jeungmiijin-tang(JIT) is formed by WGH, IJT, Sambaek-tang and Gyullyeonjichul-hwan. Sihoeokgan-tang(SET) is formed by WGH, Sihosogan-san(SSS) and Jigolpi-eum. Wolgukbohwa-hwan(WBH) is formed by WGH, Bohwa-hwan, Mokyangjichul-hwan and Hwangnyeon-tang(HNT). Chimsa-hwan(CSH) is formed by WGH, Injinho-tang(IHT), Yungmisamneung-hwan, Jeungmisamul-tang and Sinseongugi-tang. Conclusions : SCS, CUS, or JIT has been used frequently in case of phlegm-fire. These are formulated by the combination of WGH and IJT with Samseon-san or HGH or Jichul-hwan according to the special symptoms, respectively. SET which is formulated by WGH and SSS has been used in case of stagnation of liver-qi. GDT, WBH or CSH has been used in damp-heat. These are formulated by the combination of WGH with YIS, HNT, or IHT, respectively.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.6
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• pp.1365-1380
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• 2007

Based on the theories and clinical data of oriental medicine, traditional medicinal prescriptions known to be effective to diabetic nephropathy were collected. The prescriptions were carefully examined and analyzed in order to be used as fundamental material for experiments and in clinicals. More than 40 publications related to diabetes were arranged and analyzed. Of the complications, diabetic nephropathy part of the publications were specifically focused during analysis. Data were analyzed and classified according to the quantity, prescription, differentiation of symptoms, signs and addition and subtraction of each medicine. Frequently used medicines were statistically analyzed. The most frequently used prescription was Yukmigihwang-tang(六味地黃湯) based medicine and prescriptions of its addition and subtraction, which was 15% of the total prescriptions cited. The most frequently used medicine was Astragali Radix, mentioned 192 times in the prescriptions. Hoelen was next with 180 citations, followed by Dioscoreae Rhizoma with 147 times, Rehmanniae Radix with 140, Corni Fructus with 131, Salviae Miltiorrhizae Radix with 106, Angelicae Gigantis Radix with 101, Alismatis Rhizoma with 95, Rhei Rhizoma with 90, Atractylodis Rhizoma Alba with 84, Rehmanniae Radix Preparata with 78, Leonuri Herba with 74, Moutan Cortex Radicis with 66, Aconiti Lateralis Preparata Radix with 66 Cnidii Rhizoma with 65, Pseudostellaria heterophylla with 62, Liriopis Tuber with 55, Lycii Fructus with 52, Rhei Rhizoma with 49, Codonopsis Pilosulae Radix with 44, Paeoniae Radix Rubra with 44, Schisandrae Fructus with 42, Polyporus with 42, Achyranthis Radix with 41 and Euryales Semen with 40. Medicines prescribed more than 30 grams a day included Astragali Radix, Imperatae Rhizoma, Benincasae Pericarpium, Leonuri Herba, Dioscoreae Rhizoma, Plantaginis Semen, Polyporus, Hoelen, Halloysitum Rubrum, Achyranthis Radix, Arecae Pericarpium, Phaseoli Angularis Semen, Coicis Semen, Rhei Rhizoma, Salviae Miltiorrhizae Radix, Sargassum, Ostreae Concha, Pseudostellaria heterophylla, Epimedii Herba, Rehmanniae Radix, Scrophulariae Radix and Polygonati Rhizoma. No scientific reports on the traditional medicinal aspects of diabetic nephropathy was searched. This analysis report would be able to provide the basis of developing new drug candidates for the treatment of diabetic nephropathy, as well as securing the EBM for the traditional medicines already being prescribed to the patients.

• Herbal Formula Science
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• v.20 no.2
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• pp.117-136
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• 2012

This thesis is the study on GuiLinGuBen "ShangHanZaBingLun"'s prescriptions which are totally 324, and unique 91 which are not written in current "ShangHanZaBingLun" and "JinKuiYaoLue", only in GuiLinGuBen "ShangHanZaBingLun". For modern clinacal effectiveness of GuiLinGuBen "ShangHanZaBingLun", this thesis clarifies the prescriptions' distinction between GuiLinGuBen, "ShangHanZaBingLun" and "JinKuiYaoLue". First it classifies prescriptions into 4 groups, which are only in GuiLinGuBen, in "ShangHanZaBingLun", in "JinKuiYaoLue", and in both "ShangHanZaBingLun" and "JinKuiYaoLue". Second it tabulates and describes in detail GuiLinGuBen's prescriptions about title, prescription composition, prescription volumetrin, decotion, and dosage. Third it catches distinctive characteristic of GuiLinGuBen's prescriptions by a comparative study which clarifies the differences of prescriptions between GuiLinGuBen, "ShangHanZaBingLun" and "JinKuiYaoLue". Current "ShangHanZaBingLun" and "JinKuiYaoLue"'s remedy focus on Shanghan and Jabbyong, so it has no choice but to have large remedy vaccum. The prescriptions only in GuiLinGuBen have same system with "ShangHanZaBingLun" and "JinKuiYaoLue"'s prescriptions, and contain unique Fever remover(淸熱劑) and Counterbalancer (補劑), so they could give more clinacal practice over "ShangHanZaBingLun" and "JinKuiYaoLue".

• Journal of Haehwa Medicine
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• v.8 no.1
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• pp.837-851
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• 1999

In order to inverstigate interactive effects of Samultang(SMT) and SMT composition and the principle of prescription, I examined the effects of SMT and combination of three components of SMT, In C57BL/6 mouse with oral administration of SMT and cyclophosphamide(CTX) treatment, white blood cells, platelet were counted. Also, those were anti-anemia effect for rat which have hemolytic anemia induced by phenylhydrazine. The results were summerized as follows : 1. In vivo analysis of the effect of the SMT by orally administrated C57BL/6 mice with the SMT and was treated with cyclophosphamide (CTX). When the number of white blood cell. platelet was counted, there was ameliorative effects of leucopenia or thrombocytopenia as a protection to CTX. 2. It was acknowledged that SMT and its composition increased RBC count and hemlytic significantly in rat which have hemolytic anemia. 3. Among SMT composition Angelicae gigantis Radix and Cnidii Rhizoma solution and among the combination group Rehmanniae Radix and Cnidii Rhizoma combination and SMT solution showed significant effects for hemoglobin and weight of spleen in mouse which have hemolytic anemia. Thus it was acknowledged that Rehmanniae Radix and Cnidii Rhizoma combination had effect to improve hemoglobin and weight of spleen. From above these results it was acknowledged that SMT has effects that ameliorative effects of leucopenia or thrombocytopenia as a protection to CTX and anti-anemic effect for the rat which have hemolytic anemia induced by phenylhydrazine and these effects depend upon its combination of SMT composition. Especially it was acknowleged, though there are the slight difference according to combination, that Paeoniae Radix Alba combination had improving effect for physical change. So it is though that Paeoniae Radix Alba is main material for this kind of disease and continuous study is needed.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.1
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• pp.209-213
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• 2007

In the recent, increased concern has been focused on the pharmacology and clinical utility of herbal extracts and derivatives as a drug or adjunct to chemotherapy and immunotherapy. Salicis Radicis Cortex, A decoction has been mainly used for improvement of ozena and a diuretic effect in oriental medicine, but there was no study on the molecular mechanism of Salicis Radicis Cortex as an immunomodulator. Here we investigated the role of the aqueous extract of Salicis Radicis Cortex in the expression of inflammatory mediators, surface molecule, and related receptors in vitro and in vivo. In murine macrophage RAW 264.7 cells and peritoneal macrophages of C57BL/6N mice, water extract of Salicis Radicis Cortex increased the production of secretary TNF-alpha and Nitric oxide, and the expression level of CD14, LPS co-receptor and CD86, co-stimulatory molecule compared to negative natural extract ex vivo. Moreover, i.p. injection of water extract of Salicis Radicis Cortex significantly increased the secretion level of IFN-gamma and TNF-alpha, IL-2, IL-4 and IL-5 in serum of mice in vivo. Taken together, these results suggest that Salicis Radicis Cortex may regulate the immune response by secreting Th1 and Th2 types of cytokines in vivo and the possibility of its as natural immunostimulator.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.3
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• pp.700-704
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• 2007

In the recent, increased concern has been focused on the pharmacology and clinical utility of herbal extracts and derivatives as a drug or adjunct to chemotherapy and immunotherapy. Here we investigated the role of the extract of Anethi Fructus in the expression of inflammatory mediators, surface molecule, and related receptors in vitro. In murine macrophage RAW 264.7 cells and peritoneal macrophages of C57BL/6N mice, water extract of Anethi Fructus increased the production of secretary tumor necrosis factor (TNF)-a and Nitric oxide (NO), and the expression level of CD14, LPS co-receptor and CD86, co-stimulatory molecule compared to negative natural extract ex vivo. The water extract of Anethi Fructus increased the production of interferon (IFN)-g from splenocytes. Also, water extract of Anethi Fructus increased ConA-induced cell proliferation. These results suggest that water extract of Anethi Fructus may enhance the immune response through immune modulation of macrophage and lymphocytes.

• The Journal of Korean Physical Therapy
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• v.15 no.2
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• pp.168-181
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• 2003

The purpose of this study was to investigate the effects of circuit weight training(CWT) on isokinetic muscle strength and body composition in elderly. The subjects who engaged in this experiment exercised at 40$\%$ of 1-RM, 12 repetitions, followed by 15 sec as the subject moved to the each break training program which was consist of the circuit of 10 stations performed on 3 set a day, circuits 3 days a week during 10 weeks. The assessment of isokinetic factor was in concentric flexors and extensors of right and left knee joint. Tests were performed on the Cybex 770 Isokinetic Dynamometer and body composition were estimated the three parts of chest, abdomen and anterior thigh by using skinfold caliper, calculated the average and followed by Seri and Brozek way. Statistical analysis were performed using analysis of variance paired t-test, accepting level for all significant was above $\alpha$=.05 and $\alpha$=.01. Following is as a result of 10 weeks circuit weight training. 1. At the $60_{\circ}$ /sec, the right and left knee isokinetic concentric flexors and extensors peak torque increased significantly (p < .01). 2. At the $180_{\circ}$ /sec, the right and left knee isokinetic concentric flexors and extensors peak torque increased significantly (p < .01). 3. At the $60_{\circ}$ /sec, the right and left knee isokenetic concentric flexors and extensors average power increased significantly(p < 0.5, p < .01) and at the $180_{\circ}$ /sec, the right extensors didn't show any statistical significant. 4. At the $60_{\circ}$ /sec, the right and left knee Isokinetic concentric flexors and extensors total work increased significantly(p < .05, p < .01) but at the $180_{\circ}$ /su right concentric flexors didn't show any statistical significant. 5. The body composition changed significantly(p < .01). These results suggest that 10 weeks circuit weight training increases the peak torque, average power, total work significantly and decreases the $\%$body fat significantly.

• The Journal of Korean Physical Therapy
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• v.15 no.4
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• pp.398-411
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• 2003

The purpose of this study was to investigate the effects of circuit weight training(CWT) on isokinetic muscle strength and body composition in elderly. The subjects who engaged in this experiment exercised at $40\%$ of 1-RM, 12 repetitions, followed by 15 sec as the subject moved to the each break training program which was consist of the circuit of 10 stations performed on 3 set a day, circuits 3 days a week during 10 weeks. The assessment of isokinetic factor was in concentric flexors and extensors of right and left knee joint. Tests were performed on the Cybex 770 Isokinetic Dynamometer and body composition were estimated the three parts of chest, abdomen and anterior thigh by using skinfold caliper, calculated the average and followed by Seri and Brozek way. Statistical analysis were performed using analysis of variance paired t-test, accepting level for all significant was above ${\alpha}=.05$ and ${\alpha}=.01$. Following is as a result of 10 weeks circuit weight training. 1. At the $60_{\circ}$ /sec, the right and left knee isokinetic concentric flexors and extensors peak torque increased significantly(p<.01). 2. At the $180_{\circ}$ /sec, the right and left knee isokinetic concentric flexors and extensors peak torque increased significantly(p<.01). 3. At the $60_{\circ}$ /sec, the right and left knee isokenetic concentric flexors and extensors average power increased significantly(p<.05, p<.01) and at the $180_{\circ}$ /sec, the right extensors didn't show any statistical significant. 4. At the $60_{\circ}$ /sec, the right and left knee Isokinetic concentric flexors and extensors total work increased significantly(p<.05, p<.01) but at the $180_{\circ}$ /sec right concentric flexors didn't show any statistical significant. 5. The body composition changed significantly(p<.01). These results suggest that 10 weeks circuit weight training increases the peak torque, average power, total work significantly and decreases the $\%$body fat significantly.

• Journal of Korean Medical classics
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• v.31 no.1
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• pp.139-156
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• 2018

Objectives : This paper provides a general introduction of a person Seopa Lee-yidoo and the contents of his medical text, Uigamsanjeonyogyul. The paper then investigates how this text summarized and recomposed Donguibogam. Methods : The paper first reviews the activities and academic leanings of Lee-yidoo, the author of Uigamsanjeonyogyul, as described in his book Seopa-munjip. Furthermore, the paper compares Donguibogam and Uigamsanjeonyogyul's process of summarizing Donguibogam. Based on this the paper divides these comparisons and introduces examples. Results : When the overall composition, formation, and the original contents of Uigamsanjeonyogyul were compared with the texts of Donguibogam, it was discovered that the former wholly accepted the composition of the latter but made bold summarizations. Meanwhile, Uigamsanjeonyogyul added a detailed list of contents at the beginning of the book, and its original contents provided integration, relocation, and detailed explanations of Donguibogam two sections. It gave changes to bogam's prescription configuration and explanations on the mechanism of diseases, and it also added a section for new prescriptions. Like this, Uigamsanjeonyogyul showed a great deal of knowledge regarding the clinical field. Conclusions : Uigamsanjeonyogyul which was published as a summary of Donguibogam, faithfully follows the texts of Donguibogam. At the same time, it provides summary, improvement, and rearrangement based on the author's academic leanings.

• Journal of Korean Medical classics
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• v.27 no.4
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• pp.85-99
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• 2014

Objectives : Junsaengpaljeon(遵生八牋), a book specialized in curing was published during Ming Dynasty, addressing the significance on food through Eumchanboksikjeon(飮饌服食牋). Therefore, the objective of this study is to investigate the importance and utilization of food in curing from the perspective of author Goryum(高濂). Methods : Junsaengpaljeon released by InMinWiSaeng publisher was used in this study. The author and reference books were investigated, as well as the composition and contents of Eumchanboksikjeon. This study also focused on the utilization of food cure in Eumchanboksikjeon. Results : Volume 11 to 13 in Junsaengpaljeon is about Eumchanboksikjeon. Volume 11 is composed of Seokojaeron(序古諸論), Darchunyu(茶泉類), Tangpoomyu(湯品類), Sooksuyu(熟水類), Jukmiryu(粥糜類), Kwacillbunmiunyu(果實粉麵類), Pojaryu(脯鮓類) and Chisicryubeopjoerye(治食有法條例), whereas volume 12 is composed of Gasoyu(家蔬類), Yasoryu(野蔬類), Onjoryu(醞造類) and Kookryu(麯類). Volume 13 is composed of Chumsikyu (甛食類), Beopjeyakpumryu(法製藥品類), Boxsicbongyu(服食方類) and Gojaronbangjungyakmuljihae(高子論房中藥物之害). Especially volume 11 proposed the recipe and efficacy of Tangpoomyu(湯品類), Sooksuyu(熟水類), Jukmiryu(粥糜類) and Kwacillbunmiunyu(果實粉麵類), which can be used in food curing. Conclusions : Junsaengpaljeon Eumchanboksikjeon is a book complied the foods of Ming Dynasty with the description of dietetics theory. Especially this book covers Boxsicbong(服食方) and its dietary therapy prescription, and food for elderly health; it is, therefore, highly useful in applying various areas.