Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Composition Comprising the Extract of Anethi Fructus for the Treatment and Protection of Immune Activity

시라자 추출물을 함유하는 면역질환의 치료 및 예방을 위한 면역증강용 조성물

  • Park, Gil-Soon (Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine, Wonkwang University. Department of Oriental Medicine Prescription, College of Oriental Medicine, Wonkwang University) ;
  • Chang, In-Ae (Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine, Wonkwang University. Department of Oriental Medicine Prescription, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Youn-Chul (College of Pharmacy, Wonkwang University) ;
  • Lee, Moo-Hyung (Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine, Wonkwang University. Department of Oriental Medicine Prescription, College of Oriental Medicine, Wonkwang University) ;
  • Shin, Hye-Young (Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine, Wonkwang University) ;
  • Choi, Du-Young (Department of Pediatrics, College of Medicine, Wonkwang University) ;
  • Yun, Yong-Gab (Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine, Wonkwang University. Department of Oriental Medicine Prescription, College of Oriental Medicine, Wonkwang University) ;
  • Park, Hyun (Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine, Wonkwang University)
  • 박길순 (원광대학교 인수공통감병연구센터 및 의과대학 감영생물학교실, 원광대학교 한의과대학 방제학교실) ;
  • 장인애 (원광대학교 인수공통감병연구센터 및 의과대학 감영생물학교실, 원광대학교 한의과대학 방제학교실) ;
  • 김윤철 (원광대학교 약학대학) ;
  • 이무형 (원광대학교 인수공통감병연구센터 및 의과대학 감영생물학교실, 원광대학교 한의과대학 방제학교실) ;
  • 신혜영 (원광대학교 인수공통감병연구센터 및 의과대학 감영생물학교실) ;
  • 최두영 (원광대학교 의과대학 소아과학교실) ;
  • 윤용갑 (원광대학교 인수공통감병연구센터 및 의과대학 감영생물학교실, 원광대학교 한의과대학 방제학교실) ;
  • 박현 (원광대학교 인수공통감병연구센터 및 의과대학 감영생물학교실)
  • Published : 2007.06.25
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Abstract

In the recent, increased concern has been focused on the pharmacology and clinical utility of herbal extracts and derivatives as a drug or adjunct to chemotherapy and immunotherapy. Here we investigated the role of the extract of Anethi Fructus in the expression of inflammatory mediators, surface molecule, and related receptors in vitro. In murine macrophage RAW 264.7 cells and peritoneal macrophages of C57BL/6N mice, water extract of Anethi Fructus increased the production of secretary tumor necrosis factor (TNF)-a and Nitric oxide (NO), and the expression level of CD14, LPS co-receptor and CD86, co-stimulatory molecule compared to negative natural extract ex vivo. The water extract of Anethi Fructus increased the production of interferon (IFN)-g from splenocytes. Also, water extract of Anethi Fructus increased ConA-induced cell proliferation. These results suggest that water extract of Anethi Fructus may enhance the immune response through immune modulation of macrophage and lymphocytes.

Keywords

References

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