• Genomics & Informatics
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• v.10 no.2
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• pp.117-122
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• 2012

A sample size with sufficient statistical power is critical to the success of genetic association studies to detect causal genes of human complex diseases. Genome-wide association studies require much larger sample sizes to achieve an adequate statistical power. We estimated the statistical power with increasing numbers of markers analyzed and compared the sample sizes that were required in case-control studies and case-parent studies. We computed the effective sample size and statistical power using Genetic Power Calculator. An analysis using a larger number of markers requires a larger sample size. Testing a single-nucleotide polymorphism (SNP) marker requires 248 cases, while testing 500,000 SNPs and 1 million markers requires 1,206 cases and 1,255 cases, respectively, under the assumption of an odds ratio of 2, 5% disease prevalence, 5% minor allele frequency, complete linkage disequilibrium (LD), 1:1 case/control ratio, and a 5% error rate in an allelic test. Under a dominant model, a smaller sample size is required to achieve 80% power than other genetic models. We found that a much lower sample size was required with a strong effect size, common SNP, and increased LD. In addition, studying a common disease in a case-control study of a 1:4 case-control ratio is one way to achieve higher statistical power. We also found that case-parent studies require more samples than case-control studies. Although we have not covered all plausible cases in study design, the estimates of sample size and statistical power computed under various assumptions in this study may be useful to determine the sample size in designing a population-based genetic association study.

• Research in Community and Public Health Nursing
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• v.33 no.4
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• pp.418-431
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• 2022

Purpose: The aims of this study were to examine the rate of depression among older adults living alone and to identify factors associated with depression in older adults living alone during the COVID-19 pandemic. Methods: A secondary data analysis was performed using data from the 2020 Korea Community Health Survey. The study participants were 18,824 older adults aged 65 years and over living alone. The data of the complex sample design was analyzed with consideration for weights, stratification, and clustering. Complex sample multiple logistic regression was conducted to identify factors associated with depression in older adults living alone during the COVID-19 pandemic. Results: The results showed that the rate of depression in older adults living alone was 6.3%. Older adults living alone with decreased physical activity, decreased hours of sleep, and an increased or similar frequency of meeting with friends or neighbors were found to be more likely to have depression. In terms of factors related to the practice of COVID-19 infection prevention and control rules, not disinfecting regularly and not wearing a mask indoors were related to depression. For health-related factors, fair or poor self-rated health status, not having breakfast every day, and feeling stressed were related to depression. Conclusion: It is recommended to develop tailored interventions to prevent depression among older adults living alone by considering the factors related to their depression during the COVID-19 pandemic.

• The Korean Journal of Applied Statistics
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• v.21 no.4
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• pp.675-694
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• 2008

We propose a new sampling design for the Korean Livestock Production Cost Survey. In this sampling design, the survey population is derived from the 2005’s agricultural census of Korea. And coefficient of variation(CV) is estimated from the current livestock production cost survey data, and the estimated CV’s are used to find the optimal sample size which satisfies the predetermined precision of estimation. In order to save the enumeration cost, the agriculture enumeration districts are used as a primary sampling unit(psu). Final sample is selected by double sampling. Also, we propose the estimator which is able to reflect the change of the population of livestock production households.

• Biotechnology and Bioprocess Engineering:BBE
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• v.8 no.4
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• pp.233-239
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• 2003

For the quantitative analysis of an unknown sample a calibration curve should be obtained, as analytical instruments give relative, rather than absolute measurements. Therefore, researchers should make standard samples with various known concentrations, measure each standard and the unknown sample, and then determine the concentration of the unknown by comparing the measured value to those of the standards. These procedures are tedious and time-consuming. Therefore, we developed a polymer based microfluidic device from polydimethylsiloxane, which integrates serial dilution and capillary electrophoresis functions in a single device. The integrated microchip can provide a one-step analytical tool, and thus replace the complex experimental procedures. Two plastic syringes, one containing a buffer solution and the other a standard solution, were connected to two inlet holes on a microchip, and pushed by a hydrodynamic force. The standard sample is serially diluted to various concentrations through the microfluidic networks. The diluted samples are sequentially introduced through microchannels by electro-osmotic force, and their laser-induced fluorescence signals measured by capillary electrophoresis. We demonstrate the integrated microchip performance by measuring the fluorescence signals of fluorescein at various concentrations. The calibration curve obtained from the electropherograms showed the expected linearity.

• Korean Journal of Computational Design and Engineering
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• v.12 no.4
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• pp.245-254
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• 2007

This research proposed feature extraction algorithms as an input of STEP Ap214 data, and feature parameterization process to simplify further design change and maintenance. The procedure starts with suppression of blend faces of an input solid model to generate its simplified model, where both constant and variable-radius blends are considered. Most existing cell decomposition algorithms utilize concave edges, and they usually require complex procedures and computing time in recomposing the cells. The proposed algorithm using reference features, however, was found to be more efficient through testing with a few sample cases. In addition, the algorithm is able to recognize depression features, which is another strong point compared to the existing cell decomposition approaches. The proposed algorithm was implemented on a commercial CAD system and tested with selected industrial product models, along with parameterization of recognized features for further design change.

• 한국데이터정보과학회:학술대회논문집
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• 2003.05a
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• pp.1-14
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• 2003

In man cases, the measurement error variances may be functions of the unknown true values or related covariate. In some cases, the measurement error variances increase in proportion to the value of predictor. This paper develops estimators of the parameters of a linear measurement error variance function under stratified multistage random sampling design and additional conditions. Also, this paper evaluates and compares the power of an asymptotically unbiased test with that of an asymptotically biased test. The proposed method are applied to blood sample measurements from the U.S. Third National Health and Nutrition Examination Survey(NHANES III)

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2003.04a
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• pp.441-447
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• 2003

In the study, we described on the 3D solid model be made on the AutoCAD haved an effect on the deviation of form as RP manufactures the facetres. The STL file improved the deviation of form as the facetres value but the deviation of form have the difference a little as the RP system. In result, we ruled the correlation with the 3D solid model and the RP sample manufacturing, with manufacture RP sample according to facetres value in complex shape. And we developed the program which recombination the STL file that we make use of the AutoLISP.

• Journal of Digital Convergence
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• v.11 no.3
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• pp.311-316
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• 2013

In order to maximize an efficient management of human cell resource under the cryogenic environments, in this paper, a middleware is introduced to support the function for multiple-perceiving RFID tags of intelligent sample case which can share medical information between sensor network devices. Optimized user interface is also designed for that. On based of the designing, special tasks required of a genetic resource working process can be processed on Complex Machine.

• Journal of the Korean Data and Information Science Society
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• v.28 no.2
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• pp.443-449
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• 2017

Estimation of population proportion like the distribution rate of LED TV and the prevalence of a disease are often estimated based on survey sample data. Population proportion is generally considered as a special form of population mean. In complex sampling like stratified multistage sampling with unequal probability sampling, the denominator of mean may be random variable and it is estimated like ratio estimator. In this research, we examined the estimation of distribution rate based on stratified multistage sampling, and determined some numerical outcomes using stratified random sample data with about 25% of missing observations. In the data used for this research, the survey weight was determined by deterministic way. So, the weights are not random variable, and the population distribution rate and its variance estimator can be estimated like population mean estimation. When the weights are not random variable, if one estimates the variance of proportion estimator using ratio method, then the variances may be inflated. Therefore, in estimating variance for population proportion, we need to examine the structure of data and survey design before making any decision for estimation methods.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.24 no.4
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• pp.374-385
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• 2015

In this paper, effective and user friendly CAM software is presented that automatically generates any three dimensional complex toolpaths according to a CAD drawing. In advanced manufacturing, often it is essential to scan the sample following a complex trajectory which consists of short (few microns) and multidirectional moves. The reported CAM software offers constant velocity for all short trajectory elements and provides an efficient shift of tool path direction in sharp corners of a tool trajectory, which is vital for any laser, based precision machining. The software also provides fast modification of tool path, automatic and efficient sequencing of path elements in a complicated tool trajectory, location of reference point and automatic fixing of geometrical errors in imported drawing exchange files (DXF) or DWG format files.