• 한국수정란이식학회지
• /
• 제15권3호
• /
• pp.203-210
• /
• 2000

The objective of this study was to identify a follicular fluid ingredient inhibiting the cumulus oocyte complex (COC) expansion. Thus, follicular fluid or liquid chromatographic fractions of follicular fluid was supplemented in COC culture medium. And COCs were incubated for 48 hours to investigate about cumulus expansion and also the first polar body extrusion. The results obtained were as follows; 1. The fluid of medium follicle significantly inhibited the COC expansion. 2. The fluid of large follicle inhibited the COC expansion. 3. Follicular fluid showed six major fractions at retention volumes (RVs) 1.83, 1.91, 2.15, 2.34, 2.53 and 2.74 ml after separation with Superose 12 column. Of the major fractions, fractions RV2.15, RV2.34, RV2.53 and RV2.74 inhibited both COC expansion and polar body extrusion. Especially, fractions of RV2.15 and RV2.53 significantly inhibited COC expansion, oocyte denudation and polar body extrusion. In conclusion, porcine follicular fluid contained a COC expansion inhibiting ingredient (CEI) that may be contained largely in fractions RV2.15 and RV2.53. And CEI may inhibit oocyte maturation by inhibition of oocyte denudation and extrusion of the first polar body.

• International Journal of Fluid Machinery and Systems
• /
• 제9권1호
• /
• pp.75-84
• /
• 2016

Fluid-dynamic design of fluid machinery had heavily relied on empiricism and experimental observations for many years. Since 1980s, thanks to the advancements in Computational Fluid Dynamics (CFD), a variety of flow physics have been revealed. The contribution by CFD is indispensable; however, the challenge is required not only on the advancements in CFD technologies but also innovation of "design (optimization) technologies" because of the complex interactions between 3-D flow fields and the complex 3-D flow passage configurations, etc. This paper presents historical perspective on fluid machinery flow optimization in an industry with some messages for the future.

• Structural Engineering and Mechanics
• /
• 제41권4호
• /
• pp.559-573
• /
• 2012

An adaptive modeling and simulation technique is introduced for the effective and reliable fluid-structure interaction analysis using MSC/Dytran for large-scale complex pressurized liquid containment. The proposed method is composed of a series of the global rigid sloshing analysis and the locally detailed fluid-structure analysis. The critical time at which the system exhibits the severe liquid sloshing response is sought through the former analysis, while the fluid-structure interaction in the local region of interest at the critical time is analyzed by the latter analysis. Differing from the global coarse model, the local fine model considers not only the complex geometry and flexibility of structure but the effect of internal pressure. The locally detailed FSI problem is solved in terms of multi-material volume fractions and the flow and pressure fields obtained by the global analysis at the critical time are specified as the initial conditions. An in-house program for mapping the global analysis results onto the fine-scale local FSI model is developed. The validity and effectiveness of the proposed method are verified through an illustrative numerical experiment.

• KIEAE Journal
• /
• 제8권4호
• /
• pp.37-42
• /
• 2008

In the case that high-rise building is constructed, the surrounding wind velocity increase more than 50~100%. From this cause, many wind environmental problems can be occurred. For example, ordinary wind environmental disaster may be occurred in a region, or walking disturbed. In developed countries including USA, EU, and Japan, many efforts have been made for building wind prevention by grasping previously the effects before building constructed. But, We are bearing risk of wind environmental disaster because we have not enough recognition about building wind, and have not architectural prevention counterplans. This study aims to examine wind environmental characteristics of domestic apartment complex, and effective architectural counterplans. As the basic stage for this, we investigated pre-estimate tools and risk assessment methods of building wind in apartment complex, applied to two apart complex in Cheon-An region by CFD. As the result, serious damages were not presented. But, it is obvious that various architectural counterplans will be presented by this example researches.

• Nuclear Engineering and Technology
• /
• 제51권1호
• /
• pp.31-44
• /
• 2019

This study simulated a control rod assembly (CRA), which is a part of reactor shutdown systems, in immersed and fluid flow conditions. The CRA was inserted into the reactor core within a predetermined time limit under normal and abnormal operating conditions, and the CRA (which consists of complex geometric shapes) drop behavior is numerically modeled for simulation. A full-scale prototype CRA drop test is established under room temperature and water-fluid conditions for verification and validation. This paper describes the details of the numerical modeling and analysis results of the several conditions. Results from the developed numerical simulation code are compared with the test results to verify the numerical model and developed computer code. The developed code is in very good agreement with the test results and this numerical analysis model and method may replace the experimental and CFD method to predict the drop behavior of CRA.

• 대기
• /
• 제21권1호
• /
• pp.95-108
• /
• 2011

The effects of an apartment complex on flow and pollutant dispersion in an urban area are numerically investigated using a computational fluid dynamics (CFD) model. The CFD model is based on the Reynolds-averaged Navier-Stokes equations and includes the renormalization group k-${\varepsilon}$ turbulence model. The geographic information system (GIS) data is used as an input data of the CFD model. Eight numerical simulations are carried out for different inflow directions and, for each inflow direction, the effects of an apartment complex are investigated, comparing the characteristics of flow and dispersion before and after construction of the apartment complex in detail. The observation data of automatic weather system (AWS) is analyzed. The windrose analysis shows that the wind speed and direction after the construction of the complex are quite different from those before the construction. The construction of the apartment complex resulted in the decrease in wind speed at the downwind region. It is also shown that the wind speed increased partially inside the apartment complex due to the channeling effect to satisfy the mass continuity. On the whole, the wind speed decreased at the downwind region due to the drag effect by the apartment complex. As a result, the passive pollutant concentration increased (decreased) near the downwind region of (within) the apartment complex compared with that before the construction.

• 대한본초학회지
• /
• 제28권6호
• /
• pp.95-100
• /
• 2013

Objectives : The purpose of this study was to investigate antiaging and antioxidant effects on cultured human skin fibroblast with supercritical fluid extracts of Dendropanax morbifera, Corni fructus and Lycii Fructus. Methods : Supercritical fluid extraction (SFE) technique was applied to extract from three medicinal plants including stem of Dendropanax morbifera, Corni fructus and Lycii Fructus. Antioxidant activity of extract was evaluated by two different assays as 2,2-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and super oxide dismutase (SOD) like activities. These extracts were tested for cell viability on HS68 skin fibroblast by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay. We investigated the effects of Ultraviolet-B irradiation on cytotoxicity, type 1 collagen, elastin level and oxidative damage in cultured human skin fibroblast (HS68). Recently, many studies have reported that elastin is also involved in inhibiting or repairing wrinkle formation, although collagen is a major factor in the skin wrinkle formation. Results : The extracts obtained dose-dependently increased the scavenging activity on DPPH radical scavenging activity and SOD like activity. The supercritical fluid extracts of complex herbal medicine showed low cytotoxicity as more than 100% cell viability in 100ppm/ml concentration. HS68 fibroblasts were survived 70% at $120mJ/cm^2$ UVB irradiation and treated tumor necrosis factor (TNF)-alpha. The levels of aging factors and cytotoxicity were decreased by supercritical fluid extract of complex herbal medicine. Conclusions : These results suggest that supercritical fluid extracts may have value as the potential antioxidant and antiaging medicinal plant.

• 한국전산응용수학회:학술대회논문집
• /
• 한국전산응용수학회 2003년도 KSCAM 학술발표회 프로그램 및 초록집
• /
• pp.1-1
• /
• 2003

In this talk, a reduced-order modeling methodology based on centroidal Voronoi tessellations (CVT's)is introduced. CVT's are special Voronoi tessellations for which the generators of the Voronoi diagram are also the centers of mass (means) of the corresponding Voronoi cells. The discrete data sets, CVT's are closely related to the h-means clustering techniques. Even with the use of good mesh generators, discretization schemes, and solution algorithms, the computational simulation of complex, turbulent, or chaotic systems still remains a formidable endeavor. For example, typical finite element codes may require many thousands of degrees of freedom for the accurate simulation of fluid flows. The situation is even worse for optimization problems for which multiple solutions of the complex state system are usually required or in feedback control problems for which real-time solutions of the complex state system are needed. There hava been many studies devoted to the development, testing, and use of reduced-order models for complex systems such as unsteady fluid flows. The types of reduced-ordered models that we study are those attempt to determine accurate approximate solutions of a complex system using very few degrees of freedom. To do so, such models have to use basis functions that are in some way intimately connected to the problem being approximated. Once a very low-dimensional reduced basis has been determined, one can employ it to solve the complex system by applying, e.g., a Galerkin method. In general, reduced bases are globally supported so that the discrete systems are dense; however, if the reduced basis is of very low dimension, one does not care about the lack of sparsity in the discrete system. A discussion of reduced-ordering modeling for complex systems such as fluid flows is given to provide a context for the application of reduced-order bases. Then, detailed descriptions of CVT-based reduced-order bases and how they can be constructed of complex systems are given. Subsequently, some concrete incompressible flow examples are used to illustrate the construction and use of CVT-based reduced-order bases. The CVT-based reduced-order modeling methodology is shown to be effective for these examples and is also shown to be inexpensive to apply compared to other reduced-order methods.

• 대한기계학회논문집B
• /
• 제20권9호
• /
• pp.2953-2964
• /
• 1996

왕복유동에 의한 순간 열전달현상은, 왕복유동의 두가지 특성인 왕복주파수와 왕복거리를 나타내는 .betha.와 .gamma.에 의하여 결정되고, 그 특성에 따라 세영역으로 나누어짐을 확인하였다. 영역 I에서는 일방향유동에서와 마찬가지로 열유속이 평균온도차에 비례하고, 영역 II에서는 열유속과 평균온도차간에 약 45.deg.의 위상차가 발생하지만 모두 1차 조화성분이 주로 나타났다. 한편 영역 III의 경우에는 위상차가 생길뿐만 아니라 평균온도차에 고차 조화성분이 나타났다. 기존의 방법인 복소 Nusselt수를 고차 조화성분까지 확장하면 열유속을 평균온도차로 나타낼 수 있지만 각 조화성분의 정보를 다 알아야하므로 실제 적용이 불가능하였다.

• 한국정밀공학회:학술대회논문집
• /
• 한국정밀공학회 2005년도 춘계학술대회 논문집
• /
• pp.464-467
• /
• 2005

Among several polishing techniques for micro structures, polishing process using magnetorheological(MR) fluid has advantages in the finishing process of 3-D micro structures because abrasives in the fluid can reach surfaces with complex feature and play their role. Although many researchers have been trying to reveal its polishing mechanism of the MR polishing, it has not been successful because in-situ measurement of state variables is difficult and process parameters are complex. In fact, one of the key factors for applying process control methodologies, such as Run-to-Run control, is the measuring and monitoring of slurry quality because the process strongly depends on the fluid property. Therefore, it is necessary to maintain consistent slurry quality to guarantee the process repeatability. The proposed equipment achieves the longer life cycle of MR fluid and reduces the variability of products. A new method to measure the material removal rate in MRF polishing process is also proposed and discussed.